Top 10 Hotels in Seneca, SC in 2026 (from $73) | Hoteles.com

A sunset over a lake surrounded by dense forests and residential areas.

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Oct 25 - Oct 26

Tomorrow

Oct 26 - Oct 27

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Where to stay in Seneca?

A restaurant interior with a counter, seating area, and a TV mounted on the wall.

A hotel room with a bed, desk, TV, and a bathroom visible through an open door.

A multi-story motel with a central entrance, a flag, and a parking lot with several cars.

A hotel room with a TV on a wooden cabinet, a desk with a lamp, a framed picture, and a chair.

1. Quality Inn Seneca US-123

Seneca

$85

$99 total

includes taxes & fees

Oct 31 - Nov 1

A poolside area with outdoor seating and a view of a lake and forested hills.

A modern lobby with a reception desk, seating area, and a vending machine.

A deck with outdoor seating overlooking a body of water, adjacent to a building with multiple windows.

A modern lounge area with a round table, two green armchairs, a sofa, and a TV mounted on the wall.

2. Fairfield Inn & Suites Seneca Clemson Univ Area

Seneca

$120

$132 total

includes taxes & fees

Nov 1 - Nov 2

An outdoor patio area with a fire pit, seating, and string lights.

A modern hotel with a prominent 'tru by Hilton' sign, a well-lit entrance, and a parking area.

A food court with a beverage display, seating area, and a Clemson University sign.

A modern restaurant with a central counter, seating area, and a TV displaying news.

3. Tru by Hilton Seneca Clemson

Seneca

$102

$112 total

includes taxes & fees

Nov 19 - Nov 20

A hotel room with a bed, a desk, a chair, a large window with curtains, a bathroom with a bathtub, and a flat-screen TV.

A breakfast bar with waffle makers, coffee machines, and a clock on the wall.

A reception area with a brick wall, a reception desk, and a glass door leading outside.

A multi-story hotel with a prominent entrance, parking area, and a car parked in front.

4. Best Western Seneca-Clemson

Seneca

$94

$103 total

includes taxes & fees

Oct 27 - Oct 28

A hotel dining area with a long table, multiple chairs, and a bar in the background.

A hotel pantry with shelves stocked with snacks, a microwave, and a refrigerator with beverages.

A Hampton Inn & Suites hotel with a well-lit entrance, a parking lot, and a clear view of the building's exterior.

A long, narrow hallway with white walls and a light-colored floor, leading to a door at the end.

5. Hampton Inn & Suites Seneca-Clemson Area

Seneca

$135

$149 total

includes taxes & fees

Nov 24 - Nov 25

A multi-story hotel with a swimming pool, landscaped grounds, and a parking area.

An aerial view of a multi-story hotel with a central courtyard, outdoor pool, and lounge area.

A spacious dining area with a long wooden table and patterned upholstered chairs.

A swimming pool with lounge chairs and a covered patio area, surrounded by trees and a view of a lake.

6. Lakeside Lodge Clemson

Seneca

$109

$135 total

includes taxes & fees

Oct 26 - Oct 27

A modern dining area with a high ceiling, large windows, and a buffet setup.

A modern hotel lobby with a high ceiling, comfortable seating, large windows, and a view of the parking lot.

A swimming pool with lounge chairs and a fence, surrounded by trees.

A modern hotel room with a large bed, bedside tables with lamps, a wall-mounted air conditioner, and a large window with curtains.

7. Days Inn by Wyndham Seneca / Clemson Area

Seneca

$73

$80 total

includes taxes & fees

Oct 27 - Oct 28

A cabin with a cozy interior, a wooden exterior, and a view of the forest.

A cabin in a forest with a small deck and outdoor seating area.

A wooden interior with a table, chair, and a hanging lantern.

Private kitchen

8. Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Seneca

$93

$146 total

includes taxes & fees

Nov 3 - Nov 4

A modern lounge area with a brick accent wall, a fireplace, and comfortable seating.

A modern living room with a sofa, two armchairs, a coffee table, and a potted plant.

A multi-story hotel with a prominent entrance, a parking lot, and a landscaped area with a small tree.

A hotel room with a bed, a sofa, a dining table with chairs, a coffee machine, and a TV mounted on the wall.

9. The Abernathy of Clemson

Clemson

$152

$169 total

includes taxes & fees

Nov 16 - Nov 17

A modern kitchen area with a bar counter and seating.

A Hampton Inn with a modern design, featuring a prominent entrance and outdoor seating area.

A vending area with snacks and beverages, including chips and soda.

A modern bar area with high stools and a poolside view.

10. Hampton Inn Clemson-University Area

Clemson

$97

$108 total

includes taxes & fees

Nov 22 - Nov 23

A modern bar area with a menu board, bar stools, and a countertop with various items.

A modern dining area with a bar, bar stools, and a patterned rug.

A Courtyard Marriott hotel with a brick facade, multiple floors, and a covered entrance area.

A modern lobby with a reception desk, a seating area with three chairs, a round table, and a bookshelf with books.

11. Courtyard Marriott Clemson

Clemson

$103

$115 total

includes taxes & fees

Nov 22 - Nov 23

A reception area with a reception desk, a sofa, a staircase, and a wall with artwork.

A dining area with a brick floor, wooden tables, and chairs, a kitchen counter with appliances, and large windows offering a view of the outside.

A wall with a decorative design featuring a building, trees, and a sky with clouds.

A hotel room with two beds, a desk, a television, and a clock on the wall.

12. Inn @ Clemson

Clemson

$89

$99 total

includes taxes & fees

Oct 26 - Oct 27

A golf course with a water body, trees, and a distant view of a bridge.

An outdoor patio with tables and chairs, surrounded by trees and a view of a body of water.

A golf course with a clubhouse, surrounded by dense trees and a large body of water.

A large, curved swimming pool with lounge chairs and umbrellas, surrounded by landscaped areas and a building in the background.

13. Clemson University's James F. Martin Inn

Clemson

$149

$165 total

includes taxes & fees

Oct 26 - Oct 27

A hotel lobby with a reception desk, a large tiger mural, a TV, and a seating area with a blue sofa.

A spacious room with a large window, a flat-screen TV mounted on the wall, and a seating area with sofas and chairs.

A modern kitchen with a microwave, toaster, and coffee maker. There are white bowls and a coffee station.

Room

14. Comfort Inn & Suites Clemson - University Area

Clemson

$105

$117 total

includes taxes & fees

Nov 15 - Nov 16

A kitchen with a coffee maker, microwave, and refrigerator.

A hotel room with a bed, a desk with a chair, a television, a small table, and a microwave.

A reception area with a check-in desk, a seating area with a bench, and a wall-mounted display of postcards.

A hotel room with a large bed, a bedside table, a nightstand, and a wall-mounted lamp.

15. Rodeway Inn & Suites Walhalla

Walhalla

$80

$89 total

includes taxes & fees

Nov 23 - Nov 24

A Holiday Inn Express hotel with a stone facade, large windows, and a parking lot.

A hotel room with a bed, a desk, a television, a lamp, and a sofa.

A compact living space with a sofa, a desk, a television, and a kitchenette.

A conference room with tables and chairs, a projector screen, and a carpeted floor.

16. Holiday Inn Express & Suites Clemson by IHG

Clemson

$129

$143 total

includes taxes & fees

Nov 1 - Nov 2

A dining area with a table and chairs, large windows with a view of the outside, and a green sofa.

A reception desk with a vase of flowers, framed pictures, and a printer.

A hotel room with two beds, a desk, a chair, a TV, and a painting on the wall.

A gazebo with a tiled roof and a surrounding gravel area.

17. Days Inn by Wyndham Clemson

Clemson

$80

$89 total

includes taxes & fees

Oct 26 - Oct 27

A multi-level interior with a spiral staircase, wooden railings, and a seating area with tables and chairs.

A spacious living area with a sofa, ottoman, and chairs, a dining area with a table, and a kitchen in the background.

An outdoor patio with wicker furniture, a round table, and a fountain.

A spacious restaurant with high ceilings, wooden flooring, and a mix of modern and classic furniture.

18. The Shepherd Hotel Downtown Clemson

Clemson

$209

$232 total

includes taxes & fees

Oct 26 - Oct 27

A cozy living room with a fireplace, a dining area with a table and chairs, and a large wooden door.

Private kitchen

A bedroom with a bed, bedside tables, a nightstand, a wooden floor, a door, and a wall-mounted shelf.

A room with wooden sliding doors, a small black table with a potted plant, and a circular sign with the words "stay awhile".

19. Clemson Memorabilia House

Clemson

$89

$238 total

includes taxes & fees

Nov 1 - Nov 2

A spacious indoor dining area with multiple tables and chairs, a food service counter, and a modern architectural design with balconies.

A hotel room with a bed, a desk, a TV, a mirror, and a nightstand with a lamp.

A spacious indoor area with multiple levels of balconies, seating areas, and a central open space.

A spacious indoor area with multiple seating arrangements, a ping pong table, and a bar area with purple accents.

20. Best Western Plus Clemson Hotel & Conference Center

Clemson

$105

$117 total

includes taxes & fees

Oct 27 - Oct 28

View all properties

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A restaurant interior with a counter, seating area, and a TV mounted on the wall.

A hotel room with a bed, desk, TV, and a bathroom visible through an open door.

A multi-story motel with a central entrance, a flag, and a parking lot with several cars.

A hotel room with a TV on a wooden cabinet, a desk with a lamp, a framed picture, and a chair.

Quality Inn Seneca US-123

Seneca

$94

per night

$110 total

includes taxes & fees

A hotel dining area with a long table, multiple chairs, and a bar in the background.

A hotel pantry with shelves stocked with snacks, a microwave, and a refrigerator with beverages.

A Hampton Inn & Suites hotel with a well-lit entrance, a parking lot, and a clear view of the building's exterior.

A long, narrow hallway with white walls and a light-colored floor, leading to a door at the end.

Hampton Inn & Suites Seneca-Clemson Area

Seneca

$134

per night

$147 total

includes taxes & fees

A poolside area with outdoor seating and a view of a lake and forested hills.

A modern lobby with a reception desk, seating area, and a vending machine.

A deck with outdoor seating overlooking a body of water, adjacent to a building with multiple windows.

A modern lounge area with a round table, two green armchairs, a sofa, and a TV mounted on the wall.

Fairfield Inn & Suites Seneca Clemson Univ Area

Seneca

$139

per night

$153 total

includes taxes & fees

A hotel room with a bed, a desk, a chair, a large window with curtains, a bathroom with a bathtub, and a flat-screen TV.

A breakfast bar with waffle makers, coffee machines, and a clock on the wall.

A reception area with a brick wall, a reception desk, and a glass door leading outside.

A multi-story hotel with a prominent entrance, parking area, and a car parked in front.

Best Western Seneca-Clemson

Seneca

$119

per night

$131 total

includes taxes & fees

A modern dining area with a high ceiling, large windows, and a buffet setup.

A modern hotel lobby with a high ceiling, comfortable seating, large windows, and a view of the parking lot.

A swimming pool with lounge chairs and a fence, surrounded by trees.

A modern hotel room with a large bed, bedside tables with lamps, a wall-mounted air conditioner, and a large window with curtains.

Days Inn by Wyndham Seneca / Clemson Area

Seneca

$95

per night

$105 total

includes taxes & fees

An outdoor patio area with a fire pit, seating, and string lights.

A modern hotel with a prominent 'tru by Hilton' sign, a well-lit entrance, and a parking area.

A food court with a beverage display, seating area, and a Clemson University sign.

A modern restaurant with a central counter, seating area, and a TV displaying news.

Tru by Hilton Seneca Clemson

Seneca

$139

per night

$153 total

includes taxes & fees

A cabin with a cozy interior, a wooden exterior, and a view of the forest.

A cabin in a forest with a small deck and outdoor seating area.

A wooden interior with a table, chair, and a hanging lantern.

Private kitchen

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Seneca

$119

per night

$175 total

includes taxes & fees

A restaurant interior with a counter, seating area, and a TV mounted on the wall.

A hotel room with a bed, desk, TV, and a bathroom visible through an open door.

A multi-story motel with a central entrance, a flag, and a parking lot with several cars.

A hotel room with a TV on a wooden cabinet, a desk with a lamp, a framed picture, and a chair.

Quality Inn Seneca US-123

Seneca

$94

per night

$110 total

includes taxes & fees

A poolside area with outdoor seating and a view of a lake and forested hills.

A modern lobby with a reception desk, seating area, and a vending machine.

A deck with outdoor seating overlooking a body of water, adjacent to a building with multiple windows.

A modern lounge area with a round table, two green armchairs, a sofa, and a TV mounted on the wall.

Fairfield Inn & Suites Seneca Clemson Univ Area

Seneca

$139

per night

$153 total

includes taxes & fees

A hotel dining area with a long table, multiple chairs, and a bar in the background.

A hotel pantry with shelves stocked with snacks, a microwave, and a refrigerator with beverages.

A Hampton Inn & Suites hotel with a well-lit entrance, a parking lot, and a clear view of the building's exterior.

A long, narrow hallway with white walls and a light-colored floor, leading to a door at the end.

Hampton Inn & Suites Seneca-Clemson Area

Seneca

$156

per night

$172 total

includes taxes & fees

A hotel room with a bed, a desk, a chair, a large window with curtains, a bathroom with a bathtub, and a flat-screen TV.

A breakfast bar with waffle makers, coffee machines, and a clock on the wall.

A reception area with a brick wall, a reception desk, and a glass door leading outside.

A multi-story hotel with a prominent entrance, parking area, and a car parked in front.

Best Western Seneca-Clemson

Seneca

$110

per night

$121 total

includes taxes & fees

A modern dining area with a high ceiling, large windows, and a buffet setup.

A modern hotel lobby with a high ceiling, comfortable seating, large windows, and a view of the parking lot.

A swimming pool with lounge chairs and a fence, surrounded by trees.

A modern hotel room with a large bed, bedside tables with lamps, a wall-mounted air conditioner, and a large window with curtains.

Days Inn by Wyndham Seneca / Clemson Area

Seneca

$9 off

$82

per night

$90 total

includes taxes & fees

A multi-story hotel with a swimming pool, landscaped grounds, and a parking area.

An aerial view of a multi-story hotel with a central courtyard, outdoor pool, and lounge area.

A spacious dining area with a long wooden table and patterned upholstered chairs.

A swimming pool with lounge chairs and a covered patio area, surrounded by trees and a view of a lake.

Lakeside Lodge Clemson

Seneca

$109

per night

$135 total

includes taxes & fees

An outdoor patio area with a fire pit, seating, and string lights.

A modern hotel with a prominent 'tru by Hilton' sign, a well-lit entrance, and a parking area.

A food court with a beverage display, seating area, and a Clemson University sign.

A modern restaurant with a central counter, seating area, and a TV displaying news.

Tru by Hilton Seneca Clemson

Seneca

$139

per night

$153 total

includes taxes & fees

A cabin with a cozy interior, a wooden exterior, and a view of the forest.

A cabin in a forest with a small deck and outdoor seating area.

A wooden interior with a table, chair, and a hanging lantern.

Private kitchen

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Seneca

$114

per night

$169 total

includes taxes & fees

A poolside area with outdoor seating and a view of a lake and forested hills.

A modern lobby with a reception desk, seating area, and a vending machine.

A deck with outdoor seating overlooking a body of water, adjacent to a building with multiple windows.

A modern lounge area with a round table, two green armchairs, a sofa, and a TV mounted on the wall.

Fairfield Inn & Suites Seneca Clemson Univ Area

Seneca

$129

per night

$284 total

includes taxes & fees

A hotel dining area with a long table, multiple chairs, and a bar in the background.

A hotel pantry with shelves stocked with snacks, a microwave, and a refrigerator with beverages.

A Hampton Inn & Suites hotel with a well-lit entrance, a parking lot, and a clear view of the building's exterior.

A long, narrow hallway with white walls and a light-colored floor, leading to a door at the end.

Hampton Inn & Suites Seneca-Clemson Area

Seneca

$146

per night

$321 total

includes taxes & fees

A restaurant interior with a counter, seating area, and a TV mounted on the wall.

A hotel room with a bed, desk, TV, and a bathroom visible through an open door.

A multi-story motel with a central entrance, a flag, and a parking lot with several cars.

A hotel room with a TV on a wooden cabinet, a desk with a lamp, a framed picture, and a chair.

Quality Inn Seneca US-123

Seneca

$87

per night

$205 total

includes taxes & fees

A hotel room with a bed, a desk, a chair, a large window with curtains, a bathroom with a bathtub, and a flat-screen TV.

A breakfast bar with waffle makers, coffee machines, and a clock on the wall.

A reception area with a brick wall, a reception desk, and a glass door leading outside.

A multi-story hotel with a prominent entrance, parking area, and a car parked in front.

Best Western Seneca-Clemson

Seneca

$106

per night

$234 total

includes taxes & fees

A multi-story hotel with a swimming pool, landscaped grounds, and a parking area.

An aerial view of a multi-story hotel with a central courtyard, outdoor pool, and lounge area.

A spacious dining area with a long wooden table and patterned upholstered chairs.

A swimming pool with lounge chairs and a covered patio area, surrounded by trees and a view of a lake.

Lakeside Lodge Clemson

Seneca

$119

per night

$294 total

includes taxes & fees

An outdoor patio area with a fire pit, seating, and string lights.

A modern hotel with a prominent 'tru by Hilton' sign, a well-lit entrance, and a parking area.

A food court with a beverage display, seating area, and a Clemson University sign.

A modern restaurant with a central counter, seating area, and a TV displaying news.

Tru by Hilton Seneca Clemson

Seneca

$139

per night

$306 total

includes taxes & fees

A modern dining area with a high ceiling, large windows, and a buffet setup.

A modern hotel lobby with a high ceiling, comfortable seating, large windows, and a view of the parking lot.

A swimming pool with lounge chairs and a fence, surrounded by trees.

A modern hotel room with a large bed, bedside tables with lamps, a wall-mounted air conditioner, and a large window with curtains.

Days Inn by Wyndham Seneca / Clemson Area

Seneca

$27 off

$76

per night

$167 total

includes taxes & fees

A cabin with a cozy interior, a wooden exterior, and a view of the forest.

A cabin in a forest with a small deck and outdoor seating area.

A wooden interior with a table, chair, and a hanging lantern.

Private kitchen

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Seneca

$63 off

$178

per night

$479 total

includes taxes & fees

A balcony with a view of a parking lot and houses in the background.

A rectangular swimming pool with a 3-foot depth marker, surrounded by lounge chairs and a stone wall.

A multi-story residential building with a flat roof, multiple windows, and a well-maintained lawn.

A pool table with balls, wooden cabinets, and a window with a view of greenery.

Condo on Lake Hartwell 3 Mi to Clemson Stadium

Seneca

$150

per night

$565 total

includes taxes & fees

A spacious living room with a fireplace, a television mounted on a stone wall, and a large window overlooking a forest.

A spacious living room with a high ceiling, stone walls, and a wooden staircase.

A lakeside property with two docked boats and a covered dock area.

A lakeside gazebo with a dock extending into the water, surrounded by lush greenery and a clear sky.

Lakefront Getaway Dock Fire Pit Kayak Games

Seneca

$146 off

$535

per night

$1,584 total

includes taxes & fees

A cozy bedroom with a bed, a nightstand, a lamp, a small table, a window, and a Christmas tree.

A living room with a sofa, ottoman, and a leather chair with a 'Family' pillow. There is a ceiling fan, a plant, and a window with curtains.

A home interior with a metal shelf unit displaying various items, a hallway with wooden flooring, and a door leading to another room.

A kitchen with wooden cabinets, a microwave, a stove, and a refrigerator.

8 Mi to Clemson: Peaceful Family Home w/ Yard

Seneca

$212

per night

$668 total

includes taxes & fees

A clear lake with a rocky shoreline and a tree branch overhanging the water.

A grassy area with trees and a body of water.

A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, and a dishwasher.

A two-story building with a garage, a staircase, and a view of the water.

6 Mi to South Cove Boat Ramp! Lake Keowee Escape

Seneca

$215

per night

$704 total

includes taxes & fees

A round wooden table with a flower vase and a WiFi sign, surrounded by blue cushioned benches, in a room with large windows and a hanging light fixture.

A covered porch with a ceiling fan, a wooden bench, a cushioned sofa, and a small table.

A covered porch with a flag, a tree, and a house entrance.

Interior

Screened Patio & Yard: Clemson Weekends/lakes Stay

Seneca

$242

per night

$835 total

includes taxes & fees

A grassy area with two red chairs and a table, a pond, and a dock.

A living room with a brick fireplace, a ceiling fan, a leather sofa, and a dining area with a brick wall.

An aerial view of a property with a large house, a dock, and a small boat.

A modern kitchen with white cabinets, a stainless steel refrigerator, and a built-in oven.

Clemson Basecamp! Lake Keowee Hideaway

Seneca

$340

per night

$1,125 total

includes taxes & fees

A cozy cabin interior with a dining area, kitchen, and living space.

A wooden deck with a railing, a table, and a fish sculpture.

A cozy wooden cabin bedroom with a bed, dresser, and ceiling fan.

A wooden cabin kitchen with a granite countertop, stainless steel appliances, and a clock on the wall.

Waterfront Seneca Cabin ~ 4 Mi to Boat Launch!

Seneca

$199

per night

$572 total

includes taxes & fees

Check out pet-friendly hotels in Seneca

A restaurant interior with a counter, seating area, and a TV mounted on the wall.

A hotel room with a bed, desk, TV, and a bathroom visible through an open door.

A multi-story motel with a central entrance, a flag, and a parking lot with several cars.

A hotel room with a TV on a wooden cabinet, a desk with a lamp, a framed picture, and a chair.

Quality Inn Seneca US-123

Seneca

$85

$99 total

includes taxes & fees

Oct 31 - Nov 1

An outdoor patio area with a fire pit, seating, and string lights.

A modern hotel with a prominent 'tru by Hilton' sign, a well-lit entrance, and a parking area.

A food court with a beverage display, seating area, and a Clemson University sign.

A modern restaurant with a central counter, seating area, and a TV displaying news.

Tru by Hilton Seneca Clemson

Seneca

$102

$112 total

includes taxes & fees

Nov 19 - Nov 20

A multi-story hotel with a swimming pool, landscaped grounds, and a parking area.

An aerial view of a multi-story hotel with a central courtyard, outdoor pool, and lounge area.

A spacious dining area with a long wooden table and patterned upholstered chairs.

A swimming pool with lounge chairs and a covered patio area, surrounded by trees and a view of a lake.

Lakeside Lodge Clemson

Seneca

$109

$135 total

includes taxes & fees

Oct 26 - Oct 27

A modern dining area with a high ceiling, large windows, and a buffet setup.

A modern hotel lobby with a high ceiling, comfortable seating, large windows, and a view of the parking lot.

A swimming pool with lounge chairs and a fence, surrounded by trees.

A modern hotel room with a large bed, bedside tables with lamps, a wall-mounted air conditioner, and a large window with curtains.

Days Inn by Wyndham Seneca / Clemson Area

Seneca

$73

$80 total

includes taxes & fees

Oct 27 - Oct 28

A cabin with a cozy interior, a wooden exterior, and a view of the forest.

A cabin in a forest with a small deck and outdoor seating area.

A wooden interior with a table, chair, and a hanging lantern.

Private kitchen

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Seneca

$93

$146 total

includes taxes & fees

Nov 3 - Nov 4

View all properties

You can also stay at hotels with a pool in Seneca

A hotel room with a bed, a desk, a chair, a large window with curtains, a bathroom with a bathtub, and a flat-screen TV.

A breakfast bar with waffle makers, coffee machines, and a clock on the wall.

A reception area with a brick wall, a reception desk, and a glass door leading outside.

A multi-story hotel with a prominent entrance, parking area, and a car parked in front.

Best Western Seneca-Clemson

Seneca

$94

$103 total

includes taxes & fees

Oct 27 - Oct 28

A hotel dining area with a long table, multiple chairs, and a bar in the background.

A hotel pantry with shelves stocked with snacks, a microwave, and a refrigerator with beverages.

A Hampton Inn & Suites hotel with a well-lit entrance, a parking lot, and a clear view of the building's exterior.

A long, narrow hallway with white walls and a light-colored floor, leading to a door at the end.

Hampton Inn & Suites Seneca-Clemson Area

Seneca

$135

$149 total

includes taxes & fees

Nov 24 - Nov 25

A multi-story hotel with a swimming pool, landscaped grounds, and a parking area.

An aerial view of a multi-story hotel with a central courtyard, outdoor pool, and lounge area.

A spacious dining area with a long wooden table and patterned upholstered chairs.

A swimming pool with lounge chairs and a covered patio area, surrounded by trees and a view of a lake.

Lakeside Lodge Clemson

Seneca

$109

$135 total

includes taxes & fees

Oct 26 - Oct 27

A restaurant interior with a counter, seating area, and a TV mounted on the wall.

A hotel room with a bed, desk, TV, and a bathroom visible through an open door.

A multi-story motel with a central entrance, a flag, and a parking lot with several cars.

A hotel room with a TV on a wooden cabinet, a desk with a lamp, a framed picture, and a chair.

Quality Inn Seneca US-123

Seneca

$85

$99 total

includes taxes & fees

Oct 31 - Nov 1

A poolside area with outdoor seating and a view of a lake and forested hills.

A modern lobby with a reception desk, seating area, and a vending machine.

A deck with outdoor seating overlooking a body of water, adjacent to a building with multiple windows.

A modern lounge area with a round table, two green armchairs, a sofa, and a TV mounted on the wall.

Fairfield Inn & Suites Seneca Clemson Univ Area

Seneca

$120

$132 total

includes taxes & fees

Nov 1 - Nov 2

A modern dining area with a high ceiling, large windows, and a buffet setup.

A modern hotel lobby with a high ceiling, comfortable seating, large windows, and a view of the parking lot.

A swimming pool with lounge chairs and a fence, surrounded by trees.

A modern hotel room with a large bed, bedside tables with lamps, a wall-mounted air conditioner, and a large window with curtains.

Days Inn by Wyndham Seneca / Clemson Area

Seneca

$73

$80 total

includes taxes & fees

Oct 27 - Oct 28

View all properties

Go beyond your typical stay in Seneca

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Our prices for hotels in Seneca are cheapest in December

Top neighborhoods in Seneca

A lakeside scene with autumn foliage, a clear sky, and a sunset.

A large lake surrounded by dense forests.

Downtown

Downtown Seneca charms visitors with well-preserved historical buildings that tell the story of its railroad heritage. The tree-lined Ram Cat Alley showcases local history through colorful murals, while the old courthouse square hosts seasonal farmers markets and community events. You can explore the Bertha Lee Strickland Cultural Museum or browse antique shops filled with Southern treasures. Family-owned cafes serve up delicious Southern comfort food like fried green tomatoes and barbecue. Accommodations range from historic bed & breakfasts in Victorian homes to budget-friendly motels. The entire downtown is walkable with wide sidewalks, making it easy to discover this authentic slice of small-town America at your own pace.

A sunset over a lake surrounded by dense forests and residential areas.

Serenity Bay

Lake Keowee beckons from this peaceful coastal retreat nestled in Saxony Forest. Serenity Bay lives up to its name with tree-lined streets perfect for contemplative walks. Nearby Keowee Key Golf Course offers tee times for enthusiasts, while South Beach provides sandy relaxation without the crowds. The natural setting creates an ideal escape for bird watchers and nature photographers. Vacation rentals with weathered wood siding and muted earth tones blend seamlessly into the forest canopy. Getting around requires your own wheels since public transit is limited. The neighborhood trades bustling nightlife for cricket choruses and ocean breezes filtering through pine trees—exactly what makes this hidden gem worth finding.

A sunset over a calm lake with a kayaker and a large tree on the shore.

Pine Ridge Point

Lake Keowee sparkles as the crown jewel of Pine Ridge Point, a peaceful residential haven in Seneca. Waterfront vacation homes nestle among tall pines, offering private docks and stunning views. Visitors spend days swimming in crystal-clear waters, boating across the lake, or simply unwinding on expansive decks beneath Carolina blue skies. This neighborhood is all about authentic lakeside living without commercial distractions. Most travelers cook in well-equipped rental kitchens or drive 15 minutes to Seneca for restaurants. Personal vehicles are essential for getting around, though scenic paths along the shoreline make for perfect evening strolls.

Indian Oaks

Indian Oaks gives you all the peaceful vibes of suburban life with none of the tourist chaos. This leafy neighborhood in Seneca lets you live like a local under a canopy of mature oak trees. The curved streets and manicured lawns create a park-like setting that's perfect for morning walks. Lake Keowee is just a short drive away when you need a water fix. You'll need wheels to get around since public transit is limited and restaurants aren't within walking distance. Most visitors stay in vacation rental homes with private yards and driveways. The neighborhood gets incredibly quiet after dark—ideal for travelers who want to experience authentic suburban living while having Seneca's attractions nearby.

Top landmarks in Seneca

A waterfall surrounded by autumn foliage.

High Falls County Park

High Falls County Park is worth a visit, located 7.8 mi (12.5 km) from central Seneca.

A grassy field with yellow flowers and trees in the foreground, with mountains in the background.

Blue Ridge Field

Blue Ridge Field is worth a visit, located 0.8 mi (1.2 km) from central Seneca.

World of Energy

If museums are on your list of things to see in Seneca, then you might want to head to World of Energy. If you want to experience more of the culture Seneca has to offer, head to Lake Keowee, Keowee Key Golf Course, and High Falls County Park.

Highpointe Field

Highpointe Field is worth a visit, located 5.6 mi (8.9 km) from central Seneca.

South Cove Park

South Cove Park is worth a visit, located 2 mi (3.3 km) from central Seneca.

Highpointe Lower Field

Highpointe Lower Field is worth a visit, located 5.7 mi (9.1 km) from central Seneca.

Oconee County Library Seneca Branch

Oconee County Library Seneca Branch is worth a pic or two when discovering Downtown.

Friendship Recreation Area

Friendship Recreation Area is worth a visit, located 6.5 mi (10.5 km) from central Seneca.

Learn more about Seneca

Between the crystal waters of Lake Keowee and the misty cascade of Isaqueena Falls lies a playground for outdoor enthusiasts. Kayak across the lake while keeping an eye out for bald eagles soaring overhead and blue herons stalking the shallows. The lush forests of Oconee State Park offer hiking trails for every skill level, with shade-dappled paths winding through ancient trees. Twin Lakes Recreation Area provides family-friendly spots to picnic after a morning on the water. Dog owners shouldn't miss The Pier Dog Park, where four-legged friends can splash along the shoreline. After a day of adventure, the coffeehouses in the historic downtown offer the perfect place to recharge while planning tomorrow's excursion to Keowee Key Golf Course or Lake Hartwell.

See all hotels in Seneca

A sunset over a lake surrounded by dense forests and residential areas.

Check out reviews of Seneca hotels guests love

A cabin with a cozy interior, a wooden exterior, and a view of the forest.

A cabin in a forest with a small deck and outdoor seating area.

A wooden interior with a table, chair, and a hanging lantern.

Private kitchen

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Seneca

10/10 Exceptional

United States

Jonathan

A multi-level interior with a spiral staircase, wooden railings, and a seating area with tables and chairs.

A spacious living area with a sofa, ottoman, and chairs, a dining area with a table, and a kitchen in the background.

An outdoor patio with wicker furniture, a round table, and a fountain.

A spacious restaurant with high ceilings, wooden flooring, and a mix of modern and classic furniture.

The Shepherd Hotel Downtown Clemson

Clemson

10/10 Exceptional

United States

Amy

A modern lounge area with a brick accent wall, a fireplace, and comfortable seating.

A modern living room with a sofa, two armchairs, a coffee table, and a potted plant.

A multi-story hotel with a prominent entrance, a parking lot, and a landscaped area with a small tree.

A hotel room with a bed, a sofa, a dining table with chairs, a coffee machine, and a TV mounted on the wall.

The Abernathy of Clemson

Clemson

10/10 Exceptional

United States

Michele

A hotel dining area with a long table, multiple chairs, and a bar in the background.

A hotel pantry with shelves stocked with snacks, a microwave, and a refrigerator with beverages.

A Hampton Inn & Suites hotel with a well-lit entrance, a parking lot, and a clear view of the building's exterior.

A long, narrow hallway with white walls and a light-colored floor, leading to a door at the end.

Hampton Inn & Suites Seneca-Clemson Area

Seneca

10/10 Exceptional

United States

LuAnn

A multi-story hotel with a swimming pool, landscaped grounds, and a parking area.

An aerial view of a multi-story hotel with a central courtyard, outdoor pool, and lounge area.

A spacious dining area with a long wooden table and patterned upholstered chairs.

A swimming pool with lounge chairs and a covered patio area, surrounded by trees and a view of a lake.

Lakeside Lodge Clemson

Seneca

10/10 Exceptional

United States

Maria

A hotel room with a bed, a desk, a chair, a large window with curtains, a bathroom with a bathtub, and a flat-screen TV.

A breakfast bar with waffle makers, coffee machines, and a clock on the wall.

A reception area with a brick wall, a reception desk, and a glass door leading outside.

A multi-story hotel with a prominent entrance, parking area, and a car parked in front.

Best Western Seneca-Clemson

Seneca

10/10 Exceptional

United States

Amy

A restaurant interior with a counter, seating area, and a TV mounted on the wall.

A hotel room with a bed, desk, TV, and a bathroom visible through an open door.

A multi-story motel with a central entrance, a flag, and a parking lot with several cars.

A hotel room with a TV on a wooden cabinet, a desk with a lamp, a framed picture, and a chair.

Quality Inn Seneca US-123

Seneca

10/10 Exceptional

United States

Norma

A spacious hallway with a wooden ceiling, a sofa, a chair, and a lamp.

A modern restaurant with a marble-top dining table, blue upholstered chairs, and a variety of food items displayed in the background.

A hotel with a brick facade, multiple windows, and a sign reading "The Inn at Patrick Square".

A brick building with a sign reading "The Inn at Patrick Square".

The Inn at Patrick Square

Clemson

10/10 Exceptional

United States

SHARRA

A white, two-story house with a front porch, surrounded by trees and shrubs.

A hallway with a wooden bench, a chair, a cabinet, and a painting on the wall.

A two-story building with a white exterior, a front door, and a balcony.

A dining area with round tables, black chairs, and white tablecloths.

Liberty Hall Bed and Breakfast

Pendleton

10/10 Exceptional

United States

William

A cozy living room with a fireplace, a dining area with a table and chairs, and a large wooden door.

Private kitchen

A bedroom with a bed, bedside tables, a nightstand, a wooden floor, a door, and a wall-mounted shelf.

A room with wooden sliding doors, a small black table with a potted plant, and a circular sign with the words "stay awhile".

Clemson Memorabilia House

Clemson

10/10 Exceptional

United States

Marissa

A golf course with a water body, trees, and a distant view of a bridge.

An outdoor patio with tables and chairs, surrounded by trees and a view of a body of water.

A golf course with a clubhouse, surrounded by dense trees and a large body of water.

A large, curved swimming pool with lounge chairs and umbrellas, surrounded by landscaped areas and a building in the background.

Clemson University's James F. Martin Inn

Clemson

10/10 Exceptional

United States

Margot

A hotel entrance with a stone facade, a wooden door, and potted plants.

A living room with a fireplace, a television mounted above it, and two sofas with floral cushions.

A two-story building with a brick facade, a central entrance with a curved arch, and a balcony on the second floor.

The Blackley Inn, a brick building with a sign above the entrance.

The Bleckley Inn

Anderson

10/10 Exceptional

United States

Anonymous traveler

A modern bar area with a menu board, bar stools, and a countertop with various items.

A modern dining area with a bar, bar stools, and a patterned rug.

A Courtyard Marriott hotel with a brick facade, multiple floors, and a covered entrance area.

A modern lobby with a reception desk, a seating area with three chairs, a round table, and a bookshelf with books.

Courtyard Marriott Clemson

Clemson

10/10 Exceptional

United States

Anonymous traveler

A modern coffee shop interior with a coffee machine, a counter with various items, and a seating area with red chairs.

A coffee station with two coffee machines, a coffee press, and various coffee pods and cups.

A modern hotel room with a large bed, a desk with a chair, a small table, and a nightstand with a lamp.

A Holiday Inn Express & Suites hotel with a modern architectural design, featuring a prominent entrance with columns and a flat roof.

Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG

Anderson

10/10 Exceptional

United States

Ruth

An outdoor patio area with seating arrangements, including chairs and tables, and a covered section with a view of the street.

A modern kitchen with a large island, dark cabinets, and a view of the city through large windows.

A modern hotel lobby with a central seating area, multiple tables, and a chandelier.

A modern hotel lobby with a central seating area, a bar, and a television screen.

Home2 Suites by Hilton Anderson Downtown

Anderson

10/10 Exceptional

United States

scott

Frequently Asked Questions

What accommodations do travelers like in Seneca?

Guests like Lakeside Lodge Clemson, Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy and Quality Inn Seneca US-123.

Can I book refundable accommodations in Seneca?

If you want the flexibility to change your travel plans to Seneca, most accommodations offer refundable* bookable rates. You can find these properties by searching our site and using the "fully refundable" filter to narrow the results down.

Where can I stay in Seneca if I want a budget-friendly accommodation?

Lakeside Lodge Clemson, Quality Inn Seneca US-123 and Hampton Inn & Suites Seneca-Clemson Area are a few accommodations you might want to consider that'll save you money.

Where can I stay in Seneca if I want a vacation rental instead of a hotel?

If you want to find a good alternative to a hotel, review our selection of 217 vacation homes. In addition, there are 24 apartments and 13 condos.

What will the weather in Seneca be like during my visit?

The warmest months in Seneca are usually July and August with an average temp of 76°F. January and February are the chilliest months when the average temp is 46°F. The rainiest months are December and January.

Why should I book my Seneca hotel with Hotels.com?

There are plenty of reasons to book your Seneca travel with us: our free cancellations on selected hotels* gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.