Hotels in Upstate South Carolina

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Jul 16 - Jul 17
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Jul 17 - Jul 18
This weekend
Jul 18 - Jul 20
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Jul 25 - Jul 27

Where to stay in Upstate South Carolina?

Extended Stay America Premier Suites - Greenville - Spartanburg - I-85
Welcome to our stylish reception area, featuring a digital reception desk, comfortable seating, and a unique wooden ceiling design.

Extended Stay America Premier Suites - Greenville - Spartanburg - I-85

2.5 star property
8.6 out of 10, Excellent, (163)
The price is $114
$127 total
includes taxes & fees
Aug 4 - Aug 5
Extended Stay America Premier Suites - Greenville - Spartanburg - I-85
Microtel Inn by Wyndham Duncan/Spartanburg
Situated on a quiet street, this charming home features a two-story facade and beautifully manicured grounds.

Microtel Inn by Wyndham Duncan/Spartanburg

2.0 star property
7.2 out of 10, Good, (507)
The price is $68
$75 total
includes taxes & fees
Jul 20 - Jul 21
Microtel Inn by Wyndham Duncan/Spartanburg
Sleep Inn
Enjoy a morning MEDLEY of freshly prepared breakfast items, including waffles, pastries, and fresh fruit.

Sleep Inn

2.5 star property
5.8 out of 10, (488)
The price is $63
$70 total
includes taxes & fees
Jul 25 - Jul 26
Sleep Inn
Comfort Suites At WestGate Mall
Enjoy cooking and dining in this fully equipped kitchen with a refrigerator, microwave, and toaster.

Comfort Suites At WestGate Mall

2.5 star property
8.2 out of 10, Very Good, (1000)
The price is $88
$100 total
includes taxes & fees
Jul 27 - Jul 28
Comfort Suites At WestGate Mall
Quality Inn Duncan - Spartanburg West
Work in comfort with a spacious desk and ergonomic chair, surrounded by lush greenery.

Quality Inn Duncan - Spartanburg West

2.5 star property
7.6 out of 10, Good, (343)
The price is $80
$90 total
includes taxes & fees
Jul 18 - Jul 19
Quality Inn Duncan - Spartanburg West
Baymont by Wyndham Duncan/Spartanburg
Two single beds with white and blue bedding, a flat-screen TV, and a comfortable chair await in this stylish hotel room.

Baymont by Wyndham Duncan/Spartanburg

2.5 star property
7.0 out of 10, Good, (403)
The price is $81
$90 total
includes taxes & fees
Jul 21 - Jul 22
Baymont by Wyndham Duncan/Spartanburg
Super 8 by Wyndham Greer/Spartanburg Area
Relax by the pool with lounge chairs and a lifeguard on duty.

Super 8 by Wyndham Greer/Spartanburg Area

2.0 star property
7.2 out of 10, Good, (485)
The price is $67
$76 total
includes taxes & fees
Jul 22 - Jul 23
Super 8 by Wyndham Greer/Spartanburg Area
ECHO Suites Extended Stay by Wyndham Spartanburg
Welcome to our reception area, featuring a digital display and comfortable seating.

ECHO Suites Extended Stay by Wyndham Spartanburg

2.0 star property
8.0 out of 10, Very Good, (177)
The price is $94
$104 total
includes taxes & fees
Jul 21 - Jul 22
ECHO Suites Extended Stay by Wyndham Spartanburg
Red Roof Inn & Suites Duncan
Relax in this stylish room with a large bed, sofa, and chair, perfect for unwinding.

Red Roof Inn & Suites Duncan

2.0 star property
6.8 out of 10, (331)
The price is $67
$75 total
includes taxes & fees
Jul 20 - Jul 21
Red Roof Inn & Suites Duncan
WoodSpring Suites Spartanburg - Duncan
Experience the comfort of a modern stay at WoodSpring Suites, featuring a central entrance and covered porch.

WoodSpring Suites Spartanburg - Duncan

2.5 star property
6.4 out of 10, (225)
The price is $69
$78 total
includes taxes & fees
Jul 18 - Jul 19
WoodSpring Suites Spartanburg - Duncan
stayAPT Suites Greenville Greer BMW
Relax in style with a modern sofa and armchairs, complemented by a cozy fire pit.

stayAPT Suites Greenville Greer BMW

3.0 star property
8.8 out of 10, Excellent, (80)
The price is $129
$146 total
includes taxes & fees
Jul 20 - Jul 21
stayAPT Suites Greenville Greer BMW
Woodspring Suites Greenville Airport
Woodspring Suites features a modern architectural design with a prominent entrance and a clear display of its name.

Woodspring Suites Greenville Airport

2.5 star property
8.4 out of 10, Very Good, (107)
The price is $65
$72 total
includes taxes & fees
Jul 18 - Jul 19
Woodspring Suites Greenville Airport
Hotel Hartness
Enjoy a sophisticated dining experience with a long table set for a meal, surrounded by leather chairs and expansive views of the lush landscape.

Hotel Hartness

4.0 star property
9.8 out of 10, Exceptional, (556)
The price is $187
$240 total
includes taxes & fees
Jul 20 - Jul 21
Hotel Hartness
Days Inn by Wyndham Simpsonville
Welcome to our lobby, featuring a reception desk, comfortable seating area with sofas and a table, and framed artwork on the walls.

Days Inn by Wyndham Simpsonville

2.0 star property
7.2 out of 10, Good, (373)
The price is $64
$70 total
includes taxes & fees
Jul 20 - Jul 21
Days Inn by Wyndham Simpsonville
Best Western Spartanburg Northwest
Cozy living room with a central fireplace, two sofas, and a coffee table, set amidst a patterned carpet and large windows.

Best Western Spartanburg Northwest

3.0 star property
8.2 out of 10, Very Good, (756)
The price is $85
$96 total
includes taxes & fees
Jul 24 - Jul 25
Best Western Spartanburg Northwest
Hampton Inn & Suites Greenville Airport, SC
Relax in the spacious lobby with a large seating area, central counter, and high ceiling.

Hampton Inn & Suites Greenville Airport, SC

2.5 star property
9.2 out of 10, Wonderful, (913)
The price is $101
$111 total
includes taxes & fees
Aug 8 - Aug 9
Hampton Inn & Suites Greenville Airport, SC
Days Inn by Wyndham Spartanburg Waccamaw
Enjoy communal dining in this open space with a reception desk and large windows offering views of the surrounding greenery.

Days Inn by Wyndham Spartanburg Waccamaw

2.0 star property
7.0 out of 10, Good, (702)
The price is $68
$75 total
includes taxes & fees
Jul 25 - Jul 26
Days Inn by Wyndham Spartanburg Waccamaw
Red Roof Inn Spartanburg – I-26
Guest rooms line the corridor, each with a door and room number above.

Red Roof Inn Spartanburg – I-26

2.0 star property
7.0 out of 10, Good, (716)
The price is $62
$69 total
includes taxes & fees
Jul 31 - Aug 1
Red Roof Inn Spartanburg – I-26
Quality Inn
Welcome to our lobby, featuring a reception desk, comfortable seating area, and a cozy fireplace.

Quality Inn

2.0 star property
7.0 out of 10, Good, (793)
The price is $60
$66 total
includes taxes & fees
Aug 3 - Aug 4
Quality Inn
MainStay Suites Greenville Airport
Relax by the rectangular pool surrounded by lounge chairs and umbrellas.

MainStay Suites Greenville Airport

2.5 star property
7.6 out of 10, Good, (565)
The price is $80
$88 total
includes taxes & fees
Aug 1 - Aug 2
MainStay Suites Greenville Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Great weekend hotel deals in Upstate South Carolina, SC

Showing deals for:Jul 25 - Jul 27

Image gallery for The Station by Compo Hotels

Terrace/patio
VIP Access

The Station by Compo Hotels

4.0 star property
Travelers Rest
10/10Exceptional (7 reviews)
9% off
$276 nightly
Price is $690
Total with taxes and fees
The Station by Compo Hotels

Top landmarks in Upstate South Carolina

Clemson University

Clemson University

Enjoy the collegiate vibe when you visit Clemson University, during your travels in Clemson. Experience the area's theater scene or attend a football game.

See properties in Clemson University
Clemson University

Learn more about Upstate South Carolina

Upstate South Carolina is applauded for its cultural attractions such as Heritage Park and Roper Mountain Science Center.

See all hotels in Upstate South Carolina
Greenville - Spartanburg showing a sunset, tranquil scenes and mountains
Photo by South Carolina Department of Parks, Recreation & Tourism
Open Photo by South Carolina Department of Parks, Recreation & Tourism

Check out reviews of Upstate South Carolina hotels guests love

Hyatt Regency Greenville

Hyatt Regency Greenville

10/10 Excellent
"Staff were friendly and it was clean"
Karla 1-night trip
Posted 11 hours ago
Hyatt Regency Greenville

Frequently asked questions

Can I book a refundable hotel in Upstate South Carolina?
If you're looking for the flexibility to change your travel plans to Upstate South Carolina, most hotels provide refundable* rates you can book. You can find these properties by searching our site and using the "fully refundable" filter to narrow the results down.
Where can I stay in Upstate South Carolina if I want a vacation rental instead of a traditional hotel?
If you're looking for a good alternative to a hotel, review our selection of 1073 vacation homes. In addition, there are 111 apartments and 92 condos.
Why should I book my Upstate South Carolina hotel through Hotels.com?
There are lots of reasons to book your Upstate South Carolina trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.