Hotels in Seneca

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Check prices for these dates

Tonight
Aug 21 - Aug 22
Tomorrow
Aug 22 - Aug 23
This weekend
Aug 21 - Aug 23
Next weekend
Aug 28 - Aug 30

Where to stay in Seneca?

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
Seneca
$107
$118 total
includes taxes & fees
Sep 13 - Sep 14
Tru by Hilton Seneca Clemson

Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
$76
$89 total
includes taxes & fees
Aug 27 - Aug 28
Quality Inn Seneca US-123

Best Western Seneca-Clemson

Best Western Seneca-Clemson
Seneca
$97
$107 total
includes taxes & fees
Aug 24 - Aug 25
Best Western Seneca-Clemson

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
Seneca
$119
$131 total
includes taxes & fees
Aug 27 - Aug 28
Hampton Inn & Suites Seneca-Clemson Area

Lakeside Lodge Clemson

Lakeside Lodge Clemson
Seneca
$109
$135 total
includes taxes & fees
Aug 22 - Aug 23
Lakeside Lodge Clemson

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
$80
$88 total
includes taxes & fees
Aug 22 - Aug 23
Days Inn by Wyndham Seneca / Clemson Area

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
Seneca
$120
$132 total
includes taxes & fees
Aug 30 - Aug 31
Fairfield Inn & Suites Seneca Clemson Univ Area

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Seneca
$93
$146 total
includes taxes & fees
Sep 21 - Sep 22
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Beautiful Lake Keowee Home w/ Boat Dock & Fire Pit

Beautiful Lake Keowee Home w/ Boat Dock & Fire Pit
Seneca
$389
$785 total
includes taxes & fees
Aug 23 - Aug 24
Beautiful Lake Keowee Home w/ Boat Dock & Fire Pit

Hampton Inn Clemson-University Area

Hampton Inn Clemson-University Area
Clemson
$106
$117 total
includes taxes & fees
Aug 27 - Aug 28
Hampton Inn Clemson-University Area

Clemson University's James F. Martin Inn

Clemson University's James F. Martin Inn
Clemson
$149
$165 total
includes taxes & fees
Sep 1 - Sep 2
Clemson University's James F. Martin Inn

Comfort Inn & Suites Clemson - University Area

Comfort Inn & Suites Clemson - University Area
Clemson
$105
$117 total
includes taxes & fees
Sep 13 - Sep 14
Comfort Inn & Suites Clemson - University Area

The Abernathy of Clemson

The Abernathy of Clemson
Clemson
$169
$188 total
includes taxes & fees
Sep 7 - Sep 8
The Abernathy of Clemson

Rodeway Inn & Suites Walhalla

Rodeway Inn & Suites Walhalla
Walhalla
$76
$85 total
includes taxes & fees
Sep 19 - Sep 20
Rodeway Inn & Suites Walhalla

Inn @ Clemson

Inn @ Clemson
Clemson
$99
$110 total
includes taxes & fees
Aug 23 - Aug 24
Inn @ Clemson

Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center
Clemson
$101
$112 total
includes taxes & fees
Aug 24 - Aug 25
Best Western Plus Clemson Hotel & Conference Center

Holiday Inn Express & Suites Clemson by IHG

Holiday Inn Express & Suites Clemson by IHG
Clemson
$110
$122 total
includes taxes & fees
Aug 27 - Aug 28
Holiday Inn Express & Suites Clemson by IHG

Courtyard Marriott Clemson

Courtyard Marriott Clemson
Clemson
$101
$112 total
includes taxes & fees
Aug 30 - Aug 31
Courtyard Marriott Clemson

The Inn at Patrick Square

The Inn at Patrick Square
Clemson
$149
$165 total
includes taxes & fees
Aug 23 - Aug 24
The Inn at Patrick Square

The Point At Lake Hartwell

The Point At Lake Hartwell
Townville
$125
$139 total
includes taxes & fees
Aug 23 - Aug 24
The Point At Lake Hartwell
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Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
$84
per night
$99 total
includes taxes & fees
Quality Inn Seneca US-123

Best Western Seneca-Clemson

Best Western Seneca-Clemson
Seneca
$114
per night
$125 total
includes taxes & fees
Best Western Seneca-Clemson

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
$80
per night
$88 total
includes taxes & fees
Days Inn by Wyndham Seneca / Clemson Area

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
Seneca
$134
per night
$147 total
includes taxes & fees
Hampton Inn & Suites Seneca-Clemson Area

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
Seneca
$139
per night
$153 total
includes taxes & fees
Tru by Hilton Seneca Clemson

Lakeside Lodge Clemson

Lakeside Lodge Clemson
Seneca
$109
per night
$135 total
includes taxes & fees
Lakeside Lodge Clemson

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
Seneca
$139
per night
$153 total
includes taxes & fees
Fairfield Inn & Suites Seneca Clemson Univ Area

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Seneca
$169
per night
$230 total
includes taxes & fees
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
$84
per night
$99 total
includes taxes & fees
Quality Inn Seneca US-123

Best Western Seneca-Clemson

Best Western Seneca-Clemson
Seneca
$114
per night
$125 total
includes taxes & fees
Best Western Seneca-Clemson

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
$80
per night
$88 total
includes taxes & fees
Days Inn by Wyndham Seneca / Clemson Area

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
Seneca
$134
per night
$147 total
includes taxes & fees
Hampton Inn & Suites Seneca-Clemson Area

Lakeside Lodge Clemson

Lakeside Lodge Clemson
Seneca
$109
per night
$135 total
includes taxes & fees
Lakeside Lodge Clemson

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
Seneca
$139
per night
$153 total
includes taxes & fees
Tru by Hilton Seneca Clemson

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
Seneca
$139
per night
$153 total
includes taxes & fees
Fairfield Inn & Suites Seneca Clemson Univ Area

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Seneca
$179
per night
$241 total
includes taxes & fees
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Best Western Seneca-Clemson

Best Western Seneca-Clemson
Seneca
$97
per night
$213 total
includes taxes & fees
Best Western Seneca-Clemson

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
Seneca
$114
per night
$251 total
includes taxes & fees
Tru by Hilton Seneca Clemson

Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
$80
per night
$189 total
includes taxes & fees
Quality Inn Seneca US-123

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
Seneca
$137
per night
$302 total
includes taxes & fees
Hampton Inn & Suites Seneca-Clemson Area

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
Seneca
$139
per night
$305 total
includes taxes & fees
Fairfield Inn & Suites Seneca Clemson Univ Area

Lakeside Lodge Clemson

Lakeside Lodge Clemson
Seneca
$109
per night
$271 total
includes taxes & fees
Lakeside Lodge Clemson

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
$119
per night
$262 total
includes taxes & fees
Days Inn by Wyndham Seneca / Clemson Area

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Seneca
$174
per night
$471 total
includes taxes & fees
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

6 Mi to South Cove Boat Ramp! Lake Keowee Escape

6 Mi to South Cove Boat Ramp! Lake Keowee Escape
Seneca
$215
per night
$704 total
includes taxes & fees
6 Mi to South Cove Boat Ramp! Lake Keowee Escape

8 Mi to Clemson: Peaceful Family Home w/ Yard

8 Mi to Clemson: Peaceful Family Home w/ Yard
Seneca
$187
per night
$613 total
includes taxes & fees
8 Mi to Clemson: Peaceful Family Home w/ Yard

Home w/ Lake Keowee Access: Sleeps 7, Coffee Bar

Home w/ Lake Keowee Access: Sleeps 7, Coffee Bar
Seneca
$158
per night
$583 total
includes taxes & fees
Home w/ Lake Keowee Access: Sleeps 7, Coffee Bar

Screened Patio & Yard: Clemson Weekends/lakes Stay

Screened Patio & Yard: Clemson Weekends/lakes Stay
Seneca
$206
per night
$756 total
includes taxes & fees
Screened Patio & Yard: Clemson Weekends/lakes Stay

Clemson Weekends 3 Mi From Memorial Stadium

Clemson Weekends 3 Mi From Memorial Stadium
Seneca
$242
per night
$835 total
includes taxes & fees
Clemson Weekends 3 Mi From Memorial Stadium

Waterfront Seneca Cabin ~ 4 Mi to Boat Launch!

Waterfront Seneca Cabin ~ 4 Mi to Boat Launch!
Seneca
$199
per night
$572 total
includes taxes & fees
Waterfront Seneca Cabin ~ 4 Mi to Boat Launch!

Historic Farmhouse: Memorable Moments Near Clemson

Historic Farmhouse: Memorable Moments Near Clemson
Seneca
$548
per night
$1,677 total
includes taxes & fees
Historic Farmhouse: Memorable Moments Near Clemson

Check out pet-friendly hotels in Seneca

Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
$76
$89 total
includes taxes & fees
Aug 27 - Aug 28
Quality Inn Seneca US-123

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
Seneca
$107
$118 total
includes taxes & fees
Sep 13 - Sep 14
Tru by Hilton Seneca Clemson

Lakeside Lodge Clemson

Lakeside Lodge Clemson
Seneca
$109
$135 total
includes taxes & fees
Aug 22 - Aug 23
Lakeside Lodge Clemson

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
$80
$88 total
includes taxes & fees
Aug 22 - Aug 23
Days Inn by Wyndham Seneca / Clemson Area

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Seneca
$93
$146 total
includes taxes & fees
Sep 21 - Sep 22
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
View all properties

You may also like hotels with pools in Seneca

Best Western Seneca-Clemson

Best Western Seneca-Clemson
Seneca
$97
$107 total
includes taxes & fees
Aug 24 - Aug 25
Best Western Seneca-Clemson

Lakeside Lodge Clemson

Lakeside Lodge Clemson
Seneca
$109
$135 total
includes taxes & fees
Aug 22 - Aug 23
Lakeside Lodge Clemson

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
$80
$88 total
includes taxes & fees
Aug 22 - Aug 23
Days Inn by Wyndham Seneca / Clemson Area

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
Seneca
$119
$131 total
includes taxes & fees
Aug 27 - Aug 28
Hampton Inn & Suites Seneca-Clemson Area

Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
$76
$89 total
includes taxes & fees
Aug 27 - Aug 28
Quality Inn Seneca US-123

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
Seneca
$120
$132 total
includes taxes & fees
Aug 30 - Aug 31
Fairfield Inn & Suites Seneca Clemson Univ Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Our prices for hotels in Seneca are cheapest in December
Price trends for hotels in Seneca
Pricing is based on two traveler single night rates
View properties in August
Typical weather for Seneca
August
High 31°C / low 20°C. Sunny most days.
View properties in August
31°
20°
28°
18°
23°
12°
17°
12°
10°
13°
17°
22°
10°
26°
15°
31°
19°
32°
21°
Monthly weather averages (˚C)

Top neighborhoods in Seneca

Downtown

Downtown Seneca charms visitors with well-preserved historical buildings that tell the story of its railroad heritage. The tree-lined Ram Cat Alley showcases local history through colorful murals, while the old courthouse square hosts seasonal farmers markets and community events. You can explore the Bertha Lee Strickland Cultural Museum or browse antique shops filled with Southern treasures. Family-owned cafes serve up delicious Southern comfort food like fried green tomatoes and barbecue. Accommodations range from historic bed & breakfasts in Victorian homes to budget-friendly motels. The entire downtown is walkable with wide sidewalks, making it easy to discover this authentic slice of small-town America at your own pace.

Serenity Bay

Lake Keowee beckons from this peaceful coastal retreat nestled in Saxony Forest. Serenity Bay lives up to its name with tree-lined streets perfect for contemplative walks. Nearby Keowee Key Golf Course offers tee times for enthusiasts, while South Beach provides sandy relaxation without the crowds. The natural setting creates an ideal escape for bird watchers and nature photographers. Vacation rentals with weathered wood siding and muted earth tones blend seamlessly into the forest canopy. Getting around requires your own wheels since public transit is limited. The neighborhood trades bustling nightlife for cricket choruses and ocean breezes filtering through pine trees—exactly what makes this hidden gem worth finding.

Pine Ridge Point

Lake Keowee sparkles as the crown jewel of Pine Ridge Point, a peaceful residential haven in Seneca. Waterfront vacation homes nestle among tall pines, offering private docks and stunning views. Visitors spend days swimming in crystal-clear waters, boating across the lake, or simply unwinding on expansive decks beneath Carolina blue skies. This neighborhood is all about authentic lakeside living without commercial distractions. Most travelers cook in well-equipped rental kitchens or drive 15 minutes to Seneca for restaurants. Personal vehicles are essential for getting around, though scenic paths along the shoreline make for perfect evening strolls.

Indian Oaks

Indian Oaks gives you all the peaceful vibes of suburban life with none of the tourist chaos. This leafy neighborhood in Seneca lets you live like a local under a canopy of mature oak trees. The curved streets and manicured lawns create a park-like setting that's perfect for morning walks. Lake Keowee is just a short drive away when you need a water fix. You'll need wheels to get around since public transit is limited and restaurants aren't within walking distance. Most visitors stay in vacation rental homes with private yards and driveways. The neighborhood gets incredibly quiet after dark—ideal for travelers who want to experience authentic suburban living while having Seneca's attractions nearby.

Top landmarks in Seneca

A waterfall surrounded by autumn foliage.

High Falls County Park

High Falls County Park is worth a visit, located 7.8 mi (12.5 km) from central Seneca.
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A grassy field with yellow flowers and trees in the foreground, with mountains in the background.

Blue Ridge Field

Blue Ridge Field is worth a visit, located 0.8 mi (1.2 km) from central Seneca.
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Oconee County Library Seneca Branch

Oconee County Library Seneca Branch is worth a pic or two when discovering Downtown.
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South Cove Park

South Cove Park is worth a visit, located 2 mi (3.3 km) from central Seneca.
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Friendship Recreation Area

Friendship Recreation Area is worth a visit, located 6.5 mi (10.5 km) from central Seneca.
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Seneca City Hall

Seneca City Hall is worth a pic or two when discovering Downtown.
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The Gauntlet

If you want to see a show while you're in town, try and grab some tickets at The Gauntlet in Downtown. If you enjoy the show and want to see another, Oconee Community Theatre isn't far.
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Seneca Historic District

If you're planning a bit of sightseeing head to Seneca Historic District— just one of the monuments in Downtown.
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Learn more about Seneca

Between the crystal waters of Lake Keowee and the misty cascade of Isaqueena Falls lies a playground for outdoor enthusiasts. Kayak across the lake while keeping an eye out for bald eagles soaring overhead and blue herons stalking the shallows. The lush forests of Oconee State Park offer hiking trails for every skill level, with shade-dappled paths winding through ancient trees. Twin Lakes Recreation Area provides family-friendly spots to picnic after a morning on the water. Dog owners shouldn't miss The Pier Dog Park, where four-legged friends can splash along the shoreline. After a day of adventure, the coffeehouses in the historic downtown offer the perfect place to recharge while planning tomorrow's excursion to Keowee Key Golf Course or Lake Hartwell.

See all hotels in Seneca
A calm lake with mountains in the background.

Check out reviews of Seneca hotels guests love

Lakeside Lodge Clemson

Lakeside Lodge Clemson

8/10 Good
"Nice place to stay when visiting a child at Clemson!"
Laura 1-night trip
Posted 1 day ago
Lakeside Lodge Clemson
Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area

8/10 Good
"Friendly staff, close to grocery, fast food, bank etc. close to lake keowee. Could have been cleaner,our feet were dirty just walking on the floor barefoot and trying to wipe water off the floor after coming in from the pool turned the towel brown, so the floors were definitely not getting mopped between guests. We were on ground level and came out after dark and the amount of spiders and spiderwebs kept us from walking out there the following night 😆 someone needs to take a broom around. But overall it was a reasonable price and place to stay. If it was cleaned/better maintained I wouldn't have had anything negative to say."
Valene 3-night trip
Posted 2 days ago
Days Inn by Wyndham Seneca / Clemson Area
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

10/10 Excellent
"Me and my family had a great time"
Nirumol 1-night trip
Posted 2 days ago
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area

10/10 Excellent
"This is the cleanest hotel I’ve ever been to. It’s very new. We had a room with a very nice view of the lake. Glad I found this hotel."
Lucy 1-night trip
Posted 2 days ago
Fairfield Inn & Suites Seneca Clemson Univ Area
Quality Inn Seneca US-123

Quality Inn Seneca US-123

10/10 Excellent
"Persons at front desk and management"
Michael 1-night trip
Posted 4 days ago
Quality Inn Seneca US-123

Frequently asked questions

What accommodations do travelers like in Seneca?
Can I book refundable accommodations in Seneca?
If you want the flexibility to change your travel plans to Seneca, most accommodations offer refundable* bookable rates. You can find these properties by searching our site and using the "fully refundable" filter to narrow the results down.
Where can I stay in Seneca if I want a budget-friendly accommodation?
Lakeside Lodge Clemson, Tru by Hilton Seneca Clemson and Quality Inn Seneca US-123 are a few accommodations you might want to consider that'll save you money.
Where can I stay in Seneca if I want a vacation rental instead of a hotel?
If you want to find a good alternative to a hotel, review our selection of 214 vacation homes. In addition, there are 21 apartments and 11 condos.
What will the weather in Seneca be like during my visit?
The warmest months in Seneca are usually July and August with an average temp of 76°F. January and February are the chilliest months when the average temp is 46°F. The rainiest months are December and January.
Why should I book my Seneca hotel with Hotels.com?
There are plenty of reasons to book your Seneca travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

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