Hotels in Defiance

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Where to stay in Defiance?

A hotel room with two beds, a desk with a chair, a television, and a window with curtains.

A hotel lobby with a seating area, a reception desk, and a flat-screen TV mounted on the wall.

A reception desk with a modern design, featuring a blue geometric wall and a wooden finish.

A modern hotel room with a desk, chair, and a large mirror.

1. Holiday Inn Express St. Louis West - O'Fallon by IHG

O'Fallon

$101

$119 total

includes taxes & fees

Sep 27 - Sep 28

A hotel with a prominent tower, a fountain in the courtyard, and a well-maintained garden.

A spacious living area with a staircase, a large painting, and a chandelier.

A hotel room with a large bed, a bedside lamp, a telephone, a mirror, and a bathroom with a sink and towel rack.

A formal dining table set for six with a vase of white flowers, candles, and a view of buildings through large windows.

2. The Wildwood Hotel

Wildwood

$92

$107 total

includes taxes & fees

Oct 12 - Oct 13

A hotel room with a bed, a sofa, a coffee table, and wall art.

A Sleep Inn & Suites hotel with a modern brick facade, a covered entrance, and a parking lot.

A restaurant with wooden tables and chairs, a blue wall with white floral patterns, and a counter with a coffee machine.

A hotel lobby with a reception desk, seating area, and a large potted plant.

3. Sleep Inn & Suites O'Fallon MO - Technology Drive

O'Fallon

$82

$97 total

includes taxes & fees

Oct 5 - Oct 6

A hotel room with two beds, a desk, a chair, a TV, and a large window.

A modern hotel room with a sofa, a small table, a yellow ottoman, a wooden desk, a flat-screen TV, and a bathtub.

A modern dining area with a brick fireplace, yellow and blue chairs, and a blue sofa.

A brick building with a sign reading "Comfort Inn & Suites."

4. Comfort Inn & Suites Chesterfield - St. Louis

Chesterfield

$80

$97 total

includes taxes & fees

Sep 20 - Sep 21

An outdoor patio area with a stone fire pit, wicker furniture, and a covered seating area with a view of the building's interior.

A hotel room with a large bed, bedside lamps, a TV, a desk, and a bathroom.

A hotel room with a sofa, a side table, a lamp, a flat-screen TV, and a bed with a red blanket.

A modern kitchen with wooden cabinets, a stainless steel countertop, and various appliances including a coffee maker and a rice cooker.

5. TownePlace Suites by Marriott St. Louis Chesterfield

Chesterfield

$128

$150 total

includes taxes & fees

Oct 5 - Oct 6

A spacious lobby with a high ceiling, a central seating area with sofas and a coffee table, and a large window providing natural light.

A spacious lobby with a sofa, a coffee station, and a reception desk.

A hotel with a covered entrance, multiple flags, and a well-maintained lawn.

A spacious lobby with a fireplace, comfortable seating, a large painting, and a view of the kitchen area.

6. Hilton Garden Inn St. Louis/O'Fallon MO

O'Fallon

$108

$128 total

includes taxes & fees

Oct 4 - Oct 5

A multi-story hotel with a central entrance featuring a covered patio area.

A hotel room with a desk, chair, sofa, and a window with curtains.

A hotel lobby with a sectional sofa, a fireplace, a flat-screen TV, and framed artwork on the walls.

A hotel with a swimming pool, outdoor seating, and a covered patio area.

7. Staybridge Suites O'Fallon Chesterfield by IHG

O'Fallon

$111

$131 total

includes taxes & fees

Oct 4 - Oct 5

A courtyard with a central seating area, surrounded by trees and a building with a pitched roof.

A store interior with a 'Treats' sign, snack shelves, and a chalkboard with a welcome message.

A modern dining area with a long table, multiple chairs, and pendant lighting.

A reception desk with a "WELCOME TO THE SHOW ME STATE" sign, a wooden counter, and a Hilton Honors sign.

8. Hampton Inn & Suites St. Louis/Chesterfield

Chesterfield

$110

$128 total

includes taxes & fees

Sep 20 - Sep 21

An outdoor patio area with wicker furniture and a central fire feature.

A modern hotel lobby with a bar area, seating arrangements, and a reception desk.

A modern hotel lobby with a reception desk, seating area, and a television screen displaying a map.

A Courtyard Marriott hotel with a parking lot and a green shuttle service.

9. Courtyard by Marriott St. Louis Chesterfield

Chesterfield

$121

$140 total

includes taxes & fees

Oct 11 - Oct 12

Two people in a swimming pool with colorful inflatable rings.

A lobby with a grand staircase, two patterned sofas, a glass coffee table, and a large mirror.

A spacious lobby with a stone fireplace, a chandelier, and a staircase.

A hotel room with a large bed, a desk, a TV, and a view of a pool through the glass door.

10. Holiday Inn St. Louis West Six Flags by IHG

Eureka

$101

$118 total

includes taxes & fees

Sep 21 - Sep 22

A modern kitchen area with a breakfast bar, a coffee machine, and a refrigerator displaying menu options.

A pool area with a blue pool lift chair, a pool user capacity sign, and a tiled wall.

A hotel room with two beds, a blue sofa, a small table, and a kitchenette.

A coffee station with two coffee machines and a display of coffee pods and cups.

11. Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

Chesterfield

$110

$128 total

includes taxes & fees

Sep 20 - Sep 21

A spacious lobby with a stone fireplace, seating area, and a bar with high stools.

A multi-story hotel with a central entrance, large windows, and a well-maintained lawn.

A hotel lobby with a seating area featuring two armchairs, a round coffee table, and a flat-screen TV mounted on a wooden wall.

A modern living room with a fireplace, a flat-screen TV, a sofa, a coffee table, and a dining area.

12. Residence Inn by Marriott O'Fallon

O'Fallon

$131

$155 total

includes taxes & fees

Oct 5 - Oct 6

A spacious living room with a large painting, a fireplace, a staircase, and modern furniture.

An outdoor patio with a beige sofa set, two armchairs, and a table.

A hotel room with a large bed, two sofas, a desk, and a TV.

A hotel room with a dining area, a fireplace, and a view of the outdoors.

13. Best Western Plus Washington Hotel

Washington

$129

$147 total

includes taxes & fees

Sep 16 - Sep 17

A spacious lobby with a high ceiling, a dining area, and a kitchen in the background.

A hotel room with a bathroom, a bed, a nightstand, and a window.

An indoor swimming pool with stone flooring, white walls, and a green stripe. There are chairs and a door with a sign.

A modern hotel lobby with a computer desk, a flat-screen TV, and a ceiling fan.

14. Quality Inn Near Six Flags St. Louis

Pacific

$96

$110 total

includes taxes & fees

Oct 4 - Oct 5

A Super 8 hotel with a flat facade, multiple windows, and a parking lot.

A hotel room with a flat-screen TV, a wooden dresser, a beige sofa, a teal carpet, and a window with curtains.

A hotel room with a bed, a desk, a chair, a nightstand, a lamp, and a large cityscape artwork on the wall.

A breakfast area with wooden cabinets, a coffee station, and a dining table with chairs.

15. Super 8 by Wyndham Eureka/Six Flags Nearby

Eureka

$67

$78 total

includes taxes & fees

Sep 27 - Sep 28

An indoor swimming pool with a hot tub, clear signage, and a view of the outside through large windows.

A modern dining area with yellow and blue chairs, a flat-screen TV, and a kitchen area with appliances.

A modern hotel room with a grey sofa, a wooden coffee table, a flat-screen TV, a wooden dresser, and a large window with curtains.

A hotel room with two beds, a desk with a TV, a chair, and a lamp.

16. Comfort Inn Near Six Flags St. Louis

Pacific

$99

$113 total

includes taxes & fees

Sep 20 - Sep 21

A spacious lobby with a high ceiling, a dining area, and a seating area with sofas and a coffee table.

An indoor swimming pool with clear blue water, a tiled floor, and a ceiling with square vents.

An outdoor patio area with a table and chairs, a glass door entrance, and a visible interior with a dining area.

A hotel room with a bed, a dresser, a nightstand with a lamp, a framed map on the wall, and a carpeted floor.

17. Drury Inn & Suites St. Louis St. Peters

St. Peters

$110

$126 total

includes taxes & fees

Sep 20 - Sep 21

A spacious lobby with a brown leather sofa, multiple chairs, a coffee table with a skull decoration, and a large chandelier.

A large, multi-story hotel with the name "Doubletree by Hilton" prominently displayed on the facade.

A modern building with large glass windows and a covered outdoor area with tables and chairs.

An indoor tennis court with multiple courts, a net, and players.

18. DoubleTree by Hilton Hotel St. Louis - Chesterfield

Chesterfield

$128

$148 total

includes taxes & fees

Sep 19 - Sep 20

A spacious hotel lobby with a long reception desk, multiple seating areas, and large windows allowing natural light.

An indoor swimming pool with a clear water area, a shallow end, and a tiled deck surrounding the pool. There are lounge chairs and tables on the deck, and a sign indicating a maximum capacity of 62.

A Hampton Inn with a brick facade, outdoor seating area, and a clear sky.

A snack display area with various chips and snacks, a refrigerated section, and a wall with a 'Treats' sign.

19. Hampton Inn St. Louis Wentzville

Wentzville

$130

$149 total

includes taxes & fees

Sep 28 - Sep 29

A spacious lobby with a central round table, two sofas, and a chandelier.

An indoor swimming pool area with clear signage indicating a depth of 3 feet and a no diving warning.

A Drury Plaza hotel with a modern design, featuring a curved facade, large windows, and a Drury Plaza sign on the top.

A hotel room with two beds, a patterned wall, and a view of the city through sheer curtains.

20. Drury Plaza Hotel St. Louis Chesterfield

Chesterfield

$130

$151 total

includes taxes & fees

Sep 20 - Sep 21

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Go beyond your typical stay in Defiance

Pet friendly

Pool

Apartment

Hot tub

Cottage

Family friendly

Top landmarks in Defiance

A glass of red wine on a wooden table with a vineyard in the background.

Chandler Hill Vineyards

7.8/10 (7 reviews)

Travelers might want a tour of Chandler Hill Vineyards, just one of the places to visit, and located 1.3 mi (2.1 km) from central Defiance.

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A wooden dock extending into a pond with lily pads, surrounded by lush greenery and a clear blue sky.

August A. Busch Memorial Conservation Area

8.6/10 (7 reviews)

If you like spending time outside, why not spend the afternoon at August A. Busch Memorial Conservation Area, a park located 30.2 mi (48.6 km) from the center of St. Louis.

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Sugar Creek Winery

8.0/10 (1 review)

Travelers might want a tour of Sugar Creek Winery, just one of the places to visit, and located 2.2 mi (3.5 km) from central Defiance.

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Historic Daniel Boone Home and Heritage Center

9.6/10 (4 reviews)

Historic Daniel Boone Home and Heritage Center is just one of the landmarks located 4.3 mi (7 km) from central Defiance, so you might want to stop by for a few pics during your trip.

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Yellow Farmhouse Winery

Travelers might want a tour of Yellow Farmhouse Winery, just one of the places to visit in the heart of Defiance.

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Broemmelsiek Park

Broemmelsiek Park is worth a visit, located 6.2 mi (10 km) from central Defiance.

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Matson Hill Park Trailhead

Matson Hill Park Trailhead is 2.1 mi (3.3 km) from central Defiance, why not stop by during your stay.

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Hamburg Trail Trailhead

Hamburg Trail Trailhead is in the heart of Hamburg, so why not stop by during your stay.

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Learn more about Defiance

Defiance is well-known for its attractions such as Yellow Farmhouse Winery and Chandler Hill Vineyards.

See all hotels in Defiance

A rustic covered bridge with a wooden structure and red accents, surrounded by lush greenery and trees.

Check out reviews of Defiance hotels guests love

Country Inn & Suites by Radisson, St. Charles Historic District

10/10 Excellent

"Super clean rooms, pool area was nice, delicious afternoon cookies, great coffee, beautiful location!"

Sleep Inn & Suites O'Fallon MO - Technology Drive

10/10 Excellent

"Well maintained and friendly staff"

Drury Plaza Hotel St. Louis Creve Coeur

10/10 Excellent

"Drury is always a safe bet!"

Ameristar Casino Resort and Spa

10/10 Excellent

"Everything was as promised and can’t wait to go back. Worth the drive and everything"

Hollywood Casino & Hotel St. Louis

10/10 Excellent

"Clean Bed was sooo comfy"

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

10/10 Excellent

"Staff was welcoming and polite."

Comfort Suites St Charles - St Louis

8/10 Good

"Based on pictures from their website, we expected some hot food at breakfast. Something like biscuits and gravy or scrambled eggs and sausage. There were only basic continental options with waffles and oatmeal being the only thing hot."

Drury Plaza Hotel St. Louis St. Charles

10/10 Excellent

"Great place!"

Drury Plaza Hotel St. Louis Chesterfield

10/10 Excellent

"This hotel was amazing! The staff and service was extremely friendly! I would highly recommend this hotel"

Frequently asked questions

What hotels do travelers recommend in Defiance?

Guests like The Wildwood Hotel and Sleep Inn & Suites O'Fallon MO - Technology Drive.

Can I book refundable accommodations in Defiance?

If you need the flexibility to change your plans to Defiance, most hotels offer refundable* rates you can book. You can find these accommodations by searching our site and using the "fully refundable" filter to narrow down the results.

What will the weather in Defiance be like during my vacation?

July and August are typically the warmest months in Defiance when the average temp is 76°F. January and February are the coldest months when the average temperature is 38°F. May and April are the months with the most rain.

Why should I book my Defiance hotel through Hotels.com?

There are lots of reasons to book your Defiance trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.