Hotels in Matthews
Free cancellation options if plans change
Earn rewards on every night you stay
Save more with Member Prices
Check prices for these dates
Where to stay in Matthews?
Best Western Plus Sikeston
Best Western Plus Sikeston
2.5 star property
Sikeston
8.4 out of 10, Very Good, (1003)
8.4/10
Very Good
(1003)
- Stay minutes from Central Park at this inviting hotel with an indoor pool and gym.
The price is $76
$76
$86 total
includes taxes & fees
Dec 21 - Dec 22
Super 8 by Wyndham Charleston/Sikeston East MO
Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.6 out of 10, (612)
6.6/10
(612)
- Gateway to historic Charleston with easy interstate access and free breakfast.
The price is $62
$62
$69 total
includes taxes & fees
Dec 20 - Dec 21
Pear Tree Inn Sikeston
Pear Tree Inn Sikeston
2.5 star property
Sikeston
9.4 out of 10, Exceptional, (1001)
9.4/10
Exceptional
(1001)
- Quiet, dual pool paradise near Central Park in charming Sikeston.
The price is $75
$75
$86 total
includes taxes & fees
Dec 23 - Dec 24
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very Good, (719)
8.4/10
Very Good
(719)
- Enjoy a serene stay in Sikeston, just minutes from Central Park and Depot Museum.
The price is $55
$55
$63 total
includes taxes & fees
Dec 21 - Dec 22
Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1003)
9.4/10
Exceptional
(1003)
- Peaceful highway-adjacent retreat with indoor and outdoor pool options.
The price is $90
$90
$103 total
includes taxes & fees
Dec 23 - Dec 24
Holiday Inn Express & Suites Sikeston Southwest by IHG
Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.6 out of 10, Excellent, (443)
8.6/10
Excellent
(443)
- Convenient stay near Central Park with refreshing pool and complimentary perks.
The price is $93
$93
$105 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Hampton Inn Sikeston
Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (446)
9.0/10
Wonderful
(446)
- Discover contemporary comfort with an indoor pool just off I-55 in Sikeston.
The price is $98
$98
$110 total
includes taxes & fees
Dec 28 - Dec 29
Quality Inn Charleston - Sikeston
Quality Inn Charleston - Sikeston
2.5 star property
Charleston
6.8 out of 10, (406)
6.8/10
(406)
New Orleans Inn Portageville
New Orleans Inn Portageville
2.5 star property
Portageville
8.0 out of 10, Very Good, (727)
8.0/10
Very Good
(727)
- Comfortable motel near Cape Girardeau with free WiFi and helpful 24-hour service.
The price is $63
$63
$68 total
includes taxes & fees
Dec 21 - Dec 22
Eagle Inn Charleston
Eagle Inn Charleston
2.0 star property
Charleston
6.6 out of 10, (104)
6.6/10
(104)
- Stay fit while visiting Charleston with a health club at this convenient motel.
The price is $60
$60
$67 total
includes taxes & fees
Dec 20 - Dec 21
Hampton Inn By Hilton Dexter
Hampton Inn By Hilton Dexter
2.5 star property
Dexter
10.0 out of 10, Exceptional, (2)
10/10
Exceptional
(2)
The price is $106
$106
$119 total
includes taxes & fees
Dec 28 - Dec 29
Super 8 by Wyndham Sikeston/Miner Area
Super 8 by Wyndham Sikeston/Miner Area
2.0 star property
Sikeston
6.6 out of 10, (566)
6.6/10
(566)
- Convenient Sikeston escape with free amenities and easy access to local attractions.
The price is $59
$59
$68 total
includes taxes & fees
Dec 21 - Dec 22
Days Inn and Suites by Wyndham Sikeston
Days Inn and Suites by Wyndham Sikeston
2.0 star property
Sikeston
7.2 out of 10, Good, (1001)
7.2/10
Good
(1001)
- Enjoy a peaceful night's rest and complimentary breakfast at this quiet Sikeston hotel.
The price is $63
$63
$72 total
includes taxes & fees
Dec 21 - Dec 22
Country Yard Inn and Suite
Country Yard Inn and Suite
2.0 star property
Sikeston
6.8 out of 10, (120)
6.8/10
(120)
- Enjoy a comfortable base in Sikeston with free perks and 24-hour service.
The price is $53
$53
$64 total
includes taxes & fees
Dec 20 - Dec 21
Travel Inn
Travel Inn
2.5 star property
Marston
6.0 out of 10, (116)
6.0/10
(116)
The price is $43
$43
$49 total
includes taxes & fees
Dec 20 - Dec 21
Comfort Inn & Suites Sikeston I-55
Comfort Inn & Suites Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very Good, (282)
8.4/10
Very Good
(282)
- Cozy stay near Central Park with indoor pool, free WiFi, and friendly staff.
The price is $88
$88
$101 total
includes taxes & fees
Dec 23 - Dec 24
Dexter Inn
Dexter Inn
2.5 star property
Dexter
7.0 out of 10, Good, (332)
7.0/10
Good
(332)
- Relax in scenic Dexter with free perks and a refreshing seasonal outdoor pool.
The price is $68
$68
$76 total
includes taxes & fees
Jan 3 - Jan 4, 2026
Fairfield Inn & Suites by Marriott Sikeston
Fairfield Inn & Suites by Marriott Sikeston
2.5 star property
Sikeston
9.4 out of 10, Exceptional, (40)
9.4/10
Exceptional
(40)
- Discover a modern retreat with a welcoming indoor pool and sip drinks at the bar.
The price is $101
$101
$114 total
includes taxes & fees
Dec 25 - Dec 26
Travelodge by Wyndham Dexter
Travelodge by Wyndham Dexter
2.0 star property
Dexter
7.6 out of 10, Good, (386)
7.6/10
Good
(386)
- Cozy spot with quick access to local heritage sites and convenient travel amenities.
The price is $74
$74
$83 total
includes taxes & fees
Dec 21 - Dec 22
Super 8 By Wyndham Marston
Super 8 By Wyndham Marston
2.0 star property
Marston
7.8 out of 10, Good, (39)
7.8/10
Good
(39)
- Welcoming roadside retreat with quick access to I-55 and daily breakfast service.
The price is $58
$58
$66 total
includes taxes & fees
Dec 22 - Dec 23
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Go beyond your typical stay in Matthews
Pet friendly
Family friendly
Check out reviews of Matthews hotels guests love
Travelodge by Wyndham Dexter
10/10 Excellent
"Staff was helpful and kind. The room was clean as well as the whole Hotel, although they should move the smoking area from right at the enrty way of the hotel."
Drury Inn & Suites Sikeston, MO
10/10 Excellent
"Clean room, friendly staff"
New Orleans Inn Portageville
10/10 Excellent
"Yes"
Super 8 By Wyndham Marston
10/10 Excellent
"Great hotel, great staff"
Super 8 by Wyndham Sikeston/Miner Area
10/10 Excellent
" Clean rooms , quiet , excellent hotel staff."
Hampton Inn Sikeston
10/10 Excellent
"Yes"
Fairfield Inn & Suites by Marriott Sikeston
10/10 Excellent
"Staff"
Days Inn and Suites by Wyndham Sikeston
10/10 Excellent
"Very nice room, staff was nice. The tv room and bathroom were cold. No heat in those rooms."
Best Western Plus Sikeston
10/10 Excellent
"Easy parking , quiet and comfortable bed , we’ll stop again on our way back "
Frequently asked questions
What hotels do travelers like in Matthews?
Guests like Drury Inn & Suites Sikeston, MO, Hampton Inn Sikeston and Best Western Plus Sikeston.
Can I book refundable accommodations in Matthews?
If you're looking for the flexibility to change your plans to Matthews, most hotels offer refundable* bookable rates. You can find these properties by searching our site and using the "fully refundable" filter to narrow the results down.
What will the weather in Matthews be like during my vacation?
July and August are typically the warmest months in Matthews when the average temp is 77°F. January and February are the coldest months when the average temperature is 41°F. April and March are the months with the most rain.
Why should I book my Matthews accommodation with Hotels.com?
There are lots of reasons to book your Matthews trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.