Top 10 Hotels in Panamá in 2026 (from $45)

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1. Órion Hotel

Itumbiara

$46

$48 total

includes taxes & fees

Sep 25 - Sep 26

A breakfast tray with croissants, fruit, and juice on a bed with a quilted bedspread, near a window with curtains and a view of trees and cars outside.

A riverside walkway with a patterned pavement, a palm tree, and a view of a city skyline with buildings across the river.

A multi-story building with various shops on the ground floor, including a restaurant and a store named 'La Trattoria'.

A spacious living area with a dining table, chairs, a red rug, and a chandelier.

2. Pousada Beira Rio

Itumbiara

$52

$54 total

includes taxes & fees

Sep 27 - Sep 28

A lobby with a staircase, two armchairs, a coffee table, and a framed picture on the wall.

A lobby with a checkered floor, a staircase, and a reception desk.

A building entrance with a covered parking area, a tree, and a car parked inside.

A hotel room with a bed, a nightstand, a wall-mounted air conditioner, a framed picture, and a green towel on the bed.

3. Nioja Hotel

Itumbiara

$61

$64 total

includes taxes & fees

Sep 27 - Sep 28

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Frequently Asked Questions

Can I book a refundable hotel in Panamá?

If you want the flexibility to change your plans to Panamá, most accommodations provide refundable* bookable rates. You can find these properties by searching our site and using the "fully refundable" filter to narrow down the results.

What will the weather in Panamá be like during my visit?

With an average temperature of 73°F, Panamá is a great place if you want to enjoy the sunshine year all year long.

Why should I book my Panamá hotel through Hotels.com?

There are plenty of reasons to book your Panamá travel with us: our free cancellations on selected hotels* gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.