Hotels in Santee
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Top 5 hotels in Santee at a glance
- Tru By Hilton Santee — 2.5-star hotel in Santee. Guest rating: 9.2/10 — Wonderful.
- Baymont by Wyndham Santee — 2.5-star hotel in Santee. Guest rating: 8.0/10 — Very Good.
- Hampton Inn Santee-I-95 — 2.5-star hotel in Santee. Guest rating: 9.6/10 — Exceptional.
- Best Western Plus Santee Inn — 2.5-star hotel in Santee. Guest rating: 8.8/10 — Excellent.
- Fairfield Inn & Suites by Marriott Santee — 3-star hotel in Santee. Guest rating: 9.8/10 — Exceptional.
Where to stay in Santee?

Tru By Hilton Santee
Tru By Hilton Santee
Baymont by Wyndham Santee
Baymont by Wyndham Santee
Hampton Inn Santee-I-95
Hampton Inn Santee-I-95
Best Western Plus Santee Inn
Best Western Plus Santee Inn
Fairfield Inn & Suites by Marriott Santee
Fairfield Inn & Suites by Marriott Santee
Holiday Inn Santee by IHG
Holiday Inn Santee by IHG
Comfort Inn & Suites Santee
Comfort Inn & Suites Santee
Travelodge by Wyndham Santee
Travelodge by Wyndham Santee
Super 8 by Wyndham Santee/I-95
Super 8 by Wyndham Santee/I-95
Quality Inn & Suites Santee I-95
Quality Inn & Suites Santee I-95
Red Roof Inn Santee
Red Roof Inn Santee
Econo Lodge Santee
Econo Lodge Santee
Ramada by Wyndham Santee I-95
Ramada by Wyndham Santee I-95
Bells Marina & Resort
Bells Marina & Resort
Doyles B and B at Players course LLC
Doyles B and B at Players course LLC
Sunset Inn Manning I 95
Sunset Inn Manning I 95
Red Roof Inn Orangeburg
Red Roof Inn Orangeburg
Fairfield Inn by Marriott Orangeburg
Fairfield Inn by Marriott Orangeburg
Peach Tree Inn
Peach Tree Inn
Tru by Hilton Orangeburg
Tru by Hilton OrangeburgGet last-minute hotel deals in Santee and save more



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Go beyond your typical stay in Santee
Top landmarks in Santee
Learn more about Santee
Tee off at championship golf courses or cast a line in Lake Marion's fish-rich waters where locals claim the bass practically jump into your boat. The Santee National Wildlife Refuge offers hiking trails where alligators sun themselves with reptilian nonchalance. Interstate 95 crosses the lake on a causeway that provides views worth pulling over for (safely, of course). Santee State Park delivers lakeside tranquility that makes visitors forget their phones exist. This resort town punches well above its weight with dining options that range from fresh-caught catfish to surprisingly sophisticated fare. The recent addition of the Santee Cooper Regional Water System has locals buzzing about growth while still cherishing their small-town atmosphere.

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