Hotels in Santa Isabel

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Where to stay in Santa Isabel?

A hotel with a dome and a covered entrance.

A room with two black leather chairs, a round marble table, a framed abstract painting, a lamp, and a television on the wall.

A hotel room with a shower, a sofa, a small round table, and a painting on the wall.

A hotel room with a large bed, a nightstand, a bedside table, a wall-mounted lamp, and a mirror.

1. Motel Virreyes

Mexicali

$41

$47 total

includes taxes & fees

Sep 27 - Sep 28

A hotel room with a bed, a desk, a chair, a TV, and artwork on the walls.

A swimming pool with clear blue water, surrounded by palm trees and a stone wall.

A reception desk with a wooden finish and a marble base, a neon sign above, and a snack display to the right.

A modern bar area with a long counter and multiple stools, a kitchen with stainless steel appliances, and a seating area with sofas and a patterned rug.

2. Holiday Inn Mexicali Centro Civico by IHG

Civic Center

$104

$126 total

includes taxes & fees

Oct 3 - Oct 4

A hotel with multiple floors, a restaurant, and a parking area.

A hotel room with a bed, bedside tables, a ceiling fan, a TV, a wardrobe, and a mirror.

A lobby with a glass door, a staircase, and a Christmas tree.

A restaurant with booths, a bar area with bottles, and a TV screen displaying a sports game.

3. Hotel del Norte

Mexicali Historic Center

$51

$65 total

includes taxes & fees

Sep 28 - Sep 29

A buffet area with various food dispensers, a coffee machine, and a salad bar.

A modern lounge area with a grey sofa, yellow ottoman, and a wooden coffee table. There are bar stools and a flat-screen TV mounted on a wooden wall.

A hotel room with a bed, desk, chair, and a TV on the wall.

A modern lounge area with grey sofas, a flat-screen TV mounted on a wooden panel, and a large window offering a view of the outside.

4. City Express by Marriott Mexicali

Mexicali

$70

$80 total

includes taxes & fees

Sep 27 - Sep 28

A bar area with seating, a bar counter, and a wall-mounted screen.

A hotel pool area with lounge chairs, palm trees, and a clear blue sky.

A dining table with a variety of dishes including a steak, salad, and a dessert. There are also two drinks on the table.

5. Hotel Araiza Mexicali

Mexicali

$112

$126 total

includes taxes & fees

Sep 27 - Sep 28

A hotel room with a large bed, a headboard, a wardrobe, and an air conditioning unit.

A bathroom with a large white sink, a mirror, and a toilet. There are towels with the motel's name on them.

A motel with a colorful mural on the side, a clear blue sky, and a grassy area in the foreground.

A motel named 'Diana Motel' with a covered entrance and a clear sky.

6. Motel Diana

Mexicali

$35

$40 total

includes taxes & fees

Oct 6 - Oct 7

A modern lounge area with sofas, round tables, and pendant lighting.

A modern hotel room with a large bed, a desk, a chair, a bathroom with a sink and mirror, and a view of the city through large windows.

A modern bar area with a pool table, bar stools, and a burger on the counter.

A modern office space with a large table, chairs, and a bookshelf.

7. City Express Plus by Marriott Mexicali

Mexicali

$91

$103 total

includes taxes & fees

Sep 27 - Sep 28

A modern hotel lobby with a green and orange color scheme, multiple seating areas, and digital kiosks displaying hotel information.

A reception area with a blue wall, a wooden reception desk, a digital screen, and a refrigerator.

A hotel room with two beds, a desk with a laptop, a TV mounted on the wall, and a window with a city view.

A modern cafeteria with white tables and chairs, a blue wall with a sign, and pendant lighting.

8. One Mexicali

Mexicali

$72

$81 total

includes taxes & fees

Sep 28 - Sep 29

A buffet area with various food items and a counter.

A gym with treadmills, weight machines, and dumbbells.

A hotel room with two beds, each with white linens and pillows, a wooden headboard, a nightstand with a phone and a small table, and a framed picture on the wall.

A rooftop swimming pool with a glass enclosure, a covered seating area, and a building with a red-tiled roof.

9. Calafia Hotel

Mexicali

$83

$94 total

includes taxes & fees

Sep 28 - Sep 29

A reception area with a counter, a blue wall, a potted plant, and a window with a view.

A hotel with a modern design, featuring a prominent entrance, a parking area, and a sign indicating amenities.

A bedroom with a bed, white nightstands, a red accent on the nightstands, a wall with a motivational quote, and a brown bedspread.

A clean, well-lit reception area with a counter, shelves stocked with snacks, a refrigerator, and a small plant.

10. Hotel Boulevard Mexicali

Mexicali

$43

$49 total

includes taxes & fees

Sep 29 - Sep 30

A restaurant with booths and tables, a kitchen in the background, and a ceiling fan.

A hotel reception area with a modern design, including a reception desk, wall clocks, and a sign for a new laundry service.

A hotel room with a bed, a desk with a mirror, a television, and a door labeled '103'.

11. Azteca de Oro Mexicali

Mexicali

$36

$40 total

includes taxes & fees

Oct 11 - Oct 12

A hand holding a blue drink with ice cubes, a swimming pool, palm trees, and a hotel building in the background.

A corridor with stone sculptures on the walls, a tiled floor, and a sign indicating restrooms.

A bar area with wicker chairs, a counter, and a TV screen.

An outdoor patio area with tables and chairs, surrounded by palm trees and potted plants.

12. Hotel Lucerna Mexicali

Mexicali

$111

$125 total

includes taxes & fees

Sep 27 - Sep 28

A modern kitchen with a large island, bar stools, pendant lighting, and a staircase leading to an upper level.

A modern living room with a sofa, coffee table, and shelves with decorative items.

A swimming pool with two umbrellas, lounge chairs, and potted plants.

A modern building with a stone facade, large windows, and a covered entrance area.

13. Fairfield Inn & Suites by Marriott Mexicali

Mexicali

$110

$124 total

includes taxes & fees

Oct 4 - Oct 5

A hotel with a sign reading "Cosmos Hotel" and a price tag of $795.

A fountain with a mosaic border, a building entrance, and a tiled pavement.

A hotel room with two beds, a wooden cabinet, a television, and a door.

A staircase with a wooden handrail, a ceiling fan, and a door with a black gate.

14. Hotel Cosmos Don Carlos

Mexicali

$48

$54 total

includes taxes & fees

Sep 28 - Sep 29

A pool area with lounge chairs, a covered seating area, and palm trees.

A hotel lobby with a reception desk, a large chandelier, and a modern design.

A tree with a hammock, a bench, and a building in the background.

A courtyard with a pathway, palm trees, and a building with multiple windows.

15. Hotel Colonial Mexicali

Civic Center

$85

$96 total

includes taxes & fees

Sep 27 - Sep 28

A modern hotel with a geometric facade and illuminated entryways.

A modern bedroom with a large bed, a dark headboard, and a light-colored floor.

A plate of food with rice, meat, avocado, and a lime wedge.

A motel entrance with a prominent sign, a modern architectural design, and a landscaped area with cacti.

16. Motel Olimpo

Mexicali

$36

$41 total

includes taxes & fees

Oct 27 - Oct 28

A modern spa room with a large bathtub, a bed, and a wall-mounted shower.

A modern hotel lobby with a reception desk, a large screen displaying Sky Audio, a reception area, and a seating area with a sofa and a coffee table.

A row of modern motel buildings with numbered doors, each labeled "Motel Cies."

A modern hotel lobby with a reception desk, a sofa, and framed artwork on the wall.

17. Motel Cies

Mexicali

$73

$84 total

includes taxes & fees

Sep 28 - Sep 29

A breakfast table set with plates of food, glasses of orange juice, and a basket of pastries.

A modern office space with cubicles, computers, and a view of a green wall.

A laptop on a desk with a cup, a lamp, and a chair, overlooking a hilly landscape.

A pool area with lounge chairs and a covered seating area.

18. Fiesta Inn Mexicali

Civic Center

$84

$95 total

includes taxes & fees

Oct 4 - Oct 5

A hotel room with a bed, a wardrobe, and a nightstand.

A room with a black TV mounted on the wall, a black desk with three candles, and a white sink with a mirror above it.

A tree-lined street with a building labeled "Hotel Las Fuentes."

A building with a flat roof and a balcony.

19. Motel Las Fuentes

Mexicali

$39

$48 total

includes taxes & fees

Sep 29 - Sep 30

A courtyard with a central fountain, a building with a balcony, and a tree.

A building with a green awning labeled "Chab's Restaurant" and a sign for "Siesta Real Hotel" above it.

Two people toasting with drinks at a table with a view of greenery outside.

A poolside area with lounge chairs and a menu board in the background.

20. Hotel Siesta Real

Mexicali

$77

$87 total

includes taxes & fees

Sep 28 - Sep 29

View all properties

Go beyond your typical stay in Santa Isabel

Check out reviews of Santa Isabel hotels guests love

A rooftop lounge area with outdoor seating, large windows, and a view of the cityscape.

A hotel room with two beds, a desk, a chair, and a large window with curtains.

A modern lounge area with wicker furniture, a round coffee table, and potted plants.

A reception area with a wooden reception desk, two computer monitors, a sign reading "BONVAY," and a modern chandelier.

Courtyard by Marriott Mexicali

Mexicali

10/10 Exceptional

Frequently Asked Questions

What hotels do travelers recommend in Santa Isabel?

Guests like Hotel Araiza Mexicali, Hotel Lucerna Mexicali and Extended Suites Mexicali Cataviña.

Can I book a refundable hotel in Santa Isabel?

If you need the flexibility to change your plans to Santa Isabel, most properties provide refundable* bookable rates. You can see these properties by searching our site and using the "fully refundable" filter to narrow the results down.

What will the weather in Santa Isabel be like during my trip?

July and August are typically the warmest months in Santa Isabel when the average temp is 93°F. December and January are the coldest months when the average temperature is 61°F. August and January are the months with the most rain.

Why should I book my Santa Isabel hotel through Hotels.com?

There are lots of reasons to book your Santa Isabel trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.