Hotels in Pamplico

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Where to stay in Pamplico?

An outdoor patio area with tables and chairs, a brick wall, and a glass door leading to the interior.

A spacious dining area with multiple tables and chairs, wooden flooring, and a modern chandelier.

A spacious bar area with a wooden floor, multiple bar stools, and a variety of bottles on shelves.

A spacious living room with hardwood flooring, a staircase, and a large window.

1. The Inn at the Crossroads

Lake City

$126

$142 total

includes taxes & fees

Nov 15 - Nov 16

A spacious lobby with a chandelier, seating area, and a reception desk.

A hotel entrance with a covered walkway, palm trees, and a clear sky.

A hotel room with a bed, a sofa, a desk, and a chair.

A conference room with a dark table and chairs, a vase with white flowers, and large windows with white trim.

2. Quality Inn & Suites Lake City

Lake City

$98

$110 total

includes taxes & fees

Nov 15 - Nov 16

A rooftop terrace with outdoor seating, including sofas and chairs, and a round table.

A modern bar area with a long counter, multiple bar stools, and a variety of bottles and glasses.

A modern lounge area with brick walls, large windows, and contemporary furniture.

A multi-story hotel with a modern facade, featuring a prominent 'Hyatt Place' sign on the right.

3. Hyatt Place Florence Downtown

Florence

$100

$112 total

includes taxes & fees

Nov 3 - Nov 4

A modern living room with a grey sofa, two black hanging chairs, a small table, and a TV mounted on the wall.

A modern living room with a grey sofa, a flat-screen TV, geometric wall art, and a bookshelf with decorative items.

A modern hotel with a 'Park Inn by Radisson' sign, featuring a covered entrance, multiple windows, and a parking lot.

A hotel room with a large bed, a desk with a lamp, a chair, a TV, and a window with curtains.

4. Park Inn by Radisson Florence, SC

Florence

$89

$100 total

includes taxes & fees

Oct 25 - Oct 26

A spacious lobby with a large seating area, a decorative ceiling light, and a view of the outdoors.

A brick building with a stone pillar, large potted plants, and a wreath on the door.

A hotel reception area with a counter, a 'Days Inn Lake City' award plaque, and a 'Jazmin' sign.

A hotel room with two beds, a desk, a chair, and a sofa.

5. Days Inn by Wyndham Lake City

Lake City

$98

$109 total

includes taxes & fees

Oct 19 - Oct 20

A spacious lobby with a checkered floor, a reception desk, and a chandelier.

A hotel room with two beds, a desk with a computer, a chair, and a bathroom with a mirror.

A two-story building with a brick facade, a flat roof, and a covered entrance area.

A spacious dining area with multiple tables and chairs, large windows offering a view of the parking lot, and a television mounted on the wall.

6. Howard Johnson by Wyndham Florence

Florence

$65

$72 total

includes taxes & fees

Oct 18 - Oct 19

A hotel lobby with a reception desk, seating area, and a television screen.

A Comfort Inn & Suites hotel with a covered entrance, brick facade, and multiple windows.

A hotel room with a sectional sofa, two ottomans, a bed with a green bedspread, and framed pictures on the wall.

A hotel room with a bed, a sofa, an ottoman, and a lamp.

7. Comfort Inn & Suites Florence Center Area

Florence

$101

$113 total

includes taxes & fees

Nov 5 - Nov 6

A modern hotel with a covered entrance, large windows, and a sign indicating it is a hotel.

A modern kitchen with a white countertop, three black stools, and a red accent wall.

A bar area with a neon sign, shelves of bottles, and a view of trees through large windows.

8. Aloft by Marriott Florence

Florence

$111

$130 total

includes taxes & fees

Oct 20 - Oct 21

A modern lobby with a stone column, a fireplace, and yellow rocking chairs around a central table.

A modern cafeteria with long wooden tables, green chairs, and yellow accents.

A hotel room with two beds, a desk with a chair, a television, and a window with curtains.

A hotel with a modern design, featuring a prominent sign for the 'Country Inn & Suites by Radisson.'

9. Spark by Hilton Florence North I-95, SC

Florence

$84

$98 total

includes taxes & fees

Oct 25 - Oct 26

A hotel with a covered entrance, a beige facade, and pink flowering trees.

A hotel room with a bed, a desk, a chair, a television, and a mirror.

A breakfast buffet with multiple serving dishes and a coffee station by a window with a view of trees.

A hotel lobby with a reception desk, a wall-mounted TV, a decorative wall piece, and a seating area with tables and chairs.

10. Quality Inn Mullins - Marion

Marion

$80

$87 total

includes taxes & fees

Nov 13 - Nov 14

A restaurant with brick walls, framed awards, and a bar area.

A spacious living room with a wooden floor, a ceiling fan, and a dining area with a wooden table and chairs.

A spacious kitchen with a dining area, a living room with a fireplace, and a cozy seating arrangement.

An outdoor patio area with a brick wall, a covered seating area with string lights, and potted plants.

11. Hotel Florence, Tapestry Collection by Hilton

Florence

$139

$155 total

includes taxes & fees

Oct 25 - Oct 26

A spacious lobby with a high ceiling, a central seating area, and a staircase leading to an upper level.

A La Quinta Inn & Suites hotel with a modern facade, a well-lit entrance, and a landscaped garden area.

A modern breakfast area with a buffet setup, including a microwave, coffee maker, and various food items.

A hotel room with a bed, a sofa, a desk, and a TV.

12. La Quinta Inn & Suites by Wyndham Florence

Florence

$86

$96 total

includes taxes & fees

Oct 18 - Oct 19

A hotel room with a bed, bedside table with a phone, a desk with a chair, a TV mounted on the wall, and a window with curtains.

A multi-story hotel with a prominent entrance marked '1912'.

A conference room with a wooden table, chairs, a TV, and a computer on a shelf.

A reception area with a wooden counter, a seating area with tables and chairs, and a large window with a view.

13. Microtel Inn & Suites by Wyndham Florence

Florence

$62

$69 total

includes taxes & fees

Nov 15 - Nov 16

14. Rodeway Inn Florence Downtown

Florence

$43

$49 total

includes taxes & fees

Nov 15 - Nov 16

A Holiday Inn Express & Suites building with a modern design, featuring a prominent entrance with a covered walkway and stone pillars.

A modern lobby with a reception desk, a sofa, and a patterned carpet.

A modern hotel lobby with a coffee bar, seating areas, and a reception desk.

A hotel room with two beds, a desk, a chair, a TV, and a framed picture on the wall.

15. Holiday Inn Express & Suites Latta by IHG

Latta

$95

$104 total

includes taxes & fees

Nov 15 - Nov 16

A hotel lobby with a wooden floor, multiple dining tables, chairs, and a seating area with a sofa.

A lobby with a fireplace, seating area, and a television.

A hotel room with two beds, a desk, a TV, and a window with patterned curtains.

A Hampton Inn & Suites with a large sign, brick facade, and a parking lot.

16. Hampton Inn & Suites Florence Center

Florence

$114

$128 total

includes taxes & fees

Oct 25 - Oct 26

A neatly made bed with a wooden frame, a ceiling fan, and a window with blinds.

A room with a window, air conditioning unit, and a curtain.

A stack of white towels with a bottle of lotion and a yellow bottle on top.

A black table with three potted plants and a small decorative elephant figurine.

17. Bella's Boutique Hotel

Hemingway

$117

$130 total

includes taxes & fees

Oct 17 - Oct 18

A swimming pool with lounge chairs and a building with a sign reading "BAYMONT".

A bathroom with a sink, mirror, towel rack, and a towel hanging on the wall.

A motel with a covered parking area, a gas station sign, and a row of rooms with balconies.

A modern living room with a sectional sofa, a coffee table, and a flat-screen TV mounted on the wall.

18. Super 8 by Wyndham Florence

Florence

$54

$60 total

includes taxes & fees

Oct 19 - Oct 20

A hotel entrance with a stone facade, glass doors, and a number '501' above.

A hotel reception area with a wooden floor, a reception desk, a seating area with chairs, and a decorative wall with a tree pattern.

A modern living room with a stone fireplace, a blue sofa, a brown leather chair, and a round coffee table.

A corner market with shelves stocked with snacks and beverages, and two large refrigerators.

19. Fairfield Inn & Suites by Marriott Florence I-20

Florence

$118

$132 total

includes taxes & fees

Oct 25 - Oct 26

A hotel room with a desk, chair, bed, and a yellow sofa.

A hotel dining area with wooden tables and chairs, a fireplace, and a television.

A swimming pool with lounge chairs and a building with balconies.

A hotel with a green roof, a sign reading 'Quality Inn & Suites by Choice Hotels,' and a landscaped front yard with small trees and shrubs.

20. Quality Inn & Suites Florence Civic Center

Florence

$89

$100 total

includes taxes & fees

Oct 25 - Oct 26

View all properties

Go beyond your typical stay in Pamplico

Check out reviews of Pamplico hotels guests love

Hyatt Place Florence Downtown

Florence

10/10 Exceptional

Arthur

Park Inn by Radisson Florence, SC

Florence

10/10 Exceptional

Nichole

Comfort Inn & Suites Florence Center Area

Florence

10/10 Exceptional

Roland

Holiday Inn Express & Suites Latta by IHG

Latta

10/10 Exceptional

Kathryn

A building with two red doors, one labeled 'Office' and the other '101'. There is a welcome sign and a mailbox on the wall.

A compact living space with a dining area, kitchenette, and seating area.

A compact kitchen with a dining area, a TV, and a small table.

A room with a sofa, a small table, a chair, a lamp, and a door.

Affordable Suites Florence

Florence

10/10 Exceptional

MY CL

Fairfield Inn & Suites by Marriott Florence I-20

Florence

10/10 Exceptional

Anonymous traveler

Hampton Inn & Suites Florence Center

Florence

10/10 Exceptional

Shawn

Howard Johnson by Wyndham Florence

Florence

10/10 Exceptional

Mike

A hotel room with two beds, a desk with chairs, a television, and artwork on the walls.

A modern hotel room with a kitchenette, a grey sofa, a dining area, and a sign that reads "A Great Day Starts With Breakfast."

A reception area with a wooden desk, a map on the wall, and a sign welcoming visitors to Florence, SC.

A modern lounge area with a sofa, armchairs, and small tables.

TownePlace Suites by Marriott Florence

Florence

10/10 Exceptional

Celia

Quality Inn & Suites Florence Civic Center

Florence

10/10 Exceptional

Great option for an easy overnight stay We had a very pleasant stay and found this hotel to be a convenient, comfortable stop for an overnight trip. The staff was very friendly, and check-in was quick and easy. Our room was clean, smelled fresh, and felt well cared for. We also appreciated being able to park directly in front of our room, and the well-lit parking lot added to the sense of convenience and security. The location is excellent, with easy access from I-95 and several restaurants and...

Berry

A modern kitchen with dark wooden cabinets, a stainless steel refrigerator, a microwave, and a coffee maker. There is a dining area with two red chairs and a table.

A hotel room with a bed, a desk, a TV, a refrigerator, and a painting on the wall.

A hotel room with a sofa, a dining table, a coffee maker, a TV, and artwork on the wall.

A conference room with round tables, chairs, and a carpeted floor.

Staybridge Suites Florence - Civic Center by IHG

Florence

10/10 Exceptional

William

A spacious hotel lobby with multiple seating areas, including tables and chairs, a reception desk, and a staircase leading to an upper level.

A corridor with shelves stocked with snacks and a frozen food display.

A Hampton Inn & Suites hotel with a well-lit entrance, multiple floors, and a parking area.

An indoor swimming pool with clear water, surrounded by a checkered wall pattern, and equipped with multiple seating areas and a lifeguard station.

Hampton Inn & Suites Florence-North-I-95

Florence

10/10 Exceptional

I chose Hampton Inn in Florence because, overall, in the past I have had excellent experiences with this chain. I was very pleasantly treated to a very beautifully appointed hotel setting, it was also very clean. I saw staff picking up small items or pieces of paper that had been left or dropped by a visitor. My room itself was very clean and the bed was very comfortable and the room had it's own thermostat so the temperature and whether you wished heat or air could be selected for...

Anonymous traveler

Quality Inn & Suites Lake City

Lake City

10/10 Exceptional

Brandi

Spark by Hilton Florence North I-95, SC

Florence

10/10 Exceptional

Lavonia

A hotel room with a large bed, a desk with a chair, a television, and a walk-in closet.

A reception area with a modern design, featuring a reception desk, a digital display, and a sign for Holiday Inn Express & Suites.

A coffee station with two coffee machines and a display of coffee pods and cups.

A snack and beverage display area with shelves stocked with various brands and a refrigerator with beverages.

Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG

Florence

10/10 Exceptional

Tammie

A spacious lobby with a high ceiling, a central seating area with armchairs and a coffee table, a flat-screen TV, and a dining area with tables and chairs.

A spacious lobby with a large seating area, a flat-screen TV, and a fireplace.

A modern hotel lobby with a central seating area, a large abstract painting, and a patterned carpet.

A hotel with a modern design, featuring multiple floors and a parking lot.

Residence Inn Marriott Florence

Florence

10/10 Exceptional

Staff were friendly and nice! Very accommodating to both my dogs. Room was clean and nice. Some wallpaper was bubbling but it honestly didn’t bother me. Loved the secure easy access to the building. Hotel was right next to a beautiful memorial park and very easy to get to the civic center. Pool was beautiful even though I didn’t get to use it due to weather. Looked like the pool was handicap accessible with a lift. Breakfast was amazing every morning with lots to choose from. We definitely will...

Anna

Frequently Asked Questions

Can I book refundable accommodations in Pamplico?

If you want the flexibility to change your plans to Pamplico, most hotels provide refundable* rates you can book. You can see these properties by searching our site and using the "fully refundable" filter to narrow the results down.

What will the weather in Pamplico be like during my vacation?

July and August are typically the warmest months in Pamplico when the average temp is 78°F. January and February are the coldest months when the average temperature is 50°F. August and July are the months with the most rain.

Why should I book my Pamplico hotel through Hotels.com?

There are lots of reasons to book your Pamplico trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.