Hotels in Sanctuary

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Where to stay in Sanctuary?

A spacious living room with a large flat-screen TV, a ceiling fan, and a view of the ocean through large windows.

A spacious living room with a large window overlooking a beach, wooden flooring, and a ceiling fan.

A modern kitchen with a large island, a dining area with white wicker chairs, and a view of the ocean through large windows.

A water park with a water slide, a pool, and a play structure.

1. South Seas

5.5 km from Sanctuary

Jarrett

$202

$341 total

includes taxes & fees

Nov 11 - Nov 12

A resort with a central pool, multiple lounge areas, and a beach view.

A covered porch with a view of the sea, a white railing, and two Adirondack chairs.

A sandy pathway leading to a beach with palm trees and a clear sky.

A table set for dining with a view of the sunset over the ocean.

2. Tween Waters Island Resort & Spa

3.7 km from Sanctuary

Matt

$341

$415 total

includes taxes & fees

Nov 23 - Nov 24

A covered outdoor area with a table and chairs, a ceiling fan, and a view of a beach with palm trees and a boat.

A modern kitchen with wooden cabinets, a stainless steel refrigerator, and a dining area with white chairs and a table.

A multi-story hotel with a central entrance, balconies, and palm trees.

A modern living room with a sofa, chairs, and a dining table. There is a kitchen area with cabinets and appliances.

3. Island Inn

West End, 9.6 km from Sanctuary

Andrew

$215

$240 total

includes taxes & fees

Nov 8 - Nov 9

A resort with multiple-story buildings, palm trees, and a well-maintained lawn.

A pool area with lounge chairs and a building with a red roof.

A hotel room with a bed, a view of the beach, and a window with curtains.

A hammock between palm trees with a view of the ocean.

4. Sanibel Island Beach Resort

Mid Island, 13.1 km from Sanctuary

Cary

$179

$227 total

includes taxes & fees

Oct 26 - Oct 27

A hotel pool area with multiple lounge chairs and umbrellas, surrounded by a fence and palm trees.

A gym with treadmills, elliptical machines, and stationary bikes.

A reception area with a beach view mural, a staircase, and a reception desk.

A hotel room with two beds, a desk, a chair, artwork on the walls, and a television.

5. La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

19.9 km from Sanctuary

Carol

$84

$94 total

includes taxes & fees

Oct 27 - Oct 28

A balcony with a wooden table and chairs, a hanging chair, and a view of palm trees and a pool.

A beachfront hotel with palm trees, a sandy walkway, and a pool.

A bedroom with a large bed, a desk, and a chair. There is a sliding barn door and a painting of a beach on the wall.

A resort with a pool, thatched umbrellas, and palm trees.

6. Off the Charts Inn & Out Island Resort

8.8 km from Sanctuary

Catherine

$179

$234 total

includes taxes & fees

Oct 26 - Oct 27

A balcony with a table and chairs, large windows, and a view of the sea.

A spacious living area with a high ceiling, a ceiling fan, a pool table, and a view of the outdoors.

A swimming pool with clear blue water, surrounded by lounge chairs and umbrellas, and a building with a tiled roof.

7. The Westin Cape Coral Resort At Marina Village

18.1 km from Sanctuary

jessica

$137

$197 total

includes taxes & fees

Nov 22 - Nov 23

A waterfront hotel with multiple buildings, a dock, and a calm body of water reflecting the structures.

A spacious lobby with a staircase, large windows, and a chandelier.

A spacious living area with wicker furniture, a chandelier, and large windows offering a view of palm trees and a balcony.

A resort pool area with a large pool, lounge chairs, and umbrellas.

8. Marriott Sanibel Harbour Resort & Spa

15.6 km from Sanctuary

Matthew

$207

$266 total

includes taxes & fees

Nov 8 - Nov 9

A spacious dining area with multiple tables and chairs, large windows, and a modern chandelier.

A hotel lobby with a reception desk, seating area, and a large window.

A swimming pool area with lounge chairs, a small building, and a basketball court surrounded by palm trees and greenery.

A hotel room with two beds, a large mirror, and a view of the outdoors.

9. Residence Inn by Marriott Fort Myers Sanibel

19.3 km from Sanctuary

Benjamin

$94

$105 total

includes taxes & fees

Oct 26 - Oct 27

A kitchen with white cabinets, a microwave, a sink, and a green refrigerator.

10. The Anchor Inn

Mid Island, 12.8 km from Sanctuary

Ricardo E

$158

$191 total

includes taxes & fees

Oct 27 - Oct 28

A hotel room with two beds, a wooden headboard, a nightstand with a lamp, and a window with curtains.

A swimming pool with lounge chairs and palm trees.

A Holiday Inn Express building with a clear entrance, palm trees, and a purple sky.

A modern hotel lobby with a sofa, chairs, a TV, and a dining area.

11. Holiday Inn Express Cape Coral-Fort Myers Area by IHG

23.9 km from Sanctuary

Shannon

$101

$113 total

includes taxes & fees

Nov 1 - Nov 2

A pathway flanked by palm trees and wooden buildings with thatched roofs.

A hotel room with a bed, a television, a desk, a chair, and a ceiling fan.

A compact kitchen with a stainless steel refrigerator, a microwave, a coffee maker, and a sink.

A thatched-roof structure with outdoor seating, surrounded by palm trees and a wooden deck.

12. Kona Kai Motel

Mid Island, 12.2 km from Sanctuary

Paloma

$179

$206 total

includes taxes & fees

Oct 26 - Oct 27

A spacious lobby with a high ceiling, a seating area with a sofa and chairs, a small round table, and a decorative wall with artwork.

A swimming pool with lounge chairs and palm trees, surrounded by a building with a red roof and multiple windows.

A grocery store with shelves stocked with snacks, beverages, and dairy products.

A spacious dining area with multiple tables and chairs, a flat-screen TV mounted on the wall, and artwork on the walls.

13. Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

22.9 km from Sanctuary

Frank

$86

$96 total

includes taxes & fees

Oct 29 - Oct 30

A modern living room with a TV, dining table, and chairs. There is a balcony with a view of palm trees.

A resort pool area with a clear view of the ocean, surrounded by palm trees and lounge chairs.

A well-maintained garden with a wooden deck, palm trees, and a building in the background.

A large, two-story house with a wrap-around porch and a steeply pitched roof.

14. Casa Ybel Resort

Ybel, 11.6 km from Sanctuary

Juan

$265

$296 total

includes taxes & fees

Oct 26 - Oct 27

A beachside area with colorful Adirondack chairs, a fire pit, and a view of the water.

A living room with two sofas, a coffee table, a ceiling fan, a TV, and a cabinet.

A modern kitchen with white cabinets, granite countertops, a built-in oven, and a microwave.

A balcony with wicker furniture, a pool, and a white fence.

15. Matlacha on Shoreview

20.2 km from Sanctuary

Jacquelyn

$60

$134 total

includes taxes & fees

Oct 26 - Oct 27

An outdoor seating area with tables and chairs, surrounded by palm trees and a thatched-roof structure.

A bar with multiple liquor bottles and a large American flag in the background.

A lobby with a mural of dolphins, seating area, and a reception desk.

A restaurant with a high wooden ceiling, hanging flags, and a variety of flags and decorations.

16. Dolphin Key Resort

23.8 km from Sanctuary

Patrick

$94

$105 total

includes taxes & fees

Nov 22 - Nov 23

An outdoor patio with wicker furniture, a fire feature, and string lights.

A hotel with a clear entrance, a covered waiting area, and a sign indicating a clearance height of 10'-3".

A well-stocked beverage and snack kiosk with a variety of drinks and snacks, including bottled water, soda, and packaged foods.

A modern kitchen with a central island, bar stools, and hanging pendant lights.

17. Hilton Garden Inn Ft Myers

29.5 km from Sanctuary

Wesley

$101

$113 total

includes taxes & fees

Oct 31 - Nov 1

A covered patio with tiled flooring, wooden lounge chairs, and a small table.

A modern living room with a grey sofa, a small table, and a TV mounted on the wall.

A grassy yard with palm trees and a wooden fence.

18. White Orchid Apartments

20 km from Sanctuary

Laura

$65

$105 total

includes taxes & fees

Oct 26 - Oct 27

A pathway leading to a pool area with lounge chairs and umbrellas, surrounded by tropical plants and a thatched-roof structure.

A hotel room with a large bed, a desk, a chair, and a view of the beach through the window.

A spacious bar area with wooden flooring and ceiling fans, featuring a central bar counter and multiple seating options.

A swimming pool area with lounge chairs and palm trees, surrounded by buildings and a sunset view.

19. Sanibel Inn

East End, 13.8 km from Sanctuary

Heather

$373

$480 total

includes taxes & fees

Oct 29 - Oct 30

A resort with multiple buildings featuring blue roofs, a beach, and a clear view of the ocean.

A pool area with lounge chairs and umbrellas, a wooden deck, and a view of the beach and ocean.

A modern room with a large sliding glass door leading to a balcony with a view of the beach. There is a white sofa, a small table, and a white desk with a chair.

A wooden boardwalk leading to a beach with clear skies and calm waters.

20. Shalimar Beach Resort

West End, 10.3 km from Sanctuary

Martha

$349

$389 total

includes taxes & fees

Oct 26 - Oct 27

View all properties

Compare popular hotels in Sanctuary

Property	Property class	Guest rating
Island Inn	9.4 Exceptional 1,164 reviews	View
Sanibel Island Beach Resort	9.2 Wonderful 2,384 reviews	View
Off the Charts Inn & Out Island Resort	9.6 Exceptional 164 reviews	View
The Anchor Inn	9.8 Exceptional 80 reviews	View
South Seas	8.4 Very good 1,001 reviews	View

Our prices for hotels in Sanibel are cheapest in October

Check out reviews of Sanctuary hotels guests love

DiamondHead Beach Resort

10/10 Excellent

"From the time I pulled into the property the bellhops were so helpful directed me were to go and park while I checked in . Room was ready early which was a definite Plus !!!!! Beach view from balcony was amazing got to see the amazing sunsets every day. Beach chairs and umbrella were available and set up by 9:00am . It really is a great place to stay ."

Edison Beach House

8/10 Good

"Right on the beach! Older building and aged decor / facility"

Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

8/10 Good

"Great for a quick stay before heading to Sanibel."

The Westin Cape Coral Resort At Marina Village

10/10 Excellent

"We absolutely loved our stay at The Westin Cape Coral Resort at Marina Village! From the moment we arrived, we felt like we were in the perfect place to relax, unwind, and enjoy some time away. The beautiful marina views, peaceful atmosphere, and gorgeous surroundings made our stay feel extra special. One of our favorite things was simply being able to slow down, take in the scenery, and enjoy the beauty of the waterfront. Everything about the setting made it easy to leave the stress of everyday life behind and just enjoy the moment. We left with wonderful memories and that feeling of wishing we could have stayed a little longer! It’s the kind of place that makes you want to come back, and we would happily recommend it to anyone looking for a beautiful, relaxing escape in Southwest Florida."

The Lighthouse Resort Inn & Suites

10/10 Excellent

"The staff was awesome. The front desk staff helped us through our many requests and changes for our stay, with a smile and a laugh. The room was way larger (and cleaner) than expected. The A/C was ice cold all weekend. The full sized fridge was an unexpected plus. We would recommend the Lighthouse Resort to anyone and everyone that asks us. (We are full time residents in Lee County FL, BTW) This stay would have been perfect...if only the elevator had been repaired and we didn't have to carry our bags up two flights of stairs to the third floor. We'll be back!"

Hilton Garden Inn Ft Myers

10/10 Excellent

"Staff was amazing and hotel was quiet clean and convenient"

Sundial Beach Resort & Spa

8/10 Good

"Gotta get rid of the sand chiggers."

Find out more about Sanctuary

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Hotels in Sanctuary

Room 1

Free cancellation options if plans change

Earn rewards on every night you stay

Save more with Member Prices

Check prices for these dates

Where to stay in Sanctuary?

1. South Seas

2. Tween Waters Island Resort & Spa

3. Island Inn

4. Sanibel Island Beach Resort

5. La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

6. Off the Charts Inn & Out Island Resort

7. The Westin Cape Coral Resort At Marina Village

8. Marriott Sanibel Harbour Resort & Spa

9. Residence Inn by Marriott Fort Myers Sanibel

10. The Anchor Inn

11. Holiday Inn Express Cape Coral-Fort Myers Area by IHG

12. Kona Kai Motel

13. Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

14. Casa Ybel Resort

15. Matlacha on Shoreview

16. Dolphin Key Resort

17. Hilton Garden Inn Ft Myers

18. White Orchid Apartments

19. Sanibel Inn

20. Shalimar Beach Resort

Compare popular hotels in Sanctuary

Typical weather for Sanibel

Check out reviews of Sanctuary hotels guests love

DiamondHead Beach Resort

Edison Beach House

Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

The Westin Cape Coral Resort At Marina Village

The Lighthouse Resort Inn & Suites

Hilton Garden Inn Ft Myers

Sundial Beach Resort & Spa

Keep exploring

Hotels in Sanctuary

Free cancellation options if plans change

Earn rewards on every night you stay

Save more with Member Prices

Check prices for these dates

Where to stay in Sanctuary?

1. South Seas

2. Tween Waters Island Resort & Spa

3. Island Inn

4. Sanibel Island Beach Resort

5. La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

6. Off the Charts Inn & Out Island Resort

7. The Westin Cape Coral Resort At Marina Village

8. Marriott Sanibel Harbour Resort & Spa

9. Residence Inn by Marriott Fort Myers Sanibel

10. The Anchor Inn

11. Holiday Inn Express Cape Coral-Fort Myers Area by IHG

12. Kona Kai Motel

13. Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

14. Casa Ybel Resort

15. Matlacha on Shoreview

16. Dolphin Key Resort

17. Hilton Garden Inn Ft Myers

18. White Orchid Apartments

19. Sanibel Inn

20. Shalimar Beach Resort

Compare popular hotels in Sanctuary

Price trends for hotels in Sanibel

Typical weather for Sanibel

Check out reviews of Sanctuary hotels guests love

DiamondHead Beach Resort

Edison Beach House

Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

The Westin Cape Coral Resort At Marina Village

The Lighthouse Resort Inn & Suites

Hilton Garden Inn Ft Myers

Sundial Beach Resort & Spa

Keep exploring