Hotels in Santa Isabel
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Motel Diana
Motel Diana
2.5 star property
Mexicali
8.8 out of 10, Excellent, (8)
8.8/10
Excellent
(8)
The price is $31
$31
$36 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Hotel Misión Plaza Mexicali
Hotel Misión Plaza Mexicali
2.0 star property
La Chinesca
7.4 out of 10, Good, (51)
7.4/10
Good
(51)
The price is $37
$37
$45 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Motel Marche
Motel Marche
3.0 star property
Mexicali
8.2 out of 10, Very Good, (156)
8.2/10
Very Good
(156)
The price is $66
$66
$76 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Real Inn Mexicali
Real Inn Mexicali
4.0 star property
Civic Center
8.2 out of 10, Very Good, (1572)
8.2/10
Very Good
(1572)
- Stay near the Mexico-USA border with easy access to popular Mexicali attractions.
The price is $77
$77
$87 total
includes taxes & fees
Jan 18 - Jan 19, 2026
Fiesta Inn Mexicali
Fiesta Inn Mexicali
3.5 star property
Civic Center
8.4 out of 10, Very Good, (1000)
8.4/10
Very Good
(1000)
- Convenient stay in Mexicali with fitness center and on-site dining options.
The price is $80
$80
$90 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Hotel Araiza Mexicali
Hotel Araiza Mexicali
4.0 star property
Mexicali
8.6 out of 10, Excellent, (1739)
8.6/10
Excellent
(1739)
- Enjoy Mexicali's central charm and twin pools near restaurants and shopping.
The price is $117
$117
$133 total
includes taxes & fees
Jan 15 - Jan 16, 2026
Calafia Hotel
Calafia Hotel
3.5 star property
Eguía
8.2 out of 10, Very Good, (1002)
8.2/10
Very Good
(1002)
- Enjoy relaxing stays near Mexicali's dining hubs with pool access and peaceful vibes.
The price is $78
$78
$89 total
includes taxes & fees
Jan 6 - Jan 7, 2026
Hotel Hacienda del Indio
Hotel Hacienda del Indio
3.0 star property
Mexicali
7.0 out of 10, Good, (133)
7.0/10
Good
(133)
- Enjoy rustic charm and local cuisine at this Mexicali retreat with easy forest access.
The price is $33
$33
$40 total
includes taxes & fees
Jan 1 - Jan 2, 2026
City Express by Marriott Mexicali
City Express by Marriott Mexicali
3.0 star property
Mexicali
8.2 out of 10, Very Good, (1002)
8.2/10
Very Good
(1002)
- A modern hotel near Mexico-USA border with free breakfast and thoughtful service.
The price is $72
$72
$81 total
includes taxes & fees
Jan 6 - Jan 7, 2026
Motel Cies
Motel Cies
3.0 star property
Mexicali
9.2 out of 10, Wonderful, (58)
9.2/10
Wonderful
(58)
- Modern motel in Mexicali with bar and café makes an ideal base for city exploration.
The price is $55
$55
$63 total
includes taxes & fees
Jan 14 - Jan 15, 2026
Hotel Regis
Hotel Regis
3.0 star property
Mexicali
7.2 out of 10, Good, (116)
7.2/10
Good
(116)
- Historic hotel in Mexicali with a local Mexican restaurant and convenient proximity to the border.
Hotel Lucerna Mexicali
Hotel Lucerna Mexicali
4.0 star property
Mexicali
9.2 out of 10, Wonderful, (1446)
9.2/10
Wonderful
(1446)
- Tranquil Mexican retreat near border with outdoor pool and fitness options.
The price is $105
$105
$118 total
includes taxes & fees
Jan 14 - Jan 15, 2026
Motel Paraiso
Motel Paraiso
3.0 star property
Mexicali
9.0 out of 10, Wonderful, (2)
9.0/10
Wonderful
(2)
- Unwind minutes from the border with casual dining options and modern conveniences.
The price is $98
$98
$121 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Hotel Colonial Mexicali
Hotel Colonial Mexicali
3.5 star property
Civic Center
8.0 out of 10, Very Good, (1007)
8.0/10
Very Good
(1007)
Azteca de Oro Mexicali
Azteca de Oro Mexicali
3.0 star property
Mexicali
7.8 out of 10, Good, (454)
7.8/10
Good
(454)
- Comfortable rooms just 15 minutes from Mexico-USA border with local cuisine options.
The price is $40
$40
$45 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Hotel Cosmos Don Carlos
Hotel Cosmos Don Carlos
3.0 star property
Eguía
8.0 out of 10, Very Good, (492)
8.0/10
Very Good
(492)
- Dive into Mexican culture at this Mexicali gem with an outdoor pool and regional cuisine.
Hotel Siesta Real
Hotel Siesta Real
3.0 star property
Mexicali
8.2 out of 10, Very Good, (905)
8.2/10
Very Good
(905)
- Stay at a central Mexicali hotel with easy access to the International Border Line.
The price is $76
$76
$86 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Motel Las Fuentes
Motel Las Fuentes
2.5 star property
Mexicali
7.8 out of 10, Good, (150)
7.8/10
Good
(150)
The price is $34
$34
$42 total
includes taxes & fees
Jan 1 - Jan 2, 2026
City Express Plus by Marriott Mexicali
City Express Plus by Marriott Mexicali
3.5 star property
Mexicali
8.6 out of 10, Excellent, (1008)
8.6/10
Excellent
(1008)
- Stay near Mexico-USA border with pool, restaurant, and modern comforts.
The price is $75
$75
$85 total
includes taxes & fees
Jan 18 - Jan 19, 2026
Motel Las Dunas
Motel Las Dunas
2.5 star property
Mexicali
7.6 out of 10, Good, (38)
7.6/10
Good
(38)
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Go beyond your typical stay in Santa Isabel
Family friendly
Check out reviews of Santa Isabel hotels guests love
City Express by Marriott Mexicali
10/10 Excellent
"Staff member are a plus! Clean , safe and well located. A great place to stay in Mexicali"
Fairfield Inn & Suites by Marriott Mexicali
10/10 Excellent
"n/a"
Extended Suites Mexicali Cataviña
10/10 Excellent
"Yes it was you obviously need to rent the pans and knifes but it’s ready for use"
Calafia Hotel
10/10 Excellent
"Everything was great, didnt have the breakfast but over all the staff and room was great."
Hotel Lucerna Mexicali
10/10 Excellent
"Clean Room, Amazing staff, amenities, quick check in. Little noisy because of Water fountain and vehicles.."
Hotel Colonial Mexicali
10/10 Excellent
"Everything was great"
City Express Plus by Marriott Mexicali
10/10 Excellent
"Great service with comfort and relaxing stay. Central location. "
City Express Junior by Marriott Mexicali
10/10 Excellent
"Exelent guest service "
Sleep Inn Mexicali
10/10 Excellent
"I would like to give them a 100%. They are beautiful, and they really care about everything."
Frequently asked questions
What hotels do travelers recommend in Santa Isabel?
Guests like Hotel Araiza Mexicali, Hotel Lucerna Mexicali and Real Inn Mexicali.
Can I book a refundable hotel in Santa Isabel?
If you need the flexibility to change your plans to Santa Isabel, most properties provide refundable* bookable rates. You can see these properties by searching our site and using the "fully refundable" filter to narrow the results down.
What will the weather in Santa Isabel be like during my trip?
July and August are typically the warmest months in Santa Isabel when the average temp is 93°F. December and January are the coldest months when the average temperature is 61°F. August and January are the months with the most rain.
Why should I book my Santa Isabel hotel through Hotels.com?
There are lots of reasons to book your Santa Isabel trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.