A coastal cityscape with a prominent bridge, clear blue waters, and a marina.

2 Star Hotels in South San Francisco

Free cancellation options if plans change

Earn rewards on every night you stay

Save more with Member Prices

Check prices for these dates

Tonight

Tomorrow

Next weekend

In two weeks

2 Star Hotels in South San Francisco

A courtyard with outdoor seating, a glass table, and potted plants.

A hotel lobby with wooden furniture, a fireplace, and framed pictures on the walls.

A restaurant with wooden cabinets, red upholstered chairs, and a counter with coffee machines and food displays.

A hotel room with two beds, a wooden headboard, a bedside table with a lamp, and a window with curtains.

1. Comfort Inn and Suites San Francisco Airport North

The East Side

$103

$120 total

includes taxes & fees

Oct 16 - Oct 17

A hotel room with a bed, desk, chair, television, and a microwave.

A hotel with a prominent entrance, a covered walkway, and a parking area.

A breakfast bar with various food items and a sign that says "Healthy."

A gym with cardio machines, weight machines, and a TV screen.

2. Hotel Nova SFO

South San Francisco

$130

$152 total

includes taxes & fees

Oct 2 - Oct 3

A modern building entrance with a covered walkway, large glass doors, and potted plants.

A reception area with a wooden floor, a reception desk, a clock, and a wall with framed pictures and a large bicycle poster.

A hotel room with a double bed, a desk with a chair, a large mirror, a sink with a vanity, and a small bathroom area.

A hotel hallway with an elevator, a red carpet, and a decorative wall piece.

3. Hampton Inn San Francisco Airport

The East Side

$139

$164 total

includes taxes & fees

Oct 16 - Oct 17

A modern hotel room with a large bed, a cityscape painting, a round mirror, a wooden nightstand, and a desk with a chair.

A modern kitchen with a refrigerator, a sink, and a countertop.

A multi-story hotel with a central courtyard, parking area, and a well-lit facade.

4. Days Inn by Wyndham San Francisco S/Oyster Point Airport

Paradise Valley

$93

$117 total

includes taxes & fees

Oct 18 - Oct 19

A spacious lobby with a central seating area, a reception desk, and a second-floor balcony.

A Holiday Inn Express hotel with a well-lit entrance, a parking lot, and a clear sky.

A hotel room with a bed, a desk, a chair, a sofa, and a television.

5. Holiday Inn Express San Francisco-Airport North by IHG

South San Francisco

$114

$145 total

includes taxes & fees

Oct 25 - Oct 26

A hotel room with a large window, a flat-screen TV, a glass coffee table, two wooden chairs, a patterned rug, and a potted plant.

A hotel room with two beds, each with a wooden headboard, white bedding, and a blue patterned throw. There is a nightstand with a lamp between the beds, and two framed artworks on the walls.

A Travelodge hotel with a modern design, featuring a prominent sign, a covered entrance, and a bench outside.

A rectangular swimming pool with a clear blue water, surrounded by lounge chairs and a covered seating area.

6. Travelodge by Wyndham San Francisco Airport North

South San Francisco

$74

$88 total

includes taxes & fees

Oct 25 - Oct 26

An indoor courtyard with a stone floor, a round table with chairs, and potted plants.

A courtyard with a flat roof, potted plants, and outdoor seating.

A reception area with a wooden desk, a vase of flowers, a map, and a view of the outside.

A reception area with a seating arrangement, a large window with a view of the street, and an air conditioning unit.

7. Airport Inn

Downtown South San Francisco

$130

$152 total

includes taxes & fees

Oct 2 - Oct 3

A modern seating area with a bench and a round table, a concrete wall, and a view of greenery outside.

A modern interior with a red sofa, a round table, and a bench along a glass wall.

A modern living area with a large window, a red couch, a round table, and a wall-mounted clock.

A hotel room with two beds, a desk, a chair, and a view of the outside.

8. Rodeway Inn South San Francisco Airport

South San Francisco

$88

$104 total

includes taxes & fees

Oct 25 - Oct 26

A hotel room with a bed, a desk, a chair, a TV, and a lamp.

A reception area with a reception desk, a large mirror, a clock, and a wall-mounted sign with operating hours.

A reception desk with a digital display, framed awards, and a bronze elephant statue.

A yellow building with a balcony, outdoor seating area with chairs and a table, and potted plants.

9. Inn By The SFO

Downtown South San Francisco

$89

$105 total

includes taxes & fees

Oct 4 - Oct 5

A room with a TV, two blue chairs, a small table, and a painting of the ocean.

A small round table with two black chairs, each with a metallic base.

A building with a beige exterior, a red roof, and a balcony with hanging flower baskets.

A room with a red couch, a wooden table, a red armchair, a small round table with a plant, a dartboard, and a painting of a coastal scene.

10. Americana Inn

South San Francisco

$116

$135 total

includes taxes & fees

Oct 6 - Oct 7

A hotel room with a large bed, a desk, a chair, a coffee maker, and a TV.

A reception area with a counter, decorative vases, and a view of a parking lot with a white vehicle.

A compact kitchenette with a microwave, coffee maker, and a small refrigerator.

A row of red geraniums along a sidewalk next to a building with blue shutters and a striped bench.

11. Deluxe Inn

South San Francisco

$125

$147 total

includes taxes & fees

Sep 29 - Sep 30

A hotel room with a bed, a desk with a chair, a window with curtains, and a door leading to a bathroom.

A compact room with a bed, a television, a small white refrigerator, and a heater.

A reception area with a glass door, a counter with magazines, and a view of the outside.

A covered walkway with stone walls and large windows.

12. Travelers Inn

South San Francisco

$124

$145 total

includes taxes & fees

Sep 28 - Sep 29

A neatly made bed with white linens and a folded towel, a wooden headboard, and a window with blinds.

A living room with a stone fireplace, a sofa set, a coffee table, and a chandelier.

A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, and a coffee maker on the countertop.

A residential building with a narrow front yard, a small porch, and a staircase leading to the entrance.

13. Miller Apartments

Downtown South San Francisco

$54

$139 total

includes taxes & fees

Sep 29 - Sep 30

A corridor with a view of a parking lot and distant hills.

A bathroom with a granite countertop sink, a mirror, a towel dispenser, and a black microwave.

A hotel room with two beds, a desk, a chair, and a small table.

A hotel with multiple balconies and a parking lot with several cars.

14. Royal Inn

South San Francisco

$105

$123 total

includes taxes & fees

Oct 16 - Oct 17

A spacious, well-lit atrium with a high ceiling and skylight, featuring a central seating area with a sofa and armchairs, surrounded by a patterned rug.

A modern lobby with a sofa, yellow armchair, and a round coffee table.

A modern hotel room with a large bed, bedside tables, a desk, and a window with blinds.

A modern atrium with a glass ceiling, multiple levels, and indoor plants.

15. Hotel Aluxor SFO

San Bruno

$114

$137 total

includes taxes & fees

Oct 25 - Oct 26

A hotel room with a bed, bedside tables, a desk, a chair, and a large window.

A hotel lobby with a glass door entrance, a reception desk, a large window, and a wall display of brochures.

The exterior of Gateway Suites hotel with a prominent sign, large windows, and a well-maintained garden area.

A hotel lobby with a reception desk, a dining area with wicker chairs, and a red wall with a clock.

16. Gateway Inn & Suites San Francisco SFO Airport

San Bruno

$87

$105 total

includes taxes & fees

Oct 4 - Oct 5

A hotel room with a bed, a sofa, a nightstand, and a desk. There are three framed pictures on the wall.

A reception area with a tiled counter, a fire extinguisher, a window with a view, and a wall-mounted coffee station.

A hotel kitchen with a coffee machine, tea station, and a refrigerator.

A spacious indoor area with a high ceiling, a central seating area with chairs and a table, and a mezzanine level with a railing.

17. The Atrium Hotel

San Bruno

$141

$168 total

includes taxes & fees

Oct 11 - Oct 12

A waterfront hotel with a concrete barrier, a pathway, and palm trees.

A coastal hotel with a pathway leading to the water, palm trees, and a clear view of the sea.

A modern lounge area with leather sofas, a round coffee table, and a view of the city through large windows.

A balcony with a view of a calm body of water, palm trees, and a distant shoreline.

18. Vagabond Inn Executive San Francisco Airport

Ingold - Milldale

$114

$129 total

includes taxes & fees

Oct 25 - Oct 26

A hotel room with a bed, a bedside table with a lamp, a television mounted on the wall, and a bench.

A modern lobby with leather seating, a reception desk, and a flat-screen TV.

A hotel room with a wooden dining table, a bench, a painting, a lamp, and a coffee machine.

A modern interior with a mosaic wall, a glass door entrance, and a ceiling light fixture.

19. Hotel Union Square

Union Square

$111

$130 total

includes taxes & fees

Oct 22 - Oct 23

A hotel room with two beds, a desk, a chair, and a television.

A reception area with a desk, chairs, a bulletin board with travel brochures, a window with blinds, and a door.

An office building with a red awning, a glass door entrance, and outdoor seating with chairs and tables.

A hotel room with a desk, chair, television, and a refrigerator with a coffee maker.

20. Regency Inn SFO Airport

San Bruno

$121

$139 total

includes taxes & fees

Oct 3 - Oct 4

See more properties

Top neighborhoods in South San Francisco

A panoramic view of San Francisco's South Peninsula, highlighting the city's dense urban areas, rolling hills, and the iconic Golden Gate Bridge in the distance.

An aerial view of a city with a large stadium, several schools, and a dense residential area.

An aerial view of a coastal city with a dense urban area, a large port, and a mountainous backdrop.

Downtown South San Francisco

Downtown South San Francisco buzzes with a blend of biotech innovation and cultural diversity. Corporate towers and colorful murals tell the story of this unique business hub. You'll find authentic taquerias, dim sum houses, and Filipino eateries nestled between modern office campuses along Grand Avenue. The neighborhood comes alive during weekdays when professionals fill its plazas and restaurants. Getting around is a breeze with nearby BART and Caltrain stations connecting you to San Francisco proper and beyond. Business hotels cater mostly to corporate travelers with practical amenities. The area quiets down after work hours, offering a genuine glimpse into Bay Area life away from tourist crowds.

See properties

A wooden bridge over a river, surrounded by autumn-colored vegetation and a distant mountain.

A nighttime view of the Golden Gate Bridge with its distinctive orange color and suspension cables.

A modern building complex by a calm river with sparse vegetation.

Oyster Point

Oyster Point balances sleek biotech campuses with stunning San Francisco Bay views. The waterfront promenade offers perfect spots for watching waves crash against the shore or catching a beautiful sunset. Modern plazas feature public art installations while walking paths showcase both cutting-edge architecture and natural bay ecosystems. Business travelers appreciate the corporate hotels with meeting facilities and convenient access to office buildings. Dining options cater primarily to weekday lunch crowds, with most establishments closing early evening. The area is best explored by car, though waterfront paths provide scenic strolling opportunities away from the corporate hustle.

See properties

The Golden Gate Bridge with its distinctive red towers and cables, spanning across the San Francisco Bay.

A large, modern bridge with a unique design against a clear blue sky.

The East Side

The East Side delivers authentic local life away from San Francisco's tourist traps. Catch Bay views from San Bruno Point Park or explore diverse family-owned restaurants along Grand Avenue serving up killer tacos and pho. This residential neighborhood mixes Hispanic and Asian influences that shine through local markets and casual eateries. Budget travelers appreciate the affordable motels and extended-stay options that cost way less than downtown San Francisco. Buses connect to BART and Caltrain, though having wheels helps. Most spots close early, so plan your food adventures accordingly.

See properties

A mountainous landscape with rolling hills, dense forests, and a distant view of hills.

Paradise Valley

Paradise Valley offers a peaceful retreat from San Francisco's bustle while keeping you close to the action. This quiet residential neighborhood in South San Francisco balances suburban calm with convenient access to nearby attractions. Take a stroll through San Bruno Point Park or venture to local spots like K1 Speed for some indoor racing fun. Budget-friendly accommodations make Paradise Valley an appealing base for Bay Area exploration. The neighborhood's proximity to San Francisco International Airport and major highways ensures easy connections throughout the region. With ample street parking and minimal crowds, you'll appreciate this low-key alternative to the city's more hectic districts.

See properties

The Golden Gate Bridge spanning the Golden Gate Strait, with a city skyline in the background.

Serra Highlands

Serra Highlands offers a peaceful retreat from the Bay Area buzz with its hillside streets and family-friendly vibe. While there aren't tourist attractions within the neighborhood itself, you'll enjoy stunning panoramic views, quiet walking paths, and easy access to nearby highlights like Serramonte Center. Morning fog rolling over the hills creates a mystical atmosphere worth waking up for. Getting around requires a car or rideshare, as public transit is limited in this residential area. Accommodations consist mainly of vacation rental homes with suburban comforts like driveways and yards. For dining and shopping, you'll need to venture to surrounding commercial areas, making Serra Highlands perfect for travelers seeking authentic local living.

See properties

Top landmarks in South San Francisco

San Bruno Point Park

7.8/10 (451 reviews)

If you like quiet time surrounded by flowers and greenery, hang out at San Bruno Point Park in The East Side. Our travelers also like this walkable area for its restaurants. Want to stretch your legs some more? Head to Bayfront Park and John McLaren Park, both nearby.

See properties

South San Francisco Convention Center

7.8/10 (668 reviews)

South San Francisco Convention Center is worth a visit, located 0.5 mi (0.8 km) from central South San Francisco. Hotels.com travelers also say the area is artsy and has lots of nice beaches. It's also full of great shops and restaurants, so you can spend the afternoon having a wander.

See properties

San Francisco Baking Institute

7.6/10 (423 reviews)

If you'd like to get a taste of South San Francisco student life, check out San Francisco Baking Institute in The East Side. Let yourself be amazed at the art galleries in the area— your cultural tour starts here. It's also full of great shops and restaurants, so you can spend the afternoon having a wander. South San Francisco has other landmarks you might want to visit such as Golden Gate Bridge.

See properties

See's Candies

8.0/10 (474 reviews)

See's Candies is 1.2 mi (2 km) from central South San Francisco, why not stop by during your stay. Hotels.com travelers also say the area is full of friendly people and has lots of nice beaches. It's also full of great shops and restaurants, so you can spend the afternoon having a wander. If you have fun at See's Candies, you'll love K1 Speed San Francisco, located nearby.

See properties

South San Francisco Hillside Sign

If you're planning a bit of sightseeing head to South San Francisco Hillside Sign— just one of the monuments in Paradise Valley. South San Francisco has other landmarks you might want to visit such as Golden Gate Bridge.

See properties

K1 Speed San Francisco

7.6/10 (330 reviews)

K1 Speed San Francisco is 1.1 mi (1.7 km) from central South San Francisco, why not stop by during your stay. Hotels.com travelers also say the area is full of friendly people and has lots of nice beaches. It's also full of great shops and restaurants, so you can spend the afternoon having a wander. If you have fun at K1 Speed San Francisco, you'll love See's Candies, located nearby.

See properties

Sign Hill Park

If you like quiet time surrounded by flowers and greenery, then make a stop at Sign Hill Park located 8.6 mi (13.8 km) from the center of San Francisco. Want to stretch your legs some more? Head to San Bruno Point Park and John McLaren Park, both nearby.

See properties