Hotels in Defiance

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Tonight
Dec 23 - Dec 24
Tomorrow
Dec 24 - Dec 25
This weekend
Dec 26 - Dec 28
Next weekend
Jan 2 - Jan 4

Where to stay in Defiance?

Exterior
Holiday Inn Express & Suites Wentzville St Louis West by IHG
Holiday Inn Express & Suites Wentzville St Louis West by IHG
2.5 star property
9.4 out of 10, Exceptional, (845)
  • cleanliness
    Comfy spot near Wentzville Flea Market with an indoor pool for year-round swims.
The price is $110
$132 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Holiday Inn Express & Suites Wentzville St Louis West by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top landmarks in Defiance

Missouri wineries have some of the most superb wine we've ever tasted! We recommend sipping on some chambourcin while basking in the sunshine.
Photo by Pages of Travel
Open Photo by Pages of Travel

Chandler Hill Vineyards

Travelers might want a tour of Chandler Hill Vineyards, just one of the places to visit, and located 1.3 mi (2.1 km) from central Defiance.
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Wetlands landscape with a bird blind and cloudy sky reflected in a lake at the August A. Busch Memorial Conservation Area in St. Charles County Missouri

August A. Busch Memorial Conservation Area

If you like spending time outside, why not spend the afternoon at August A. Busch Memorial Conservation Area, a park located 30.2 mi (48.6 km) from the center of St. Louis.
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Learn more about Defiance

Defiance is well-known for its attractions such as Yellow Farmhouse Winery and Chandler Hill Vineyards.

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A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri

Check out reviews of Defiance hotels guests love

Drury Inn & Suites Southwest St. Louis

Drury Inn & Suites Southwest St. Louis

10/10 Excellent
"Great staff. Everyone was very happy to help. Enjoyed our stay. "
Anthony 1-night trip
Posted 23 hours ago
Drury Inn & Suites Southwest St. Louis

Frequently asked questions

What hotels do travelers recommend in Defiance?
Guests like The Wildwood Hotel.
Can I book refundable accommodations in Defiance?
If you need the flexibility to change your plans to Defiance, most hotels offer refundable* rates you can book. You can find these accommodations by searching our site and using the "fully refundable" filter to narrow down the results.
What will the weather in Defiance be like during my vacation?
July and August are typically the warmest months in Defiance when the average temp is 76°F. January and February are the coldest months when the average temperature is 38°F. May and April are the months with the most rain.
Why should I book my Defiance hotel through Hotels.com?
There are lots of reasons to book your Defiance trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.