A coastal archaeological site with ruins and boats on the water.

Business Hotels in Santiago

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Business Hotels in Santiago

A pool area with lounge chairs and a covered seating area, surrounded by modern buildings.

A restaurant with booths and tables, wooden paneling, and green plants.

A spacious lobby with a central water feature, multiple seating areas, and a curved ceiling with hanging lights.

A modern hotel with a prominent entrance, outdoor seating area, and a handicap-accessible parking space.

1. Hotel Mykonos Panama

Nuevo Santiago

$90

$99 total

includes taxes & fees

Sep 30 - Oct 1

A modern lobby with a sofa, armchairs, a desk, and a large window offering a view of the cityscape.

A lobby with a reception desk, two armchairs, a sofa, and a table with a lamp.

A bathroom with a tiled shower wall, a sink, and a towel rack.

A hotel room with two single beds, a desk with a chair, a television, and a door.

2. Hotel Plaza Los Tucanes

Nuevo Santiago

$52

$57 total

includes taxes & fees

Sep 30 - Oct 1

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Top landmarks in Santiago

Escuela Normal Juan Demostenes Arosemena

9.2/10 (9 reviews)

If you'd like to get a taste of Santiago student life, check out Escuela Normal Juan Demostenes Arosemena, in the heart of the town.

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Catedral of Santiago Apostol

8.8/10 (13 reviews)

If you're planning a bit of sightseeing during your trip, head to Catedral of Santiago Apostol— just one of the monuments in central Santiago.

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Omar Torrijos Herrera Stadium

8.4/10 (9 reviews)

You can catch an event at Omar Torrijos Herrera Stadium, located 0.6 mi (1 km) from central Santiago.

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Plaza Banconal

8.6/10 (12 reviews)

If you like shopping, take time out to go to Plaza Banconal when in Santiago.

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About the destination

If you're looking to discover somewhere new, look no further than Santiago. Whether you're planning to stay for a night or for the week, the area around Santiago has accommodations to fit every need. Search for hotels in Santiago with Hotels.com by checking our online map. Our map displays the areas and neighborhoods around all Santiago hotels so you can see how close you are from landmarks and attractions, and then refine your search within the larger area. The best Santiago hotel deals are here with our lowest price guarantee.