Hotels in Santa Cruz de la Sierra

Free cancellation options if plans change

Earn rewards on every night you stay

Save more with Member Prices

Check prices for these dates

Next weekend
In two weeks

Where to stay in Santa Cruz de la Sierra?

Hospedium Hotel Soterraña
Hospedium Hotel Soterraña
3.0 star property
Madronera
8.8 out of 10, Excellent, (38 reviews)
  • cleanliness
    Relax in colonial elegance near Badajoz with garden terrace and two restaurants.
The price is $75
$83 total
includes taxes & fees
Feb 9 - Feb 10
Hospedium Hotel Soterraña
Eurostars Palacio Santa Marta
Eurostars Palacio Santa Marta
4.0 star property
Trujillo
9.2 out of 10, Wonderful, (331 reviews)
  • cleanliness
    Experience Trujillo's rich history with access to Plaza Mayor and a refreshing pool.
The price is $63
$69 total
includes taxes & fees
Mar 11 - Mar 12
Eurostars Palacio Santa Marta
Hostal Hueso
Hostal Hueso
2.0 star property
Trujillo
8.2 out of 10, Very Good, (23 reviews)
The price is $70
$77 total
includes taxes & fees
Feb 20 - Feb 21
Hostal Hueso
Parador de Trujillo
Parador de Trujillo
4.0 star property
Trujillo
9.2 out of 10, Wonderful, (225 reviews)
  • cleanliness
    Recharge in a refurbished palace with an outdoor pool and terrace in Trujillo.
The price is $81
$89 total
includes taxes & fees
Feb 10 - Feb 11
Parador de Trujillo
Hostal León
Hostal León
2.0 star property
Trujillo
7.6 out of 10, Good, (52 reviews)
  • cleanliness
    Discover old-world charm in historic Trujillo, where comfort meets convenience.
The price is $59
$65 total
includes taxes & fees
Feb 9 - Feb 10
Hostal León
Plaza Sandra
Plaza Sandra
3.0 star property
Trujillo
9.6 out of 10, Exceptional, (52 reviews)
  • cleanliness
    Relax in Trujillo at this aparthotel with pool, garden, and spa services.
Plaza Sandra
Hotel Izan Trujillo
Hotel Izan Trujillo
4.0 star property
Trujillo
8.8 out of 10, Excellent, (209 reviews)
  • cleanliness
    Historic charm in Trujillo with regional cuisine and seasonal outdoor pool.
The price is $73
$80 total
includes taxes & fees
Feb 9 - Feb 10
Hotel Izan Trujillo
Finca la Desa
Finca la Desa
3.0 star property
Miajadas
9.8 out of 10, Exceptional, (7 reviews)
The price is $82
$90 total
includes taxes & fees
Feb 9 - Feb 10
Finca la Desa
Casa Rural Las Canteras
Casa Rural Las Canteras
3.0 star property
Trujillo
8.2 out of 10, Very Good, (33 reviews)
  • cleanliness
    Step back to Trujillo's ancient landscape in a countryside retreat with castle views.
The price is $96
$105 total
includes taxes & fees
Feb 9 - Feb 10
Casa Rural Las Canteras
Hospedium Hotel Triana
Hospedium Hotel Triana
3.0 star property
Miajadas
7.8 out of 10, Good, (19 reviews)
  • cleanliness
    Tranquil retreat in Miajadas with 24-hour service and on-site dining options.
The price is $90
$99 total
includes taxes & fees
Feb 9 - Feb 10
Hospedium Hotel Triana
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Santa Cruz de la Sierra

The region around Santa Cruz de la Sierra is home to attractions such as Juan Pizarro de Orellana Palace and City Walls.

Catedral de Santa Cruz de la Sierra

Check out reviews of Santa Cruz de la Sierra hotels guests love

Frequently asked questions

What hotels do travelers recommend in Santa Cruz de la Sierra?
Can I book refundable hotels in Santa Cruz de la Sierra?
If you need the flexibility to change your plans to Santa Cruz de la Sierra, most properties provide refundable* rates you can book. You can see these accommodations by searching our site and using the "fully refundable" filter to narrow the results down.
What will the weather in Santa Cruz de la Sierra be like during my trip?
July and August are typically the warmest months in Santa Cruz de la Sierra when the average temp is 77°F. January and February are the coldest months when the average temperature is 47°F. October and December are the months with the most rain.
Why should I book my Santa Cruz de la Sierra hotel through Hotels.com?
There are lots of reasons to book your Santa Cruz de la Sierra trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.