Hotels in Irene

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Where to stay in Irene?

A modern living room with a fireplace, seating area, and large windows.

A modern reception area with wooden paneling, a reception desk, and a refrigerated display case.

A patio with outdoor seating, stone wall, and large windows.

A Fairfield by Marriott hotel with a modern design, featuring a prominent entrance and a stone facade.

1. Fairfield Inn & Suites by Marriott Yankton

Yankton

$121

$133 total

includes taxes & fees

Nov 8 - Nov 9

A reception desk with a blue and white geometric wall design, a wooden accent panel, and a sign for Holiday Inn Express & Suites.

An indoor swimming pool with clear blue water, surrounded by white chairs and tables.

A hotel room with a desk, two chairs, a sofa, a lamp, and a window with curtains.

A hotel room with a bed, a desk with a television, a chair, a lamp, and a window with curtains.

2. Holiday Inn Express & Suites Yankton by IHG

Yankton

$118

$130 total

includes taxes & fees

Nov 10 - Nov 11

A hotel lobby with a reception desk, seating area, and a large window with a view of a building.

A Comfort Inn hotel with a covered entrance, a parking lot, and a clear sky.

A hotel reception area with a long counter, coffee machines, and a television screen displaying a program.

A hotel room with two beds, a desk, a chair, and a framed picture on the wall.

3. Comfort Inn Yankton SD

Yankton

$93

$103 total

includes taxes & fees

Nov 8 - Nov 9

A hotel room with two beds, a desk, a chair, a window with curtains, a wall-mounted TV, and a large wall art piece.

A reception area with a counter, a mounted sign, a wall-mounted picture, a door, and a potted plant.

A breakfast area with a coffee machine, a TV, and a clock on the wall.

A bathroom with a sink, mirror, towel rack, toilet, and shower curtain.

4. Super 8 by Wyndham Yankton

Yankton

$86

$96 total

includes taxes & fees

Nov 1 - Nov 2

A hotel room with two beds, a large framed waterfall painting, a lamp, and a window with curtains.

A hotel sign with the name "Super 8" and a blank board below it.

A small kitchenette with wooden cabinets, a microwave, and a shelf with various items.

A lobby with a reception desk, two armchairs, a coffee table, and potted plants.

5. Super 8 by Wyndham Beresford

Beresford

$71

$77 total

includes taxes & fees

Oct 19 - Oct 20

A hotel room with two beds, a desk, a chair, and a lamp.

A hotel room with a sofa, a television, a desk with a chair, a lamp, a microwave, a framed picture, and a fireplace.

A swimming pool with a tiled floor, a pool ladder, and lounge chairs.

A kitchen with wooden cabinets, a dining area with chairs, a refrigerator, and a microwave.

6. Econo Lodge Inn & Suites Yankton

Yankton

$68

$76 total

includes taxes & fees

Nov 5 - Nov 6

A lobby with a stone fireplace, leather seating, a bar area, and a staircase.

A modern living room with a sofa set, a coffee table, and a rug.

A bar area with a long counter, multiple stools, and hanging glassware.

An indoor swimming pool with a slide, a basketball hoop, and a covered seating area.

7. Best Western Kelly Inn

Yankton

$98

$109 total

includes taxes & fees

Oct 25 - Oct 26

A spacious kitchen with a large island, modern pendant lights, and a ceiling fan.

A modern kitchen with stainless steel appliances, dark wood cabinets, and a tiled floor.

A spacious room with wooden walls and ceiling, featuring a large chandelier, multiple windows, and a central seating area with tables and chairs.

A modern kitchen with dark cabinets, stainless steel appliances, and a large window.

8. Lewis and Clark Resort

Yankton

$113

$120 total

includes taxes & fees

Nov 1 - Nov 2

A balcony with a metal table and chairs, overlooking a park with trees and a lake.

A spacious living room with a sofa, a dining table, and a kitchen area in the background.

A spacious kitchen with wooden cabinets, a large island with bar stools, and a dining area with a sofa and coffee table.

A kitchen with granite countertops, wooden cabinets, stainless steel appliances, and a large window.

9. Downtown Yankton Apartment w/ Patio & River View!

Yankton

$150

$329 total

includes taxes & fees

Oct 25 - Oct 26

View all properties

Go beyond your typical stay in Irene

Pet friendly

Pool

Family friendly

Check out reviews of Irene hotels guests love

Fairfield Inn & Suites by Marriott Yankton

10/10 Excellent

"Most comfortable bed of our vacation!"

Super 8 by Wyndham Yankton

10/10 Excellent

"Very clean, they have done a lot of updates since the last time I stayed at the property"

Best Western Kelly Inn

10/10 Excellent

"Clean room, hotel itself was clean, hotel staff was excellent, right there willing to help if need be, maintenance man was absolutely great, helped me with a minor infraction, I just thought the staff in the restaurant could have a little more ambition , otherwise I loved the stay!"

Lewis and Clark Resort

10/10 Excellent

"Had a great time except for the neighbors keeping us up until 2-3:00 am. Kitchen floor was not very clean."

Frequently asked questions

Can I book refundable hotels in Irene?

If you're looking for the flexibility to change your plans to Irene, most accommodations provide refundable* bookable rates. You can see these properties by searching our site and using the "fully refundable" filter to narrow down the results.

What will the weather in Irene be like during my vacation?

July and August are typically the warmest months in Irene when the average temp is 72°F. January and February are the coldest months when the average temperature is 26°F. June and May are the months with the most rain.

Why should I book my Irene accommodation with Hotels.com?

There are lots of reasons to book your Irene trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

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