Hotels in Cairo
Free cancellation options if plans change
Earn rewards on every night you stay
Save more with Member Prices
Check prices for these dates
Tonight
Aug 14 - Aug 15Tomorrow
Aug 15 - Aug 16This weekend
Aug 14 - Aug 16Next weekend
Aug 21 - Aug 23Top 5 hotels in Cairo at a glance
- 1. Quality Inn Cairo I-57 — 2.5-star hotel in Cairo. Guest rating: 6.4/10.
- 2. Super 8 by Wyndham Charleston/Sikeston East MO — 2-star hotel in Charleston. Guest rating: 6.6/10.
- 3. La Center Motel — 2-star hotel in La Center. Guest rating: 7.6/10 — Good.
- 4. Eagle Inn Charleston — 2-star hotel in Charleston. Guest rating: 6.6/10.
- 5. The Riverstone Hotel Charleston-Sikeston — 2.5-star hotel in Charleston. Guest rating: 6.8/10.
Where to stay in Cairo?
1. Quality Inn Cairo I-57
Quality Inn Cairo I-57Cairo
$72
$80 total
includes taxes & fees
Aug 20 - Aug 21
2. Super 8 by Wyndham Charleston/Sikeston East MO
Super 8 by Wyndham Charleston/Sikeston East MOCharleston
$60
$66 total
includes taxes & fees
Aug 16 - Aug 17
3. La Center Motel
La Center MotelLa Center
$54
$63 total
includes taxes & fees
Aug 15 - Aug 16
4. Eagle Inn Charleston
Eagle Inn CharlestonCharleston
$69
$77 total
includes taxes & fees
Aug 15 - Aug 16
5. The Riverstone Hotel Charleston-Sikeston
The Riverstone Hotel Charleston-SikestonCharleston
$66
$74 total
includes taxes & fees
Sep 7 - Sep 8
6. Quiet Country Stay: Modern Home Near Paducah
Quiet Country Stay: Modern Home Near PaducahCunningham
$149
$290 total
includes taxes & fees
Aug 17 - Aug 18
Go beyond your typical stay in Cairo
Pet friendly
Our prices for hotels in Cairo are cheapest in September
Our prices for hotels in Cairo are cheapest in September
Price trends for hotels in Cairo
Pricing is based on two traveler single night rates
Top landmarks in Cairo
Fort Defiance State Park
7.4/10 (15 reviews)
Fort Defiance State Park is 2.3 mi (3.7 km) from central Cairo, why not stop by during your stay.
Learn more about Cairo
Cairo is well-known for its attractions such as Mississippi River and Ohio River Valley. The city has something for everyone including sights like Fort Defiance State Park within a small-town setting.
See all hotels in Cairo
Check out reviews of Cairo hotels guests love
The Riverstone Hotel Charleston-Sikeston
8/10 Good
"The ad and picture for the hotel is a little deceiving. It shows a large fountain in front of the front lobby. There was none. This is the former Quality Inn Hotel was not good at all. The hotel has been cleaned up and rebranded. The room was nice. My only concern was all the bugs that were outside the room door and flew into the room when you opened your door at night. The other thing that I did not like was the surprise $100 fee that I had to pay up front for potential damage to the room. This fee was returned during check out."
Super 8 by Wyndham Charleston/Sikeston East MO
10/10 Excellent
"Nice staff. Very accommodating."
La Center Motel
10/10 Excellent
"Great AC unit in the room!"
Eagle Inn Charleston
10/10 Excellent
"Great"