Hotels in Seneca

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Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
2.0 star property
Seneca
9.8 out of 10, Exceptional, (64 reviews)
  • cleanliness
    Waterfront escape with full kitchenettes and patios on beautiful Lake Hartwell.
The price is $69
$120 total
includes taxes & fees
Mar 9 - Mar 10
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Quality Inn Seneca Clemson Area US-123
Quality Inn Seneca Clemson Area US-123
2.5 star property
Downtown
8.0 out of 10, Very Good, (684 reviews)
  • cleanliness
    Stay close to Clemson University with pool access and traveler-approved helpful staff.
The price is $78
$92 total
includes taxes & fees
Mar 11 - Mar 12
Quality Inn Seneca Clemson Area US-123
Days Inn by Wyndham Seneca / Clemson Area
Days Inn by Wyndham Seneca / Clemson Area
2.0 star property
Seneca
6.8 out of 10, (731 reviews)
  • cleanliness
    Enjoy a family getaway near Clemson University with a pool and complimentary breakfast.
The price is $72
$79 total
includes taxes & fees
Mar 7 - Mar 8
Days Inn by Wyndham Seneca / Clemson Area
Lakeside Lodge Clemson
Lakeside Lodge Clemson
2.5 star property
Seneca
9.0 out of 10, Wonderful, (1,003 reviews)
  • cleanliness
    Experience the heart of Clemson with quick access to Lake Keowee and university.
The price is $109
$135 total
includes taxes & fees
Mar 8 - Mar 9
Lakeside Lodge Clemson
Tru by Hilton Seneca Clemson
Tru by Hilton Seneca Clemson
2.5 star property
Seneca
9.2 out of 10, Wonderful, (815 reviews)
  • cleanliness
    Stay minutes from Clemson University with free Wi-Fi and on-the-go breakfast.
The price is $116
$127 total
includes taxes & fees
Mar 17 - Mar 18
Tru by Hilton Seneca Clemson
Best Western Seneca-Clemson
Best Western Seneca-Clemson
2.5 star property
Seneca
8.4 out of 10, Very Good, (651 reviews)
  • cleanliness
    Relax near Clemson University with a seasonal pool and complimentary amenities.
The price is $97
$107 total
includes taxes & fees
Mar 12 - Mar 13
Best Western Seneca-Clemson
Fairfield Inn & Suites Seneca Clemson Univ Area
Fairfield Inn & Suites Seneca Clemson Univ Area
3.0 star property
Seneca
9.4 out of 10, Exceptional, (210 reviews)
  • cleanliness
    Relax in a scenic lakeside area with fitness options and complimentary perks.
The price is $125
$138 total
includes taxes & fees
Mar 9 - Mar 10
Fairfield Inn & Suites Seneca Clemson Univ Area
Hampton Inn & Suites Seneca-Clemson Area
Hampton Inn & Suites Seneca-Clemson Area
2.5 star property
Seneca
9.2 out of 10, Wonderful, (683 reviews)
  • cleanliness
    Experience Lake Keowee adventures at this Seneca hotel with seasonal pool.
The price is $123
$136 total
includes taxes & fees
Mar 8 - Mar 9
Hampton Inn & Suites Seneca-Clemson Area
Baymont by Wyndham Easley/Greenville
Baymont by Wyndham Easley/Greenville
2.5 star property
Easley
7.4 out of 10, Good, (785 reviews)
The price is $75
$83 total
includes taxes & fees
Mar 12 - Mar 13
Baymont by Wyndham Easley/Greenville
Quality Inn & Suites Easley - Greenville
Quality Inn & Suites Easley - Greenville
2.5 star property
Easley
7.0 out of 10, Good, (409 reviews)
  • cleanliness
    Convenient Easley hotel near Greenville with seasonal pool and daily breakfast.
The price is $52
$58 total
includes taxes & fees
Mar 22 - Mar 23
Quality Inn & Suites Easley - Greenville
Days Inn by Wyndham Easley/Greenville/Clemson Area
Days Inn by Wyndham Easley/Greenville/Clemson Area
2.0 star property
Easley
6.2 out of 10, (835 reviews)
  • cleanliness
    Contemporary motel with outdoor pool in Easley near recreation center and hiking paths.
The price is $69
$77 total
includes taxes & fees
Mar 7 - Mar 8
Days Inn by Wyndham Easley/Greenville/Clemson Area
Hampton Inn Anderson/ Alliance Business Park
Hampton Inn Anderson/ Alliance Business Park
2.5 star property
Anderson
9.2 out of 10, Wonderful, (823 reviews)
  • cleanliness
    Peaceful Anderson stay with outdoor pool and complimentary daily breakfast.
The price is $114
$126 total
includes taxes & fees
Mar 15 - Mar 16
Hampton Inn Anderson/ Alliance Business Park
Holiday Inn Express Anderson by IHG
Holiday Inn Express Anderson by IHG
2.5 star property
Anderson
8.6 out of 10, Excellent, (386 reviews)
  • cleanliness
    Experience peaceful rest near Anderson Motor Speedway with an outdoor pool.
The price is $105
$117 total
includes taxes & fees
Mar 22 - Mar 23
Holiday Inn Express Anderson by IHG
Spacious Anderson Home: Great for Group Retreats
Spacious Anderson Home: Great for Group Retreats
3.0 star property
Anderson
Spacious Anderson Home: Great for Group Retreats
The Bleckley Inn
The Bleckley Inn
3.5 star property
Anderson
9.8 out of 10, Exceptional, (410 reviews)
  • cleanliness
    A downtown Anderson boutique stay with a scenic rooftop terrace and southern cuisine.
The price is $261
$290 total
includes taxes & fees
Mar 26 - Mar 27
The Bleckley Inn
Home2 Suites by Hilton Anderson Downtown
Home2 Suites by Hilton Anderson Downtown
3.0 star property
Anderson
9.4 out of 10, Exceptional, (228 reviews)
  • cleanliness
    Experience comfort just minutes from Lake Hartwell, with free breakfast and parking.
The price is $140
$155 total
includes taxes & fees
Mar 29 - Mar 30
Home2 Suites by Hilton Anderson Downtown
Horizon Inn & Suites
Horizon Inn & Suites
2.0 star property
Anderson
4.8 out of 10, (268 reviews)
  • cleanliness
    Relax just 10 minutes from Lake Hartwell at this modern Anderson retreat with fitness.
The price is $48
$57 total
includes taxes & fees
Mar 8 - Mar 9
Horizon Inn & Suites
Super 8 by Wyndham Anderson/Clemson Area
Super 8 by Wyndham Anderson/Clemson Area
2.5 star property
Anderson
6.6 out of 10, (277 reviews)
  • cleanliness
    Stay close to Lake Hartwell at this relaxed hotel with free breakfast and parking.
The price is $70
$78 total
includes taxes & fees
Mar 8 - Mar 9
Super 8 by Wyndham Anderson/Clemson Area
Quality Inn Clemson near University
Quality Inn Clemson near University
2.5 star property
Anderson
7.0 out of 10, Good, (900 reviews)
  • cleanliness
    Central location near Anderson attractions with a seasonal outdoor pool.
The price is $54
$60 total
includes taxes & fees
Mar 29 - Mar 30
Quality Inn Clemson near University
Holiday Inn Anderson by IHG
Holiday Inn Anderson by IHG
3.0 star property
Anderson
8.8 out of 10, Excellent, (706 reviews)
  • cleanliness
    Serene lakeside stay with convenient fitness center and outdoor pool access.
The price is $114
$127 total
includes taxes & fees
Mar 15 - Mar 16
Holiday Inn Anderson by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Check out pet-friendly hotels in Seneca

You may also like hotels with pools in Seneca

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

When is the best time to visit Seneca?

Our prices for hotels in Seneca are cheapest in May
Price trends for hotels in Seneca
Pricing is based on two traveler single night rates
View properties in March
Currently viewing crowd sizes and weather for March.
Typical weather for Seneca
March
High 17°C / low 6°C. Sunny most days.
View properties in March
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March, no crowd data, average high temperature 17 degrees Celsius, average low temperature 6 degrees Celsius. Sunny most days.
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April, no crowd data, average high temperature 22 degrees Celsius, average low temperature 10 degrees Celsius. Sunny most days.
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26°
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May, no crowd data, average high temperature 26 degrees Celsius, average low temperature 15 degrees Celsius. Sunny most days.
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June, no crowd data, average high temperature 31 degrees Celsius, average low temperature 19 degrees Celsius. Sunny most days.
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July, no crowd data, average high temperature 32 degrees Celsius, average low temperature 21 degrees Celsius. Sunny most days.
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31°
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August, no crowd data, average high temperature 31 degrees Celsius, average low temperature 20 degrees Celsius. Sunny most days.
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September, no crowd data, average high temperature 28 degrees Celsius, average low temperature 18 degrees Celsius. Sunny most days.
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October, no crowd data, average high temperature 23 degrees Celsius, average low temperature 12 degrees Celsius. Sunny most days.
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November, no crowd data, average high temperature 17 degrees Celsius, average low temperature 6 degrees Celsius. Sunny most days.
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December, no crowd data, average high temperature 12 degrees Celsius, average low temperature 4 degrees Celsius. Sunny most days.
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January, no crowd data, average high temperature 10 degrees Celsius, average low temperature 1 degrees Celsius. Partly sunny.
13°
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February, no crowd data, average high temperature 13 degrees Celsius, average low temperature 3 degrees Celsius. Partly sunny.
Monthly weather averages (˚C)

Top neighborhoods in Seneca

Downtown

Downtown Seneca charms visitors with well-preserved historical buildings that tell the story of its railroad heritage. The tree-lined Ram Cat Alley showcases local history through colorful murals, while the old courthouse square hosts seasonal farmers markets and community events. You can explore the Bertha Lee Strickland Cultural Museum or browse antique shops filled with Southern treasures. Family-owned cafes serve up delicious Southern comfort food like fried green tomatoes and barbecue. Accommodations range from historic bed & breakfasts in Victorian homes to budget-friendly motels. The entire downtown is walkable with wide sidewalks, making it easy to discover this authentic slice of small-town America at your own pace.

Serenity Bay

Lake Keowee beckons from this peaceful coastal retreat nestled in Saxony Forest. Serenity Bay lives up to its name with tree-lined streets perfect for contemplative walks. Nearby Keowee Key Golf Course offers tee times for enthusiasts, while South Beach provides sandy relaxation without the crowds. The natural setting creates an ideal escape for bird watchers and nature photographers. Vacation rentals with weathered wood siding and muted earth tones blend seamlessly into the forest canopy. Getting around requires your own wheels since public transit is limited. The neighborhood trades bustling nightlife for cricket choruses and ocean breezes filtering through pine trees—exactly what makes this hidden gem worth finding.

Pine Ridge Point

Lake Keowee sparkles as the crown jewel of Pine Ridge Point, a peaceful residential haven in Seneca. Waterfront vacation homes nestle among tall pines, offering private docks and stunning views. Visitors spend days swimming in crystal-clear waters, boating across the lake, or simply unwinding on expansive decks beneath Carolina blue skies. This neighborhood is all about authentic lakeside living without commercial distractions. Most travelers cook in well-equipped rental kitchens or drive 15 minutes to Seneca for restaurants. Personal vehicles are essential for getting around, though scenic paths along the shoreline make for perfect evening strolls.

Indian Oaks

Indian Oaks gives you all the peaceful vibes of suburban life with none of the tourist chaos. This leafy neighborhood in Seneca lets you live like a local under a canopy of mature oak trees. The curved streets and manicured lawns create a park-like setting that's perfect for morning walks. Lake Keowee is just a short drive away when you need a water fix. You'll need wheels to get around since public transit is limited and restaurants aren't within walking distance. Most visitors stay in vacation rental homes with private yards and driveways. The neighborhood gets incredibly quiet after dark—ideal for travelers who want to experience authentic suburban living while having Seneca's attractions nearby.

Top landmarks in Seneca

Learn more about Seneca

Between the crystal waters of Lake Keowee and the misty cascade of Isaqueena Falls lies a playground for outdoor enthusiasts. Kayak across the lake while keeping an eye out for bald eagles soaring overhead and blue herons stalking the shallows. The lush forests of Oconee State Park offer hiking trails for every skill level, with shade-dappled paths winding through ancient trees. Twin Lakes Recreation Area provides family-friendly spots to picnic after a morning on the water. Dog owners shouldn't miss The Pier Dog Park, where four-legged friends can splash along the shoreline. After a day of adventure, the coffeehouses in the historic downtown offer the perfect place to recharge while planning tomorrow's excursion to Keowee Key Golf Course or Lake Hartwell.

Lake Keowee South Carolina

Check out reviews of Seneca hotels guests love

Frequently asked questions

What accommodations do travelers like in Seneca?
Can I book refundable accommodations in Seneca?
If you want the flexibility to change your travel plans to Seneca, most accommodations offer refundable* bookable rates. You can find these properties by searching our site and using the "fully refundable" filter to narrow the results down.
Where can I stay in Seneca if I want a budget-friendly accommodation?
Lakeside Lodge Clemson, Hampton Inn & Suites Seneca-Clemson Area and Tru by Hilton Seneca Clemson are a few accommodations you might want to consider that'll save you money.
Where can I stay in Seneca if I want a vacation rental instead of a hotel?
If you want to find a good alternative to a hotel, review our selection of 202 vacation homes. In addition, there are 17 apartments and 12 condos.
What will the weather in Seneca be like during my visit?
The warmest months in Seneca are usually July and August with an average temp of 76°F. January and February are the chilliest months when the average temp is 46°F. The rainiest months are December and January.
Why should I book my Seneca hotel with Hotels.com?
There are plenty of reasons to book your Seneca travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.