Hotels in Isla Santa María

Free cancellation options if plans change

Earn rewards on every night you stay

Save more with Member Prices

Check prices for these dates

Tonight
Aug 31 - Sep 1
Tomorrow
Sep 1 - Sep 2
This weekend
Sep 4 - Sep 6
Next weekend
Sep 11 - Sep 13

Where to stay in Isla Santa María?

Enchanted Galapagos Lodge

Enchanted Galapagos Lodge
Bella Vista
Enchanted Galapagos Lodge

Suymar Ecolodge Galapagos

Suymar Ecolodge Galapagos
Bella Vista
$64
$89 total
Sep 3 - Sep 4
Suymar Ecolodge Galapagos

Twin Hotel Galapagos

Twin Hotel Galapagos
Bella Vista
$61
$61 total
Sep 1 - Sep 2
Twin Hotel Galapagos

Hotel Palace Galapagos

Hotel Palace Galapagos
Puerto Ayora
$69
$69 total
Sep 15 - Sep 16
Hotel Palace Galapagos

HOTEL CROSSMAN

HOTEL CROSSMAN
Puerto Ayora
$61
$61 total
Sep 30 - Oct 1
HOTEL CROSSMAN

Posada del Mar

Posada del Mar
Puerto Ayora
$73
$73 total
Sep 1 - Sep 2
Posada del Mar

BAY VIEW HOUSE

BAY VIEW HOUSE
Puerto Ayora
$135
$143 total
Sep 30 - Oct 1
BAY VIEW HOUSE

Plaza Luna Suites

Plaza Luna Suites
Puerto Ayora
$197
$197 total
Sep 1 - Sep 2
Plaza Luna Suites

Capitan Max B&B

Capitan Max B&B
Puerto Ayora
$77
$77 total
Sep 9 - Sep 10
Capitan Max B&B

Hotel Flamingo

Hotel Flamingo
Puerto Ayora
$161
$161 total
Sep 1 - Sep 2
Hotel Flamingo

Acacia Galapagos Boutique Hotel

Acacia Galapagos Boutique Hotel
Puerto Ayora
$206
$206 total
Sep 7 - Sep 8
Acacia Galapagos Boutique Hotel

Maidith Galapagos Inn

Maidith Galapagos Inn
Puerto Ayora
$117
$117 total
Sep 30 - Oct 1
Maidith Galapagos Inn

El Barranco Galapagos

El Barranco Galapagos
Puerto Ayora
$223
$223 total
Sep 5 - Sep 6
El Barranco Galapagos

Ikala Galapagos Hotel

Ikala Galapagos Hotel
Puerto Ayora
$270
$297 total
Sep 1 - Sep 2
Ikala Galapagos Hotel

Galapagos Verde Azul

Galapagos Verde Azul
Puerto Ayora
$89
$89 total
Sep 4 - Sep 5
Galapagos Verde Azul

Hotel Ninfa

Hotel Ninfa
Puerto Ayora
$131
$131 total
Sep 1 - Sep 2
Hotel Ninfa

Angermeyer Waterfront Inn

Angermeyer Waterfront Inn
Puerto Ayora
$282
$310 total
Sep 15 - Sep 16
Angermeyer Waterfront Inn

Lonesome George Ecolodge

Lonesome George Ecolodge
Puerto Ayora
$100
$100 total
Sep 1 - Sep 2
Lonesome George Ecolodge

Natura Gardens Galápagos Hotel

Natura Gardens Galápagos Hotel
Bella Vista
$209
$209 total
Sep 1 - Sep 2
Natura Gardens Galápagos Hotel

Hostal Costa del Pacifico

Hostal Costa del Pacifico
Puerto Ayora
$44
$44 total
Sep 5 - Sep 6
Hostal Costa del Pacifico
View all properties

Top landmarks in Isla Santa María

A sea turtle swimming underwater.
Photo by Tove Martin

Post Office Bay

Post Office Bay is 4 mi (6.4 km) from central Isla Santa María, why not stop by during your stay.
See properties
Two seals resting on a sandy beach with a rocky shoreline and a sunset in the background.
Photo by Delen Wong

Punta Suarez

Punta Suarez is 47.5 mi (76.4 km) from central Isla Santa María, why not stop by during your stay.
See properties

Learn more about Isla Santa María

Isla Santa María is well-known for its attractions such as Galápagos National Park and Post Office Bay.

See all hotels in Isla Santa María
A beach with sea lions resting on the sand and a cruise ship in the distance.
Photo by Delen Wong

Check out reviews of Isla Santa María hotels guests love

Angermeyer Waterfront Inn

Angermeyer Waterfront Inn

10/10 Excellent
"The staff is amazing! They are so helpful including Maria Soledad and Rebeca. The location is truly unique, A water taxi ride is needed to get to the hotel from downtown. It's fun and easy and only cost $1 per person. 6 options with included breakfast are all excellent. Recommend booking with breakfast."
Matt 3-night trip
Posted 21 hours ago
Angermeyer Waterfront Inn
Hotel Cucuve

Hotel Cucuve

10/10 Excellent
"Everything was up to expectations, great stay!"
Sylvia 4-night trip
Posted 2 days ago
Hotel Cucuve
Hotel La Casa de Judy

Hotel La Casa de Judy

10/10 Excellent
"This hotel was a great choice. Close enough to walk into town, great views, clean room (including bathroom) and friendly and helpful staff."
Alexandra 1-night trip
Posted 3 days ago
Hotel La Casa de Judy
Hotel Ninfa

Hotel Ninfa

10/10 Excellent
"Staff was really friendly and helpful"
Kleber 4-night trip
Posted 8 days ago
Hotel Ninfa
Hotel Fiesta

Hotel Fiesta

10/10 Excellent
"Clean, safe, very friendly staff. close to port and main shopping/dining. lovely pool, affordable drinks at bar and good breakfast."
Daniel 2-night trip
Posted 9 days ago
Hotel Fiesta
Fernandina Hotel & Spa Galápagos

Fernandina Hotel & Spa Galápagos

8/10 Good
"Everything was convenient and easy. Staff were very helpful. All went well"
Prithvish 3-night trip
Posted 11 days ago
Fernandina Hotel & Spa Galápagos
Hotel Coloma Galapagos

Hotel Coloma Galapagos

8/10 Good
"quirky simple hotel. Owner helped us carry the luggage up the stairs. it's on Baltra Ave near more locally owned businesses but close to the Malecon (walkway along the shore) and all the tourist places. Very friendly staff (Sandra & Magali) who cooked a nice breakfast for us every morning. Good reasonably priced seafood meal down the street at the Rustica. We stopped in the Bike shop also down the street about renting E-bikes and received some more restaurant suggestions. People said Buenas Dias to us in the street."
jack 3-night trip
Posted 12 days ago
Hotel Coloma Galapagos
Galapagos Verde Azul

Galapagos Verde Azul

8/10 Good
"Our room was spotless. The floors were mopped everyday. All of the wildlife in the area was magical."
Stan 6-night trip
Posted 13 days ago
Galapagos Verde Azul
Hotel el descanso del Guia

Hotel el descanso del Guia

10/10 Excellent
"Really quirky hotel which we loved. Very central and staff were great."
Gordon 3-night trip
Posted 2 weeks ago
Hotel el descanso del Guia

Frequently asked questions

Can I book refundable hotels in Isla Santa María?
If you're looking for the flexibility to change your plans to Isla Santa María, most properties provide refundable* rates you can book. You can find these properties by searching our site and using the "fully refundable" filter to narrow the results down.
What will the weather in Isla Santa María be like during my trip?
With an average temperature of 72°F, Isla Santa María is a great place if you want to enjoy the sunshine year all year long.
Why should I book my Isla Santa María hotel through Hotels.com?
There are plenty of reasons to book your Isla Santa María travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.