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Hotels in Mesilla

October 2026
9
November 2026

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This weekend
Oct 9 - Oct 11
Next weekend
Oct 16 - Oct 18

Where to stay in Mesilla?

A pool area with a fountain, palm trees, and outdoor seating.
A brick pathway lined with lush greenery and stone columns, leading to a covered area with a pergola.
A spacious atrium with a central fountain, large potted plants, and a high ceiling with skylights.
A fountain with a lotus design in a pool, surrounded by a balustrade and palm trees.

1. Hotel Encanto de Las Cruces

Hotel Encanto de Las Cruces
Las Cruces
$119
$164 total
includes taxes & fees
Nov 1 - Nov 2
Hotel Encanto de Las Cruces
A lobby with a stone fireplace, sofas, and a glass coffee table.
A living room with a sofa, ottoman, TV, and a desk with a chair. There is a kitchen in the background.
An indoor swimming pool with a hot tub, tiled flooring, and a high ceiling with beams.
A courtyard with outdoor seating, a small tree, and a stone wall.

2. Drury Inn & Suites Las Cruces

Drury Inn & Suites Las Cruces
Las Cruces
$106
$123 total
includes taxes & fees
Nov 1 - Nov 2
Drury Inn & Suites Las Cruces
A coffee station with a basket containing coffee packets and a coffee maker.
A breakfast bar with coffee machines, a fruit bowl, and stacked paper cups.
A Days Inn with a large sign, a flag, and a well-maintained entrance area.
An outdoor patio with wooden benches and a grill area.

3. Days Inn by Wyndham Las Cruces

Days Inn by Wyndham Las Cruces
Las Cruces
$49
$58 total
includes taxes & fees
Nov 1 - Nov 2
Days Inn by Wyndham Las Cruces
A hotel room with two beds, a desk with a TV, a chair, and two lamps.
A kitchen with a wooden counter, coffee machines, a microwave, and various appliances.
A multi-story hotel with a central entrance, balconies, and a parking area.
A lobby with a reception desk, American flag, and a green carpet with 'Quinta Suites' logo.

4. La Quinta Inn & Suites by Wyndham Las Cruces Organ Mountain

La Quinta Inn & Suites by Wyndham Las Cruces Organ Mountain
Las Cruces
$59
$70 total
includes taxes & fees
Nov 1 - Nov 2
La Quinta Inn & Suites by Wyndham Las Cruces Organ Mountain
A spacious lobby with a central dining area, multiple seating options, and a modern chandelier.
A gym with treadmills, elliptical machines, and exercise bikes.
A hotel with a modern facade, multiple parking spaces, and a well-lit entrance.
An indoor swimming pool with clear water, tiled edges, and a metal safety railing.

5. Hampton Inn & Suites Las Cruces I-10

Hampton Inn & Suites Las Cruces I-10
Las Cruces
$118
$136 total
includes taxes & fees
Oct 18 - Oct 19
Hampton Inn & Suites Las Cruces I-10
A spacious lobby with a high ceiling, a central chandelier, and large windows allowing natural light.
A breakfast buffet with various food items, including fruits, pastries, and hot beverages.
An outdoor patio with a built-in fireplace, surrounded by yellow cushioned chairs and a pergola overhead.
A spacious living room with a fireplace, leather sofas, a wooden coffee table with fruit, and patterned rugs.

6. Hilton Garden Inn Las Cruces

Hilton Garden Inn Las Cruces
Las Cruces
$101
$117 total
includes taxes & fees
Nov 8 - Nov 9
Hilton Garden Inn Las Cruces
A buffet area with a variety of baked goods, a coffee station, and a decorative plant.
A cozy living room with a wooden sofa and armchair, a wooden coffee table, and a patterned rug.
A patio with a table and chairs, a large tree, a fountain, and a pool in the background.
Lobby

7. Best Western Mission Inn

Best Western Mission Inn
Las Cruces
$80
$93 total
includes taxes & fees
Oct 11 - Oct 12
Best Western Mission Inn
A hotel room with a bed, a TV mounted on the wall, a desk, and a sofa.
A pool area with lounge chairs and umbrellas, surrounded by a fence and a building with multiple windows and balconies.
A modern hotel with a flat roof, large windows, and a well-lit entrance.
A compact kitchenette with a microwave, a small sink, and a refrigerator.

8. Springhill Suites By Marriott Las Cruces

Springhill Suites By Marriott Las Cruces
Las Cruces
$112
$129 total
includes taxes & fees
Oct 18 - Oct 19
Springhill Suites By Marriott Las Cruces
A spacious indoor courtyard with tiled flooring, wooden furniture, and a balcony with a railing.
An indoor swimming pool with tiled flooring, a metal pool ladder, and a few lounge chairs.
A dining area with a table and chairs, a remote control on a rug, and a door leading to another room.
A lobby with a tiled floor, a staircase, and a patterned wall hanging.

9. Ramada Hotel & Conference Center by Wyndham Las Cruces

Ramada Hotel & Conference Center by Wyndham Las Cruces
Las Cruces
$77
$89 total
includes taxes & fees
Oct 11 - Oct 12
Ramada Hotel & Conference Center by Wyndham Las Cruces
A spacious hotel lobby with a long reception desk, multiple seating areas, and large windows allowing natural light.
A hotel room with a sofa, a dining table, a kitchen area with a microwave, refrigerator, and sink.
A spacious living area with a fireplace, comfortable seating, and a television.
A reception desk with a marble top, framed pictures on the wall, a lamp, and a sign that reads "welcome to Las Cruces."

10. Hampton Inn & Suites Las Cruces I-25

Hampton Inn & Suites Las Cruces I-25
Las Cruces
$114
$132 total
includes taxes & fees
Oct 25 - Oct 26
Hampton Inn & Suites Las Cruces I-25
A hotel room with a bed, a desk with a chair, a television, a mirror, a lamp, a microwave, and a minibar.
A hotel room with a large bed, a desk, a dresser, a vanity with a mirror, and a painting on the wall.
A hotel with a pool area, stone walls, and a palm tree.
A hotel kitchen area with a coffee station, a refrigerator, and a sign indicating a fresh juice bar.

11. Quality Inn & Suites Las Cruces - University Area

Quality Inn & Suites Las Cruces - University Area
Las Cruces
$55
$65 total
includes taxes & fees
Nov 8 - Nov 9
Quality Inn & Suites Las Cruces - University Area
A spacious hotel lobby with a modern design, featuring a reception desk, seating area, and potted plants.
A hotel room with a large bed, a desk, a chair, a flat-screen TV, and a window with curtains.
A hotel room with a bed, a sofa, a desk, and a TV. There are framed pictures on the wall.
A modern hotel room with a blue sofa, armchairs, a flat-screen TV, and framed pictures on the wall.

12. Comfort Suites University Las Cruces

Comfort Suites University Las Cruces
Las Cruces
$83
$97 total
includes taxes & fees
Nov 1 - Nov 2
Comfort Suites University Las Cruces
An outdoor patio area with seating arrangements, including sofas and chairs, under a covered structure with a wooden ceiling.
A Courtyard by Marriott hotel with a modern facade, multiple windows, and a covered entrance area.
A modern hotel lobby with a large sofa, armchairs, a coffee table, and a TV.
A modern coffee shop interior with a wooden counter, seating area, and menu boards.

13. Courtyard by Marriott Las Cruces at NMSU

Courtyard by Marriott Las Cruces at NMSU
Las Cruces
$152
$175 total
includes taxes & fees
Oct 18 - Oct 19
Courtyard by Marriott Las Cruces at NMSU
A living room with a sofa, two armchairs, a coffee table, and a lamp.
A spacious lobby with a wooden floor, a reception desk, and a staircase with a green wall featuring a white leaf pattern.
A modern dining area with tables and chairs, a kitchen area with appliances, and artwork on the walls.
A hotel room with a bed, a desk with a television, a chair, and a wardrobe.

14. Sleep Inn University

Sleep Inn University
Las Cruces
$59
$69 total
includes taxes & fees
Nov 8 - Nov 9
Sleep Inn University
A pool area with a hot tub, lounge chairs, and a lifeguard stand.
A hotel room with a blue accent wall, a sofa, a bed, a desk, and a mirror.
A hotel with a modern design, featuring a covered entrance and multiple floors.
A spacious living area with a fireplace, a television mounted above it, and a seating arrangement including a sofa and chairs.

15. Comfort Suites Las Cruces I-25 North

Comfort Suites Las Cruces I-25 North
Las Cruces
$103
$123 total
includes taxes & fees
Nov 1 - Nov 2
Comfort Suites Las Cruces I-25 North
A modern breakfast bar with a coffee machine, cereal and fruit options, and a yogurt, eggs, and milk dispenser.
A modern hotel lobby with a wooden ceiling, a seating area with a sofa and chairs, a small table with a computer, and a decorative wall with a map design.
A reception area with two reception desks, a blue geometric wall design, and a sign for 'Holiday Inn Express & Suites'.
A large, modern building with a curved roof and large glass windows, likely a hotel or conference center.

16. Holiday Inn Express & Suites Las Cruces North by IHG

Holiday Inn Express & Suites Las Cruces North by IHG
Las Cruces
$127
$147 total
includes taxes & fees
Oct 18 - Oct 19
Holiday Inn Express & Suites Las Cruces North by IHG
A swimming pool with clear blue water, surrounded by lounge chairs and a tiled wall.
A covered outdoor area with a patio, seating, and a small lawn.
A hotel dining area with multiple tables and chairs, a coffee station, and a reception desk.
A golf course with a mountain range in the background.

17. Comfort Inn & Suites Las Cruces Mesilla

Comfort Inn & Suites Las Cruces Mesilla
Las Cruces
$101
$117 total
includes taxes & fees
Nov 1 - Nov 2
Comfort Inn & Suites Las Cruces Mesilla
A multi-story building with a stone facade, a central entrance with a wooden archway, and a blue car parked in front.
A restaurant with a bar area, wooden chairs, a round table, and wall art.
A swimming pool with a curved edge, surrounded by palm trees and a building with a tiled roof.
An outdoor patio with stone pillars, green chairs, and a table.

18. Staybridge Suites Las Cruces by IHG

Staybridge Suites Las Cruces by IHG
Las Cruces
$107
$124 total
includes taxes & fees
Nov 1 - Nov 2
Staybridge Suites Las Cruces by IHG
A hotel room with a large bed, two bedside lamps, a desk with a chair, a window with curtains, and a cityscape painting on the wall.
A hotel with a stone facade, a covered entrance, and a parking lot.
A hotel lobby with a reception desk, seating area, and a ceiling fan.
A hotel room with a sofa, a brown leather chair, a television, a desk with a lamp, a microwave, and a window with curtains.

19. Super 8 by Wyndham Las Cruces/White Sands Area

Super 8 by Wyndham Las Cruces/White Sands Area
Las Cruces
$51
$60 total
includes taxes & fees
Nov 6 - Nov 7
Super 8 by Wyndham Las Cruces/White Sands Area
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Go beyond your typical stay in Mesilla

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Top landmarks in Mesilla

Mesillia Plaza

9.2/10 (5 reviews)
Get a few outdoor pics when passing through Mesillia Plaza, located 0.4 mi (0.7 km) from central Mesilla.
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Fountain Theatre

9.2/10 (19 reviews)
Fountain Theatre is 0.4 mi (0.7 km) from central Mesilla, why not stop by during your stay. If you enjoy the show and want to see another, Fountain Theater is just a short walk away.
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Fountain Theater

8.6/10 (14 reviews)
Fountain Theater is 0.5 mi (0.8 km) from central Mesilla, why not stop by during your stay. If you enjoy the show and want to see another, Fountain Theatre is just a short walk away.
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San Albino Basilica

You might want to get your camera out and head to San Albino Basilica— just one of the landmarks located 0.4 mi (0.7 km) from central Mesilla.
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Learn more about Mesilla

Centuries-old adobe buildings frame the historic plaza, where the Confederate Territory of Arizona once claimed its brief capital. Duck into La Posta de Mesilla, a former stagecoach stop now serving chile rellenos that locals defend with patriotic fervor. The Fountain Theatre screens independent films in what might be the oldest movie house in the Southwest. Browse galleries where artists capture desert light in ways that make you understand why Georgia O'Keeffe never left. The Mesilla Plaza, a National Historic Landmark, hosts festivals where the smell of roasting green chiles mingles with mariachi music. Las Cruces sits just next door with its Museum of Nature & Science when you've had your fill of history.

See all hotels in Mesilla
A rustic building with a wooden door, a hanging red chili, and a cactus plant.

Check out reviews of Mesilla hotels guests love

A lobby with a stone fireplace, sofas, and a glass coffee table.
A living room with a sofa, ottoman, TV, and a desk with a chair. There is a kitchen in the background.
An indoor swimming pool with a hot tub, tiled flooring, and a high ceiling with beams.
A courtyard with outdoor seating, a small tree, and a stone wall.

Drury Inn & Suites Las Cruces

Drury Inn & Suites Las Cruces
Las Cruces

10/10 Exceptional

United States
Robert
Drury Inn & Suites Las Cruces
A spacious lobby with a central dining area, multiple seating options, and a modern chandelier.
A gym with treadmills, elliptical machines, and exercise bikes.
A hotel with a modern facade, multiple parking spaces, and a well-lit entrance.
An indoor swimming pool with clear water, tiled edges, and a metal safety railing.

Hampton Inn & Suites Las Cruces I-10

Hampton Inn & Suites Las Cruces I-10
Las Cruces

10/10 Exceptional

United States
Anonymous traveler
Hampton Inn & Suites Las Cruces I-10
A buffet area with a variety of baked goods, a coffee station, and a decorative plant.
A cozy living room with a wooden sofa and armchair, a wooden coffee table, and a patterned rug.
A patio with a table and chairs, a large tree, a fountain, and a pool in the background.
Lobby

Best Western Mission Inn

Best Western Mission Inn
Las Cruces

10/10 Exceptional

United States
Lauren
Best Western Mission Inn
A coffee station with a basket containing coffee packets and a coffee maker.
A breakfast bar with coffee machines, a fruit bowl, and stacked paper cups.
A Days Inn with a large sign, a flag, and a well-maintained entrance area.
An outdoor patio with wooden benches and a grill area.

Days Inn by Wyndham Las Cruces

Days Inn by Wyndham Las Cruces
Las Cruces

10/10 Exceptional

United States
Robert
Days Inn by Wyndham Las Cruces
A hotel room with two beds, a desk with a TV, a chair, and two lamps.
A kitchen with a wooden counter, coffee machines, a microwave, and various appliances.
A multi-story hotel with a central entrance, balconies, and a parking area.
A lobby with a reception desk, American flag, and a green carpet with 'Quinta Suites' logo.

La Quinta Inn & Suites by Wyndham Las Cruces Organ Mountain

La Quinta Inn & Suites by Wyndham Las Cruces Organ Mountain
Las Cruces

10/10 Exceptional

United States
Wendy
La Quinta Inn & Suites by Wyndham Las Cruces Organ Mountain
A spacious lobby with a high ceiling, a central chandelier, and large windows allowing natural light.
A breakfast buffet with various food items, including fruits, pastries, and hot beverages.
An outdoor patio with a built-in fireplace, surrounded by yellow cushioned chairs and a pergola overhead.
A spacious living room with a fireplace, leather sofas, a wooden coffee table with fruit, and patterned rugs.

Hilton Garden Inn Las Cruces

Hilton Garden Inn Las Cruces
Las Cruces

10/10 Exceptional

United States
Amy
Hilton Garden Inn Las Cruces
An outdoor seating area with a fire pit, sofas, and chairs.
A modern cafe with an 'inspired table' sign, a 'good morning' greeting, and a variety of seating options including tables and chairs.
A modern lounge area with a sofa, chairs, and tables, featuring pendant lighting and large windows.
A modern hotel room with a large bed, a desk with a computer, a television, and a kitchenette.

Home2 Suites by Hilton Las Cruces

Home2 Suites by Hilton Las Cruces
Las Cruces

10/10 Exceptional

United States
FERNANDO
Home2 Suites by Hilton Las Cruces
A hotel room with a bathtub, a sofa, a bed, a desk, and a television.
A room with a ceiling fan, a framed painting, a sofa, a desk, a chair, and a small kitchenette.
A coffee station with two coffee machines, a coffee press, and various coffee pods and cups.
An indoor swimming pool with clear water, marked depth lines, and a no diving sign.

Holiday Inn Express Hotel and Suites Las Cruces by IHG

Holiday Inn Express Hotel and Suites Las Cruces by IHG
Las Cruces

10/10 Exceptional

United States
Debbie J
Holiday Inn Express Hotel and Suites Las Cruces by IHG
A spacious hotel lobby with a modern design, featuring a reception desk, seating area, and potted plants.
A hotel room with a large bed, a desk, a chair, a flat-screen TV, and a window with curtains.
A hotel room with a bed, a sofa, a desk, and a TV. There are framed pictures on the wall.
A modern hotel room with a blue sofa, armchairs, a flat-screen TV, and framed pictures on the wall.

Comfort Suites University Las Cruces

Comfort Suites University Las Cruces
Las Cruces

10/10 Exceptional

United States
Beatriz
Comfort Suites University Las Cruces
An outdoor patio area with wicker furniture, a barbecue grill, and a stone wall.
A TownePlace Suites Marriott hotel with a stone facade, multiple windows, and a covered entrance.
A pool area with blue chairs and a no diving sign.
A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.

Towneplace Suites by Marriott Las Cruces

Towneplace Suites by Marriott Las Cruces
Las Cruces

10/10 Exceptional

United States
Marisa
Towneplace Suites by Marriott Las Cruces

Frequently Asked Questions

What hotels do travelers like in Mesilla?

Guests like Hotel Encanto de Las Cruces, Ramada Hotel & Conference Center by Wyndham Las Cruces and La Quinta Inn & Suites by Wyndham Las Cruces Organ Mountain.

Can I book a refundable hotel in Mesilla?

If you want the flexibility to change your travel plans to Mesilla, most accommodations offer refundable* rates you can book. You can find these properties by searching our site and using the "fully refundable" filter to narrow down the results.

Where can I stay in Mesilla if I want a vacation rental instead of a traditional hotel?

If you're looking for a good alternative to a hotel, review our selection of 8 vacation homes.

What will the weather in Mesilla be like during my trip?

The warmest months in Mesilla are usually June and July with an average temp of 82°F. January and December are the chilliest months when the average temp is 48°F. The rainiest months are August and September.

Why should I book my Mesilla accommodation with Hotels.com?

There are plenty of reasons to book your Mesilla travel with us: our free cancellations on selected hotels* gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.