Hotels in Santee
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Fairfield Inn & Suites by Marriott Santee
Fairfield Inn & Suites by Marriott Santee
2.5 star property
Santee
9.8 out of 10, Exceptional, (1000)
9.8/10
Exceptional
(1000)
The price is $121
$121
$134 total
includes taxes & fees
Dec 25 - Dec 26
Tru By Hilton Santee
Tru By Hilton Santee
2.5 star property
Santee
9.2 out of 10, Wonderful, (639)
9.2/10
Wonderful
(639)
The price is $98
$98
$109 total
includes taxes & fees
Jan 19 - Jan 20, 2026
Hampton Inn Santee-I-95
Hampton Inn Santee-I-95
2.5 star property
Santee
9.6 out of 10, Exceptional, (1001)
9.6/10
Exceptional
(1001)
The price is $133
$133
$148 total
includes taxes & fees
Jan 18 - Jan 19, 2026
Baymont by Wyndham Santee
Baymont by Wyndham Santee
2.5 star property
Santee
8.0 out of 10, Very Good, (1413)
8.0/10
Very Good
(1413)
The price is $80
$80
$89 total
includes taxes & fees
Dec 21 - Dec 22
Holiday Inn Santee by IHG
Holiday Inn Santee by IHG
3.0 star property
Santee
8.2 out of 10, Very Good, (972)
8.2/10
Very Good
(972)
The price is $104
$104
$115 total
includes taxes & fees
Dec 22 - Dec 23
Travelodge by Wyndham Santee
Travelodge by Wyndham Santee
2.0 star property
Santee
7.0 out of 10, Good, (678)
7.0/10
Good
(678)
The price is $61
$61
$68 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Comfort Inn & Suites Santee
Comfort Inn & Suites Santee
2.5 star property
Santee
8.0 out of 10, Very Good, (1004)
8.0/10
Very Good
(1004)
The price is $105
$105
$117 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Red Roof Inn Santee
Red Roof Inn Santee
2.0 star property
Santee
6.6 out of 10, (637)
6.6/10
(637)
The price is $70
$70
$78 total
includes taxes & fees
Dec 21 - Dec 22
Best Western Plus Santee Inn
Best Western Plus Santee Inn
2.5 star property
Santee
8.8 out of 10, Excellent, (1000)
8.8/10
Excellent
(1000)
The price is $118
$118
$131 total
includes taxes & fees
Dec 25 - Dec 26
Quality Inn & Suites Santee I-95
Quality Inn & Suites Santee I-95
2.5 star property
Santee
6.0 out of 10, (455)
6.0/10
(455)
The price is $54
$54
$66 total
includes taxes & fees
Dec 25 - Dec 26
Super 8 by Wyndham Santee
Super 8 by Wyndham Santee
2.0 star property
Santee
6.8 out of 10, (440)
6.8/10
(440)
The price is $75
$75
$83 total
includes taxes & fees
Dec 28 - Dec 29
Econo Lodge Santee
Econo Lodge Santee
2.0 star property
Santee
6.4 out of 10, (309)
6.4/10
(309)
The price is $63
$63
$70 total
includes taxes & fees
Jan 7 - Jan 8, 2026
Ramada by Wyndham Santee I-95
Ramada by Wyndham Santee I-95
2.0 star property
Santee
6.2 out of 10, (541)
6.2/10
(541)
The price is $72
$72
$80 total
includes taxes & fees
Jan 18 - Jan 19, 2026
Bells Marina & Resort
Bells Marina & Resort
2.5 star property
Eutawville
8.6 out of 10, Excellent, (79)
8.6/10
Excellent
(79)
The price is $77
$77
$85 total
includes taxes & fees
Dec 22 - Dec 23
Peach Tree Inn
Peach Tree Inn
2.5 star property
St. George
7.2 out of 10, Good, (137)
7.2/10
Good
(137)
The price is $50
$50
$54 total
includes taxes & fees
Dec 22 - Dec 23
Starlight Stays
Starlight Stays
2.5 star property
Manning
7.0 out of 10, Good, (7)
7.0/10
Good
(7)
The price is $68
$68
$76 total
includes taxes & fees
Dec 28 - Dec 29
Fairfield Inn by Marriott Orangeburg
Fairfield Inn by Marriott Orangeburg
2.5 star property
Orangeburg
8.4 out of 10, Very Good, (695)
8.4/10
Very Good
(695)
The price is $84
$84
$93 total
includes taxes & fees
Dec 28 - Dec 29
SureStay Hotel by Best Western Manning
SureStay Hotel by Best Western Manning
2.5 star property
Manning
8.6 out of 10, Excellent, (1005)
8.6/10
Excellent
(1005)
The price is $85
$85
$94 total
includes taxes & fees
Dec 21 - Dec 22
Tru by Hilton Orangeburg
Tru by Hilton Orangeburg
2.5 star property
Orangeburg
9.2 out of 10, Wonderful, (1008)
9.2/10
Wonderful
(1008)
The price is $106
$106
$117 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Hampton Inn Manning
Hampton Inn Manning
2.5 star property
Manning
8.4 out of 10, Very Good, (1000)
8.4/10
Very Good
(1000)
The price is $119
$119
$133 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Check out pet-friendly hotels in Santee
9.2 out of 10, Wonderful, (639)
9.2/10
Wonderful
(639)
The price is $98
$98
$109 total
includes taxes & fees
Jan 19 - Jan 20, 2026
8.0 out of 10, Very Good, (1413)
8.0/10
Very Good
(1413)
The price is $80
$80
$89 total
includes taxes & fees
Dec 21 - Dec 22
Fairfield Inn & Suites by Marriott Santee
Fairfield Inn & Suites by Marriott Santee2.5 star property
Santee
9.8 out of 10, Exceptional, (1000)
9.8/10
Exceptional
(1000)
The price is $121
$121
$134 total
includes taxes & fees
Dec 25 - Dec 26
9.6 out of 10, Exceptional, (1001)
9.6/10
Exceptional
(1001)
The price is $133
$133
$148 total
includes taxes & fees
Jan 18 - Jan 19, 2026
8.2 out of 10, Very Good, (972)
8.2/10
Very Good
(972)
The price is $104
$104
$115 total
includes taxes & fees
Dec 22 - Dec 23
8.8 out of 10, Excellent, (1000)
8.8/10
Excellent
(1000)
The price is $118
$118
$131 total
includes taxes & fees
Dec 25 - Dec 26
7.0 out of 10, Good, (678)
7.0/10
Good
(678)
The price is $61
$61
$68 total
includes taxes & fees
Jan 5 - Jan 6, 2026
6.6 out of 10, (637)
6.6/10
(637)
The price is $70
$70
$78 total
includes taxes & fees
Dec 21 - Dec 22
6.0 out of 10, (455)
6.0/10
(455)
The price is $54
$54
$66 total
includes taxes & fees
Dec 25 - Dec 26
6.2 out of 10, (541)
6.2/10
(541)
The price is $72
$72
$80 total
includes taxes & fees
Jan 18 - Jan 19, 2026
You may also like hotels with pools in Santee
9.2 out of 10, Wonderful, (639)
9.2/10
Wonderful
(639)
The price is $98
$98
$109 total
includes taxes & fees
Jan 19 - Jan 20, 2026
Fairfield Inn & Suites by Marriott Santee
Fairfield Inn & Suites by Marriott Santee2.5 star property
Santee
9.8 out of 10, Exceptional, (1000)
9.8/10
Exceptional
(1000)
The price is $121
$121
$134 total
includes taxes & fees
Dec 25 - Dec 26
9.6 out of 10, Exceptional, (1001)
9.6/10
Exceptional
(1001)
The price is $133
$133
$148 total
includes taxes & fees
Jan 18 - Jan 19, 2026
8.2 out of 10, Very Good, (972)
8.2/10
Very Good
(972)
The price is $104
$104
$115 total
includes taxes & fees
Dec 22 - Dec 23
8.0 out of 10, Very Good, (1004)
8.0/10
Very Good
(1004)
The price is $105
$105
$117 total
includes taxes & fees
Jan 11 - Jan 12, 2026
8.8 out of 10, Excellent, (1000)
8.8/10
Excellent
(1000)
The price is $118
$118
$131 total
includes taxes & fees
Dec 25 - Dec 26
6.0 out of 10, (455)
6.0/10
(455)
The price is $54
$54
$66 total
includes taxes & fees
Dec 25 - Dec 26
6.8 out of 10, (440)
6.8/10
(440)
The price is $75
$75
$83 total
includes taxes & fees
Dec 28 - Dec 29
6.2 out of 10, (541)
6.2/10
(541)
The price is $72
$72
$80 total
includes taxes & fees
Jan 18 - Jan 19, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Go beyond your typical stay in Santee
Pet friendly
Family friendly
When is the best time to visit Santee?
When is the best time to visit Santee?Our prices for hotels in Santee are cheapest in January
When is the best time to visit Santee?
When is the best time to visit Santee?
Our prices for hotels in Santee are cheapest in January
Price trends for hotels in Santee
Pricing is based on two traveler single night rates
Currently viewing crowd sizes and weather for December.
Typical weather for Santee
December
High crowds
High 15°C / low 7°C. Sunny most days.
View properties in December 15°
December, High crowds, average high temperature 15 degrees Celsius, average low temperature 7 degrees Celsius. Sunny most days.
7°
13°
January, Low crowds, average high temperature 13 degrees Celsius, average low temperature 4 degrees Celsius. Sunny most days.
4°
16°
February, Low crowds, average high temperature 16 degrees Celsius, average low temperature 6 degrees Celsius. Sunny most days.
6°
19°
March, High crowds, average high temperature 19 degrees Celsius, average low temperature 9 degrees Celsius. Sunny most days.
9°
24°
April, Moderate crowds, average high temperature 24 degrees Celsius, average low temperature 13 degrees Celsius. Sunny most days.
13°
28°
May, Moderate crowds, average high temperature 28 degrees Celsius, average low temperature 17 degrees Celsius. Sunny most days.
17°
31°
June, Moderate crowds, average high temperature 31 degrees Celsius, average low temperature 21 degrees Celsius. Sunny most days.
21°
33°
July, Moderate crowds, average high temperature 33 degrees Celsius, average low temperature 23 degrees Celsius. Sunny most days.
23°
32°
August, Low crowds, average high temperature 32 degrees Celsius, average low temperature 23 degrees Celsius. Sunny most days.
23°
29°
September, Low crowds, average high temperature 29 degrees Celsius, average low temperature 20 degrees Celsius. Sunny most days.
20°
24°
October, High crowds, average high temperature 24 degrees Celsius, average low temperature 15 degrees Celsius. Sunny most days.
15°
19°
November, High crowds, average high temperature 19 degrees Celsius, average low temperature 9 degrees Celsius. Sunny most days.
9°
Monthly weather averages (˚C)
Top landmarks in Santee
Learn more about Santee
Tee off at championship golf courses or cast a line in Lake Marion's fish-rich waters where locals claim the bass practically jump into your boat. The Santee National Wildlife Refuge offers hiking trails where alligators sun themselves with reptilian nonchalance. Interstate 95 crosses the lake on a causeway that provides views worth pulling over for (safely, of course). Santee State Park delivers lakeside tranquility that makes visitors forget their phones exist. This resort town punches well above its weight with dining options that range from fresh-caught catfish to surprisingly sophisticated fare. The recent addition of the Santee Cooper Regional Water System has locals buzzing about growth while still cherishing their small-town atmosphere.
Check out reviews of Santee hotels guests love
Comfort Inn & Suites Santee
10/10 Excellent
"Staff was pleasant and helpful with restaurant information, room clean. "
Tru By Hilton Santee
10/10 Excellent
"Clean room. Courteous staff. And a really fun vibe! "
Hampton Inn Santee-I-95
10/10 Excellent
"The hotel was easy to get to and the staff was wonderful. The bed was soooo comfortable. "
Fairfield Inn & Suites by Marriott Santee
10/10 Excellent
"Spotless clean room
The staff was so courteous and friendly
"
Baymont by Wyndham Santee
10/10 Excellent
"Very friendly staff. "
Travelodge by Wyndham Santee
10/10 Excellent
"Clean , staff very courteous. Pet friendly!clean, friendly, on the beach, dog friendly beach area"
Super 8 by Wyndham Santee
10/10 Excellent
"The staff was very friendly and helpful. Room was clean and beds were so comfortable. "
Wyndham Vacation Resorts Lake Marion
10/10 Excellent
"Excellent "
Quality Inn & Suites
10/10 Excellent
"Everything went as expected"
Frequently asked questions
What accommodations do travelers like in Santee?
Hampton Inn Santee-I-95, Fairfield Inn & Suites by Marriott Santee and Tru By Hilton Santee are all accommodations that are popular with guests.
Can I book refundable accommodations in Santee?
If you want the flexibility to change your plans to Santee, most accommodations provide refundable* rates you can book. You can see these properties by searching our site and using the "fully refundable" filter to narrow down the results.
Where should I stay in Santee if I'm looking for a reasonably priced accommodation?
A few inexpensive options worth considering are Tru By Hilton Santee, Baymont by Wyndham Santee and Hampton Inn Santee-I-95.
Where can I stay in Santee if I want a vacation rental instead of a hotel?
Browse 9 vacation homes on our site. You also might want to book one of 94 condos for your trip.
What will the weather in Santee be like during my vacation?
July and August are typically the warmest months in Santee when the average temp is 79°F. January and February are the coldest months when the average temperature is 52°F. August and July are the months with the most rain.
Why should I book my Santee hotel with Hotels.com?
There are lots of reasons to book your Santee trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.