Hotels in Southern Illinois

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Tonight
May 23 - May 24
Tomorrow
May 24 - May 25
This weekend
May 23 - May 25
Next weekend
May 30 - Jun 1

Where to stay in Southern Illinois?

Drury Plaza Hotel Mt. Vernon
Lobby

Drury Plaza Hotel Mt. Vernon

3.0 star property
9.6 out of 10, Exceptional, (1322)
The price is $94
$106 total
includes taxes & fees
Jun 22 - Jun 23
Drury Plaza Hotel Mt. Vernon
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Great weekend hotel deals in Southern Illinois, IL

Showing deals for:Jun 6 - Jun 8

Image gallery for Makanda Inn

Front of property - evening/night

Makanda Inn

3.5 star property
Makanda
10/10Exceptional (32 reviews)
10% off
Price is $493
$216 nightly
$493 total
Total includes taxes and fees
Makanda Inn

Top landmarks in Southern Illinois

Campus Lake at Southern Illinois University in Carbondale, IL.

Southern Illinois University

Take a campus tour or just explore the area of Southern Illinois University, during your trip to Carbondale. Check out the shops and top-notch restaurants in this family-friendly area.

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Southern Illinois University

Learn more about Southern Illinois

Southern Illinois is applauded for its entertainment and live music with such cultural attractions as Effingham Performance Center and Popeye Museum. Visitors highlight this family-friendly city's sports while sights include Jefferson County Fairgrounds and Salem Fairgrounds.

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Southern Illinois showing forest scenes, a sunset and landscape views
Photo by Southernmost Illinois Tourism Bureau
Open Photo by Southernmost Illinois Tourism Bureau

Frequently asked questions

Can I book refundable hotels in Southern Illinois?
If you want the flexibility to change your travel plans to Southern Illinois, most accommodations offer refundable* bookable rates. You can find these accommodations by searching our site and using the “fully refundable” filter to narrow down the results.
Where can I stay in Southern Illinois if I want a vacation home instead of a traditional hotel?
If you’re looking for a good alternative to a hotel, review our selection of 261 vacation homes. In addition, there are 77 apartments and 6 condos.
Why should I book my Southern Illinois hotel through Hotels.com?
There are plenty of reasons to book your Southern Illinois travel with us: our free cancellations on selected hotels* gives you the flexibility you’re looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.