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Hotels in Jackson

October 2026
November 2026

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This weekend
Oct 2 - Oct 4
Next weekend
Oct 9 - Oct 11

Where to stay in Jackson?

A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.
A hotel room with two beds, a nightstand, a lamp, and a chair.
A reception desk with a large mural of a bridge, wooden reception area, and a potted plant.
An outdoor patio with tables and chairs, a stone wall, and large windows.

1. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Jackson
$84
$91 total
includes taxes & fees
Sep 29 - Sep 30
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.
A restaurant with a brick wall, a flat-screen TV, and a bar area.
A Drury Inn & Suites building with a traditional architectural style, featuring a covered entrance and multiple windows.
An indoor swimming pool with a wooden ceiling, lounge chairs, and a lifeguard chair.

2. Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
Jackson
$84
$89 total
includes taxes & fees
Oct 11 - Oct 12
Drury Inn & Suites Jackson MO
A spacious lobby with large windows, comfortable seating, and a modern ceiling design.
A gym with treadmills, an elliptical, a bench, and a rack of dumbbells.
A room with large windows, two red upholstered chairs, a small table, and a potted plant.
A breakfast bar with coffee machines, a cereal dispenser, and a fruit display.

3. Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau
Jackson
$76
$82 total
includes taxes & fees
Oct 25 - Oct 26
Comfort Suites Jackson-Cape Girardeau
A kitchen with dark wooden cabinets, a stainless steel refrigerator, a black stove, a microwave, and a sink.
A trophy labeled "Town House Inn" with "Cape Girardeau County, Missouri" and "2025" on it.
A bathroom with a granite countertop sink, a mirror, two hair dryers mounted on the wall, and a trash bin.
A hotel room with two beds, a wooden dresser, a bathroom with a shower, and a kitchen area.

4. Town House Inn

Town House Inn
Jackson
$71
$77 total
includes taxes & fees
Sep 29 - Sep 30
Town House Inn
A modern retail area with a display of local items and snacks.
A modern indoor seating area with blue sofas and tables, a patterned carpet, and large windows offering a view of the outdoors.
An outdoor patio area with seating arrangements, including a sofa and chairs, and a table.
A hotel room with two beds, a desk, a chair, a TV, and a window with a view.

5. Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
Cape Girardeau
$89
$102 total
includes taxes & fees
Oct 4 - Oct 5
Tru By Hilton Cape Girardeau
A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.
A spacious corridor with a high ceiling, recessed lighting, and a series of posters on the walls.
A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.
An indoor swimming pool with clear blue water, surrounded by beige walls and large windows.

6. Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
Cape Girardeau
$100
$113 total
includes taxes & fees
Oct 4 - Oct 5
Drury Plaza Hotel Cape Girardeau Conference Center
A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.
A hotel room with two beds, a window with curtains, an air conditioning unit, and a lamp on a nightstand.
A Dear Tree Inn building with a covered entrance and a clear sky at dusk.
A modern dining area with wooden tables and chairs, a kitchen area with a tiled backsplash, and framed pictures on the wall.

7. Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
Cape Girardeau
$72
$81 total
includes taxes & fees
Oct 4 - Oct 5
Pear Tree Inn Cape Girardeau West
A spacious living area with a high ceiling, a green accent wall, and a wooden balcony railing.
A reception desk with a green wall, a wooden door, and a sign that reads 'QUALITY INN.'
A hotel room with a large bathtub, a bed with a wooden headboard, a nightstand with a lamp, and a painting of a building on the wall.
A hotel room with a flat-screen TV, a microwave, a sofa, a lamp, and a window with curtains.

8. Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North
Cape Girardeau
$60
$68 total
includes taxes & fees
Oct 4 - Oct 5
Quality Inn Cape Girardeau North
A hotel room with a large bed, two bedside lamps, a chair, and a wooden headboard.
A hotel room with a large bed, two bedside tables, a desk with a chair, and two lamps.
A bowl of cereal with raisins and milk, a half orange, and a sandwich on a table with a yellow napkin.
A plate of mixed greens salad with cherry tomatoes and croutons, a bowl of baked pasta, and a glass of red wine on a wooden table.

9. Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
Cape Girardeau
$92
$104 total
includes taxes & fees
Oct 6 - Oct 7
Drury Inn & Suites Cape Girardeau
A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.
A living room with a stone fireplace, a television mounted above it, and a large sofa with cushions.
A spacious hotel lobby with a high ceiling, a central seating area with sofas and chairs, a fireplace, and a television mounted on the wall.
A hotel room with a bed, desk, chair, TV, and a small kitchenette area.

10. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Cape Girardeau
$101
$115 total
includes taxes & fees
Oct 4 - Oct 5
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
A spacious lobby with a curved staircase, large windows, and a seating area with a rug.
A hotel room with two beds, a desk, a chair, and a view of the city.
A modern living room with a large sectional sofa, a flat-screen TV, and a view of the sea through large windows.
A modern outdoor seating area with a fire feature, a stone wall, and a view of the sunset.

11. The Riverview

The Riverview
Cape Girardeau
$114
$129 total
includes taxes & fees
Sep 29 - Sep 30
The Riverview
A spacious dining area with high ceilings, large windows, and modern lighting fixtures.
A large indoor swimming pool with clear blue water, surrounded by tiled flooring and blue walls.
An outdoor patio with stone walls, wicker furniture, and large windows.
A gym with exercise equipment, a treadmill, and a wall-mounted TV.

12. Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
Cape Girardeau
$106
$119 total
includes taxes & fees
Oct 4 - Oct 5
Hampton Inn Cape Girardeau I 55 East
A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.
An indoor swimming pool with lounge chairs and tables, large windows, and a view of the outside.
A reception area with a wooden reception desk, a glass door leading to a storage room, and a decorative wall piece.
A modern living room with a sofa, a coffee table, and a dining area with chairs and a table.

13. Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
Cape Girardeau
$101
$114 total
includes taxes & fees
Oct 4 - Oct 5
Fairfield Inn & Suites by Marriott Cape Girardeau
A hotel with a modern design, featuring a prominent sign for Candlewood Suites. There are multiple parking spaces visible in front of the building.
An indoor swimming pool with tiled flooring, a seating area with chairs, and a staircase leading to a door.
A hotel entrance with a large tree, a well-maintained garden with various plants and flowers, and a parking lot.
A hotel room with a bed, a TV, a desk, and a chair.

14. Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG
Cape Girardeau
$85
$101 total
includes taxes & fees
Oct 11 - Oct 12
Candlewood Suites Cape Girardeau by IHG
A spacious lobby with marble flooring, elegant seating, and a grand staircase.
A lobby with seating areas, a reception desk, and a bar.
A modern hotel lobby with a framed advertisement for breakfast at the new Bistro, a seating area with sofas and a coffee table, and a decorative mirror reflecting the space.
A Courtyard by Marriott hotel with a modern brick facade, large windows, and a covered entrance area.

15. Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
Cape Girardeau
$125
$142 total
includes taxes & fees
Oct 8 - Oct 9
Courtyard by Marriott Cape Girardeau Downtown
A hotel room with a bed, desk, chair, television, and two wall-mounted lamps.
A bathroom with a marble wall and a white bathtub.
A hotel room with a kitchenette, a bed, a dining table with chairs, a TV mounted on the wall, and a dresser.
A hotel room with a large bed, two bedside tables, a nightstand, a telephone, and two wall-mounted lamps.

16. Town House Inn Cape Giradreau

Town House Inn Cape Giradreau
Cape Girardeau
$75
$88 total
includes taxes & fees
Sep 29 - Sep 30
Town House Inn Cape Giradreau
A living room with a blue wall, a fireplace, a sofa, and a chair.
A brick building with a sign reading "Mercantile & Hotel".
A hotel room with two beds, a vanity with a mirror, a chair, and a dresser.
A bar area with stools and a counter where a bartender is serving drinks.

17. EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel
Marble Hill
$117
$127 total
includes taxes & fees
Oct 4 - Oct 5
EC Reed's Mercantile and Hotel
A hotel room with a large bathtub, a sofa, a small table, a TV, and a window with curtains.
A spacious lobby with a checkered floor, two sofas with patterned cushions, a computer desk, and a reception area with a glass door.
A hotel lobby with two sofas, a coffee table, lamps, and a large window with a plant.
A hotel room with a large bed, a desk with a chair, a television, and a small table with a lamp.

18. Super 8 by Wyndham Perryville

Super 8 by Wyndham Perryville
Perryville
$71
$82 total
includes taxes & fees
Oct 4 - Oct 5
Super 8 by Wyndham Perryville
A rustic cabin-style lodging with a covered porch, picnic tables, and a fire pit.
A cabin interior with a kitchenette, a ceiling fan, a television, a sofa, and a window with blinds.
A lakeside RV resort with wooden cabins, a picnic area, and a reflection in the water.
A swimming pool with a small water slide, surrounded by lounge chairs and umbrellas.

19. Perryville RV Resort

Perryville RV Resort
Perryville
$66
$76 total
includes taxes & fees
Sep 30 - Oct 1
Perryville RV Resort
A hotel room with a large bed, a nightstand, a lamp, a chair, and a mirror.
A kitchen counter with a coffee machine, a kettle, and storage boxes.
A swimming pool with a diving board, pool rules signs, and lounge chairs.
A buffet with various food items, including omelets and other dishes, served in metal containers with glass lids.

20. Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG
Perryville
$105
$120 total
includes taxes & fees
Oct 4 - Oct 5
Holiday Inn Express & Suites Perryville by IHG
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Go beyond your typical stay in Jackson

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Pet friendly
Pet friendly
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Pool
Pool
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Hot tub
Hot tub
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Family friendly
Family friendly
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Spa
Spa
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Apart hotel
Apart hotel
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Cottage
Our prices for hotels in Jackson are cheapest in December

Price trends for hotels in Jackson

Pricing is based on two traveler single night rates
View properties in September

September

High 28°C / low 17°C. Sunny most days.
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14°
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Monthly weather averages (˚C)

Top landmarks in Jackson

Litz Park

8.6/10 (14 reviews)
Litz Park is worth a visit, located 0.8 mi (1.3 km) from central Jackson.
See properties

Lake Boutin

Lake Boutin is 11 mi (17.6 km) from central Jackson, why not stop by during your stay.
See properties

Indian Creek Wild Area

Indian Creek Wild Area is 11.2 mi (18 km) from central Jackson, why not stop by during your stay.
See properties

Vancill Hollow Natural Area

Vancill Hollow Natural Area is 11.6 mi (18.7 km) from central Jackson, why not stop by during your stay.
See properties

Learn more about Jackson

Jackson is well-known for its attractions such as Trail of Tears State Park and Mississippi River. This family-friendly city has something for everyone including restaurants as well as sights like Lake Boutin and Indian Creek Wild Area. All are within a rural setting.

See all hotels in Jackson
A historic building with a dome and columns, surrounded by trees and a paved walkway.

Check out reviews of Jackson hotels guests love

A kitchen with dark wooden cabinets, a stainless steel refrigerator, a black stove, a microwave, and a sink.
A trophy labeled "Town House Inn" with "Cape Girardeau County, Missouri" and "2025" on it.
A bathroom with a granite countertop sink, a mirror, two hair dryers mounted on the wall, and a trash bin.
A hotel room with two beds, a wooden dresser, a bathroom with a shower, and a kitchen area.

Town House Inn

Town House Inn
Jackson

10/10 Exceptional

United States
larry
Town House Inn
A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.
A restaurant with a brick wall, a flat-screen TV, and a bar area.
A Drury Inn & Suites building with a traditional architectural style, featuring a covered entrance and multiple windows.
An indoor swimming pool with a wooden ceiling, lounge chairs, and a lifeguard chair.

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
Jackson

10/10 Exceptional

United States
Nicole
Drury Inn & Suites Jackson MO
A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.
A hotel room with two beds, a nightstand, a lamp, and a chair.
A reception desk with a large mural of a bridge, wooden reception area, and a potted plant.
An outdoor patio with tables and chairs, a stone wall, and large windows.

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Jackson

10/10 Exceptional

United States
Alexandra
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.
A hotel room with two beds, a window with curtains, an air conditioning unit, and a lamp on a nightstand.
A Dear Tree Inn building with a covered entrance and a clear sky at dusk.
A modern dining area with wooden tables and chairs, a kitchen area with a tiled backsplash, and framed pictures on the wall.

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
Cape Girardeau

10/10 Exceptional

United States
Kimberly
Pear Tree Inn Cape Girardeau West
A modern retail area with a display of local items and snacks.
A modern indoor seating area with blue sofas and tables, a patterned carpet, and large windows offering a view of the outdoors.
An outdoor patio area with seating arrangements, including a sofa and chairs, and a table.
A hotel room with two beds, a desk, a chair, a TV, and a window with a view.

Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
Cape Girardeau

10/10 Exceptional

United States
Tara
Tru By Hilton Cape Girardeau
A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.
A spacious corridor with a high ceiling, recessed lighting, and a series of posters on the walls.
A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.
An indoor swimming pool with clear blue water, surrounded by beige walls and large windows.

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
Cape Girardeau

10/10 Exceptional

United States
Janet
Drury Plaza Hotel Cape Girardeau Conference Center
A hotel room with a large bed, two bedside lamps, a chair, and a wooden headboard.
A hotel room with a large bed, two bedside tables, a desk with a chair, and two lamps.
A bowl of cereal with raisins and milk, a half orange, and a sandwich on a table with a yellow napkin.
A plate of mixed greens salad with cherry tomatoes and croutons, a bowl of baked pasta, and a glass of red wine on a wooden table.

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
Cape Girardeau

10/10 Exceptional

United States
StephM
Drury Inn & Suites Cape Girardeau
A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.
A living room with a stone fireplace, a television mounted above it, and a large sofa with cushions.
A spacious hotel lobby with a high ceiling, a central seating area with sofas and chairs, a fireplace, and a television mounted on the wall.
A hotel room with a bed, desk, chair, TV, and a small kitchenette area.

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Cape Girardeau

10/10 Exceptional

United States
Lisa
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
A spacious lobby with a curved staircase, large windows, and a seating area with a rug.
A hotel room with two beds, a desk, a chair, and a view of the city.
A modern living room with a large sectional sofa, a flat-screen TV, and a view of the sea through large windows.
A modern outdoor seating area with a fire feature, a stone wall, and a view of the sunset.

The Riverview

The Riverview
Cape Girardeau

10/10 Exceptional

United States
Mark
The Riverview
A spacious lobby with marble flooring, elegant seating, and a grand staircase.
A lobby with seating areas, a reception desk, and a bar.
A modern hotel lobby with a framed advertisement for breakfast at the new Bistro, a seating area with sofas and a coffee table, and a decorative mirror reflecting the space.
A Courtyard by Marriott hotel with a modern brick facade, large windows, and a covered entrance area.

Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
Cape Girardeau

10/10 Exceptional

United States
Sheila and keith
Courtyard by Marriott Cape Girardeau Downtown
A modern kitchen with a large island, stainless steel appliances, and exposed brick walls.
A large building with multiple green-roofed structures, surrounded by well-maintained lawns and a parking area.
A spacious living area with a large window, a ceiling fan, and a kitchen area with modern appliances.
A bedroom with a bed, a bench, a ceiling fan, a mirror, and a wooden floor.

Urban Lofts

Urban Lofts
Perryville

10/10 Exceptional

United States
Gregory
Urban Lofts

Frequently Asked Questions

What accommodations do travelers like in Jackson?

Guests like La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau, Drury Inn & Suites Jackson MO and Comfort Suites Jackson-Cape Girardeau.

Can I book a refundable hotel in Jackson?

If you need the flexibility to change your travel plans to Jackson, most properties offer refundable* rates you can book. You can see these accommodations by searching our site and using the "fully refundable" filter to narrow the results down.

Where should I consider staying in Jackson if I'm looking for a budget-friendly accommodation?

Comfort Suites Jackson-Cape Girardeau is an accommodation you might want to consider that'll save you money.

Where can I stay in Jackson if I want a vacation home instead of a hotel?

Browse 5 vacation homes on our site.

What will the weather in Jackson be like during my visit?

July and August are typically the warmest months in Jackson when the average temp is 76°F. January and February are the coldest months when the average temperature is 40°F. April and March are the months with the most rain.

Why should I book my Jackson hotel through Hotels.com?

There are lots of reasons to book your Jackson trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.