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Hotels in Mousie

November 2026
December 2026

Free cancellation options if plans change

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Check prices for these dates

This weekend
Oct 23 - Oct 25
Next weekend
Oct 30 - Nov 1

Where to stay in Mousie?

A hotel room with a bed, desk, and a painting on the wall.
A modern kitchen with a coffee station, a flat-screen TV, and a dining area with tables and chairs.
A hotel lobby with a reception desk, a seating area with a rocking chair, a vending machine, and a refrigerator.
A laundry room with two Whirlpool washing machines and a white sink.

1. Spark by Hilton Prestonsburg

Spark by Hilton Prestonsburg
Prestonsburg
$93
$102 total
includes taxes & fees
Nov 12 - Nov 13
Spark by Hilton Prestonsburg
A hotel room with two beds, a sofa, a desk with a lamp, and a TV.
A reception area with a wooden counter, a cash register, a computer, a small refrigerator stocked with snacks, and a security camera on the wall.
A buffet setup with various food items and a coffee station.
A hotel lounge with blue armchairs, a red sofa, a fireplace, and a wall-mounted TV displaying a weather forecast.

2. Comfort Suites Prestonsburg West

Comfort Suites Prestonsburg West
Prestonsburg
$101
$115 total
includes taxes & fees
Nov 15 - Nov 16
Comfort Suites Prestonsburg West
A playground with swings, slides, and a small pavilion.
A laundry area with a front-loading washer and dryer, a sign instructing to clean out the dryer vent after each use, and a shelf above the machines.
A motel with a parking lot, a red building, and a white fence.
A room with two chairs, a small table with a lamp, a TV on a shelf, and a window with a view of the outside.

3. Daniel Boone Motor Inn

Daniel Boone Motor Inn
Pikeville
$72
$80 total
includes taxes & fees
Oct 23 - Oct 24
Daniel Boone Motor Inn
A modern hotel room with a dining area, a living room, and a kitchen.
A hotel with a covered entrance, a sign reading "Quality Inn & Suites by Wyndham," and a parking lot.
A vending machine with a Pepsi advertisement and a variety of snacks.
A compact kitchen with a microwave, coffee maker, and a sink.

4. Quality Inn & Suites Prestonsburg next to Mountain Arts Center

Quality Inn & Suites Prestonsburg next to Mountain Arts Center
Prestonsburg
$102
$116 total
includes taxes & fees
Nov 11 - Nov 12
Quality Inn & Suites Prestonsburg next to Mountain Arts Center
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Go beyond your typical stay in Mousie

pet friendly image
Pet friendly
Pet friendly
Pool image
Pool
Pool
Family friendly image
Family friendly
Family friendly
Cottage image
Cottage
Cottage

Check out reviews of Mousie hotels guests love

A hotel room with a bed, desk, and a painting on the wall.
A modern kitchen with a coffee station, a flat-screen TV, and a dining area with tables and chairs.
A hotel lobby with a reception desk, a seating area with a rocking chair, a vending machine, and a refrigerator.
A laundry room with two Whirlpool washing machines and a white sink.

Spark by Hilton Prestonsburg

Spark by Hilton Prestonsburg
Prestonsburg

10/10 Exceptional

United States
Faye
Spark by Hilton Prestonsburg
A hotel room with two beds, a sofa, a desk with a lamp, and a TV.
A reception area with a wooden counter, a cash register, a computer, a small refrigerator stocked with snacks, and a security camera on the wall.
A buffet setup with various food items and a coffee station.
A hotel lounge with blue armchairs, a red sofa, a fireplace, and a wall-mounted TV displaying a weather forecast.

Comfort Suites Prestonsburg West

Comfort Suites Prestonsburg West
Prestonsburg

10/10 Exceptional

United States
Anonymous traveler
Comfort Suites Prestonsburg West
A modern hotel room with a dining area, a living room, and a kitchen.
A hotel with a covered entrance, a sign reading "Quality Inn & Suites by Wyndham," and a parking lot.
A vending machine with a Pepsi advertisement and a variety of snacks.
A compact kitchen with a microwave, coffee maker, and a sink.

Quality Inn & Suites Prestonsburg next to Mountain Arts Center

Quality Inn & Suites Prestonsburg next to Mountain Arts Center
Prestonsburg

10/10 Exceptional

United States
Ron
Quality Inn & Suites Prestonsburg next to Mountain Arts Center
A playground with swings, slides, and a small pavilion.
A laundry area with a front-loading washer and dryer, a sign instructing to clean out the dryer vent after each use, and a shelf above the machines.
A motel with a parking lot, a red building, and a white fence.
A room with two chairs, a small table with a lamp, a TV on a shelf, and a window with a view of the outside.

Daniel Boone Motor Inn

Daniel Boone Motor Inn
Pikeville

10/10 Exceptional

United States
Kelly
Daniel Boone Motor Inn

Frequently Asked Questions

Can I book a refundable hotel in Mousie?

If you want the flexibility to change your travel plans to Mousie, most accommodations provide refundable* bookable rates. You can see these accommodations by searching our site and using the "fully refundable" filter to narrow down the results.

What will the weather in Mousie be like during my trip?

July and August are typically the warmest months in Mousie when the average temp is 73°F. January and February are the coldest months when the average temperature is 40°F. July and May are the months with the most rain.

Why should I book my Mousie accommodation with Hotels.com?

There are lots of reasons to book your Mousie trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.