Hotels in Santa Isabel

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Check prices for these dates

Tonight
Nov 12 - Nov 13
Tomorrow
Nov 13 - Nov 14
This weekend
Nov 13 - Nov 15
Next weekend
Nov 20 - Nov 22

Where to stay in Santa Isabel?

A modern lounge area with sofas, round tables, and pendant lighting.

1. City Express Plus by Marriott Mexicali

City Express Plus by Marriott Mexicali
3.5 star property
Mexicali
8.8 out of 10, Excellent, (1,045 reviews)
Refresh at the outdoor pool or savor bites at the restaurant after exploring Mexicali. Just 15 minutes from the International Border Line with free breakfast, WiFi, and parking. Clean rooms and attentive staff make this hotel a convenient base near Arenia Casino.
The price is $69
$78 total
includes taxes & fees
Nov 26 - Nov 27
City Express Plus by Marriott Mexicali
A buffet area with various food dispensers, a coffee machine, and a salad bar.

2. City Express by Marriott Mexicali

City Express by Marriott Mexicali
3.0 star property
Mexicali
8.6 out of 10, Excellent, (1,000 reviews)
Take in Mexico's desert charm at this Mexicali hotel with complimentary parking, WiFi, and daily continental breakfast. The health club offers workout options after business meetings, while the attentive staff ensures a comfortable stay near Eagles Nest Stadium and Arenia Casino.
The price is $62
$70 total
includes taxes & fees
Nov 25 - Nov 26
City Express by Marriott Mexicali
A modern kitchen with a large island, bar stools, pendant lighting, and a staircase leading to an upper level.

3. Fairfield Inn & Suites by Marriott Mexicali

Fairfield Inn & Suites by Marriott Mexicali
3.0 star property
Mexicali
9.6 out of 10, Exceptional, (1,000 reviews)
Step into relaxation at this Mexicali hotel with free WiFi, parking, and daily buffet breakfast. Dive into the outdoor pool after exploring nearby Plaza Cataviña and Plaza La Gran Via. Business travelers appreciate the convenient location and exceptional staff service.
The price is $105
$119 total
includes taxes & fees
Dec 11 - Dec 12
Fairfield Inn & Suites by Marriott Mexicali
A modern hotel lobby with a green and orange color scheme, multiple seating areas, and digital kiosks displaying hotel information.

4. One Mexicali

One Mexicali
3.0 star property
Mexicali
8.4 out of 10, Very good, (1,000 reviews)
Feel the vibrant energy of Mexicali at this conveniently located hotel just 15 minutes from the Mexico-USA border. Start your day with complimentary buffet breakfast before exploring nearby Arenia Casino. Free parking and WiFi add value to your border city stay.
The price is $64
$72 total
includes taxes & fees
Dec 13 - Dec 14
One Mexicali
A hand holding a blue drink with ice cubes, a swimming pool, palm trees, and a hotel building in the background.

5. Hotel Lucerna Mexicali

Hotel Lucerna Mexicali
4.0 star property
Mexicali
9.2 out of 10, Wonderful, (1,827 reviews)
Discover peaceful comfort at this Mexicali hotel featuring lush gardens, a refreshing outdoor pool, and convenient restaurant with bar. Just 15 minutes from the USA border and close to Eagles Nest Stadium and Arenia Casino.
The price is $102
$116 total
includes taxes & fees
Nov 15 - Nov 16
Hotel Lucerna Mexicali
A bar area with seating, a bar counter, and a wall-mounted screen.

6. Hotel Araiza Mexicali

Hotel Araiza Mexicali
4.0 star property
Mexicali
8.8 out of 10, Excellent, (1,937 reviews)
Immerse yourself in vibrant Mexicali with 2 refreshing outdoor pools and convenient dining at Fonda de Mexicali. Just minutes from Eagles Nest Stadium and Arenia Casino, this hotel offers free WiFi and parking with attentive staff ready to assist.
The price is $114
$129 total
includes taxes & fees
Nov 17 - Nov 18
Hotel Araiza Mexicali
A modern dining area with a sofa, tables, and chairs.

7. City Express Junior by Marriott Mexicali

City Express Junior by Marriott Mexicali
3.0 star property
Mexicali
8.2 out of 10, Very good, (1,003 reviews)
Wake up to a complimentary continental breakfast at this well-maintained Mexicali hotel. Free WiFi and parking add value, while proximity to Casino Caliente and Plaza La Gran Via offers entertainment options just moments away.
The price is $48
$54 total
includes taxes & fees
Dec 12 - Dec 13
City Express Junior by Marriott Mexicali
A breakfast table set with plates of food, glasses of orange juice, and a basket of pastries.

8. Fiesta Inn Mexicali

Fiesta Inn Mexicali
3.5 star property
Civic Center
8.6 out of 10, Excellent, (1,000 reviews)
This business-friendly Mexicali hotel puts you near Vicente Guerrero Park and Sol Children's Museum. Enjoy the fitness center or grab a meal at the restaurant, then unwind with a drink at the bar. Free WiFi and parking enhance your experience.
The price is $84
$95 total
includes taxes & fees
Dec 13 - Dec 14
Fiesta Inn Mexicali
Two people toasting with drinks at a table with a view of greenery outside.

9. Hotel Siesta Real

Hotel Siesta Real
3.0 star property
Mexicali
8.4 out of 10, Very good, (1,001 reviews)
Escape to Hotel Siesta Real, where the outdoor pool offers a refreshing retreat after exploring nearby attractions like Arenia Casino and Eagles Nest Stadium. With free WiFi, parking, and convenient breakfast options, this comfortable base is just 38 minutes from the airport.
The price is $65
$74 total
includes taxes & fees
Nov 17 - Nov 18
Hotel Siesta Real
A poolside area with wicker furniture, a small table with a towel, and a wooden stool.

10. Holiday Inn Express & Suites Mexicali by IHG

Holiday Inn Express & Suites Mexicali by IHG
3.0 star property
Mexicali
9.4 out of 10, Exceptional, (1,001 reviews)
Enjoy convenient access to the International Border Line Mexico-USA from this Mexicali hotel with an outdoor pool and fitness center. Free breakfast, WiFi, and parking add value while helpful staff enhance your stay near Plaza La Gran Via.
The price is $121
$137 total
includes taxes & fees
Nov 14 - Nov 15
Holiday Inn Express & Suites Mexicali by IHG
A lobby with a glass door, a staircase, and a Christmas tree.

11. Hotel del Norte

Hotel del Norte
3.0 star property
Mexicali Historic Center
8.4 out of 10, Very good, (1,009 reviews)
This friendly business hotel in Mexicali offers free breakfast, WiFi, and parking. Enjoy Mexican cuisine at RESTAURANTE DEL NORTE for lunch and dinner, or grab something quick at the snack bar. House of Culture and Rockwood Plaza are located nearby.
The price is $48
$62 total
includes taxes & fees
Nov 22 - Nov 23
Hotel del Norte
A buffet area with various food items and a counter.

12. Calafia Hotel

Calafia Hotel
3.5 star property
Mexicali
8.8 out of 10, Excellent, (1,000 reviews)
This quiet hotel offers an outdoor pool and on-site dining at Cafeteria Palmira. Located just 15 minutes from the Mexico-USA border with easy access to Eagles Nest Stadium and Arenia Casino, guests appreciate the helpful staff and clean, tranquil accommodations.
The price is $69
$77 total
includes taxes & fees
Dec 1 - Dec 2
Calafia Hotel
A modern bar area with high stools, a counter, and a kitchen in the background.

13. Holiday Inn Mexicali Centro Civico by IHG

Holiday Inn Mexicali Centro Civico by IHG
3.5 star property
Civic Center
9.2 out of 10, Wonderful, (52 reviews)
The price is $112
$135 total
includes taxes & fees
Dec 13 - Dec 14
Holiday Inn Mexicali Centro Civico by IHG
A rooftop lounge area with outdoor seating, large windows, and a view of the cityscape.

14. Courtyard by Marriott Mexicali

Courtyard by Marriott Mexicali
3.0 star property
Mexicali
9.4 out of 10, Exceptional, (1,008 reviews)
Relax at this Mexicali hotel with convenient border access and international dining at Kitchen & Bar. Work out in the fitness center and unwind on the terrace after exploring nearby Plaza La Gran Via and Plaza Cataviña. Clean rooms and helpful staff enhance your stay.
The price is $130
$147 total
includes taxes & fees
Nov 22 - Nov 23
Courtyard by Marriott Mexicali
A fountain with a mosaic border, a building entrance, and a tiled pavement.

15. Hotel Cosmos Don Carlos

Hotel Cosmos Don Carlos
3.0 star property
Mexicali
8.0 out of 10, Very good, (578 reviews)
Vibrant Mexicali hotel with a refreshing outdoor pool, where authentic Mexican flavors await at Fonda Don Carlos restaurant. Located near Eagles Nest Stadium and Arenia Casino, with free WiFi and parking for easy exploration.
The price is $42
$47 total
includes taxes & fees
Dec 7 - Dec 8
Hotel Cosmos Don Carlos
A restaurant with booths and tables, a kitchen in the background, and a ceiling fan.

16. Azteca de Oro Mexicali

Azteca de Oro Mexicali
3.0 star property
Mexicali
8.0 out of 10, Very good, (606 reviews)
Experience Mexican hospitality at this Mexicali hotel, just a short drive from the International Border Line. Enjoy complimentary breakfast at Restaurante Azteca de Oro, plus free WiFi and parking while exploring nearby Sol Children's Museum and Vicente Guerrero Park.
The price is $41
$46 total
includes taxes & fees
Nov 18 - Nov 19
Azteca de Oro Mexicali
A pool area with lounge chairs, a covered seating area, and palm trees.

17. Hotel Colonial Mexicali

Hotel Colonial Mexicali
3.5 star property
Civic Center
8.0 out of 10, Very good, (1,019 reviews)
The price is $88
$100 total
includes taxes & fees
Nov 20 - Nov 21
Hotel Colonial Mexicali
A refrigerated display case with various dairy products and beverages.

18. Extended Suites Mexicali Cataviña

Extended Suites Mexicali Cataviña
3.0 star property
Mexicali
8.0 out of 10, Very good, (2,599 reviews)
The price is $82
$99 total
includes taxes & fees
Nov 23 - Nov 24
Extended Suites Mexicali Cataviña
A lobby with teal armchairs, a large potted plant, and a wall with information about Baja California.

19. Hotel Hacienda del Indio

Hotel Hacienda del Indio
3.0 star property
Mexicali
7.4 out of 10, Good, (156 reviews)
Immerse yourself in Mexicali's culture at this welcoming hotel with a restaurant serving local fare. Just minutes from City Forest and Zoo, and Sol Children's Museum, this retreat offers free WiFi and convenient parking for explorers.
The price is $39
$48 total
includes taxes & fees
Nov 21 - Nov 22
Hotel Hacienda del Indio
Property entrance

20. Hotel Regis

Hotel Regis
3.0 star property
Mexicali
7.4 out of 10, Good, (127 reviews)
Immerse in Mexicali's charm at this historic establishment, featuring the authentic Villa Don Nacho restaurant serving Mexican cuisine. Located within 15 minutes of the Mexico-USA border and near Eagles Nest Stadium and Arenia Casino, this hotel offers free WiFi and room service.
The price is $51
$61 total
includes taxes & fees
Nov 17 - Nov 18
Hotel Regis
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Go beyond your typical stay in Santa Isabel

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Check out reviews of Santa Isabel hotels guests love

A modern kitchen with a large island, bar stools, pendant lighting, and a staircase leading to an upper level.
Fairfield Inn & Suites by Marriott Mexicali

Fairfield Inn & Suites by Marriott Mexicali

Fairfield Inn & Suites by Marriott Mexicali
Mexicali

10/10 Exceptional

From the moment we checked in, I was amazed at the incredible staff, they were friendly, knowledgeable, and friendly. The complimentary breakfast was delicious, with anything you would want.
United States
Gabriel
Reviewed September 13, 2025
Fairfield Inn & Suites by Marriott Mexicali

Frequently Asked Questions

What hotels do travelers recommend in Santa Isabel?

Guests like Hotel Araiza Mexicali, Hotel Lucerna Mexicali and Extended Suites Mexicali Cataviña.

Can I book a refundable hotel in Santa Isabel?

If you need the flexibility to change your plans to Santa Isabel, most properties provide refundable* bookable rates. You can see these properties by searching our site and using the "fully refundable" filter to narrow the results down.

What will the weather in Santa Isabel be like during my trip?

July and August are typically the warmest months in Santa Isabel when the average temp is 93°F. December and January are the coldest months when the average temperature is 61°F. August and January are the months with the most rain.

Why should I book my Santa Isabel hotel through Hotels.com?

There are lots of reasons to book your Santa Isabel trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.