Hotels in Defiance

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Check prices for these dates

Tonight
Mar 24 - Mar 25
Tomorrow
Mar 25 - Mar 26
This weekend
Mar 27 - Mar 29
Next weekend
Apr 3 - Apr 5

Where to stay in Defiance?

Standard Room, 2 Queen Beds | In-room safe, desk, laptop workspace, blackout drapes
Super 8 by Wyndham Warrenton
Super 8 by Wyndham Warrenton
2.0 star property
Warrenton
7.4 out of 10, Good, (635 reviews)
  • cleanliness
    Wake up refreshed at this peaceful Warrenton motel with soundproof accommodations.
The price is $54
$62 total
includes taxes & fees
Mar 31 - Apr 1
Super 8 by Wyndham Warrenton
Lobby
Quality Inn Foristell
Quality Inn Foristell
2.5 star property
Foristell
8.2 out of 10, Very Good, (954 reviews)
  • cleanliness
    Comfortable lodge near Cedar Lake Cellars with peaceful sleep for road warriors.
The price is $78
$88 total
includes taxes & fees
Apr 9 - Apr 10
Quality Inn Foristell
Indoor pool
Baymont by Wyndham Warrenton
Baymont by Wyndham Warrenton
2.5 star property
Warrenton
7.6 out of 10, Good, (1,000 reviews)
  • cleanliness
    Stay close to Veterans Memorial with indoor pool and complimentary perks.
The price is $80
$91 total
includes taxes & fees
Mar 31 - Apr 1
Baymont by Wyndham Warrenton
Reception
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
3.0 star property
Fenton
8.0 out of 10, Very Good, (1,157 reviews)
  • cleanliness
    Central Fenton stay with both indoor and outdoor pools for year-round swimming.
The price is $89
$103 total
includes taxes & fees
Mar 29 - Mar 30
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Exterior
WoodSpring Suites St Peters-OFallon
WoodSpring Suites St Peters-OFallon
2.5 star property
St. Peters
9.0 out of 10, Wonderful, (59 reviews)
  • cleanliness
    Within a 15-minute drive of Ameristar Casino, enjoy extended stay comfort.
The price is $89
$105 total
includes taxes & fees
Mar 28 - Mar 29
WoodSpring Suites St Peters-OFallon
Family Studio Suite (No Elevator Access) | Egyptian cotton sheets, premium bedding, down comforters, pillowtop beds
River Sirens Hotel
River Sirens Hotel
2.5 star property
Washington
9.8 out of 10, Exceptional, (191 reviews)
  • cleanliness
    River Sirens Hotel offers proximity to Lafayette Plaza with free parking and WiFi.
The price is $132
$151 total
includes taxes & fees
Mar 29 - Mar 30
River Sirens Hotel
Reception
Hampton Inn St. Louis Wentzville
Hampton Inn St. Louis Wentzville
2.5 star property
Wentzville
9.0 out of 10, Wonderful, (674 reviews)
  • cleanliness
    Comfortable rooms near Wentzville Flea Market with indoor pool year-round.
The price is $119
$136 total
includes taxes & fees
Apr 6 - Apr 7
Hampton Inn St. Louis Wentzville
Lobby
Drury Inn & Suites St. Louis St. Peters
Drury Inn & Suites St. Louis St. Peters
3.0 star property
St. Peters
9.4 out of 10, Exceptional, (1,007 reviews)
  • cleanliness
    Tranquil retreat near Mid Rivers Mall with indoor pool and complimentary breakfast.
The price is $110
$126 total
includes taxes & fees
Mar 29 - Mar 30
Drury Inn & Suites St. Louis St. Peters
Lobby lounge
Fairfield Inn & Suites Wentzville
Fairfield Inn & Suites Wentzville
3.0 star property
Wentzville
9.0 out of 10, Wonderful, (665 reviews)
  • cleanliness
    Experience relaxing stays with indoor pool and fitness facilities in Wentzville.
The price is $132
$152 total
includes taxes & fees
Mar 29 - Mar 30
Fairfield Inn & Suites Wentzville
Exterior
Holiday Inn Express St. Louis West - O'Fallon by IHG
Holiday Inn Express St. Louis West - O'Fallon by IHG
2.5 star property
O'Fallon
8.6 out of 10, Excellent, (887 reviews)
  • cleanliness
    Comfort near St. Louis with free perks and friendly service to enhance your visit.
The price is $95
$112 total
includes taxes & fees
Apr 5 - Apr 6
Holiday Inn Express St. Louis West - O'Fallon by IHG
Lobby
Super 8 by Wyndham Washington
Super 8 by Wyndham Washington
2.0 star property
Washington
8.4 out of 10, Very Good, (714 reviews)
  • cleanliness
    Wake up to peaceful mornings near Washington Square with a free breakfast to start your day.
The price is $83
$94 total
includes taxes & fees
Mar 31 - Apr 1
Super 8 by Wyndham Washington
Lobby
Quality Inn Near Six Flags St. Louis
Quality Inn Near Six Flags St. Louis
2.5 star property
Pacific
8.4 out of 10, Very Good, (366 reviews)
  • cleanliness
    Stay minutes from Six Flags St. Louis at this quiet hotel with free breakfast.
The price is $109
$125 total
includes taxes & fees
Mar 26 - Mar 27
Quality Inn Near Six Flags St. Louis
Lobby
Drury Plaza Hotel St. Louis Chesterfield
Drury Plaza Hotel St. Louis Chesterfield
3.0 star property
Chesterfield
9.8 out of 10, Exceptional, (1,104 reviews)
  • cleanliness
    Experience comfort in Chesterfield with dual pools and complimentary breakfast daily.
The price is $130
$151 total
includes taxes & fees
Apr 3 - Apr 4
Drury Plaza Hotel St. Louis Chesterfield
Front of property - evening/night
Cedar Creek
Cedar Creek
3.0 star property
New Haven
9.0 out of 10, Wonderful, (265 reviews)
  • cleanliness
    Taking a swing at nature just steps from the green at this golf lodge in New Haven.
The price is $164
$175 total
includes taxes & fees
Mar 28 - Mar 29
Cedar Creek
Lobby
Best Western Plus Washington Hotel
Best Western Plus Washington Hotel
2.5 star property
Washington
9.2 out of 10, Wonderful, (667 reviews)
  • cleanliness
    Stay near the train station with easy access to Washington's popular parks.
The price is $129
$147 total
includes taxes & fees
Mar 29 - Mar 30
Best Western Plus Washington Hotel
Studio, 2 Double Beds, Accessible, Non Smoking | Desk, blackout drapes, iron/ironing board, free WiFi
Extended Stay America Suites St Louis St Peters
Extended Stay America Suites St Louis St Peters
2.5 star property
St. Peters
7.0 out of 10, Good, (630 reviews)
  • cleanliness
    Peaceful retreat near Ameristar Casino, with free WiFi and complimentary parking.
The price is $80
$92 total
includes taxes & fees
Mar 29 - Mar 30
Extended Stay America Suites St Louis St Peters
In-room safe, desk, laptop workspace, blackout drapes
TownePlace Suites by Marriott Wentzville
TownePlace Suites by Marriott Wentzville
3.0 star property
Wentzville
9.4 out of 10, Exceptional, (50 reviews)
  • cleanliness
    Comfortable extended-stay hotel near Wentzville attractions with daily breakfast.
The price is $151
$178 total
includes taxes & fees
Mar 29 - Mar 30
TownePlace Suites by Marriott Wentzville
Lobby
Drury Inn & Suites Southwest St. Louis
Drury Inn & Suites Southwest St. Louis
3.0 star property
Valley Park
9.6 out of 10, Exceptional, (1,007 reviews)
  • cleanliness
    Splash into comfort at Valley Park with indoor and outdoor pools for year-round fun.
The price is $115
$135 total
includes taxes & fees
Apr 3 - Apr 4
Drury Inn & Suites Southwest St. Louis
Premium bedding, desk, iron/ironing board, free WiFi
Sleep Inn & Suites O'Fallon MO - Technology Drive
Sleep Inn & Suites O'Fallon MO - Technology Drive
2.5 star property
O'Fallon
9.0 out of 10, Wonderful, (1,000 reviews)
  • cleanliness
    Enjoy a quiet stay in O'Fallon with indoor swimming and fitness amenities.
The price is $79
$93 total
includes taxes & fees
Apr 15 - Apr 16
Sleep Inn & Suites O'Fallon MO - Technology Drive
Exterior
Holiday Inn Express Warrenton by IHG
Holiday Inn Express Warrenton by IHG
2.5 star property
Warrenton
9.0 out of 10, Wonderful, (527 reviews)
  • cleanliness
    Quiet retreat with complimentary perks and convenient Warrenton location.
The price is $142
$162 total
includes taxes & fees
Apr 5 - Apr 6
Holiday Inn Express Warrenton by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Showing deals for:Apr 3 - Apr 5
Apartment (0 Bedroom) | Front of property
The Merlot Bungalow Defiance Tiny Home on Trail

The Merlot Bungalow Defiance Tiny Home on Trail

The Merlot Bungalow Defiance Tiny Home on Trail
3.0 star property
Defiance
The price is $135
per night
$456 total
includes taxes & fees
The Merlot Bungalow Defiance Tiny Home on Trail

Top landmarks in Defiance

Missouri wineries have some of the most superb wine we've ever tasted! We recommend sipping on some chambourcin while basking in the sunshine.
Photo by Pages of Travel
Open Photo by Pages of Travel

Chandler Hill Vineyards

Sip Missouri and California wines on a 4,500-square-foot terrace overlooking scenic vineyards. Come late afternoon to catch golden sunsets while enjoying live music and locally-inspired dishes from their full kitchen.
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Wetlands landscape with a bird blind and cloudy sky reflected in a lake at the August A. Busch Memorial Conservation Area in St. Charles County Missouri

August A. Busch Memorial Conservation Area

The Busch Conservation Area spans nearly 7,000 acres with 30 lakes and miles of trails for hiking and wildlife spotting. Look for the hidden WWII-era munitions bunkers while exploring this natural playground.
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Learn more about Defiance

Defiance is well-known for its attractions such as Chandler Hill Vineyards and Matson Hill Park Trailhead.

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A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri

Check out reviews of Defiance hotels guests love

Sonesta ES Suites St. Louis - Chesterfield

Sonesta ES Suites St. Louis - Chesterfield

8/10 Good
"Will come back because of the pet friendly property. The staff were great. A little outdated especially rugs but love the space and layout."
regina 3-night trip
Posted 4 hours ago
Sonesta ES Suites St. Louis - Chesterfield

Frequently asked questions

What hotels do travelers recommend in Defiance?
Guests like The Wildwood Hotel.
Can I book refundable accommodations in Defiance?
If you need the flexibility to change your plans to Defiance, most hotels offer refundable* rates you can book. You can find these accommodations by searching our site and using the "fully refundable" filter to narrow down the results.
What will the weather in Defiance be like during my vacation?
July and August are typically the warmest months in Defiance when the average temp is 76°F. January and February are the coldest months when the average temperature is 38°F. May and April are the months with the most rain.
Why should I book my Defiance hotel through Hotels.com?
There are lots of reasons to book your Defiance trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.