Hotels in San Sisto

October 2026
14
November 2026

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Check prices for these dates

This weekend
Oct 16 - Oct 18
Next weekend
Oct 23 - Oct 25

Where to stay in San Sisto?

1. Relais dell'Olmo

Relais dell'Olmo
Perugia
$115
$127 total
includes taxes & fees
Oct 27 - Oct 28
Relais dell'Olmo

2. La Meridiana Bleisure Hotel

La Meridiana Bleisure Hotel
Perugia
$87
$102 total
includes taxes & fees
Nov 8 - Nov 9
La Meridiana Bleisure Hotel

3. Best Western Hotel Quattrotorri Perugia

Best Western Hotel Quattrotorri Perugia
Perugia
$106
$124 total
includes taxes & fees
Oct 30 - Oct 31
Best Western Hotel Quattrotorri Perugia

4. Hotel Perugia Plaza

Hotel Perugia Plaza
Perugia
$139
$159 total
includes taxes & fees
Nov 10 - Nov 11
Hotel Perugia Plaza

5. Hotel Grifone

Hotel Grifone
Perugia
$95
$110 total
includes taxes & fees
Nov 10 - Nov 11
Hotel Grifone

6. Chocohotel

Chocohotel
Perugia
$125
$143 total
includes taxes & fees
Oct 18 - Oct 19
Chocohotel

7. Hotel Sangallo Palace

Hotel Sangallo Palace
Perugia
$111
$128 total
includes taxes & fees
Oct 18 - Oct 19
Hotel Sangallo Palace

8. Hotel Sacro Cuore

Hotel Sacro Cuore
Perugia
$80
$91 total
includes taxes & fees
Oct 15 - Oct 16
Hotel Sacro Cuore

9. Hotel Giò Wine e Jazz Area

Hotel Giò Wine e Jazz Area
Perugia
$108
$125 total
includes taxes & fees
Oct 18 - Oct 19
Hotel Giò Wine e Jazz Area

10. TH Perugia - Castello di Monterone

TH Perugia - Castello di Monterone
Perugia
$223
$253 total
includes taxes & fees
Oct 18 - Oct 19
TH Perugia - Castello di Monterone

11. Rosetta Hotel Perugia, Tapestry Collection by Hilton

Rosetta Hotel Perugia, Tapestry Collection by Hilton
Old Town Perugia
$166
$190 total
includes taxes & fees
Nov 8 - Nov 9
Rosetta Hotel Perugia, Tapestry Collection by Hilton

12. Hotel Priori Secret Garden

Hotel Priori Secret Garden
Old Town Perugia
$155
$177 total
includes taxes & fees
Nov 12 - Nov 13
Hotel Priori Secret Garden

13. Locanda Stella

Locanda Stella
Perugia
$99
$113 total
includes taxes & fees
Oct 17 - Oct 18
Locanda Stella

14. Locanda della Posta - Etruria Collection

Locanda della Posta - Etruria Collection
Old Town Perugia
$194
$221 total
includes taxes & fees
Oct 23 - Oct 24
Locanda della Posta - Etruria Collection

15. Posta Donini 1579 UNA Esperienze

Posta Donini 1579 UNA Esperienze
Perugia
$154
$178 total
includes taxes & fees
Oct 20 - Oct 21
Posta Donini 1579 UNA Esperienze

16. The Bank Hotel - Etruria Collection

The Bank Hotel - Etruria Collection
Old Town Perugia
$168
$190 total
includes taxes & fees
Oct 29 - Oct 30
The Bank Hotel - Etruria Collection

17. Residenza il Punto

Residenza il Punto
Perugia
$130
$146 total
includes taxes & fees
Nov 2 - Nov 3
Residenza il Punto

18. Hotel Sant'Ercolano

Hotel Sant'Ercolano
Old Town Perugia
$69
$80 total
includes taxes & fees
Oct 18 - Oct 19
Hotel Sant'Ercolano

19. Sina Brufani

Sina Brufani
Old Town Perugia
$229
$260 total
includes taxes & fees
Nov 1 - Nov 2
Sina Brufani

20. Primavera Mini Hotel

Primavera Mini Hotel
Old Town Perugia
$80
$94 total
includes taxes & fees
Oct 25 - Oct 26
Primavera Mini Hotel
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Go beyond your typical stay in San Sisto

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Hot tub
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Spa
Spa
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Family friendly
Family friendly
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Apart hotel
Apart hotel
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Apart­ment
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Cabin
Cabin
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Condo
Condo
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Villa
Villa
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Waterpark
Waterpark
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Farm
Farm

Top landmarks in San Sisto

Perugina Chocolate Factory

8.6/10 (58 reviews)
Perugina Chocolate Factory is 0.5 mi (0.9 km) from central San Sisto, why not stop by during your stay. If you have fun at Perugina Chocolate Factory, you'll love Citta della Domenica and Don Nello Palloni Centro Culturale, both located nearby.
See properties

Check out reviews of San Sisto hotels guests love

Relais dell'Olmo

Relais dell'Olmo
Perugia

10/10 Exceptional

United States
Anonymous traveler
Relais dell'Olmo

La Meridiana Bleisure Hotel

La Meridiana Bleisure Hotel
Perugia

10/10 Exceptional

United States
Tahmina
La Meridiana Bleisure Hotel

TH Perugia - Castello di Monterone

TH Perugia - Castello di Monterone
Perugia

10/10 Exceptional

United States
Mark
TH Perugia - Castello di Monterone

Hotel Priori Secret Garden

Hotel Priori Secret Garden
Old Town Perugia

10/10 Exceptional

United States
Eric
Hotel Priori Secret Garden

Locanda Stella

Locanda Stella
Perugia

10/10 Exceptional

United States
Telma
Locanda Stella

Residenza il Punto

Residenza il Punto
Perugia

10/10 Exceptional

United States
Gina
Residenza il Punto

Hotel Sangallo Palace

Hotel Sangallo Palace
Perugia

10/10 Exceptional

United States
Nicole
Hotel Sangallo Palace

Chocohotel

Chocohotel
Perugia

10/10 Exceptional

United States
Julie
Chocohotel

Hotel Perugia Plaza

Hotel Perugia Plaza
Perugia

10/10 Exceptional

United States
Jesmeet
Hotel Perugia Plaza

Hotel Sacro Cuore

Hotel Sacro Cuore
Perugia

10/10 Exceptional

United States
Anaisa
Hotel Sacro Cuore

The Bank Hotel - Etruria Collection

The Bank Hotel - Etruria Collection
Old Town Perugia

10/10 Exceptional

United States
Luis
The Bank Hotel - Etruria Collection

Rosetta Hotel Perugia, Tapestry Collection by Hilton

Rosetta Hotel Perugia, Tapestry Collection by Hilton
Old Town Perugia

10/10 Exceptional

United States
Suria
Rosetta Hotel Perugia, Tapestry Collection by Hilton

Sina Brufani

Sina Brufani
Old Town Perugia

10/10 Exceptional

United States
Brian
Sina Brufani

Posta Donini 1579 UNA Esperienze

Posta Donini 1579 UNA Esperienze
Perugia

10/10 Exceptional

United States
Anonymous traveler
Posta Donini 1579 UNA Esperienze

Hotel Giò Wine e Jazz Area

Hotel Giò Wine e Jazz Area
Perugia

10/10 Exceptional

United States
Della
Hotel Giò Wine e Jazz Area

Primavera Mini Hotel

Primavera Mini Hotel
Old Town Perugia

10/10 Exceptional

United States
Anonymous traveler
Primavera Mini Hotel

Borgo Tre Vaselle

Borgo Tre Vaselle
Torgiano

10/10 Exceptional

United States
Alex
Borgo Tre Vaselle

Frequently Asked Questions

What hotels do travelers like in San Sisto?

Can I book refundable hotels in San Sisto?

If you want the flexibility to change your plans to San Sisto, most hotels provide refundable* bookable rates. You can find these accommodations by searching our site and using the "fully refundable" filter to narrow down the results.

What will the weather in San Sisto be like during my vacation?

The warmest months in San Sisto are usually August and July with an average temp of 72°F. January and February are the chilliest months when the average temp is 44°F. The rainiest months are November and October.

Why should I book my San Sisto accommodation with Hotels.com?

There are plenty of reasons to book your San Sisto travel with us: our free cancellations on selected hotels* gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.