Hotels in Pamplico

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Where to stay in Pamplico?

An outdoor patio area with tables and chairs, a brick wall, and a glass door leading to the interior.

A spacious lobby with a grand staircase, plush seating, and a modern kitchen area.

A spacious bar area with a wooden floor, multiple bar stools, and a variety of bottles on shelves.

A spacious living room with hardwood flooring, a staircase, and a large window.

1. The Inn at the Crossroads

Lake City

$116

$130 total

includes taxes & fees

Oct 27 - Oct 28

A spacious lobby with a chandelier, seating area, and a reception desk.

A spacious lobby with a chandelier, sofas, a reception desk, and a large window.

A conference room with a dark table and chairs, a vase with white flowers, and large windows with white trim.

A hotel entrance with a covered walkway, palm trees, and a clear sky.

2. Quality Inn & Suites Lake City

Lake City

$99

$110 total

includes taxes & fees

Nov 12 - Nov 13

A spacious lobby with a large seating area, a decorative ceiling light, and a view of the outdoors.

A hotel room with two beds, a desk, a chair, and a sofa.

A hotel reception area with a counter, a 'Days Inn Lake City' award plaque, and a 'Jazmin' sign.

A brick building with a stone pillar, large potted plants, and a wreath on the door.

3. Days Inn by Wyndham Lake City

Lake City

$98

$109 total

includes taxes & fees

Nov 10 - Nov 11

A rooftop terrace with outdoor seating, including sofas and chairs, and a round table.

A modern bar area with a long counter, bar stools, and a variety of bottles and glasses.

A modern lounge area with brick walls, large windows, and contemporary furniture.

A multi-story hotel with a modern facade, featuring a prominent 'Hyatt Place' sign on the right.

4. Hyatt Place Florence Downtown

Florence

$100

$112 total

includes taxes & fees

Nov 3 - Nov 4

A modern living room with a grey sofa, two black hanging chairs, a small table, and a TV mounted on the wall.

A hotel room with a large bed, a desk with a lamp, a chair, a TV, and a window with curtains.

A modern living room with a grey sofa, a flat-screen TV, geometric wall art, and a bookshelf with decorative items.

A modern kitchen with a patterned backsplash, wooden cabinets, and stainless steel appliances.

5. Park Inn by Radisson Florence, SC

Florence

$89

$100 total

includes taxes & fees

Oct 18 - Oct 19

A spacious lobby with a checkered floor, a reception desk, and a chandelier.

A two-story building with a brick facade, a flat roof, and a covered entrance area.

A vending area with snack and drink options, including Pepsi refrigerators and a 'MARKET' display with various products.

A hotel room with two beds, a desk with a computer, a chair, and a bathroom with a mirror.

6. Howard Johnson by Wyndham Florence

Florence

$65

$72 total

includes taxes & fees

Oct 15 - Oct 16

A hotel room with a desk, chair, bed, and a yellow sofa.

A hotel with a green roof, a sign reading 'Quality Inn & Suites by Choice Hotels,' and a landscaped front yard with small trees and shrubs.

A reception desk with a stone wall backdrop, a sign reading 'Quality Choice Hotels,' and a reception area with a wooden reception desk and two chairs.

A swimming pool with lounge chairs and a building with balconies.

7. Quality Inn & Suites Florence Civic Center

Florence

$88

$99 total

includes taxes & fees

Oct 20 - Oct 21

A modern lobby with a stone column, a fireplace, and yellow rocking chairs around a central table.

A hotel with a modern design, featuring a prominent sign for the 'Country Inn & Suites by Radisson.'

An outdoor patio with a wooden table and wicker chairs, a barbecue grill, and a swimming pool in the background.

A hotel room with two beds, a desk with a chair, a television, and a window with curtains.

8. Spark by Hilton Florence North I-95, SC

Florence

$84

$98 total

includes taxes & fees

Oct 25 - Oct 26

A hotel with a modern design, multiple floors, and a parking lot.

A restaurant with a bar area, seating, and a kitchen visible in the background.

A swimming pool with lounge chairs and a building with balconies in the background.

A reception area with a Best Western sign, a reception desk, a waiting area with a blue patterned sofa, and a potted plant.

9. Best Western Inn

Florence

$89

$100 total

includes taxes & fees

Oct 15 - Oct 16

A hotel lobby with a reception desk, seating area, and a television screen.

A Comfort Inn & Suites hotel with a covered entrance, brick facade, and multiple windows.

A hotel room with a bed, a sofa, an ottoman, and a lamp.

A spacious dining area with multiple tables and chairs, large windows, and a flat-screen TV mounted on the wall.

10. Comfort Inn & Suites Florence Center Area

Florence

$101

$113 total

includes taxes & fees

Nov 3 - Nov 4

A modern hotel with a covered entrance, large windows, and a sign indicating it is a hotel.

A bar area with a neon sign, shelves of bottles, and a view of trees through large windows.

A modern lounge area with a pool table, sofas, and yellow chairs.

11. Aloft by Marriott Florence

Florence

$111

$130 total

includes taxes & fees

Oct 18 - Oct 19

A spacious lobby with a high ceiling, a central seating area, and a staircase leading to an upper level.

A hotel room with a bed, sofa, TV, and a desk.

A La Quinta Inn & Suites hotel with a modern facade, a well-lit entrance, and a landscaped garden area.

A hotel room with a bed, a sofa, a desk, and a TV.

12. La Quinta Inn & Suites by Wyndham Florence

Florence

$86

$96 total

includes taxes & fees

Oct 18 - Oct 19

A restaurant with brick walls, framed awards, and a bar area.

A spacious kitchen with a dining area, a living room with a fireplace, and a cozy seating arrangement.

A spacious living room with a wooden floor, a ceiling fan, and a dining area with a wooden table and chairs.

A bar area with a curved counter, multiple stools, and a brick wall backdrop.

13. Hotel Florence, Tapestry Collection by Hilton

Florence

$118

$132 total

includes taxes & fees

Nov 1 - Nov 2

A Holiday Inn Express & Suites building with a modern design, featuring a prominent entrance with a covered walkway and stone pillars.

A modern hotel lobby with a coffee bar, seating areas, and a reception desk.

A modern lobby with a reception desk, a sofa, and a patterned carpet.

An outdoor patio with blue chairs and umbrellas, a stone-tiled floor, and a glass door leading to an indoor area.

14. Holiday Inn Express & Suites Latta by IHG

Latta

$101

$110 total

includes taxes & fees

Nov 1 - Nov 2

A hotel room with a bed, bedside table with a phone, a desk with a chair, a TV mounted on the wall, and a window with curtains.

A multi-story hotel with a prominent entrance marked '1912'.

A reception area with a wooden counter, a seating area with tables and chairs, and a large window with a view.

A modern kitchen with dark wood cabinets, stainless steel appliances, and a large juice dispenser.

15. Microtel Inn & Suites by Wyndham Florence

Florence

$65

$73 total

includes taxes & fees

Oct 15 - Oct 16

A hotel entrance with a stone facade, glass doors, and a number '501' above.

A hotel reception area with a wooden floor, a reception desk, a seating area with chairs, and a decorative wall with a tree pattern.

An indoor swimming pool with a tiled floor, a pool ladder, and lounge chairs.

A modern living room with a stone fireplace, a blue sofa, a brown leather chair, and a round coffee table.

16. Fairfield Inn & Suites by Marriott Florence I-20

Florence

$118

$132 total

includes taxes & fees

Oct 25 - Oct 26

A hotel with a covered entrance, a beige facade, and pink flowering trees.

A hotel lobby with a reception desk, a wall-mounted TV, a decorative wall piece, and a seating area with tables and chairs.

A hotel room with a bed, a desk, a chair, a television, and a mirror.

A living room with a sofa, a coffee table, a chair, and two framed floral paintings on the wall.

17. Quality Inn Mullins - Marion

Marion

$83

$91 total

includes taxes & fees

Nov 6 - Nov 7

A hotel room with two beds, a wooden headboard, a nightstand, and three sunset paintings on the wall.

A lobby with a reception desk, seating area, and artwork on the walls.

A Days Inn hotel with a modern design, featuring a parking lot and well-maintained landscaping.

A modern kitchen with a central island, a dining area with chairs, a large window with a view of palm trees, and a flat-screen TV mounted on the wall.

18. Days Inn by Wyndham Florence Near Civic Center

Florence

$65

$73 total

includes taxes & fees

Oct 15 - Oct 16

19. Rodeway Inn Florence Downtown

Florence

$43

$49 total

includes taxes & fees

Nov 12 - Nov 13

A swimming pool with lounge chairs and a building with a sign reading "BAYMONT".

A hotel room with a large bed, a desk, a chair, a TV, and a painting of a waterfall on the wall.

A bathroom with a sink, mirror, towel rack, and a towel hanging on the wall.

A modern living room with a sectional sofa, a coffee table, and a flat-screen TV mounted on the wall.

20. Super 8 by Wyndham Florence

Florence

$54

$60 total

includes taxes & fees

Oct 18 - Oct 19

View all properties

Go beyond your typical stay in Pamplico

Check out reviews of Pamplico hotels guests love

Hyatt Place Florence Downtown

Florence

10/10 Exceptional

A corridor with shelves stocked with snacks and a frozen food display.

Hampton Inn & Suites Florence-North-I-95

Florence

10/10 Exceptional

I chose Hampton Inn in Florence because, overall, in the past I have had excellent experiences with this chain. I was very pleasantly treated to a very beautifully appointed hotel setting, it was also very clean. I saw staff picking up small items or pieces of paper that had been left or dropped by a visitor. My room itself was very clean and the bed was very comfortable and the room had it's own thermostat so the temperature and whether you wished heat or air could be selected for...

Anonymous traveler

Quality Inn & Suites Florence Civic Center

Florence

10/10 Exceptional

Great option for an easy overnight stay We had a very pleasant stay and found this hotel to be a convenient, comfortable stop for an overnight trip. The staff was very friendly, and check-in was quick and easy. Our room was clean, smelled fresh, and felt well cared for. We also appreciated being able to park directly in front of our room, and the well-lit parking lot added to the sense of convenience and security. The location is excellent, with easy access from I-95 and several restaurants and...

Berry

A spacious lobby with a high ceiling, a central seating area with armchairs and a coffee table, a flat-screen TV, and a dining area with tables and chairs.

A modern hotel lobby with a fireplace, seating area, and a reception desk.

A modern hotel lobby with a central seating area, a large abstract painting, and a patterned carpet.

A hotel with a modern design, featuring multiple floors and a parking lot.

Residence Inn Marriott Florence

Florence

10/10 Exceptional

Staff were friendly and nice! Very accommodating to both my dogs. Room was clean and nice. Some wallpaper was bubbling but it honestly didn’t bother me. Loved the secure easy access to the building. Hotel was right next to a beautiful memorial park and very easy to get to the civic center. Pool was beautiful even though I didn’t get to use it due to weather. Looked like the pool was handicap accessible with a lift. Breakfast was amazing every morning with lots to choose from. We definitely will...

Anna

A hotel room with a desk, a green armchair, a small purple ottoman, a bed with a white headboard, and a large window.

A hotel room with a bed, a desk, a green sofa, and a painting on the wall.

A spacious lobby with a reception desk, seating area with patterned chairs, and a coffee station.

Home2 Suites by Hilton Florence, SC

Florence

10/10 Exceptional

Alejandra

Quality Inn & Suites Lake City

Lake City

10/10 Exceptional

Brandi

Frequently Asked Questions

Can I book refundable accommodations in Pamplico?

If you want the flexibility to change your plans to Pamplico, most hotels provide refundable* rates you can book. You can see these properties by searching our site and using the "fully refundable" filter to narrow the results down.

What will the weather in Pamplico be like during my vacation?

July and August are typically the warmest months in Pamplico when the average temp is 78°F. January and February are the coldest months when the average temperature is 50°F. August and July are the months with the most rain.

Why should I book my Pamplico hotel through Hotels.com?

There are lots of reasons to book your Pamplico trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.