Hotels in Sanctuary

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A spacious kitchen with a large island, white cabinetry, and a view through the windows.

A bunk bed room with a ceiling fan, a patterned rug, and a dresser with drawers.

A spacious living room with a ceiling fan, a dining area, and a kitchen in the background.

1. South Seas

5.5 km from Sanctuary

Jarrett

$202

$341 total

includes taxes & fees

Nov 11 - Nov 12

A resort with a central pool, multiple lounge areas, and a beach view.

A sandy pathway leading to a beach with palm trees and a clear sky.

A hotel room with a bed, a desk, a TV, a ceiling fan, and a view of the outdoors.

A covered porch with a view of the sea, a white railing, and two Adirondack chairs.

2. Tween Waters Island Resort & Spa

3.7 km from Sanctuary

Nicholas J

$287

$355 total

includes taxes & fees

Nov 9 - Nov 10

A resort with multiple-story buildings, palm trees, and a well-maintained lawn.

A pool area with lounge chairs and a building with a red roof.

A beach with a variety of seashells and pebbles.

A hotel room with a bed, a view of the beach, and a window with curtains.

3. Sanibel Island Beach Resort

Mid Island, 13.1 km from Sanctuary

Cary

$179

$227 total

includes taxes & fees

Oct 25 - Oct 26

A balcony with a wooden table and chairs, a hanging chair, and a view of palm trees and a pool.

A modern kitchen with grey cabinets, a stainless steel refrigerator, a microwave, and a sink. There is a painting of a flamingo on the wall.

A resort with a pool, thatched umbrellas, and palm trees.

A beachfront hotel with palm trees, a sandy walkway, and a pool.

4. Off the Charts Inn & Out Island Resort

8.8 km from Sanctuary

Catherine

$179

$234 total

includes taxes & fees

Oct 26 - Oct 27

A covered outdoor area with a table and chairs, a ceiling fan, and a view of a beach with palm trees and a boat.

A multi-story hotel with a central entrance, balconies, and palm trees.

A beach with a view of the ocean and a sunset.

A modern kitchen with wooden cabinets, a stainless steel refrigerator, and a dining area with white chairs and a table.

5. Island Inn

West End, 9.6 km from Sanctuary

Andrew

$280

$312 total

includes taxes & fees

Oct 31 - Nov 1

A hotel pool area with multiple lounge chairs and umbrellas, surrounded by a fence and palm trees.

A reception area with a beach view mural, a staircase, and a reception desk.

A modern lobby with a white brick wall, a flat-screen TV, and colorful abstract paintings. There are several seating areas with different styles of chairs.

A spacious indoor dining area with high ceilings, large windows, and modern orange chairs and white tables.

6. La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

19.9 km from Sanctuary

Carol

$72

$80 total

includes taxes & fees

Oct 28 - Oct 29

A balcony with a table and chairs, large windows, and a view of the sea.

An outdoor seating area with round tables and pink cushions, palm trees, and string lights against a twilight sky.

A spacious living area with a high ceiling, a ceiling fan, a pool table, and a view of the outdoors.

7. The Westin Cape Coral Resort At Marina Village

18.1 km from Sanctuary

jessica

$146

$208 total

includes taxes & fees

Nov 15 - Nov 16

A waterfront hotel with multiple buildings, a dock, and a calm body of water reflecting the structures.

A table set for two on a beach with a view of the sea and distant islands.

A resort pool area with a large pool, lounge chairs, and umbrellas.

A spacious lobby with a staircase, large windows, and a chandelier.

8. Marriott Sanibel Harbour Resort & Spa

15.6 km from Sanctuary

Matthew

$207

$266 total

includes taxes & fees

Nov 4 - Nov 5

A spacious dining area with multiple tables and chairs, large windows, and a modern chandelier.

A modern hotel room with a large bed, two armchairs, a small side table with a lamp, and a large window with blinds.

A swimming pool area with lounge chairs, a small building, and a basketball court surrounded by palm trees and greenery.

A hotel lobby with a reception desk, seating area, and a large window.

9. Residence Inn by Marriott Fort Myers Sanibel

19.3 km from Sanctuary

Benjamin

$94

$105 total

includes taxes & fees

Oct 25 - Oct 26

A boat-shaped deck chair with cushions, positioned on a wooden deck with a white fence.

A kitchen with white cabinets, a microwave, a sink, and a green refrigerator.

10. The Anchor Inn

Mid Island, 12.8 km from Sanctuary

Ricardo E

$142

$174 total

includes taxes & fees

Oct 27 - Oct 28

A spacious lobby with a high ceiling, a seating area with a sofa and chairs, a small round table, and a decorative wall with artwork.

A swimming pool with lounge chairs and palm trees, surrounded by a building with a red roof and multiple windows.

A spacious dining area with multiple tables and chairs, a flat-screen TV mounted on the wall, and artwork on the walls.

A reception desk with a wooden panel design, a welcome sign for 'Sunshine State', and a motivational rug on the floor.

11. Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

22.9 km from Sanctuary

Felicia

$78

$87 total

includes taxes & fees

Oct 29 - Oct 30

A modern living room with a TV, dining table, and chairs. There is a balcony with a view of palm trees.

A well-maintained garden with a wooden deck, palm trees, and a building in the background.

A wooden pathway leading to a beach with a clear view of the ocean.

A large, two-story house with a wrap-around porch and a steeply pitched roof.

12. Casa Ybel Resort

Ybel, 11.6 km from Sanctuary

Juan

$238

$265 total

includes taxes & fees

Oct 25 - Oct 26

A pathway flanked by palm trees and wooden buildings with thatched roofs.

A compact kitchen with a stainless steel refrigerator, a microwave, a coffee maker, and a sink.

A thatched-roof structure with outdoor seating, surrounded by palm trees and a wooden deck.

A clear blue pool with lounge chairs and umbrellas, surrounded by palm trees and a thatched-roof structure.

13. Kona Kai Motel

Mid Island, 12.2 km from Sanctuary

Paloma

$179

$206 total

includes taxes & fees

Oct 26 - Oct 27

An outdoor patio with tables and chairs, umbrellas, and a pool in the background.

A swimming pool with lounge chairs and palm trees.

A modern reception desk with a digital display, a cash register, and a customer service counter.

A modern indoor space with a large table, chairs, and a television.

14. Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

23.1 km from Sanctuary

Phillip

$84

$94 total

includes taxes & fees

Oct 25 - Oct 26

A covered patio with tiled flooring, wooden lounge chairs, and a small table.

A grassy yard with palm trees and a wooden fence.

A modern living room with a grey sofa, a small table, and a TV mounted on the wall.

15. White Orchid Apartments

20 km from Sanctuary

Laura

$65

$105 total

includes taxes & fees

Oct 23 - Oct 24

A resort with multiple buildings featuring blue roofs, a beach, and a clear view of the ocean.

A hotel room with a large bed, a desk, a chair, and a view of the beach through the window.

A modern room with a large sliding glass door leading to a balcony with a view of the beach. There is a white sofa, a small table, and a white desk with a chair.

A pool area with lounge chairs and umbrellas, a wooden deck, and a view of the beach and ocean.

16. Shalimar Beach Resort

West End, 10.3 km from Sanctuary

Martha

$349

$389 total

includes taxes & fees

Oct 25 - Oct 26

A sign for Sunshine Island Inn with a palm tree and beach scene.

A hotel room with a bed, a TV, a desk with chairs, a kitchenette, and a sliding glass door to a pool area.

A living room with a sofa, chairs, a wooden table, a ceiling fan, and a kitchen area with a refrigerator and sink.

A poolside area with lounge chairs and umbrellas, surrounded by palm trees and a white fence.

17. Sunshine Island Inn

East End, 14.3 km from Sanctuary

Benjamin

$199

$229 total

includes taxes & fees

Oct 23 - Oct 24

A modern living room with a flat-screen TV, a floor lamp, a dining table, and a sofa.

Two grey armchairs with red cushions, a floor lamp, and a window with blinds.

A modern bedroom with a bed, two bedside tables with lamps, a small table with a vase, two armchairs, and a painting on the wall.

A dining area with a table set for two, a television mounted on the wall, and a sliding glass door leading to a balcony.

18. Lazy Cuckoo Inn

22.1 km from Sanctuary

Richard

$59

$98 total

includes taxes & fees

Oct 23 - Oct 24

A beachside area with colorful Adirondack chairs, a fire pit, and a view of the water.

A bedroom with a large bed, a TV mounted on the wall, two bedside tables with lamps, and a window with blinds.

A modern kitchen with white cabinets, granite countertops, a built-in oven, and a microwave.

A living room with two sofas, a coffee table, a ceiling fan, a TV, and a cabinet.

19. Matlacha on Shoreview

20.2 km from Sanctuary

Jacquelyn

$60

$134 total

includes taxes & fees

Oct 25 - Oct 26

An outdoor seating area with tables and chairs, surrounded by palm trees and a thatched-roof structure.

A lobby with a mural of dolphins, seating area, and a reception desk.

A nighttime view of a bar with a pool in front.

A bar with multiple liquor bottles and a large American flag in the background.

20. Dolphin Key Resort

23.8 km from Sanctuary

Patrick

$94

$105 total

includes taxes & fees

Nov 22 - Nov 23

View all properties

Compare popular hotels in Sanctuary

Property	Property class	Guest rating
Tween Waters Island Resort & Spa	8.6 Excellent 1,000 reviews	View
Shalimar Beach Resort	9.8 Exceptional 108 reviews	View
South Seas	8.4 Very good 1,003 reviews	View
Sanibel Island Beach Resort	9.2 Wonderful 2,375 reviews	View
Island Inn	9.4 Exceptional 1,164 reviews	View

Our prices for hotels in Sanibel are cheapest in October

Check out reviews of Sanctuary hotels guests love

Holiday Inn Express Cape Coral-Fort Myers Area by IHG

10/10 Excellent

"Excellent hotel if you want to stay there for a few days"

Sanibel Island Beach Resort

10/10 Excellent

"Easy check in and check out. Steps from the beach. Very clean. Comfortable beds."

Pink Shell Beach Resort and Marina

10/10 Excellent

"Loved the time there, want to return again!"

Edison Beach House

8/10 Good

"Nice room on the beach, nice to have laundry in room"

Margaritaville Beach Resort Fort Myers

10/10 Excellent

"Great atmosphere I love all the music"

DiamondHead Beach Resort

10/10 Excellent

"excellent place will stay again!"

Hilton Garden Inn Ft Myers

10/10 Excellent

"I stay often in Fort Myers (family), this is 1st at Garden Inn, I will definitely stay here in the future. Everything was immaculate, staff is friendly and ever so helpful. The rates were less than what I had been paying for someplace a few mins closer to the family. Discovered Garden Inn was <5 mins further, worth the extra few mins at less the cost. We ordered a breakfast to take to our room, cooked to order and plentiful."

The Westin Cape Coral Resort At Marina Village

10/10 Excellent

"Very clean and nice place!"

Sundial Beach Resort & Spa

8/10 Good

"Gotta get rid of the sand chiggers."

Find out more about Sanctuary

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Hotels in Sanctuary

Room 1

Free cancellation options if plans change

Earn rewards on every night you stay

Save more with Member Prices

Check prices for these dates

Where to stay in Sanctuary?

1. South Seas

2. Tween Waters Island Resort & Spa

3. Sanibel Island Beach Resort

4. Off the Charts Inn & Out Island Resort

5. Island Inn

6. La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

7. The Westin Cape Coral Resort At Marina Village

8. Marriott Sanibel Harbour Resort & Spa

9. Residence Inn by Marriott Fort Myers Sanibel

10. The Anchor Inn

11. Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

12. Casa Ybel Resort

13. Kona Kai Motel

14. Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

15. White Orchid Apartments

16. Shalimar Beach Resort

17. Sunshine Island Inn

18. Lazy Cuckoo Inn

19. Matlacha on Shoreview

20. Dolphin Key Resort

Compare popular hotels in Sanctuary

Typical weather for Sanibel

Check out reviews of Sanctuary hotels guests love

Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Sanibel Island Beach Resort

Pink Shell Beach Resort and Marina

Edison Beach House

Margaritaville Beach Resort Fort Myers

DiamondHead Beach Resort

Hilton Garden Inn Ft Myers

The Westin Cape Coral Resort At Marina Village

Sundial Beach Resort & Spa

Keep exploring

Hotels in Sanctuary

Free cancellation options if plans change

Earn rewards on every night you stay

Save more with Member Prices

Check prices for these dates

Where to stay in Sanctuary?

1. South Seas

2. Tween Waters Island Resort & Spa

3. Sanibel Island Beach Resort

4. Off the Charts Inn & Out Island Resort

5. Island Inn

6. La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

7. The Westin Cape Coral Resort At Marina Village

8. Marriott Sanibel Harbour Resort & Spa

9. Residence Inn by Marriott Fort Myers Sanibel

10. The Anchor Inn

11. Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

12. Casa Ybel Resort

13. Kona Kai Motel

14. Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

15. White Orchid Apartments

16. Shalimar Beach Resort

17. Sunshine Island Inn

18. Lazy Cuckoo Inn

19. Matlacha on Shoreview

20. Dolphin Key Resort

Compare popular hotels in Sanctuary

Price trends for hotels in Sanibel

Typical weather for Sanibel

Check out reviews of Sanctuary hotels guests love

Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Sanibel Island Beach Resort

Pink Shell Beach Resort and Marina

Edison Beach House

Margaritaville Beach Resort Fort Myers

DiamondHead Beach Resort

Hilton Garden Inn Ft Myers

The Westin Cape Coral Resort At Marina Village

Sundial Beach Resort & Spa

Keep exploring