Hotels in Sanctuary

Free cancellation options if plans change

Earn rewards on every night you stay

Save more with Member Prices

Check prices for these dates

Tonight
Oct 17 - Oct 18
Tomorrow
Oct 18 - Oct 19
Next weekend
Oct 23 - Oct 25
In two weeks
Oct 30 - Nov 1

Where to stay in Sanctuary?

A beachfront hotel with a central entrance, outdoor seating, and palm trees.
A restaurant with multiple tables and chairs, large windows with a view of the ocean, and hanging pendant lights.
A beach with palm trees, string lights, and beach chairs.
A beachside restaurant with outdoor seating, a pool area, and palm trees.

1. South Seas

South Seas
5.5 km from Sanctuary
United States
Jarrett
$202
$341 total
includes taxes & fees
Nov 11 - Nov 12
South Seas
A resort with a central pool, multiple lounge areas, and a beach view.
A table set for dining with a view of the sunset over the ocean.
A sandy pathway leading to a beach with palm trees and a clear sky.
A hotel room with a bed, a desk, a TV, a ceiling fan, and a view of the outdoors.

2. Tween Waters Island Resort & Spa

Tween Waters Island Resort & Spa
3.7 km from Sanctuary
United States
Nicholas J
$215
$275 total
includes taxes & fees
Oct 28 - Oct 29
Tween Waters Island Resort & Spa
A balcony with a wooden table and chairs, a hanging chair, and a view of palm trees and a pool.
A modern kitchen with grey cabinets, a stainless steel refrigerator, a microwave, and a sink. There is a painting of a flamingo on the wall.
A resort with a pool, thatched umbrellas, and palm trees.
A beachfront hotel with palm trees, a sandy walkway, and a pool.

3. Off the Charts Inn & Out Island Resort

Off the Charts Inn & Out Island Resort
8.8 km from Sanctuary
United States
Catherine
$179
$234 total
includes taxes & fees
Oct 22 - Oct 23
Off the Charts Inn & Out Island Resort
A beach with a variety of seashells and pebbles.
A landscaped area with palm trees and a view of the ocean.
A hotel room with a bed, a view of the beach, and a window with curtains.
A pool area with lounge chairs and a building with a red roof.

4. Sanibel Island Beach Resort

Sanibel Island Beach Resort
Mid Island, 13.1 km from Sanctuary
United States
Cary
$179
$227 total
includes taxes & fees
Oct 18 - Oct 19
Sanibel Island Beach Resort
A hotel pool area with multiple lounge chairs and umbrellas, surrounded by a fence and palm trees.
A modern lobby with a white brick wall, a flat-screen TV, and colorful abstract paintings. There are several seating areas with different styles of chairs.
A spacious indoor dining area with high ceilings, large windows, and modern orange chairs and white tables.
A modern lobby with a fireplace, seating area, and artwork.

5. La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
19.9 km from Sanctuary
United States
Carol
$72
$80 total
includes taxes & fees
Oct 26 - Oct 27
La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
A spacious dining area with multiple tables and chairs, large windows, and a modern chandelier.
A swimming pool area with lounge chairs, a small building, and a basketball court surrounded by palm trees and greenery.
A hotel room with two beds, a large mirror, and a view of the outdoors.
A hotel lobby with a reception desk, seating area, and a large window.

6. Residence Inn by Marriott Fort Myers Sanibel

Residence Inn by Marriott Fort Myers Sanibel
19.3 km from Sanctuary
United States
Benjamin
$86
$96 total
includes taxes & fees
Oct 18 - Oct 19
Residence Inn by Marriott Fort Myers Sanibel
A beach with a view of the ocean and a sunset.
A covered outdoor area with a table and chairs, a ceiling fan, and a view of a beach with palm trees and a boat.
A modern kitchen with wooden cabinets, a stainless steel refrigerator, and a dining area with white chairs and a table.
A modern living room with a sofa, chairs, and a dining table. There is a kitchen area with cabinets and appliances.

7. Island Inn

Island Inn
West End, 9.6 km from Sanctuary
United States
Andrew
$280
$312 total
includes taxes & fees
Oct 30 - Oct 31
Island Inn
A balcony with a table and chairs, large windows, and a view of the sea.
A swimming pool with clear blue water, surrounded by lounge chairs and umbrellas, and a building with a tiled roof.
Spa
A spacious living area with a high ceiling, a ceiling fan, a pool table, and a view of the outdoors.

8. The Westin Cape Coral Resort At Marina Village

The Westin Cape Coral Resort At Marina Village
18.1 km from Sanctuary
United States
jessica
$146
$208 total
includes taxes & fees
Oct 25 - Oct 26
The Westin Cape Coral Resort At Marina Village
A waterfront hotel with multiple buildings, a dock, and a calm body of water reflecting the structures.
A spacious lobby with a staircase, large windows, and a chandelier.
A resort pool area with a large pool, lounge chairs, and umbrellas.
A spacious living area with wicker furniture, a chandelier, and large windows offering a view of palm trees and a balcony.

9. Marriott Sanibel Harbour Resort & Spa

Marriott Sanibel Harbour Resort & Spa
15.6 km from Sanctuary
United States
Matthew
$223
$284 total
includes taxes & fees
Nov 1 - Nov 2
Marriott Sanibel Harbour Resort & Spa
A hotel room with two beds, a wooden headboard, a nightstand with a lamp, and a window with curtains.
A coffee station with two coffee machines, a coffee press, and various coffee cups and containers.
A breakfast station with a bakery section and a display for breakfast items.
A modern hotel room with a wooden desk, a flat-screen TV, a chair, a wardrobe, and a framed picture on the wall.

10. Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Holiday Inn Express Cape Coral-Fort Myers Area by IHG
23.9 km from Sanctuary
United States
Shannon
$100
$112 total
includes taxes & fees
Oct 21 - Oct 22
Holiday Inn Express Cape Coral-Fort Myers Area by IHG
Living area
Room
Dining
A kitchen with white cabinets, a microwave, a sink, and a green refrigerator.

11. The Anchor Inn

The Anchor Inn
Mid Island, 12.8 km from Sanctuary
United States
Ricardo E
$142
$174 total
includes taxes & fees
Oct 19 - Oct 20
The Anchor Inn
A modern hotel lobby with a seating area, a reception desk, and a dining area.
A reception desk with a "Welcome to the Sun Shine State" sign, a wooden wall, and a minibar.
A modern hotel room with a flat-screen TV mounted on a wooden console, a microwave, a small sink, and a yellow chair.
A hotel room with a bed, a desk, a chair, a TV, and a mirror.

12. Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL

Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL
22.6 km from Sanctuary
United States
Amy
$93
$103 total
includes taxes & fees
Oct 25 - Oct 26
Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL
A modern living room with a TV, dining table, and chairs. There is a balcony with a view of palm trees.
A wooden pathway leading to a beach with a clear view of the ocean.
A large, two-story house with a wrap-around porch and a steeply pitched roof.
A well-maintained garden with a wooden deck, palm trees, and a building in the background.

13. Casa Ybel Resort

Casa Ybel Resort
Ybel, 11.6 km from Sanctuary
United States
Juan
$238
$265 total
includes taxes & fees
Oct 18 - Oct 19
Casa Ybel Resort
A pathway flanked by palm trees and wooden buildings with thatched roofs.
A clear blue pool with lounge chairs and umbrellas, surrounded by palm trees and a thatched-roof structure.
A hotel room with a bed, a television, a desk, a chair, and a ceiling fan.
A compact kitchen with a stainless steel refrigerator, a microwave, a coffee maker, and a sink.

14. Kona Kai Motel

Kona Kai Motel
Mid Island, 12.2 km from Sanctuary
United States
Paloma
$179
$206 total
includes taxes & fees
Oct 19 - Oct 20
Kona Kai Motel
An outdoor seating area with tables and chairs, surrounded by palm trees and a thatched-roof structure.
A bar with multiple liquor bottles and a large American flag in the background.
A lobby with a mural of dolphins, seating area, and a reception desk.
A nighttime view of a bar with a pool in front.

15. Dolphin Key Resort

Dolphin Key Resort
23.8 km from Sanctuary
United States
Patrick
$95
$106 total
includes taxes & fees
Nov 9 - Nov 10
Dolphin Key Resort
A spacious living room with a grey sofa, striped armchair, and a woven coffee table. Large windows offer a view of a tropical garden.
A modern living room with a sofa, a coffee table, and a dining area with a table and chairs.
A garden with a thatched-roof structure, palm trees, and a gravel path.
A bedroom with a bed, nightstands, a ceiling fan, a window with a view of greenery, and a sliding glass door.

16. Driftwood Inn

Driftwood Inn
Mid Island, 13.1 km from Sanctuary
United States
Heather
$216
$482 total
includes taxes & fees
Oct 18 - Oct 19
Driftwood Inn
A pathway leading to a pool area with lounge chairs and umbrellas, surrounded by tropical plants and a thatched-roof structure.
A spacious bar area with wooden flooring and ceiling fans, featuring a central bar counter and multiple seating options.
A swimming pool area with lounge chairs and palm trees, surrounded by buildings and a sunset view.
A wooden boardwalk leading to a beach with greenery on both sides.

17. Sanibel Inn

Sanibel Inn
East End, 13.8 km from Sanctuary
United States
Heather
$335
$437 total
includes taxes & fees
Nov 16 - Nov 17
Sanibel Inn
A row of turquoise Adirondack chairs with umbrellas, a wooden deck, and a marina in the background.
A room with a large aquarium, a dining table with chairs, a refrigerator, and a wall-mounted TV displaying a resort advertisement.
A covered outdoor area with a boat-shaped planter filled with plants, surrounded by rocks and palm trees.
A marina with rows of blue Adirondack chairs under turquoise umbrellas, wooden docks, and boats.

18. Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

Latitude 26 Waterfront Boutique Resort - Fort Myers Beach
21.5 km from Sanctuary
United States
Jorge
$97
$108 total
includes taxes & fees
Oct 18 - Oct 19
Latitude 26 Waterfront Boutique Resort - Fort Myers Beach
Room
Outdoor pool
Check-in/check-out kiosk
Exterior

19. Fountain Cottages Inn

Fountain Cottages Inn
24.2 km from Sanctuary
United States
Lisa
$28
$137 total
includes taxes & fees
Oct 21 - Oct 22
Fountain Cottages Inn
An outdoor patio with tables and chairs, umbrellas, and a pool in the background.
A swimming pool with lounge chairs and palm trees.
A modern reception desk with a digital display, a cash register, and a customer service counter.
A modern indoor space with a large table, chairs, and a television.

20. Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG
23.1 km from Sanctuary
United States
Phillip
$96
$107 total
includes taxes & fees
Oct 21 - Oct 22
Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG
View all properties
Our prices for hotels in Sanibel are cheapest in October
Price trends for hotels in Sanibel
Pricing is based on two traveler single night rates
View properties in October
Typical weather for Sanibel
October
High 29°C / low 23°C. Sunny most days.
View properties in October
29°
23°
25°
20°
23°
18°
21°
15°
23°
17°
24°
18°
27°
21°
29°
23°
30°
26°
31°
27°
31°
27°
30°
26°
Monthly weather averages (˚C)

Check out reviews of Sanctuary hotels guests love

Lani Kai Beachfront Resort

Lani Kai Beachfront Resort

10/10 Excellent
"It was great with anything you want to food music jet ski and many other things to get into"
Robert 1-night trip
Posted 2 hours ago
Lani Kai Beachfront Resort
Sanibel Island Beach Resort

Sanibel Island Beach Resort

10/10 Excellent
"No elevator. Limited menu in restaurant. Great room. Clean. Comfortable bed. It was close to a lot of nice restaurants and the the shell 🐚 museum which is a m i"
Cindy 7-night trip
Posted 3 hours ago
Sanibel Island Beach Resort
La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

10/10 Excellent
"Everything was clean and breakfast was excellent. The downfall was we were looking forward to the hot tub. Whirl pool. It was shut down. We have been coming here for 29 years and always looked forward to it.. it’s a shame it is broken. It is advertised on the website."
Catina 1-night trip
Posted 6 hours ago
La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
The Lighthouse Resort Inn & Suites

The Lighthouse Resort Inn & Suites

10/10 Excellent
"Great pool, bar and location ."
Thomas 1-night trip
Posted 9 hours ago
The Lighthouse Resort Inn & Suites
Sundial Beach Resort & Spa

Sundial Beach Resort & Spa

8/10 Good
"Gotta get rid of the sand chiggers."
Jelani 1-night trip
Posted 20 hours ago
Sundial Beach Resort & Spa
The Westin Cape Coral Resort At Marina Village

The Westin Cape Coral Resort At Marina Village

10/10 Excellent
"Good"
Yunely 2-night trip
Posted 21 hours ago
The Westin Cape Coral Resort At Marina Village
Hilton Garden Inn Ft Myers

Hilton Garden Inn Ft Myers

8/10 Good
"Front desk staff “Gabby” very helpful very kind"
Carol 1-night trip
Posted 1 day ago
Hilton Garden Inn Ft Myers
Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

10/10 Excellent
"Na"
Zhear 5-night trip
Posted 2 days ago
Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway
Candlewood Suites Fort Myers Sanibel Gateway by IHG

Candlewood Suites Fort Myers Sanibel Gateway by IHG

10/10 Excellent
"Excellent"
arlene 2-night trip
Posted 5 days ago
Candlewood Suites Fort Myers Sanibel Gateway by IHG
Find out more about Sanctuary

Keep exploring