Hotels in Santee

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Check prices for these dates

Tonight

Sep 22 - Sep 23

Tomorrow

Sep 23 - Sep 24

This weekend

Sep 25 - Sep 27

Next weekend

Where to stay in Santee?

A breakfast area with a self-service counter, refrigerated display, and a digital menu board.

A hotel room with two beds, a desk, and a large window with a view.

A modern hotel with a blue and white facade, a covered entrance, and palm trees in front.

A modern hotel lobby with a central reception desk, a children's play area, and a restaurant named "Top It Break."

1. Tru By Hilton Santee

Santee

$99

$110 total

includes taxes & fees

Oct 4 - Oct 5

A hotel room with two beds, a grey armchair, a nightstand with a phone, and a cityscape picture on the wall.

A spacious dining area with multiple tables and chairs, large windows, and a patterned carpet.

A hotel corridor with blue doors, a covered walkway, and a parking lot in the background.

A lobby with two leather armchairs, a marble-topped table, and a patterned carpet.

2. Baymont by Wyndham Santee

Santee

$80

$89 total

includes taxes & fees

Sep 23 - Sep 24

A hotel dining area with multiple tables and chairs, a large flat-screen TV, and a patterned wall design.

A modern hotel with a swimming pool, outdoor seating, and a sign reading "Hampton Inn".

A hotel room with a bed, desk, chair, lamp, kitchenette, and a door.

A Hampton Inn hotel at night with a well-lit facade and a parking lot in the foreground.

3. Hampton Inn Santee-I-95

Santee

$127

$141 total

includes taxes & fees

Oct 8 - Oct 9

A patio area with wicker furniture, a stone fire pit, and outdoor seating.

A reception desk with a wooden panel wall and a circular decorative piece above it.

A multi-story hotel with a prominent sign, a covered entrance, and a parking lot.

A modern living room with a stone wall, a flat-screen TV, a fireplace, and a dining area with a round table and chairs.

4. Fairfield Inn & Suites by Marriott Santee

Santee

$134

$149 total

includes taxes & fees

Sep 29 - Sep 30

A hotel entrance with a sign reading "Best Western PLISS."

A spacious kitchen with white cabinets, a dining area with red patterned chairs, and a fireplace.

A modern kitchen with a red accent wall, white cabinetry, and a built-in espresso machine.

A hotel room with two large beds, a wooden headboard, bedside tables with lamps, a wardrobe, and a view of the outdoors through a window.

5. Best Western Plus Santee Inn

Santee

$119

$132 total

includes taxes & fees

Oct 4 - Oct 5

A water park with a pool, slides, and umbrellas.

A reception desk with a wooden panel backdrop and a neon sign.

A hotel room with two beds, a desk, a chair, a TV, and a large window with curtains.

A cobblestone street lined with colorful buildings, a palm tree, and flowering trees.

6. Holiday Inn Santee by IHG

Santee

$100

$111 total

includes taxes & fees

Oct 18 - Oct 19

A hotel room with a large bed, a desk, a chair, a desk lamp, and a wall-mounted lamp.

A room with a black console table displaying coffee and tea options, a large window, and a sliding glass door leading to a dining area with red chairs.

A spacious lobby with a modern staircase, seating area with orange and teal chairs, and a fireplace.

A modern living room with teal and orange chairs, a grey sofa, a fireplace, and a staircase.

7. Comfort Inn & Suites Santee

Santee

$107

$119 total

includes taxes & fees

Sep 27 - Sep 28

A hotel room with two beds, a desk, a mirror, and a wall-mounted TV.

A room with a flat-screen TV mounted on the wall, a small round table with a computer and keyboard, a chair, and a framed picture above the table.

A kitchen with a countertop, cabinets, a microwave, and a sink.

A motel with a brick facade, a covered entrance, and a satellite dish.

8. Travelodge by Wyndham Santee

Santee

$64

$71 total

includes taxes & fees

Sep 24 - Sep 25

A modern kitchen with dark cabinets, a granite countertop, a ceiling fan, a flat-screen TV, and a breakfast bar with pastries.

A spacious kitchen with a central island, a chandelier, and a sign indicating 'Quality' on the wall.

A hotel room with a bed, bedside tables, a chair, a desk, and a mirror.

A hotel room with a flat-screen TV, a desk with a chair, a microwave, and a refrigerator.

9. Quality Inn & Suites Santee I-95

Santee

$61

$73 total

includes taxes & fees

Sep 24 - Sep 25

A church with a triangular roof, a central entrance, and a bell tower.

A hotel room with a bed, a desk, a chair, a door, and a window with curtains.

A hotel reception area with a wooden reception desk, a digital screen displaying 'Free Wi-Fi All Rooms,' and a 'Red Roof Inn' sign on the wall.

A hotel room with a television mounted on the wall displaying a sports game, a desk with a lamp, a chair, and a refrigerator.

10. Red Roof Inn Santee

Santee

$63

$70 total

includes taxes & fees

Sep 27 - Sep 28

A dining area with multiple tables and chairs, a ceiling fan, and large windows.

A two-story building with a beige facade, large windows, and a central entrance.

A swimming pool with lounge chairs and umbrellas, surrounded by a fence and a building with large windows.

11. Super 8 by Wyndham Santee/I-95

Santee

$64

$71 total

includes taxes & fees

Sep 28 - Sep 29

A hotel room with two beds, a desk, a chair, a lamp, and a window with curtains.

A building with a red roof, a yellow door, and a brick facade.

A hotel room with two beds, a desk, a chair, a lamp, and a bathroom with a mirror and sink.

A bathroom with a sink, mirror, and a shower area.

12. Econo Lodge Santee

Santee

$63

$70 total

includes taxes & fees

Oct 19 - Oct 20

A conference room with round tables, black chairs, and white tablecloths.

A gym with treadmills, an elliptical, dumbbells, and a bench.

A pool table area with multiple tables and chairs, a bar area with a counter and shelves, and a patterned carpet.

13. Ramada by Wyndham Santee I-95

Santee

$83

$92 total

includes taxes & fees

Sep 27 - Sep 28

A hotel room with two beds, a desk, a chair, and a mirror.

A wooden pergola with a bench, a well-maintained lawn, and a parking area with buildings in the background.

A modern cafe with a stone backsplash, wooden cabinets, and yellow chairs.

A two-story building with a sign indicating it is a hotel.

14. SureStay Hotel by Best Western Manning

Manning

$90

$100 total

includes taxes & fees

Sep 23 - Sep 24

A stone fireplace with a television mounted above it, a small statue on the mantel, and a wooden cabinet to the left.

A corner market with a refrigerator stocked with beverages and snacks.

A modern bar area with a stone fireplace, a flat-screen TV, and a coffee station.

A reception area with a wooden reception desk, a welcome mat, a vending machine, and a clock on the wall.

15. Fairfield Inn by Marriott Orangeburg

Orangeburg

$101

$112 total

includes taxes & fees

Oct 4 - Oct 5

A Red Roof Inn with two red leather armchairs and a small wooden table in front of a stone-patterned wall.

A reception desk with a digital screen displaying 'Welcome' and 'Red Roof Inn.' There is a clock on the wall, a window with a view of a parking lot, and a refrigerator with 'Carolina's' branding.

A hotel room with a large bed, bedside tables, a desk, and a chair.

A hotel reception area with a counter, coffee machines, and a refrigerator.

16. Red Roof Inn Orangeburg

Orangeburg

$58

$65 total

includes taxes & fees

Sep 28 - Sep 29

A tent with a view of a lake and boats, a wooden chair, and a potted plant.

A tent with two beds, a small table, and a chair.

A modern room with a grey sofa, a small table, and a view of a lake and parked car through large glass doors.

A modern, two-story mobile home with a metal exterior, large windows, and a visible kitchen area.

17. Bells Marina & Resort

Eutawville

$82

$94 total

includes taxes & fees

Sep 24 - Sep 25

A two-story building with a sign reading "PachTree Inn".

A compact hotel room with a kitchenette, a television, a desk, and a chair.

A reception desk with a clock, framed certificates, and a window with a view.

A clean, well-lit dining area with round tables and chairs, a kitchen in the background, and a decorative leaf on the wall.

18. Peach Tree Inn

St. George

$65

$70 total

includes taxes & fees

Oct 1 - Oct 2

A bathroom with a large bathtub, a mirror, a sink, and a television.

A sign for Baymont by Wyndham with a 'God Bless America' plaque, surrounded by greenery and traffic cones.

A spacious lobby with a modern design, featuring a large sofa, a coffee table, and a television mounted on the wall.

A reception area with two grey armchairs, a wooden floor, and a painting of a tree-lined path on the wall.

19. Baymont by Wyndham Manning

Manning

$80

$89 total

includes taxes & fees

Sep 23 - Sep 24

A self-service kiosk with a beverage cooler, microwave, and various food items.

A breakfast counter with a sign reading 'TOP IT BREAKFAST,' a coffee machine, a yogurt dispenser, and various food items.

A modern hotel lobby with a reception desk, blue and gray seating, a TV screen, and unique pendant lighting.

A pool table in a room with a colorful mural, chairs, and a sofa.

20. Tru by Hilton Orangeburg

Orangeburg

$114

$127 total

includes taxes & fees

Oct 6 - Oct 7

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A hotel room with two beds, a grey armchair, a nightstand with a phone, and a cityscape picture on the wall.

A spacious dining area with multiple tables and chairs, large windows, and a patterned carpet.

A hotel corridor with blue doors, a covered walkway, and a parking lot in the background.

A lobby with two leather armchairs, a marble-topped table, and a patterned carpet.

Baymont by Wyndham Santee

Santee

$80

per night

$89 total

includes taxes & fees

A breakfast area with a self-service counter, refrigerated display, and a digital menu board.

A hotel room with two beds, a desk, and a large window with a view.

A modern hotel with a blue and white facade, a covered entrance, and palm trees in front.

A modern hotel lobby with a central reception desk, a children's play area, and a restaurant named "Top It Break."

Tru By Hilton Santee

Santee

$129

per night

$143 total

includes taxes & fees

A hotel dining area with multiple tables and chairs, a large flat-screen TV, and a patterned wall design.

A modern hotel with a swimming pool, outdoor seating, and a sign reading "Hampton Inn".

A hotel room with a bed, desk, chair, lamp, kitchenette, and a door.

A Hampton Inn hotel at night with a well-lit facade and a parking lot in the foreground.

Hampton Inn Santee-I-95

Santee

$150

per night

$167 total

includes taxes & fees

A hotel entrance with a sign reading "Best Western PLISS."

A spacious kitchen with white cabinets, a dining area with red patterned chairs, and a fireplace.

A modern kitchen with a red accent wall, white cabinetry, and a built-in espresso machine.

A hotel room with two large beds, a wooden headboard, bedside tables with lamps, a wardrobe, and a view of the outdoors through a window.

Best Western Plus Santee Inn

Santee

$135

per night

$150 total

includes taxes & fees

A hotel room with a large bed, a desk, a chair, a desk lamp, and a wall-mounted lamp.

A room with a black console table displaying coffee and tea options, a large window, and a sliding glass door leading to a dining area with red chairs.

A spacious lobby with a modern staircase, seating area with orange and teal chairs, and a fireplace.

A modern living room with teal and orange chairs, a grey sofa, a fireplace, and a staircase.

Comfort Inn & Suites Santee

Santee

$125

per night

$138 total

includes taxes & fees

A patio area with wicker furniture, a stone fire pit, and outdoor seating.

A reception desk with a wooden panel wall and a circular decorative piece above it.

A multi-story hotel with a prominent sign, a covered entrance, and a parking lot.

A modern living room with a stone wall, a flat-screen TV, a fireplace, and a dining area with a round table and chairs.

Fairfield Inn & Suites by Marriott Santee

Santee

$149

per night

$165 total

includes taxes & fees

A water park with a pool, slides, and umbrellas.

A reception desk with a wooden panel backdrop and a neon sign.

A hotel room with two beds, a desk, a chair, a TV, and a large window with curtains.

A cobblestone street lined with colorful buildings, a palm tree, and flowering trees.

Holiday Inn Santee by IHG

Santee

$134

per night

$149 total

includes taxes & fees

A hotel room with two beds, a desk, a mirror, and a wall-mounted TV.

A room with a flat-screen TV mounted on the wall, a small round table with a computer and keyboard, a chair, and a framed picture above the table.

A kitchen with a countertop, cabinets, a microwave, and a sink.

A motel with a brick facade, a covered entrance, and a satellite dish.

Travelodge by Wyndham Santee

Santee

$65

per night

$72 total

includes taxes & fees

A modern kitchen with dark cabinets, a granite countertop, a ceiling fan, a flat-screen TV, and a breakfast bar with pastries.

A spacious kitchen with a central island, a chandelier, and a sign indicating 'Quality' on the wall.

A hotel room with a bed, bedside tables, a chair, a desk, and a mirror.

A hotel room with a flat-screen TV, a desk with a chair, a microwave, and a refrigerator.

Quality Inn & Suites Santee I-95

Santee

$69

per night

$82 total

includes taxes & fees

A church with a triangular roof, a central entrance, and a bell tower.

A hotel room with a bed, a desk, a chair, a door, and a window with curtains.

A hotel reception area with a wooden reception desk, a digital screen displaying 'Free Wi-Fi All Rooms,' and a 'Red Roof Inn' sign on the wall.

A hotel room with a television mounted on the wall displaying a sports game, a desk with a lamp, a chair, and a refrigerator.

Red Roof Inn Santee

Santee

$70

per night

$78 total

includes taxes & fees

A dining area with multiple tables and chairs, a ceiling fan, and large windows.

A two-story building with a beige facade, large windows, and a central entrance.

A swimming pool with lounge chairs and umbrellas, surrounded by a fence and a building with large windows.

Super 8 by Wyndham Santee/I-95

Santee

$75

per night

$83 total

includes taxes & fees

A hotel room with two beds, a desk, a chair, a lamp, and a window with curtains.

A building with a red roof, a yellow door, and a brick facade.

A hotel room with two beds, a desk, a chair, a lamp, and a bathroom with a mirror and sink.

A bathroom with a sink, mirror, and a shower area.

Econo Lodge Santee

Santee

$80

per night

$89 total

includes taxes & fees

A conference room with round tables, black chairs, and white tablecloths.

A gym with treadmills, an elliptical, dumbbells, and a bench.

A pool table area with multiple tables and chairs, a bar area with a counter and shelves, and a patterned carpet.

Ramada by Wyndham Santee I-95

Santee

$84

per night

$93 total

includes taxes & fees

A hotel room with two beds, a grey armchair, a nightstand with a phone, and a cityscape picture on the wall.

A spacious dining area with multiple tables and chairs, large windows, and a patterned carpet.

A hotel corridor with blue doors, a covered walkway, and a parking lot in the background.

A lobby with two leather armchairs, a marble-topped table, and a patterned carpet.

Baymont by Wyndham Santee

Santee

$80

per night

$89 total

includes taxes & fees

A breakfast area with a self-service counter, refrigerated display, and a digital menu board.

A hotel room with two beds, a desk, and a large window with a view.

A modern hotel with a blue and white facade, a covered entrance, and palm trees in front.

A modern hotel lobby with a central reception desk, a children's play area, and a restaurant named "Top It Break."

Tru By Hilton Santee

Santee

$129

per night

$143 total

includes taxes & fees

A hotel dining area with multiple tables and chairs, a large flat-screen TV, and a patterned wall design.

A modern hotel with a swimming pool, outdoor seating, and a sign reading "Hampton Inn".

A hotel room with a bed, desk, chair, lamp, kitchenette, and a door.

A Hampton Inn hotel at night with a well-lit facade and a parking lot in the foreground.

Hampton Inn Santee-I-95

Santee

$150

per night

$167 total

includes taxes & fees

A hotel entrance with a sign reading "Best Western PLISS."

A spacious kitchen with white cabinets, a dining area with red patterned chairs, and a fireplace.

A modern kitchen with a red accent wall, white cabinetry, and a built-in espresso machine.

A hotel room with two large beds, a wooden headboard, bedside tables with lamps, a wardrobe, and a view of the outdoors through a window.

Best Western Plus Santee Inn

Santee

$135

per night

$150 total

includes taxes & fees

A patio area with wicker furniture, a stone fire pit, and outdoor seating.

A reception desk with a wooden panel wall and a circular decorative piece above it.

A multi-story hotel with a prominent sign, a covered entrance, and a parking lot.

A modern living room with a stone wall, a flat-screen TV, a fireplace, and a dining area with a round table and chairs.

Fairfield Inn & Suites by Marriott Santee

Santee

$149

per night

$165 total

includes taxes & fees

A water park with a pool, slides, and umbrellas.

A reception desk with a wooden panel backdrop and a neon sign.

A hotel room with two beds, a desk, a chair, a TV, and a large window with curtains.

A cobblestone street lined with colorful buildings, a palm tree, and flowering trees.

Holiday Inn Santee by IHG

Santee

$129

per night

$143 total

includes taxes & fees

A hotel room with a large bed, a desk, a chair, a desk lamp, and a wall-mounted lamp.

A room with a black console table displaying coffee and tea options, a large window, and a sliding glass door leading to a dining area with red chairs.

A spacious lobby with a modern staircase, seating area with orange and teal chairs, and a fireplace.

A modern living room with teal and orange chairs, a grey sofa, a fireplace, and a staircase.

Comfort Inn & Suites Santee

Santee

$127

per night

$141 total

includes taxes & fees

A hotel room with two beds, a desk, a mirror, and a wall-mounted TV.

A room with a flat-screen TV mounted on the wall, a small round table with a computer and keyboard, a chair, and a framed picture above the table.

A kitchen with a countertop, cabinets, a microwave, and a sink.

A motel with a brick facade, a covered entrance, and a satellite dish.

Travelodge by Wyndham Santee

Santee

$65

per night

$72 total

includes taxes & fees

A modern kitchen with dark cabinets, a granite countertop, a ceiling fan, a flat-screen TV, and a breakfast bar with pastries.

A spacious kitchen with a central island, a chandelier, and a sign indicating 'Quality' on the wall.

A hotel room with a bed, bedside tables, a chair, a desk, and a mirror.

A hotel room with a flat-screen TV, a desk with a chair, a microwave, and a refrigerator.

Quality Inn & Suites Santee I-95

Santee

$64

per night

$77 total

includes taxes & fees

A church with a triangular roof, a central entrance, and a bell tower.

A hotel room with a bed, a desk, a chair, a door, and a window with curtains.

A hotel reception area with a wooden reception desk, a digital screen displaying 'Free Wi-Fi All Rooms,' and a 'Red Roof Inn' sign on the wall.

A hotel room with a television mounted on the wall displaying a sports game, a desk with a lamp, a chair, and a refrigerator.

Red Roof Inn Santee

Santee

$70

per night

$78 total

includes taxes & fees

A dining area with multiple tables and chairs, a ceiling fan, and large windows.

A two-story building with a beige facade, large windows, and a central entrance.

A swimming pool with lounge chairs and umbrellas, surrounded by a fence and a building with large windows.

Super 8 by Wyndham Santee/I-95

Santee

$75

per night

$83 total

includes taxes & fees

A hotel room with two beds, a desk, a chair, a lamp, and a window with curtains.

A building with a red roof, a yellow door, and a brick facade.

A hotel room with two beds, a desk, a chair, a lamp, and a bathroom with a mirror and sink.

A bathroom with a sink, mirror, and a shower area.

Econo Lodge Santee

Santee

$80

per night

$89 total

includes taxes & fees

A conference room with round tables, black chairs, and white tablecloths.

A gym with treadmills, an elliptical, dumbbells, and a bench.

A pool table area with multiple tables and chairs, a bar area with a counter and shelves, and a patterned carpet.

Ramada by Wyndham Santee I-95

Santee

$85

per night

$94 total

includes taxes & fees

A breakfast area with a self-service counter, refrigerated display, and a digital menu board.

A hotel room with two beds, a desk, and a large window with a view.

A modern hotel with a blue and white facade, a covered entrance, and palm trees in front.

A modern hotel lobby with a central reception desk, a children's play area, and a restaurant named "Top It Break."

Tru By Hilton Santee

Santee

$119

per night

$263 total

includes taxes & fees

A hotel dining area with multiple tables and chairs, a large flat-screen TV, and a patterned wall design.

A modern hotel with a swimming pool, outdoor seating, and a sign reading "Hampton Inn".

A hotel room with a bed, desk, chair, lamp, kitchenette, and a door.

A Hampton Inn hotel at night with a well-lit facade and a parking lot in the foreground.

Hampton Inn Santee-I-95

Santee

$145

per night

$322 total

includes taxes & fees

A hotel entrance with a sign reading "Best Western PLISS."

A spacious kitchen with white cabinets, a dining area with red patterned chairs, and a fireplace.

A modern kitchen with a red accent wall, white cabinetry, and a built-in espresso machine.

A hotel room with two large beds, a wooden headboard, bedside tables with lamps, a wardrobe, and a view of the outdoors through a window.

Best Western Plus Santee Inn

Santee

$140

per night

$311 total

includes taxes & fees

A patio area with wicker furniture, a stone fire pit, and outdoor seating.

A reception desk with a wooden panel wall and a circular decorative piece above it.

A multi-story hotel with a prominent sign, a covered entrance, and a parking lot.

A modern living room with a stone wall, a flat-screen TV, a fireplace, and a dining area with a round table and chairs.

Fairfield Inn & Suites by Marriott Santee

Santee

$161

per night

$358 total

includes taxes & fees

A hotel room with two beds, a grey armchair, a nightstand with a phone, and a cityscape picture on the wall.

A spacious dining area with multiple tables and chairs, large windows, and a patterned carpet.

A hotel corridor with blue doors, a covered walkway, and a parking lot in the background.

A lobby with two leather armchairs, a marble-topped table, and a patterned carpet.

Baymont by Wyndham Santee

Santee

$100

per night

$222 total

includes taxes & fees

A water park with a pool, slides, and umbrellas.

A reception desk with a wooden panel backdrop and a neon sign.

A hotel room with two beds, a desk, a chair, a TV, and a large window with curtains.

A cobblestone street lined with colorful buildings, a palm tree, and flowering trees.

Holiday Inn Santee by IHG

Santee

$146

per night

$323 total

includes taxes & fees

A hotel room with a large bed, a desk, a chair, a desk lamp, and a wall-mounted lamp.

A room with a black console table displaying coffee and tea options, a large window, and a sliding glass door leading to a dining area with red chairs.

A spacious lobby with a modern staircase, seating area with orange and teal chairs, and a fireplace.

A modern living room with teal and orange chairs, a grey sofa, a fireplace, and a staircase.

Comfort Inn & Suites Santee

Santee

$137

per night

$304 total

includes taxes & fees

A modern kitchen with dark cabinets, a granite countertop, a ceiling fan, a flat-screen TV, and a breakfast bar with pastries.

A spacious kitchen with a central island, a chandelier, and a sign indicating 'Quality' on the wall.

A hotel room with a bed, bedside tables, a chair, a desk, and a mirror.

A hotel room with a flat-screen TV, a desk with a chair, a microwave, and a refrigerator.

Quality Inn & Suites Santee I-95

Santee

$73

per night

$174 total

includes taxes & fees

A hotel room with two beds, a desk, a mirror, and a wall-mounted TV.

A room with a flat-screen TV mounted on the wall, a small round table with a computer and keyboard, a chair, and a framed picture above the table.

A kitchen with a countertop, cabinets, a microwave, and a sink.

A motel with a brick facade, a covered entrance, and a satellite dish.

Travelodge by Wyndham Santee

Santee

$71

per night

$158 total

includes taxes & fees

A church with a triangular roof, a central entrance, and a bell tower.

A hotel room with a bed, a desk, a chair, a door, and a window with curtains.

A hotel reception area with a wooden reception desk, a digital screen displaying 'Free Wi-Fi All Rooms,' and a 'Red Roof Inn' sign on the wall.

A hotel room with a television mounted on the wall displaying a sports game, a desk with a lamp, a chair, and a refrigerator.

Red Roof Inn Santee

Santee

$72

per night

$160 total

includes taxes & fees

A dining area with multiple tables and chairs, a ceiling fan, and large windows.

A two-story building with a beige facade, large windows, and a central entrance.

A swimming pool with lounge chairs and umbrellas, surrounded by a fence and a building with large windows.

Super 8 by Wyndham Santee/I-95

Santee

$77

per night

$170 total

includes taxes & fees

A hotel room with two beds, a desk, a chair, a lamp, and a window with curtains.

A building with a red roof, a yellow door, and a brick facade.

A hotel room with two beds, a desk, a chair, a lamp, and a bathroom with a mirror and sink.

A bathroom with a sink, mirror, and a shower area.

Econo Lodge Santee

Santee

$71

per night

$158 total

includes taxes & fees

A conference room with round tables, black chairs, and white tablecloths.

A gym with treadmills, an elliptical, dumbbells, and a bench.

A pool table area with multiple tables and chairs, a bar area with a counter and shelves, and a patterned carpet.

Ramada by Wyndham Santee I-95

Santee

$107

per night

$236 total

includes taxes & fees

A modern kitchen with a central island, stainless steel appliances, and a large TV in the living area.

A covered porch with wooden railings and two red chairs.

A modern living room with a black sofa set, a small wooden table, and a kitchen area with a refrigerator and microwave.

A compact kitchen with a dishwasher, a sink, and a black microwave.

2 Mi to Lake Marion! Pet-friendly Home w/ Yard

Santee

$181

per night

$639 total

includes taxes & fees

Check out pet-friendly hotels in Santee

A patio area with wicker furniture, a stone fire pit, and outdoor seating.

A reception desk with a wooden panel wall and a circular decorative piece above it.

A multi-story hotel with a prominent sign, a covered entrance, and a parking lot.

A modern living room with a stone wall, a flat-screen TV, a fireplace, and a dining area with a round table and chairs.

Fairfield Inn & Suites by Marriott Santee

Santee

$134

$149 total

includes taxes & fees

Sep 29 - Sep 30

A breakfast area with a self-service counter, refrigerated display, and a digital menu board.

A hotel room with two beds, a desk, and a large window with a view.

A modern hotel with a blue and white facade, a covered entrance, and palm trees in front.

A modern hotel lobby with a central reception desk, a children's play area, and a restaurant named "Top It Break."

Tru By Hilton Santee

Santee

$99

$110 total

includes taxes & fees

Oct 4 - Oct 5

A hotel room with two beds, a grey armchair, a nightstand with a phone, and a cityscape picture on the wall.

A spacious dining area with multiple tables and chairs, large windows, and a patterned carpet.

A hotel corridor with blue doors, a covered walkway, and a parking lot in the background.

A lobby with two leather armchairs, a marble-topped table, and a patterned carpet.

Baymont by Wyndham Santee

Santee

$80

$89 total

includes taxes & fees

Sep 23 - Sep 24

A hotel dining area with multiple tables and chairs, a large flat-screen TV, and a patterned wall design.

A modern hotel with a swimming pool, outdoor seating, and a sign reading "Hampton Inn".

A hotel room with a bed, desk, chair, lamp, kitchenette, and a door.

A Hampton Inn hotel at night with a well-lit facade and a parking lot in the foreground.

Hampton Inn Santee-I-95

Santee

$127

$141 total

includes taxes & fees

Oct 8 - Oct 9

A hotel entrance with a sign reading "Best Western PLISS."

A spacious kitchen with white cabinets, a dining area with red patterned chairs, and a fireplace.

A modern kitchen with a red accent wall, white cabinetry, and a built-in espresso machine.

A hotel room with two large beds, a wooden headboard, bedside tables with lamps, a wardrobe, and a view of the outdoors through a window.

Best Western Plus Santee Inn

Santee

$119

$132 total

includes taxes & fees

Oct 4 - Oct 5

A hotel room with two beds, a desk, a mirror, and a wall-mounted TV.

A room with a flat-screen TV mounted on the wall, a small round table with a computer and keyboard, a chair, and a framed picture above the table.

A kitchen with a countertop, cabinets, a microwave, and a sink.

A motel with a brick facade, a covered entrance, and a satellite dish.

Travelodge by Wyndham Santee

Santee

$64

$71 total

includes taxes & fees

Sep 24 - Sep 25

A water park with a pool, slides, and umbrellas.

A reception desk with a wooden panel backdrop and a neon sign.

A hotel room with two beds, a desk, a chair, a TV, and a large window with curtains.

A cobblestone street lined with colorful buildings, a palm tree, and flowering trees.

Holiday Inn Santee by IHG

Santee

$100

$111 total

includes taxes & fees

Oct 18 - Oct 19

A modern kitchen with dark cabinets, a granite countertop, a ceiling fan, a flat-screen TV, and a breakfast bar with pastries.

A spacious kitchen with a central island, a chandelier, and a sign indicating 'Quality' on the wall.

A hotel room with a bed, bedside tables, a chair, a desk, and a mirror.

A hotel room with a flat-screen TV, a desk with a chair, a microwave, and a refrigerator.

Quality Inn & Suites Santee I-95

Santee

$61

$73 total

includes taxes & fees

Sep 24 - Sep 25

A dining area with multiple tables and chairs, a ceiling fan, and large windows.

A two-story building with a beige facade, large windows, and a central entrance.

A swimming pool with lounge chairs and umbrellas, surrounded by a fence and a building with large windows.

Super 8 by Wyndham Santee/I-95

Santee

$64

$71 total

includes taxes & fees

Sep 28 - Sep 29

A church with a triangular roof, a central entrance, and a bell tower.

A hotel room with a bed, a desk, a chair, a door, and a window with curtains.

A hotel reception area with a wooden reception desk, a digital screen displaying 'Free Wi-Fi All Rooms,' and a 'Red Roof Inn' sign on the wall.

A hotel room with a television mounted on the wall displaying a sports game, a desk with a lamp, a chair, and a refrigerator.

Red Roof Inn Santee

Santee

$63

$70 total

includes taxes & fees

Sep 27 - Sep 28

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You can also stay at hotels with a pool in Santee

A patio area with wicker furniture, a stone fire pit, and outdoor seating.

A reception desk with a wooden panel wall and a circular decorative piece above it.

A multi-story hotel with a prominent sign, a covered entrance, and a parking lot.

A modern living room with a stone wall, a flat-screen TV, a fireplace, and a dining area with a round table and chairs.

Fairfield Inn & Suites by Marriott Santee

Santee

$134

$149 total

includes taxes & fees

Sep 29 - Sep 30

A breakfast area with a self-service counter, refrigerated display, and a digital menu board.

A hotel room with two beds, a desk, and a large window with a view.

A modern hotel with a blue and white facade, a covered entrance, and palm trees in front.

A modern hotel lobby with a central reception desk, a children's play area, and a restaurant named "Top It Break."

Tru By Hilton Santee

Santee

$99

$110 total

includes taxes & fees

Oct 4 - Oct 5

A hotel dining area with multiple tables and chairs, a large flat-screen TV, and a patterned wall design.

A modern hotel with a swimming pool, outdoor seating, and a sign reading "Hampton Inn".

A hotel room with a bed, desk, chair, lamp, kitchenette, and a door.

A Hampton Inn hotel at night with a well-lit facade and a parking lot in the foreground.

Hampton Inn Santee-I-95

Santee

$127

$141 total

includes taxes & fees

Oct 8 - Oct 9

A hotel room with a large bed, a desk, a chair, a desk lamp, and a wall-mounted lamp.

A room with a black console table displaying coffee and tea options, a large window, and a sliding glass door leading to a dining area with red chairs.

A spacious lobby with a modern staircase, seating area with orange and teal chairs, and a fireplace.

A modern living room with teal and orange chairs, a grey sofa, a fireplace, and a staircase.

Comfort Inn & Suites Santee

Santee

$107

$119 total

includes taxes & fees

Sep 27 - Sep 28

A hotel entrance with a sign reading "Best Western PLISS."

A spacious kitchen with white cabinets, a dining area with red patterned chairs, and a fireplace.

A modern kitchen with a red accent wall, white cabinetry, and a built-in espresso machine.

A hotel room with two large beds, a wooden headboard, bedside tables with lamps, a wardrobe, and a view of the outdoors through a window.

Best Western Plus Santee Inn

Santee

$119

$132 total

includes taxes & fees

Oct 4 - Oct 5

A water park with a pool, slides, and umbrellas.

A reception desk with a wooden panel backdrop and a neon sign.

A hotel room with two beds, a desk, a chair, a TV, and a large window with curtains.

A cobblestone street lined with colorful buildings, a palm tree, and flowering trees.

Holiday Inn Santee by IHG

Santee

$100

$111 total

includes taxes & fees

Oct 18 - Oct 19

A modern kitchen with dark cabinets, a granite countertop, a ceiling fan, a flat-screen TV, and a breakfast bar with pastries.

A spacious kitchen with a central island, a chandelier, and a sign indicating 'Quality' on the wall.

A hotel room with a bed, bedside tables, a chair, a desk, and a mirror.

A hotel room with a flat-screen TV, a desk with a chair, a microwave, and a refrigerator.

Quality Inn & Suites Santee I-95

Santee

$61

$73 total

includes taxes & fees

Sep 24 - Sep 25

A conference room with round tables, black chairs, and white tablecloths.

A gym with treadmills, an elliptical, dumbbells, and a bench.

A pool table area with multiple tables and chairs, a bar area with a counter and shelves, and a patterned carpet.

Ramada by Wyndham Santee I-95

Santee

$83

$92 total

includes taxes & fees

Sep 27 - Sep 28

A dining area with multiple tables and chairs, a ceiling fan, and large windows.

A two-story building with a beige facade, large windows, and a central entrance.

A swimming pool with lounge chairs and umbrellas, surrounded by a fence and a building with large windows.

Super 8 by Wyndham Santee/I-95

Santee

$64

$71 total

includes taxes & fees

Sep 28 - Sep 29

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

View all properties

Go beyond your typical stay in Santee

Pet friendly

Pool

Family friendly

Our prices for hotels in Santee are cheapest in November

Top landmarks in Santee

Santee State Park

8.0/10 (219 reviews)

Santee State Park is 2.7 mi (4.4 km) from central Santee, why not stop by during your stay.

Santee Cooper Country Club

7.8/10 (94 reviews)

You might want to play some rounds at Santee Cooper Country Club, located 0.6 mi (1 km) from central Santee. If Santee Cooper Country Club doesn't quite scratch your golfing itch, Santee National Golf Club is also nearby.

Santee National Golf Club

8.0/10 (74 reviews)

You might want to practice your swing at Santee National Golf Club, a golf course located 0.8 mi (1.4 km) from central Santee. If Santee National Golf Club doesn't quite scratch your golfing itch, Santee Cooper Country Club is also nearby.

Santee Town Hall

Santee Town Hall is worth a visit, located 1 mi (1.6 km) from central Santee.

Learn more about Santee

Tee off at championship golf courses or cast a line in Lake Marion's fish-rich waters where locals claim the bass practically jump into your boat. The Santee National Wildlife Refuge offers hiking trails where alligators sun themselves with reptilian nonchalance. Interstate 95 crosses the lake on a causeway that provides views worth pulling over for (safely, of course). Santee State Park delivers lakeside tranquility that makes visitors forget their phones exist. This resort town punches well above its weight with dining options that range from fresh-caught catfish to surprisingly sophisticated fare. The recent addition of the Santee Cooper Regional Water System has locals buzzing about growth while still cherishing their small-town atmosphere.

See all hotels in Santee

A tree with Spanish moss and autumn leaves in a body of water.

Check out reviews of Santee hotels guests love

Tru By Hilton Santee

Tru By Hilton Santee

10/10 Excellent

"The elevator was full of fingerprints. Old ones"

Baymont by Wyndham Santee

Baymont by Wyndham Santee

8/10 Good

"Shower head leaked all the time, toilet ran too long, toilet seat was loose. Bathroom needed to be caulked. Room was very small. Breakfast was not good at all."

SureStay Hotel by Best Western Manning

SureStay Hotel by Best Western Manning

8/10 Good

"I have stayed here several times and have always thought it was great. It’s starting to slip. Last time I was there I got up early to leave and there were cars double parked making it very hard to get out. This time check in felt like I was a bother. A car was parked in the spot obviously for the room right i n front of the spot. The group next door was very loud and slamming doors. The rooms are starting to need little things like painting and patching. The entry doors need work. I hope to stay again but will definitely think twice now."

Hampton Inn Santee-I-95

Hampton Inn Santee-I-95

10/10 Excellent

"Nice breakfast. Easybparking. Very clean room and wonderful staff"

Bells Marina & Resort

Bells Marina & Resort

10/10 Excellent

"Love it"

Holiday Inn Santee by IHG

Holiday Inn Santee by IHG

10/10 Excellent

"Room was very clean and large. Staff were very friendly and enjoyed the breakfast."

Travelodge by Wyndham Santee

Travelodge by Wyndham Santee

10/10 Excellent

"Great service"

Red Roof Inn Santee

Red Roof Inn Santee

10/10 Excellent

"Nice place. Clean & mattress was super comfy!"

Frequently asked questions

What accommodations do travelers like in Santee?

Guests like Tru By Hilton Santee, Baymont by Wyndham Santee and Fairfield Inn & Suites by Marriott Santee.

Can I book refundable accommodations in Santee?

If you want the flexibility to change your plans to Santee, most accommodations provide refundable* rates you can book. You can see these properties by searching our site and using the "fully refundable" filter to narrow down the results.

Where should I stay in Santee if I'm looking for a reasonably priced accommodation?

A few inexpensive options worth considering are Tru By Hilton Santee, Baymont by Wyndham Santee and Comfort Inn & Suites Santee.

Where can I stay in Santee if I want a vacation rental instead of a hotel?

Browse 9 vacation homes on our site. You also might want to book one of 122 condos for your trip.

What will the weather in Santee be like during my vacation?

July and August are typically the warmest months in Santee when the average temp is 79°F. January and February are the coldest months when the average temperature is 52°F. August and July are the months with the most rain.

Why should I book my Santee hotel with Hotels.com?

There are lots of reasons to book your Santee trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

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