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Hotels in Cape Girardeau

October 2026
November 2026

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This weekend
Sep 25 - Sep 27
Next weekend
Oct 2 - Oct 4

Where to stay in Cape Girardeau?

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.
An indoor swimming pool with clear blue water, surrounded by beige walls and large windows.
A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.
A spacious corridor with a high ceiling, recessed lighting, and a series of posters on the walls.

1. Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
Cape Girardeau
$100
$113 total
includes taxes & fees
Sep 27 - Sep 28
Drury Plaza Hotel Cape Girardeau Conference Center
A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.
A reception area with a wooden reception desk, two blue armchairs with orange cushions, a patterned side table, and a wall-mounted lamp.
A hotel room with two beds, a window with curtains, an air conditioning unit, and a lamp on a nightstand.
A modern dining area with wooden tables and chairs, a kitchen area with a tiled backsplash, and framed pictures on the wall.

2. Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
Cape Girardeau
$72
$81 total
includes taxes & fees
Sep 27 - Sep 28
Pear Tree Inn Cape Girardeau West
A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.
A living room with a stone fireplace, a television mounted above it, and a large sofa with cushions.
A spacious hotel lobby with a high ceiling, a central seating area with sofas and chairs, a fireplace, and a television mounted on the wall.
A hotel room with a bed, desk, chair, TV, and a small kitchenette area.

3. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Cape Girardeau
$101
$115 total
includes taxes & fees
Sep 27 - Sep 28
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
A hotel room with a large bed, two bedside lamps, a chair, and a wooden headboard.
A bowl of cereal with raisins and milk, a half orange, and a sandwich on a table with a yellow napkin.
A hotel room with a large bed, two bedside tables, a desk with a chair, and two lamps.
A breakfast setting with waffles, scrambled eggs, toast, a glass of orange juice, and a white mug on a table with a green placemat.

4. Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
Cape Girardeau
$90
$102 total
includes taxes & fees
Oct 4 - Oct 5
Drury Inn & Suites Cape Girardeau
A spacious dining area with high ceilings, large windows, and modern lighting fixtures.
A large indoor swimming pool with clear blue water, surrounded by tiled flooring and blue walls.
A gym with exercise equipment, a treadmill, and a wall-mounted TV.
An outdoor patio with stone walls, wicker furniture, and large windows.

5. Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
Cape Girardeau
$106
$119 total
includes taxes & fees
Oct 4 - Oct 5
Hampton Inn Cape Girardeau I 55 East
A spacious lobby with a curved staircase, large windows, and a seating area with a rug.
A modern living room with a large sectional sofa, a flat-screen TV, and a view of the sea through large windows.
A modern bar area with a herringbone patterned wall, a long counter with bar stools, and a variety of bottles and glasses.
A modern outdoor seating area with a fire feature, a stone wall, and a view of the sunset.

6. The Riverview

The Riverview
Cape Girardeau
$114
$129 total
includes taxes & fees
Sep 29 - Sep 30
The Riverview
A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.
An indoor swimming pool with lounge chairs and tables, large windows, and a view of the outside.
A Fairfield by Marriott hotel with a modern design, featuring a stone facade, multiple floors, and a well-lit entrance.
A reception area with a wooden reception desk, a glass door leading to a storage room, and a decorative wall piece.

7. Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
Cape Girardeau
$101
$114 total
includes taxes & fees
Oct 1 - Oct 2
Fairfield Inn & Suites by Marriott Cape Girardeau
A spacious lobby with marble flooring, elegant seating, and a grand staircase.
A Courtyard by Marriott hotel with a modern brick facade, large windows, and a covered entrance area.
A lobby with seating areas, a reception desk, and a bar.
A spacious living room with a sofa set, a coffee table, and a dining area.

8. Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
Cape Girardeau
$125
$142 total
includes taxes & fees
Oct 2 - Oct 3
Courtyard by Marriott Cape Girardeau Downtown
A modern retail area with a display of local items and snacks.
A modern indoor seating area with blue sofas and tables, a patterned carpet, and large windows offering a view of the outdoors.
A modern lounge area with seating options including sofas, chairs, and a hanging chair, with large windows providing a view of the outdoors.
An outdoor patio area with seating arrangements, including a sofa and chairs, and a table.

9. Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
Cape Girardeau
$89
$102 total
includes taxes & fees
Sep 30 - Oct 1
Tru By Hilton Cape Girardeau
A hotel with a modern design, featuring a prominent sign for Candlewood Suites. There are multiple parking spaces visible in front of the building.
A hotel patio with a gazebo, outdoor seating, and a view of the road.
A hotel room with a bed, a TV, a desk, and a chair.
A hotel entrance with a large tree, a well-maintained garden with various plants and flowers, and a parking lot.

10. Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG
Cape Girardeau
$85
$101 total
includes taxes & fees
Oct 11 - Oct 12
Candlewood Suites Cape Girardeau by IHG
A spacious living area with a high ceiling, a green accent wall, and a wooden balcony railing.
A restaurant with multiple tables and chairs, an exit sign, a television, and a counter with food items.
A hotel room with a flat-screen TV, a microwave, a sofa, a lamp, and a window with curtains.
A reception desk with a green wall, a wooden door, and a sign that reads 'QUALITY INN.'

11. Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North
Cape Girardeau
$59
$67 total
includes taxes & fees
Sep 30 - Oct 1
Quality Inn Cape Girardeau North
A hotel room with a bed, desk, chair, television, and two wall-mounted lamps.
A hotel room with a large bed, two bedside tables, a nightstand, a telephone, and two wall-mounted lamps.
A motel with multiple floors, a parking lot, and a staircase leading to the upper floors.
A bathroom with a marble wall and a white bathtub.

12. Town House Inn Cape Giradreau

Town House Inn Cape Giradreau
Cape Girardeau
$75
$88 total
includes taxes & fees
Sep 24 - Sep 25
Town House Inn Cape Giradreau
A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.
A Drury Inn & Suites building with a traditional architectural style, featuring a covered entrance and multiple windows.
A restaurant with a brick wall, a flat-screen TV, and a bar area.
A hotel room with two beds, a brick wall, and a wooden headboard.

13. Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
Jackson
$85
$90 total
includes taxes & fees
Sep 27 - Sep 28
Drury Inn & Suites Jackson MO
A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.
An outdoor patio with tables and chairs, a stone wall, and large windows.
A hotel room with two beds, a nightstand, a lamp, and a chair.
A reception desk with a large mural of a bridge, wooden reception area, and a potted plant.

14. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Jackson
$84
$91 total
includes taxes & fees
Sep 24 - Sep 25
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
A spacious lobby with large windows, comfortable seating, and a modern ceiling design.
A hotel room with a bed, a dark sofa, an ottoman, a lamp, and artwork on the wall.
A room with large windows, two red upholstered chairs, a small table, and a potted plant.
A gym with treadmills, an elliptical, a bench, and a rack of dumbbells.

15. Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau
Jackson
$76
$82 total
includes taxes & fees
Oct 22 - Oct 23
Comfort Suites Jackson-Cape Girardeau
A kitchen with dark wooden cabinets, a stainless steel refrigerator, a black stove, a microwave, and a sink.
A hotel room with two beds, a wooden dresser, a bathroom with a shower, and a kitchen area.
A trophy labeled "Town House Inn" with "Cape Girardeau County, Missouri" and "2025" on it.

16. Town House Inn

Town House Inn
Jackson
$71
$77 total
includes taxes & fees
Sep 24 - Sep 25
Town House Inn
A living room with a blue wall, a fireplace, a sofa, and a chair.
A bar area with stools and a counter where a bartender is serving drinks.
A sign for EC REED'S MERCANTILE & HOTEL with a geometric design.
A brick building with a sign reading "Mercantile & Hotel".

17. EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel
Marble Hill
$101
$110 total
includes taxes & fees
Sep 24 - Sep 25
EC Reed's Mercantile and Hotel
A rustic lodge with a steeply pitched roof, a central entrance with a door, and a porch with multiple lights.
A rustic building with a thatched roof, surrounded by dense greenery and a gravel path leading to it.
A stone building with a patio area, string lights, and outdoor seating.
A cozy living room with a brown leather sofa, a wooden coffee table, and a window with a view of trees.

18. Makanda Inn

Makanda Inn
Makanda
$262
$299 total
includes taxes & fees
Sep 24 - Sep 25
Makanda Inn
View all properties

Check out pet-friendly hotels in Cape Girardeau

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.
An indoor swimming pool with clear blue water, surrounded by beige walls and large windows.
A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.
A spacious corridor with a high ceiling, recessed lighting, and a series of posters on the walls.

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
Cape Girardeau
$100
$113 total
includes taxes & fees
Sep 27 - Sep 28
Drury Plaza Hotel Cape Girardeau Conference Center
A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.
A reception area with a wooden reception desk, two blue armchairs with orange cushions, a patterned side table, and a wall-mounted lamp.
A hotel room with two beds, a window with curtains, an air conditioning unit, and a lamp on a nightstand.
A modern dining area with wooden tables and chairs, a kitchen area with a tiled backsplash, and framed pictures on the wall.

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
Cape Girardeau
$72
$81 total
includes taxes & fees
Sep 27 - Sep 28
Pear Tree Inn Cape Girardeau West
A spacious dining area with high ceilings, large windows, and modern lighting fixtures.
A large indoor swimming pool with clear blue water, surrounded by tiled flooring and blue walls.
A gym with exercise equipment, a treadmill, and a wall-mounted TV.
An outdoor patio with stone walls, wicker furniture, and large windows.

Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
Cape Girardeau
$106
$119 total
includes taxes & fees
Oct 4 - Oct 5
Hampton Inn Cape Girardeau I 55 East
A hotel room with a large bed, two bedside lamps, a chair, and a wooden headboard.
A bowl of cereal with raisins and milk, a half orange, and a sandwich on a table with a yellow napkin.
A hotel room with a large bed, two bedside tables, a desk with a chair, and two lamps.
A breakfast setting with waffles, scrambled eggs, toast, a glass of orange juice, and a white mug on a table with a green placemat.

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
Cape Girardeau
$90
$102 total
includes taxes & fees
Oct 4 - Oct 5
Drury Inn & Suites Cape Girardeau
A modern retail area with a display of local items and snacks.
A modern indoor seating area with blue sofas and tables, a patterned carpet, and large windows offering a view of the outdoors.
A modern lounge area with seating options including sofas, chairs, and a hanging chair, with large windows providing a view of the outdoors.
An outdoor patio area with seating arrangements, including a sofa and chairs, and a table.

Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
Cape Girardeau
$89
$102 total
includes taxes & fees
Sep 30 - Oct 1
Tru By Hilton Cape Girardeau
A hotel with a modern design, featuring a prominent sign for Candlewood Suites. There are multiple parking spaces visible in front of the building.
A hotel patio with a gazebo, outdoor seating, and a view of the road.
A hotel room with a bed, a TV, a desk, and a chair.
A hotel entrance with a large tree, a well-maintained garden with various plants and flowers, and a parking lot.

Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG
Cape Girardeau
$85
$101 total
includes taxes & fees
Oct 11 - Oct 12
Candlewood Suites Cape Girardeau by IHG
A hotel room with a bed, desk, chair, television, and two wall-mounted lamps.
A hotel room with a large bed, two bedside tables, a nightstand, a telephone, and two wall-mounted lamps.
A motel with multiple floors, a parking lot, and a staircase leading to the upper floors.
A bathroom with a marble wall and a white bathtub.

Town House Inn Cape Giradreau

Town House Inn Cape Giradreau
Cape Girardeau
$75
$88 total
includes taxes & fees
Sep 24 - Sep 25
Town House Inn Cape Giradreau
View all properties

You can also stay at hotels with a pool in Cape Girardeau

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.
An indoor swimming pool with clear blue water, surrounded by beige walls and large windows.
A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.
A spacious corridor with a high ceiling, recessed lighting, and a series of posters on the walls.

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
Cape Girardeau
$100
$113 total
includes taxes & fees
Sep 27 - Sep 28
Drury Plaza Hotel Cape Girardeau Conference Center
A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.
A living room with a stone fireplace, a television mounted above it, and a large sofa with cushions.
A spacious hotel lobby with a high ceiling, a central seating area with sofas and chairs, a fireplace, and a television mounted on the wall.
A hotel room with a bed, desk, chair, TV, and a small kitchenette area.

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Cape Girardeau
$101
$115 total
includes taxes & fees
Sep 27 - Sep 28
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
A hotel room with a large bed, two bedside lamps, a chair, and a wooden headboard.
A bowl of cereal with raisins and milk, a half orange, and a sandwich on a table with a yellow napkin.
A hotel room with a large bed, two bedside tables, a desk with a chair, and two lamps.
A breakfast setting with waffles, scrambled eggs, toast, a glass of orange juice, and a white mug on a table with a green placemat.

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
Cape Girardeau
$90
$102 total
includes taxes & fees
Oct 4 - Oct 5
Drury Inn & Suites Cape Girardeau
A spacious dining area with high ceilings, large windows, and modern lighting fixtures.
A large indoor swimming pool with clear blue water, surrounded by tiled flooring and blue walls.
A gym with exercise equipment, a treadmill, and a wall-mounted TV.
An outdoor patio with stone walls, wicker furniture, and large windows.

Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
Cape Girardeau
$106
$119 total
includes taxes & fees
Oct 4 - Oct 5
Hampton Inn Cape Girardeau I 55 East
A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.
An indoor swimming pool with lounge chairs and tables, large windows, and a view of the outside.
A Fairfield by Marriott hotel with a modern design, featuring a stone facade, multiple floors, and a well-lit entrance.
A reception area with a wooden reception desk, a glass door leading to a storage room, and a decorative wall piece.

Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
Cape Girardeau
$101
$114 total
includes taxes & fees
Oct 1 - Oct 2
Fairfield Inn & Suites by Marriott Cape Girardeau
A modern retail area with a display of local items and snacks.
A modern indoor seating area with blue sofas and tables, a patterned carpet, and large windows offering a view of the outdoors.
A modern lounge area with seating options including sofas, chairs, and a hanging chair, with large windows providing a view of the outdoors.
An outdoor patio area with seating arrangements, including a sofa and chairs, and a table.

Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
Cape Girardeau
$89
$102 total
includes taxes & fees
Sep 30 - Oct 1
Tru By Hilton Cape Girardeau
A hotel with a modern design, featuring a prominent sign for Candlewood Suites. There are multiple parking spaces visible in front of the building.
A hotel patio with a gazebo, outdoor seating, and a view of the road.
A hotel room with a bed, a TV, a desk, and a chair.
A hotel entrance with a large tree, a well-maintained garden with various plants and flowers, and a parking lot.

Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG
Cape Girardeau
$85
$101 total
includes taxes & fees
Oct 11 - Oct 12
Candlewood Suites Cape Girardeau by IHG
A spacious living area with a high ceiling, a green accent wall, and a wooden balcony railing.
A restaurant with multiple tables and chairs, an exit sign, a television, and a counter with food items.
A hotel room with a flat-screen TV, a microwave, a sofa, a lamp, and a window with curtains.
A reception desk with a green wall, a wooden door, and a sign that reads 'QUALITY INN.'

Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North
Cape Girardeau
$59
$67 total
includes taxes & fees
Sep 30 - Oct 1
Quality Inn Cape Girardeau North
View all properties

Go beyond your typical stay in Cape Girardeau

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Pet friendly
Pet friendly
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Pool
Pool
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Hot tub
Hot tub
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Spa
Spa
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Family friendly
Family friendly
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Cottage
Cottage
Our prices for hotels in Cape Girardeau are cheapest in December

Price trends for hotels in Cape Girardeau

Pricing is based on two traveler single night rates
View properties in September

September

High 28°C / low 17°C. Sunny most days.
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11°
13°
4°
9°
1°
6°
-2°
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-1°
14°
5°
19°
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Monthly weather averages (˚C)

Top landmarks in Cape Girardeau

A large, historic building with a dome and columns, surrounded by well-maintained lawns and trees.

Southeast Missouri State University

8.8/10 (248 reviews)
If you'd like to get a taste of Cape Girardeau student life, check out Southeast Missouri State University, located 0.9 mi (1.4 km) from central Cape Girardeau.
See properties
A cable-stayed bridge over a river with a rocky shoreline in the foreground.

Riverfront Bridge Park

8.8/10 (129 reviews)
Riverfront Bridge Park is worth a visit, located 0.7 mi (1.1 km) from central Cape Girardeau.
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Century Casino & Hotel Cape Girardeau

8.4/10 (176 reviews)
Century Casino & Hotel Cape Girardeau is 0.5 mi (0.8 km) from central Cape Girardeau, why not stop by during your stay.
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Hunter Valley Winery

7.4/10 (48 reviews)
Travelers might want a tour of Hunter Valley Winery, just one of the places to visit, and located 9.3 mi (14.9 km) from central Cape Girardeau.
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Riverfront Park

8.0/10 (2 reviews)
Riverfront Park is worth a visit when in central Cape Girardeau.
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Show Me Center

8.6/10 (40 reviews)
You can catch an event at Show Me Center, located 1.1 mi (1.8 km) from central Cape Girardeau.
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Cape Splash Family Aquatic Center

8.6/10 (21 reviews)
Why not give yourself a treat with a trip to Cape Splash Family Aquatic Center, one of the family attractions located 3.1 mi (5.1 km) from central Cape Girardeau. If you have fun at Cape Splash Family Aquatic Center, you'll love Cape Girardeau Conservation Nature Center, located nearby.
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Cape Rock Park

8.6/10 (36 reviews)
Cape Rock Park is worth a visit, located 1.9 mi (3.1 km) from central Cape Girardeau.
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Learn more about Cape Girardeau

Hugging the Mississippi River, this college town reveals its history through vibrant floodwall murals that transform concrete into an outdoor gallery. Southeast Missouri State University brings youthful energy to streets lined with locally-owned shops and cafes. The River Campus hosts performances in a former seminary with river views. Explore the Cape Girardeau Conservation Nature Center or paddle the Mississippi. Trail of Tears State Park offers hiking paths with panoramic vistas that explain why settlers chose this dramatic spot. The Cape Riverfront Market buzzes with farmers and artisans, while the historic downtown invites exploration with red-brick buildings housing quirky boutiques and restaurants serving hearty Midwestern fare with surprising sophistication.

See all hotels in Cape Girardeau
A nighttime view of a bridge with its cables illuminated against a starry sky.

Check out reviews of Cape Girardeau hotels guests love

A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.
A living room with a stone fireplace, a television mounted above it, and a large sofa with cushions.
A spacious hotel lobby with a high ceiling, a central seating area with sofas and chairs, a fireplace, and a television mounted on the wall.
A hotel room with a bed, desk, chair, TV, and a small kitchenette area.

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Cape Girardeau

10/10 Exceptional

United States
Amanda
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.
An indoor swimming pool with clear blue water, surrounded by beige walls and large windows.
A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.
A spacious corridor with a high ceiling, recessed lighting, and a series of posters on the walls.

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
Cape Girardeau

10/10 Exceptional

United States
Janet
Drury Plaza Hotel Cape Girardeau Conference Center
A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.
A Drury Inn & Suites building with a traditional architectural style, featuring a covered entrance and multiple windows.
A restaurant with a brick wall, a flat-screen TV, and a bar area.
A hotel room with two beds, a brick wall, and a wooden headboard.

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
Jackson

10/10 Exceptional

United States
Nicole
Drury Inn & Suites Jackson MO
A spacious lobby with marble flooring, elegant seating, and a grand staircase.
A Courtyard by Marriott hotel with a modern brick facade, large windows, and a covered entrance area.
A lobby with seating areas, a reception desk, and a bar.
A spacious living room with a sofa set, a coffee table, and a dining area.

Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
Cape Girardeau

10/10 Exceptional

United States
Keri
Courtyard by Marriott Cape Girardeau Downtown
A hotel room with a large bed, two bedside lamps, a chair, and a wooden headboard.
A bowl of cereal with raisins and milk, a half orange, and a sandwich on a table with a yellow napkin.
A hotel room with a large bed, two bedside tables, a desk with a chair, and two lamps.
A breakfast setting with waffles, scrambled eggs, toast, a glass of orange juice, and a white mug on a table with a green placemat.

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
Cape Girardeau

10/10 Exceptional

United States
StephM
Drury Inn & Suites Cape Girardeau
A spacious lobby with a curved staircase, large windows, and a seating area with a rug.
A modern living room with a large sectional sofa, a flat-screen TV, and a view of the sea through large windows.
A modern bar area with a herringbone patterned wall, a long counter with bar stools, and a variety of bottles and glasses.
A modern outdoor seating area with a fire feature, a stone wall, and a view of the sunset.

The Riverview

The Riverview
Cape Girardeau

10/10 Exceptional

United States
Mark
The Riverview
A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.
A reception area with a wooden reception desk, two blue armchairs with orange cushions, a patterned side table, and a wall-mounted lamp.
A hotel room with two beds, a window with curtains, an air conditioning unit, and a lamp on a nightstand.
A modern dining area with wooden tables and chairs, a kitchen area with a tiled backsplash, and framed pictures on the wall.

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
Cape Girardeau

10/10 Exceptional

United States
Kimberly
Pear Tree Inn Cape Girardeau West
A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.
An outdoor patio with tables and chairs, a stone wall, and large windows.
A hotel room with two beds, a nightstand, a lamp, and a chair.
A reception desk with a large mural of a bridge, wooden reception area, and a potted plant.

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Jackson

10/10 Exceptional

United States
Alexandra
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
A kitchen with dark wooden cabinets, a stainless steel refrigerator, a black stove, a microwave, and a sink.
A hotel room with two beds, a wooden dresser, a bathroom with a shower, and a kitchen area.
A trophy labeled "Town House Inn" with "Cape Girardeau County, Missouri" and "2025" on it.

Town House Inn

Town House Inn
Jackson

10/10 Exceptional

United States
larry
Town House Inn

Frequently Asked Questions

What hotels do travelers recommend in Cape Girardeau?

Guests like Drury Plaza Hotel Cape Girardeau Conference Center, The Riverview and Pear Tree Inn Cape Girardeau West.

Can I book a refundable hotel in Cape Girardeau?

If you need the flexibility to change your travel plans to Cape Girardeau, most accommodations offer refundable* bookable rates. You can find these properties by searching our site and using the "fully refundable" filter to narrow down the results.

Where can I stay in Cape Girardeau if I'm looking for an affordable accommodation?

Pear Tree Inn Cape Girardeau West, Candlewood Suites Cape Girardeau by IHG and Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG are a few accommodations you might want to consider that'll save you money.

Where can I stay in Cape Girardeau if I want a vacation rental instead of a hotel?

If you want a good alternative to a hotel, look over our selection of 30 vacation homes. In addition, you can choose from 20 apartments.

What will the weather in Cape Girardeau be like during my vacation?

July and August are typically the warmest months in Cape Girardeau when the average temp is 76°F. January and February are the coldest months when the average temperature is 40°F. April and March are the months with the most rain.

Why should I book my Cape Girardeau hotel through Hotels.com?

There are lots of reasons to book your Cape Girardeau trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.