Hotels in Clarksdale

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Where to stay in Clarksdale?

A pool area with a rock formation backdrop, a wooden post, and a sign indicating a clinic.

A wooden reception desk with a moose mural, a mounted cow head, and a framed map on the wall.

A hotel room with a large bed, a fireplace, a TV, and a jacuzzi.

A cozy log cabin interior with a fireplace, wooden furniture, and a television.

1. Stoney Creek Hotel St. Joseph

St. Joseph

$134

$155 total

includes taxes & fees

Sep 13 - Sep 14

A lobby with a seating area, a reception desk, and a chandelier.

A Drury Inn & Suites hotel with a modern architectural design, featuring a covered entrance and a parking lot.

A hotel lobby with a reception desk, seating area, and a refrigerator.

An indoor swimming pool with clear water, surrounded by lounge chairs and tables, and large windows providing natural light.

2. Drury Inn & Suites St Joseph

St. Joseph

$110

$127 total

includes taxes & fees

Sep 20 - Sep 21

An indoor swimming pool with clear lane markings, a lifeguard chair, and a pool ladder.

A Hampton Inn by Hilton building with a modern facade, large windows, and a well-lit entrance.

A neatly made bed with white linens and a headboard.

A reception desk with a clock, a framed picture, and a wall with a 'smile' sign.

3. Hampton Inn St. Joseph

St. Joseph

$89

$103 total

includes taxes & fees

Oct 4 - Oct 5

A modern living room with a blue sofa, a fireplace, and a stone accent wall.

An indoor swimming pool with clear water, a lifeguard chair, and a pool ladder.

A restaurant with a long wooden table, chairs, and a bar area.

A Fairfield Inn & Suites Marriott hotel entrance with a modern design, including a prominent overhang and a stone pillar.

4. Fairfield Inn & Suites by Marriott St. Joseph

St. Joseph

$105

$122 total

includes taxes & fees

Oct 4 - Oct 5

A hotel room with a bed, a sofa, a small table, a microwave, and a TV.

A coffee station with two espresso machines, a sign reading "MUST HAVE COFFEE", and a display of coffee-related products.

A hotel reception area with two reception desks, a wall-mounted sign, and a patterned carpet.

A coffee station with two coffee machines, a coffee press, and various coffee pods and cups.

5. Holiday Inn Express Hotel & Suites St. Joseph by IHG

St. Joseph

$101

$117 total

includes taxes & fees

Oct 4 - Oct 5

A swimming pool with a hot tub, a ladder, and a slide.

A hotel room with a large bed, two bedside tables with lamps, a desk, and a chair.

A reception area with a coffee station, a potted plant, and a banner promoting breakfast.

A hotel room with a brown sofa, a wooden coffee table, a desk with a chair, and a lamp. There are three framed pictures on the wall, a window with curtains, and a radiator.

6. Quality Inn Cameron

Cameron

$116

$129 total

includes taxes & fees

Sep 27 - Sep 28

A hotel room with a large bed, two bedside tables, a nightstand, a red wall, and a framed picture on the wall.

A Red Roof Inn with a covered entrance, air conditioning units, and a parking lot with marked spaces.

A hotel room with a bed, a desk, a chair, a television, and an air conditioning unit.

A kitchen with wooden cabinets, a toaster, a fruit bowl, and a waffle maker.

7. Red Roof Inn Cameron

Cameron

$86

$95 total

includes taxes & fees

Oct 1 - Oct 2

A hotel room with two beds, a desk, a television, and a bathroom visible through an open door.

A cozy room with a coffee machine, a clock, and a potted plant.

A modern kitchen with granite countertops, wooden cabinets, and a central island.

A hotel with a covered outdoor area, a brick building, and a sign for a nearby Subway.

8. SureStay Hotel by Best Western Cameron

Cameron

$78

$86 total

includes taxes & fees

Sep 18 - Sep 19

A hotel room with a sofa, two beds, a patterned ottoman, a wall art piece, and a window with a view.

9. Home2 Suites By Hilton St. Joseph

St. Joseph

$114

$132 total

includes taxes & fees

Oct 4 - Oct 5

A multi-story hotel with a 'My Place' sign, featuring a stone facade and a covered entrance.

A modern restaurant with a bar area, seating arrangements, and a kitchen in the background.

A hotel room with a bed, a desk, a chair, a kitchenette, and a framed picture on the wall.

10. My Place Hotel St Joseph MO

St. Joseph

$92

$107 total

includes taxes & fees

Sep 20 - Sep 21

A hotel room with a large bed, a red wall, and a cityscape painting above the bed.

A hotel room with a television, a lamp, a microwave, and a desk with a chair.

A restaurant with green tables and red chairs, a counter with a coffee machine, and a painting on the wall.

11. AmeriStay Inn

St. Joseph

$72

$83 total

includes taxes & fees

Sep 30 - Oct 1

A hotel bathroom with a wooden bathtub, a desk with a lamp, a chair, a television, and a microwave.

A reception area with a marble counter, a fish tank, a welcome sign, and a 'Super 8' sign.

A hotel room with a bed, a desk with a computer, a chair, a TV, and a window with a view.

An indoor swimming pool with clear water, surrounded by white plastic chairs and tables, and a lifeguard sign on the wall.

12. Super 8 by Wyndham Cameron

Cameron

$88

$97 total

includes taxes & fees

Oct 10 - Oct 11

A large, historic brick building with a prominent tower and a grand entrance.

A grand room with a red patterned carpet, a large potted plant, a wooden staircase, and a chandelier.

A traditional room with a fireplace, ornate chandelier, and classic furniture.

A brick building with a covered porch and a large bush of white flowers.

13. Vineyard Mansion & Carriage House Bed & Breakfast

St. Joseph

$107

$157 total

includes taxes & fees

Sep 20 - Sep 21

A hotel room with two beds, a desk, a chair, and a television.

A hallway with a 7UP vending machine, white doors, and a brown mat.

A building with a 'welcome' sign, a number '6' on the door, and a covered entrance area.

A hotel reception area with a wooden counter, a coffee machine, a phone, and a television.

14. Motel 6 Saint Joseph, MO

St. Joseph

$60

$69 total

includes taxes & fees

Oct 4 - Oct 5

A large brick building with multiple windows and a covered porch area.

A covered porch with columns, potted plants, and a brick wall.

A red brick building with a garden in front.

A traditional interior with a fireplace, a wooden staircase, and a patterned floor.

15. Whiskey Mansion

St. Joseph

$156

$181 total

includes taxes & fees

Sep 10 - Sep 11

A gazebo with a metal roof and wooden benches.

A lobby with a fireplace, a table with four chairs, and a patterned carpet.

A hotel room with a wooden desk, two red chairs, a TV mounted on the wall, a mirror, and a wardrobe.

A hotel room with two beds, a nightstand with a lamp, a small table, a mirror, and a window.

16. Econo Lodge Cameron

Cameron

$75

$83 total

includes taxes & fees

Sep 27 - Sep 28

A reception desk with a "WELCOME" sign, a clock, and a mirror.

A hotel room with two beds, a desk with a chair, a microwave, a TV, and a small shelf with toiletries.

A park bench with metal supports and a wooden seat, surrounded by trees and a gravel path.

A building with a covered entrance, brick walls, and a white roof.

17. Motel 6 Cameron, MO

Cameron

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Go beyond your typical stay in Clarksdale

Pet friendly

Pool

Family friendly

Check out reviews of Clarksdale hotels guests love

Home2 Suites By Hilton St. Joseph

10/10 Excellent

"Location was close to restaurants and shopping."

Drury Inn & Suites St Joseph

10/10 Excellent

"Very clean friendly staff."

SureStay Hotel by Best Western Cameron

8/10 Good

"Y"

Hampton Inn St. Joseph

8/10 Good

"Clean rooms,staff was very helpful. Pet friendy."

Holiday Inn Express Hotel & Suites St. Joseph by IHG

10/10 Excellent

"Clean room with comfortable bed. Wonderful breakfast buffet."

Vineyard Mansion & Carriage House Bed & Breakfast

10/10 Excellent

"Marcena was so welcoming and took great care of me. If I come back to St. Jo, I'd.love to stay there again. Thank you!"

My Place Hotel St Joseph MO

10/10 Excellent

"Never stayed at one. It was awesome. Very clean room with tons of amenities. Staff was wonderful and the parking was great. Kitchen was very useful."

Whiskey Mansion

10/10 Excellent

"The breakfast was truly amazing. Everything prepared from scratch. The host was so friendly and helpful.If you love old mansions you’ll love Whiskey Mansion."

Motel 6 Saint Joseph, MO

8/10 Good

"Yes. Air was nice and cool! No pets with me."

Frequently asked questions

Can I book a refundable hotel in Clarksdale?

If you're looking for the flexibility to change your plans to Clarksdale, most accommodations offer refundable* rates you can book. You can see these accommodations by searching our site and using the "fully refundable" filter to narrow the results down.

What will the weather in Clarksdale be like during my visit?

The warmest months in Clarksdale are usually July and August with an average temp of 74°F. January and February are the chilliest months when the average temp is 33°F. The rainiest months are May and July.

Why should I book my Clarksdale hotel with Hotels.com?

There are plenty of reasons to book your Clarksdale travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

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