Hotels in Santa Cruz de la Sierra

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Where to stay in Santa Cruz de la Sierra?

A historic stone courtyard with cobblestone flooring, a central fountain, and buildings with traditional architecture.

A swimming pool with lounge chairs and a stone building in the background.

A bar area with a round mirror, wooden stools, and a tiled floor.

A banquet hall with round tables, red chairs, and a high arched ceiling.

Parador de Trujillo

Trujillo

$94

$103 total

includes taxes & fees

Aug 30 - Aug 31

A stone building with a tiled roof, a stone patio, and a grassy area.

An outdoor dining area with stone flooring, tables, and chairs, surrounded by greenery and a stone building.

A checkered floor, a staircase, and a reception desk in a building with yellow walls and green doors.

A rustic bar area with wooden stools, a checkered tablecloth, and a brick wall.

Hospedium Hotel Soterraña

Madronera

$73

$80 total

includes taxes & fees

Sep 11 - Sep 12

A courtyard with white buildings, a cobblestone path, and potted plants.

A white-walled room with a large arched mirror, a red vase with green plants, and wooden boxes on a bench.

A covered outdoor seating area with a stone floor, white walls, and arches.

A dining area with a wooden table and chairs, a window with a view of trees, a fireplace, and a bookshelf.

Finca El Azahar

Trujillo

$182

$200 total

includes taxes & fees

Sep 2 - Sep 3

A historic building with a sign for "Eurostars" and a large entrance door.

A balcony with a bench and a cup, overlooking a historic cityscape with buildings and a clear sky.

A reception area with a wooden counter, a glass door, and a stone wall.

A swimming pool with lounge chairs and a tower structure in the background.

Eurostars Palacio Santa Marta

Trujillo

$80

$88 total

includes taxes & fees

Sep 28 - Sep 29

A sunset view with a stone pathway, trees, and a fence.

A modern hotel room with a large bed, a flat-screen TV, a desk with a phone and a small table, and a view of the city through large windows.

A wine cellar with wooden racks and a bar area.

A dining area with a wooden table set for four, a wine rack with bottles, and a meat display case.

Finca la Desa

Miajadas

$70

$77 total

includes taxes & fees

Aug 31 - Sep 1

A lobby with a wooden cart displaying food and drinks, surrounded by arches and potted plants.

A corridor with red walls, stone columns, and a tiled floor.

A spacious courtyard with red seating and tables, stone arches, and potted plants.

A pool area with a tiled deck, lounge chairs, and a table with candles.

Hotel Izan Trujillo

Trujillo

$74

$81 total

includes taxes & fees

Aug 30 - Aug 31

A restaurant with checkered tablecloths, wooden chairs, and a stone wall.

A stone building with a sign reading "Hotel Center."

A hallway with a brick archway, a staircase, and a potted plant.

A bar area with brick walls, a wooden bar counter, and black bar stools.

Hostal Hueso

Trujillo

$68

$75 total

includes taxes & fees

Sep 2 - Sep 3

A stone-walled dining area with tables set for two, each with a red tablecloth and wine glasses.

A building with a sign reading "HOTEL RESTAURANT LÉON".

A garden with various flowering plants and a stone wall in the background.

A room with a bed, a wooden chair, and a vase with branches.

Hostal León

Trujillo

$58

$64 total

includes taxes & fees

Sep 2 - Sep 3

A stone-walled hallway with a dark door, a staircase, and a potted plant.

A spacious living area with wicker furniture, a stone wall, and a view of the outside.

A stone-walled corridor with a tiled floor, a black bookshelf, and a potted plant.

Plaza Sandra

Trujillo

$78

$86 total

includes taxes & fees

Sep 14 - Sep 15

Alojamientos Plaza Mayor

Trujillo

$33

$37 total

includes taxes & fees

Aug 30 - Aug 31

A hotel room with a large bed, two bedside tables, a nightstand, a door leading to a bathroom, and a wall-mounted light fixture.

A compact living space with a kitchenette, dining area, and a TV.

A building with a sign reading "Ruralis El Altozano".

A compact kitchen with wooden cabinets, a stainless steel range hood, a microwave, and a refrigerator. There is a dining table with chairs and a coffee maker.

Hostal Ruralis Altozano

Montánchez

$47

$52 total

includes taxes & fees

Sep 21 - Sep 22

An outdoor dining area with tables and chairs, a white canopy, and potted plants.

A conference room with rows of chairs, a projector screen, and a speaker.

A hotel entrance with a reception desk, a potted plant, and a planter with small plants.

A buffet area with a glass display case, a counter with a coffee machine, and a seating area with a striped column.

Hospedium Hotel Triana

Miajadas

$88

$97 total

includes taxes & fees

Aug 31 - Sep 1

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Learn more about Santa Cruz de la Sierra

The region around Santa Cruz de la Sierra is home to attractions such as Palacio de la Conquista and Plaza Mayor.

See all hotels in Santa Cruz de la Sierra

A large brick church with two bell towers and palm trees in front.

Check out reviews of Santa Cruz de la Sierra hotels guests love

Hotel Izan Trujillo

10/10 Excellent

"Nice hotel with a secure room for cycles for those on tour like me. Nice rooms and good facilities. Restaurant is good but also great places to eat on the Plaza."

Parador de Trujillo

10/10 Excellent

"We had half board abd the meal was fantastic. I had the selection of meats to start and my wife had a sort of tomato mousse. The olive oil was out of this world and my main course fillet was one of the best that I have ever had. We have been trying to find a reason to travel that way again and wish we had booked for 2 nights or more. It’s a lovely little town, with a beautiful square. A great place as a base to visit Caceres or Guadalupe. We will definitely return!"

Hospedium Hotel Soterraña

10/10 Excellent

"The staff was friendly and helpful, the rooms clean. The food was also good. We liked the location, minutes away drive to Trujillo and a great stop if coming from a city like Sevilla heading to Madrid. We enjoyed our stay !"

Plaza Sandra

10/10 Excellent

"Era un lugar limpio y acogedor, y había muchos sitios a los que se podía ir andando. El personal fue muy atento. Aparcar fue todo un reto, sobre todo cerca del mercado semanal. Pasamos una estancia muy agradable."

Eurostars Palacio Santa Marta

10/10 Excellent

"We had a wonderful stay at Eurostars Palacio Santa Marta. The hotel is set inside a beautifully restored historic building just steps from Plaza Mayor, making it perfect for exploring Trujillo on foot. Our room was spacious, comfortable, and very quiet. Alba was warm, welcoming, and made everything easy. Overall, an excellent stay in a charming location — we’d happily return."

Finca la Desa

10/10 Excellent

"This is a diamond in the west country of Spain. Everything about this place was exceptional."

Frequently asked questions

What hotels do travelers recommend in Santa Cruz de la Sierra?

Guests like Parador de Trujillo, Eurostars Palacio Santa Marta and Hotel Izan Trujillo.

Can I book refundable hotels in Santa Cruz de la Sierra?

If you need the flexibility to change your plans to Santa Cruz de la Sierra, most properties provide refundable* rates you can book. You can see these accommodations by searching our site and using the "fully refundable" filter to narrow the results down.

What will the weather in Santa Cruz de la Sierra be like during my trip?

July and August are typically the warmest months in Santa Cruz de la Sierra when the average temp is 77°F. January and February are the coldest months when the average temperature is 47°F. October and December are the months with the most rain.

Why should I book my Santa Cruz de la Sierra hotel through Hotels.com?

There are lots of reasons to book your Santa Cruz de la Sierra trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

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