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Hotels in San Francisco

November 2026
December 2026

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This weekend
Oct 23 - Oct 25
Next weekend
Oct 30 - Nov 1

Where to stay in San Francisco?

A pool area with lounge chairs and a covered seating area, surrounded by modern buildings.
A restaurant with booths and tables, wooden paneling, and green plants.
A modern hotel with a prominent entrance, outdoor seating area, and a handicap-accessible parking space.
A spacious lobby with modern seating, a central coffee table, and decorative hanging lights.

1. Hotel Mykonos Panama

Hotel Mykonos Panama
Nuevo Santiago
$90
$99 total
includes taxes & fees
Oct 20 - Oct 21
Hotel Mykonos Panama
A pool surrounded by palm trees and a tiled roof structure.
A building with a curved facade, a balcony with metal railings, and a door with a sign.
A spacious room with a high ceiling, a large window, and a wooden door leading to another area. There are several potted plants and a small table with a vase.
A tree in a stone planter in a well-lit indoor space with a stone wall and a door in the background.

2. Hotel Gran David

Hotel Gran David
Santiago
$88
$97 total
includes taxes & fees
Oct 20 - Oct 21
Hotel Gran David
A swimming pool with a water slide, surrounded by palm trees and lounge chairs.
A multi-story hotel with balconies, a pool, and a reflection in the water.
A hammock suspended between two white walls in a room with a balcony.
A modern bedroom with a large bed, a small table, and a chair. There is a window with curtains and a lamp on the wall.

3. HOTEL VISTA LAGO

HOTEL VISTA LAGO
La Pena
$77
$84 total
includes taxes & fees
Oct 20 - Oct 21
HOTEL VISTA LAGO
A modern lobby with a sofa, armchairs, a desk, and a large window offering a view of the cityscape.
A bathroom with a tiled shower wall, a sink, and a towel rack.
A hotel room with a dark wooden desk, two cushioned chairs, a large mirror, and two table lamps.
A lobby with a reception desk, two armchairs, a sofa, and a table with a lamp.

4. Hotel Plaza Los Tucanes

Hotel Plaza Los Tucanes
Nuevo Santiago
$46
$50 total
includes taxes & fees
Oct 24 - Oct 25
Hotel Plaza Los Tucanes
Restaurant
A blue building with a tiled porch, surrounded by lush greenery and a garden.
A room with two beds, a refrigerator, and a coat rack.
Hotel Anachoreo with a corrugated metal roof, surrounded by tropical vegetation.

5. Hotel Anachoreo

Hotel Anachoreo
Santa Fe
$85
$93 total
includes taxes & fees
Oct 20 - Oct 21
Hotel Anachoreo
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Go beyond your typical stay in San Francisco

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Pet friendly
Pet friendly
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Pool
Pool
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Spa
Spa
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Family friendly
Family friendly

Check out reviews of San Francisco hotels guests love

A swimming pool with a water slide, surrounded by palm trees and lounge chairs.
A multi-story hotel with balconies, a pool, and a reflection in the water.
A hammock suspended between two white walls in a room with a balcony.
A modern bedroom with a large bed, a small table, and a chair. There is a window with curtains and a lamp on the wall.

HOTEL VISTA LAGO

HOTEL VISTA LAGO
La Pena

10/10 Exceptional

United States
Victor
HOTEL VISTA LAGO
A pool area with lounge chairs and a covered seating area, surrounded by modern buildings.
A restaurant with booths and tables, wooden paneling, and green plants.
A modern hotel with a prominent entrance, outdoor seating area, and a handicap-accessible parking space.
A spacious lobby with modern seating, a central coffee table, and decorative hanging lights.

Hotel Mykonos Panama

Hotel Mykonos Panama
Nuevo Santiago

10/10 Exceptional

United States
BTraveler
Hotel Mykonos Panama
A pool surrounded by palm trees and a tiled roof structure.
A building with a curved facade, a balcony with metal railings, and a door with a sign.
A spacious room with a high ceiling, a large window, and a wooden door leading to another area. There are several potted plants and a small table with a vase.
A tree in a stone planter in a well-lit indoor space with a stone wall and a door in the background.

Hotel Gran David

Hotel Gran David
Santiago

10/10 Exceptional

United States
Agostina
Hotel Gran David
A modern lobby with a sofa, armchairs, a desk, and a large window offering a view of the cityscape.
A bathroom with a tiled shower wall, a sink, and a towel rack.
A hotel room with a dark wooden desk, two cushioned chairs, a large mirror, and two table lamps.
A lobby with a reception desk, two armchairs, a sofa, and a table with a lamp.

Hotel Plaza Los Tucanes

Hotel Plaza Los Tucanes
Nuevo Santiago

10/10 Exceptional

United States
Olopilel
Hotel Plaza Los Tucanes

Frequently Asked Questions

What accommodations do travelers recommend in San Francisco?

Guests like Hotel Gran David, HOTEL VISTA LAGO and Hotel Plaza Los Tucanes.

Can I book refundable accommodations in San Francisco?

If you need the flexibility to change your travel plans to San Francisco, most hotels offer refundable* rates you can book. You can see these properties by searching our site and using the "fully refundable" filter to narrow down the results.

What will the weather in San Francisco be like during my trip?

With an average temperature of 77°F during the coldest months, San Francisco is a great place to visit any time of year.

Why should I book my San Francisco accommodation with Hotels.com?

There are plenty of reasons to book your San Francisco travel with us: our free cancellations on selected hotels* gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.