Hotels in Pamplico

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Where to stay in Pamplico?

An outdoor patio area with tables and chairs, a brick wall, and a glass door leading to the interior.

A spacious bar area with a wooden floor, multiple bar stools, and a variety of bottles on shelves.

A spacious dining area with multiple tables and chairs, wooden flooring, and a modern chandelier.

A spacious living room with hardwood flooring, a staircase, and a large window.

1. The Inn at the Crossroads

Lake City

$112

$126 total

includes taxes & fees

Oct 29 - Oct 30

A spacious lobby with a chandelier, seating area, and a reception desk.

A hotel entrance with a covered walkway, palm trees, and a clear sky.

A hotel room with a bed, a sofa, a desk, and a chair.

A conference room with a dark table and chairs, a vase with white flowers, and large windows with white trim.

2. Quality Inn & Suites Lake City

Lake City

$102

$114 total

includes taxes & fees

Oct 26 - Oct 27

A rooftop terrace with outdoor seating, including sofas and chairs, and a round table.

A modern bar area with a long counter, bar stools, and a variety of bottles and glasses.

A multi-story hotel with a modern facade, featuring a prominent 'Hyatt Place' sign on the right.

A modern lounge area with brick walls, large windows, and contemporary furniture.

3. Hyatt Place Florence Downtown

Florence

$110

$123 total

includes taxes & fees

Oct 5 - Oct 6

A hotel lobby with a reception desk, seating area, and a television screen.

A spacious dining area with multiple tables and chairs, large windows, and a flat-screen TV mounted on the wall.

A hotel room with a bed, a sofa, an ottoman, and a lamp.

A Comfort Inn & Suites hotel with a covered entrance, brick facade, and multiple windows.

4. Comfort Inn & Suites Florence Center Area

Florence

$101

$113 total

includes taxes & fees

Oct 19 - Oct 20

A spacious lobby with a checkered floor, a reception desk, and a chandelier.

A hotel room with two beds, a desk with a computer, a chair, and a bathroom with a mirror.

A spacious dining area with multiple tables and chairs, large windows offering a view of the parking lot, and a television mounted on the wall.

A two-story building with a brick facade, a flat roof, and a covered entrance area.

5. Howard Johnson by Wyndham Florence

Florence

$65

$72 total

includes taxes & fees

Sep 30 - Oct 1

A hotel room with two beds, a desk with a TV, and a bathroom visible through an open door.

A coffee station with two coffee machines, a coffee press, and various coffee-related items on a wooden counter.

A hotel reception area with a modern design, including a reception desk, seating area, and a dining section.

A large, two-story building with a central entrance flanked by columns, labeled "DIR FRANK B. LEE NURSING BUILDING."

6. Holiday Inn Express & Suites Florence I-95 @ Hwy 327 by IHG

Florence

$114

$138 total

includes taxes & fees

Oct 4 - Oct 5

A restaurant with brick walls, framed awards, and a bar area.

An outdoor patio area with a brick wall, a covered seating area with string lights, and potted plants.

A spacious living room with a wooden floor, a ceiling fan, and a dining area with a wooden table and chairs.

A bar area with a curved counter, multiple stools, and a brick wall backdrop.

7. Hotel Florence, Tapestry Collection by Hilton

Florence

$127

$142 total

includes taxes & fees

Oct 22 - Oct 23

A spacious lobby with a large seating area, a decorative ceiling light, and a view of the outdoors.

A brick building with a stone pillar, large potted plants, and a wreath on the door.

A living room with a sofa, chairs, a coffee table, a cabinet, and decorative items.

A hotel room with two beds, a desk, a chair, and a sofa.

8. Days Inn by Wyndham Lake City

Lake City

$98

$109 total

includes taxes & fees

Oct 22 - Oct 23

A hotel entrance with a stone facade, glass doors, and a number '501' above.

A modern living room with a stone fireplace, a blue sofa, a brown leather chair, and a round coffee table.

A hotel reception area with a wooden floor, a reception desk, a seating area with chairs, and a decorative wall with a tree pattern.

A corner market with shelves stocked with snacks and beverages, and two large refrigerators.

9. Fairfield Inn & Suites by Marriott Florence I-20

Florence

$127

$142 total

includes taxes & fees

Oct 2 - Oct 3

A hotel with a modern design, multiple floors, and a parking lot.

A swimming pool with lounge chairs and a building with balconies in the background.

A restaurant with a bar area, seating, and a kitchen visible in the background.

A hotel room with a checkered sofa, a bed, a desk, and a framed picture on the wall.

10. Best Western Inn

Florence

$89

$100 total

includes taxes & fees

Sep 30 - Oct 1

A hotel with a covered entrance, a beige facade, and pink flowering trees.

A living room with a sofa, a coffee table, a chair, and two framed floral paintings on the wall.

A breakfast buffet with multiple serving dishes and a coffee station by a window with a view of trees.

A hotel room with a bed, a desk, a chair, a television, and a mirror.

11. Quality Inn Mullins - Marion

Marion

$81

$89 total

includes taxes & fees

Oct 25 - Oct 26

A modern lobby with a stone column, a fireplace, and yellow rocking chairs around a central table.

A modern cafeteria with long wooden tables, green chairs, and yellow accents.

A hotel room with two beds, a desk with a chair, a television, and a window with curtains.

An outdoor patio with a wooden table and wicker chairs, a barbecue grill, and a swimming pool in the background.

12. Spark by Hilton Florence North I-95, SC

Florence

$81

$95 total

includes taxes & fees

Oct 5 - Oct 6

A spacious room with a large window, a kitchenette, and two chairs.

A covered walkway with steps leading to a building.

A reception area with a reception desk, a large window, and a door.

A modern office entrance with a glass door, a 'PULL' sign, a reception desk, and a view of the parking area.

13. Florence Inn and Suites

Florence

$48

$53 total

includes taxes & fees

Oct 1 - Oct 2

A modern lobby with seating areas, a reception desk, and a large wall with a decorative panel.

An outdoor patio area with tables and chairs, a barbecue grill, and a large window overlooking a fenced area.

A modern coffee station with a counter, coffee machines, and a seating area with chairs.

A hotel room with a bed, a blue sofa, a brown ottoman, a black office chair, a desk, a lamp, and three framed pictures on the wall.

14. Comfort Suites Florence I-95

Florence

$91

$106 total

includes taxes & fees

Oct 25 - Oct 26

A spacious lobby with a high ceiling, a central seating area, and a staircase leading to an upper level.

A modern breakfast area with a buffet setup, including a microwave, coffee maker, and various food items.

A hotel room with a bed, a sofa, a desk, and a TV.

A hotel room with a bed, sofa, TV, and a desk.

15. La Quinta Inn & Suites by Wyndham Florence

Florence

$89

$100 total

includes taxes & fees

Oct 5 - Oct 6

A hotel room with a large bed, a desk with a chair, a television, and a walk-in closet.

A modern office space with a long table, two chairs, a desk with a computer, and a wall-mounted colorful artwork.

A coffee station with two coffee machines and a display of coffee pods and cups.

A Holiday Inn Express & Suites hotel with a covered entrance, palm trees, and a clear sky.

16. Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG

Florence

$114

$128 total

includes taxes & fees

Oct 11 - Oct 12

A modern living room with a grey sofa, two black hanging chairs, a small table, and a TV mounted on the wall.

A modern living room with a grey sofa, a flat-screen TV, geometric wall art, and a bookshelf with decorative items.

A modern kitchen with a patterned backsplash, wooden cabinets, and stainless steel appliances.

A modern hotel with a 'Park Inn by Radisson' sign, featuring a covered entrance, multiple windows, and a parking lot.

17. Park Inn by Radisson Florence, SC

Florence

$89

$100 total

includes taxes & fees

Oct 4 - Oct 5

A hotel room with two beds, a wooden headboard, a nightstand, and three sunset paintings on the wall.

A modern kitchen with a central island, a dining area with chairs, a large window with a view of palm trees, and a flat-screen TV mounted on the wall.

A lobby with a reception desk, seating area, and artwork on the walls.

A modern hotel room with a large bed, two armchairs, a desk with a computer, and a decorative wall.

18. Days Inn by Wyndham Florence Near Civic Center

Florence

$69

$77 total

includes taxes & fees

Sep 30 - Oct 1

A swimming pool with lounge chairs and a building with a sign reading "BAYMONT".

A motel with a covered parking area, a gas station sign, and a row of rooms with balconies.

A hotel room with a large bed, a desk, a chair, a TV, and a painting of a waterfall on the wall.

A bathroom with a sink, mirror, towel rack, and a towel hanging on the wall.

19. Super 8 by Wyndham Florence

Florence

$52

$58 total

includes taxes & fees

Sep 30 - Oct 1

A hotel room with two beds, a desk with chairs, a television, and artwork on the walls.

A modern kitchen with a coffee station, a dining area with a table and chairs, and a living area with a sofa and a coffee table.

A self-service beverage station with refrigerated and non-refrigerated drink options, snack shelves, and a sign indicating the location.

A modern lounge area with a sofa, armchairs, and small tables.

20. TownePlace Suites by Marriott Florence

Florence

$118

$132 total

includes taxes & fees

Sep 30 - Oct 1

View all properties

Go beyond your typical stay in Pamplico

Check out reviews of Pamplico hotels guests love

Hyatt Place Florence Downtown

Florence

10/10 Exceptional

Arthur

Comfort Inn & Suites Florence Center Area

Florence

10/10 Exceptional

Roland

Fairfield Inn & Suites by Marriott Florence I-20

Florence

10/10 Exceptional

Anonymous traveler

Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG

Florence

10/10 Exceptional

Tammie

Howard Johnson by Wyndham Florence

Florence

10/10 Exceptional

Mike

TownePlace Suites by Marriott Florence

Florence

10/10 Exceptional

Celia

A modern kitchen with dark wooden cabinets, a stainless steel refrigerator, a microwave, and a coffee maker. There is a dining area with two red chairs and a table.

A conference room with round tables, chairs, and a carpeted floor.

An outdoor kitchen area with a grill, a pool, and a covered seating area.

A hotel room with a bed, a desk, a TV, a refrigerator, and a painting on the wall.

Staybridge Suites Florence - Civic Center by IHG

Florence

10/10 Exceptional

William

Park Inn by Radisson Florence, SC

Florence

10/10 Exceptional

Nichole

A Holiday Inn Express & Suites building with a modern design, featuring a prominent entrance with a covered walkway and stone pillars.

A hotel room with two beds, a desk, a chair, a TV, and a framed picture on the wall.

A modern lobby with a reception desk, a sofa, and a patterned carpet.

A modern hotel lobby with a coffee bar, seating areas, and a reception desk.

Holiday Inn Express & Suites Latta by IHG

Latta

10/10 Exceptional

Kathryn

A hotel lobby with a wooden floor, multiple dining tables, chairs, and a seating area with a sofa.

A hotel room with two beds, a desk, a TV, and a window with patterned curtains.

A hotel lobby with a reception desk, seating area, and a welcome mat.

A lobby with a fireplace, seating area, and a television.

Hampton Inn & Suites Florence Center

Florence

10/10 Exceptional

Shawn

A spacious hotel lobby with multiple seating areas, including tables and chairs, a reception desk, and a staircase leading to an upper level.

An indoor swimming pool with clear water, surrounded by a checkered wall pattern, and equipped with multiple seating areas and a lifeguard station.

A Hampton Inn & Suites hotel with a well-lit entrance, multiple floors, and a parking area.

A lobby with leather sofas, a coffee table, potted plants, and a reception desk.

Hampton Inn & Suites Florence-North-I-95

Florence

10/10 Exceptional

I chose Hampton Inn in Florence because, overall, in the past I have had excellent experiences with this chain. I was very pleasantly treated to a very beautifully appointed hotel setting, it was also very clean. I saw staff picking up small items or pieces of paper that had been left or dropped by a visitor. My room itself was very clean and the bed was very comfortable and the room had it's own thermostat so the temperature and whether you wished heat or air could be selected for...

Anonymous traveler

A building with two red doors, one labeled 'Office' and the other '101'. There is a welcome sign and a mailbox on the wall.

A compact living space with a dining area, kitchenette, and seating area.

A room with a sofa, a small table, a chair, a lamp, and a door.

A compact kitchen with a dining area, a TV, and a small table.

Affordable Suites Florence

Florence

10/10 Exceptional

MY CL

Quality Inn & Suites Lake City

Lake City

10/10 Exceptional

Brandi

An outdoor seating area with a fire pit, cushioned seating, and a pergola with string lights.

A modern hotel restaurant with a breakfast bar, seating area, and a view of the city.

A modern lounge area with seating, tables, and a pool table.

A modern hotel with a prominent 'TRU by Hilton' sign, a well-lit entrance, and a landscaped front yard.

Tru by Hilton Florence I-95

Florence

10/10 Exceptional

Robert

A hotel room with a desk, chair, bed, and a yellow sofa.

A swimming pool with lounge chairs and a building with balconies.

A hotel dining area with wooden tables and chairs, a fireplace, and a television.

A hotel with a green roof, a sign reading 'Quality Inn & Suites by Choice Hotels,' and a landscaped front yard with small trees and shrubs.

Quality Inn & Suites Florence Civic Center

Florence

10/10 Exceptional

Great option for an easy overnight stay We had a very pleasant stay and found this hotel to be a convenient, comfortable stop for an overnight trip. The staff was very friendly, and check-in was quick and easy. Our room was clean, smelled fresh, and felt well cared for. We also appreciated being able to park directly in front of our room, and the well-lit parking lot added to the sense of convenience and security. The location is excellent, with easy access from I-95 and several restaurants and...

Berry

Spark by Hilton Florence North I-95, SC

Florence

10/10 Exceptional

Revenel

A spacious lobby with a high ceiling, a central seating area with armchairs and a coffee table, a flat-screen TV, and a dining area with tables and chairs.

A modern hotel lobby with a fireplace, seating area, and a reception desk.

A modern hotel lobby with a central seating area, a large abstract painting, and a patterned carpet.

A hotel with a modern design, featuring multiple floors and a parking lot.

Residence Inn Marriott Florence

Florence

10/10 Exceptional

Staff were friendly and nice! Very accommodating to both my dogs. Room was clean and nice. Some wallpaper was bubbling but it honestly didn’t bother me. Loved the secure easy access to the building. Hotel was right next to a beautiful memorial park and very easy to get to the civic center. Pool was beautiful even though I didn’t get to use it due to weather. Looked like the pool was handicap accessible with a lift. Breakfast was amazing every morning with lots to choose from. We definitely will...

Anna

Frequently Asked Questions

Can I book refundable accommodations in Pamplico?

If you want the flexibility to change your plans to Pamplico, most hotels provide refundable* rates you can book. You can see these properties by searching our site and using the "fully refundable" filter to narrow the results down.

What will the weather in Pamplico be like during my vacation?

July and August are typically the warmest months in Pamplico when the average temp is 78°F. January and February are the coldest months when the average temperature is 50°F. August and July are the months with the most rain.

Why should I book my Pamplico hotel through Hotels.com?

There are lots of reasons to book your Pamplico trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.