Hotels in East Prairie

Free cancellation options if plans change

Earn rewards on every night you stay

Save more with Member Prices

Check prices for these dates

Tonight
Nov 15 - Nov 16
Tomorrow
Nov 16 - Nov 17
Next weekend
Nov 20 - Nov 22
In two weeks
Nov 27 - Nov 29

Where to stay in East Prairie?

A hotel lobby with a central bar area, multiple dining tables and chairs, large windows, and a patterned carpet.

1. Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very good, (1,002 reviews)
Experience comfort at this Sikeston hotel, offering free breakfast and parking close to Central Park. The helpful staff welcomes guests to enjoy the indoor pool and fitness center. With easy access to Sikeston Depot Museum, you'll find everything needed for a convenient Missouri stay.
The price is $70
$80 total
includes taxes & fees
Dec 14 - Dec 15
Best Western Plus Sikeston I-55
A hotel room with a bed, a desk with a chair, a TV, two bedside lamps, and a large window.

2. Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area
2.0 star property
Sikeston
7.0 out of 10, Good, (696 reviews)
Cozy lodging near Central Park and Sikeston Depot Museum with complimentary breakfast, WiFi, and parking. Just 29 minutes from Cape Girardeau Municipal Airport, this Super 8 offers comfortable accommodations for exploring the area.
The price is $58
$66 total
includes taxes & fees
Nov 22 - Nov 23
Super 8 by Wyndham Sikeston/Miner Area
An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.

3. Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.6 out of 10, Exceptional, (1,004 reviews)
Escape to this serene Sikeston hotel with both indoor and outdoor pools near restaurants and shopping. The fitness center, free breakfast, WiFi and parking enhance your stay, while the helpful staff ensures comfort just minutes from Central Park.
The price is $94
$108 total
includes taxes & fees
Nov 22 - Nov 23
Drury Inn & Suites Sikeston, MO
A modern hotel room with a large bed, a smaller bed, a desk, and a chair. There is a window with curtains and a painting on the wall.

4. Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston
2.0 star property
Sikeston
7.4 out of 10, Good, (1,001 reviews)
Travelers rave about this serene retreat with helpful staff and clean rooms. Take advantage of free WiFi, parking, and on-the-go breakfast. Work out in the fitness center before exploring Central Park and Sikeston Depot Museum nearby.
The price is $66
$76 total
includes taxes & fees
Nov 17 - Nov 18
Days Inn and Suites by Wyndham Sikeston
A hotel room with a large bed, a desk with a computer, a chair, a window with a view, and a wall-mounted TV.

5. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very good, (831 reviews)
This peaceful hotel offers a complimentary continental breakfast, free WiFi, and convenient parking. Located near I-55 Exit 67, guests consistently praise the helpful staff and clean rooms that provide a quiet retreat after exploring local attractions.
The price is $69
$79 total
includes taxes & fees
Nov 16 - Nov 17
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
A hotel room with two beds, a desk, a chair, a TV, and a mirror.

6. Country Yard Inn and Suite

Country Yard Inn and Suite
2.0 star property
Sikeston
6.8 out of 10, Good, (164 reviews)
This welcoming motel offers convenience with complimentary WiFi and parking, plus round-the-clock front desk assistance. Explore nearby Central Park and Sikeston Depot Museum before returning to your comfortable accommodations.
The price is $58
$70 total
includes taxes & fees
Nov 16 - Nov 17
Country Yard Inn and Suite
An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.

7. Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (118 reviews)
Located in Sikeston, this hotel offers free breakfast, WiFi, and parking. Take a refreshing swim in the indoor pool or grab a bite at the restaurant. Nearby attractions include Central Park and Sikeston Depot Museum for local exploration.
The price is $110
$125 total
includes taxes & fees
Nov 21 - Nov 22
Fairfield Inn & Suites by Marriott Sikeston
A building with a fountain and flower beds in front.

8. The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
2.5 star property
Charleston
6.8 out of 10, Good, (444 reviews)
The price is $66
$74 total
includes taxes & fees
Nov 17 - Nov 18
The Riverstone Hotel Charleston-Sikeston
A Hampton Inn with a stone facade, outdoor seating area, and a fire pit.

9. Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (661 reviews)
Dive into vacation mode at this welcoming hotel with an indoor pool and fitness center near Central Park. After enjoying the complimentary breakfast, explore Sikeston Depot Museum before returning to relax in modern rooms with free WiFi.
The price is $100
$114 total
includes taxes & fees
Nov 22 - Nov 23
Hampton Inn Sikeston
A buffet with various food items, including omelets and baked goods, served in metal containers.

10. Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.8 out of 10, Excellent, (528 reviews)
Experience Sikeston from this hotel with free breakfast, WiFi, and parking. Take a morning dip in the indoor pool or hit the fitness center. Near Central Park and Sikeston Depot Museum, guests love the helpful staff and clean rooms.
The price is $95
$108 total
includes taxes & fees
Dec 13 - Dec 14
Holiday Inn Express & Suites Sikeston Southwest by IHG
A hotel room with a large bed, a desk, a television, and a bathroom visible through an open door.

11. Eagle Inn Charleston

Eagle Inn Charleston
2.0 star property
Charleston
6.6 out of 10, Good, (107 reviews)
Active travelers will appreciate the health club at this comfortable Charleston motel. Free WiFi keeps you connected, while complimentary parking saves you money. Located within driving distance of Cape Girardeau Municipal Airport for easy regional access.
The price is $66
$74 total
includes taxes & fees
Nov 16 - Nov 17
Eagle Inn Charleston
A hotel room with a large bed, two bedside lamps, a framed picture of a bridge, and a wooden nightstand with a phone.

12. Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.8 out of 10, Good, (686 reviews)
This Charleston motel offers complimentary WiFi, parking, and on-the-go breakfast daily. Located with convenient interstate access to Cape Girardeau, guests consistently praise the helpful staff. The comfortable accommodations provide a practical base for exploring southeastern Missouri.
The price is $59
$66 total
includes taxes & fees
Dec 1 - Dec 2
Super 8 by Wyndham Charleston/Sikeston East MO
A hotel room with a bed, a desk with a TV, a chair, a bathroom with a bathtub, and a window with curtains.

13. Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very good, (322 reviews)
Warm comfort awaits at this Sikeston hotel where the indoor pool invites morning swims. Just minutes from Central Park and Sikeston Depot Museum, enjoy free WiFi, parking, and a fitness center while helpful staff enhance your stay.
The price is $84
$96 total
includes taxes & fees
Nov 22 - Nov 23
Comfort Inn & Suites Sikeston I-55
Property amenity

14. TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston
3.0 star property
Sikeston
9.2 out of 10, Wonderful, (33 reviews)
The price is $109
$124 total
includes taxes & fees
Nov 22 - Nov 23
TownePlace Suites by Marriott Sikeston
A modern hotel room with a large bed, bedside tables, a nightstand, a wall-mounted lamp, a window with a view of a road, and a wall-mounted air conditioner.

15. Super 8 By Wyndham Marston

Super 8 By Wyndham Marston
2.0 star property
Marston
8.0 out of 10, Very good, (82 reviews)
Discover comfort at this Marston hotel, just off Interstate 55. Wake up to a complimentary full breakfast before exploring nearby attractions. Free WiFi and parking add value to your stay in this convenient Missouri location.
The price is $58
$66 total
includes taxes & fees
Nov 17 - Nov 18
Super 8 By Wyndham Marston
A reception area with a reception desk, two blue armchairs, a round table, and a glass door leading outside.

16. Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America
2.5 star property
Union City
9.2 out of 10, Wonderful, (456 reviews)
Slip into this inviting Union City hotel just minutes from Discovery Park of America's interactive exhibits. After exploring nearby attractions, unwind in the refreshing indoor pool or maintain your routine in the 24-hour fitness center. Free breakfast, WiFi and parking enhance your value-packed stay.
The price is $71
$84 total
includes taxes & fees
Dec 6 - Dec 7
Sleep Inn at Discovery Park of America
A hotel lobby with a reception desk, seating area, and a large window.

17. Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.4 out of 10, Good, (298 reviews)
Set off I-57 in Cairo, this welcoming hotel provides complimentary full breakfast and self parking. Explore nearby Fort Defiance State Park or take a short drive to Ballard Wildlife Management Area while enjoying free WiFi throughout your stay.
The price is $70
$78 total
includes taxes & fees
Dec 4 - Dec 5
Quality Inn Cairo I-57
A living room with a sofa, chairs, a glass coffee table, and a TV.

18. Hospitality House Union City I 69 / US 51

Hospitality House Union City I 69 / US 51
2.5 star property
Union City
6.8 out of 10, Good, (414 reviews)
Discover this Union City hotel offering a seasonal outdoor pool and onsite restaurant. Free breakfast, WiFi, and parking add convenience. Visitors appreciate the helpful staff and proximity to County Market Place and Reelfoot Shopping Center.
The price is $48
$57 total
includes taxes & fees
Nov 16 - Nov 17
Hospitality House Union City I 69 / US 51
A modern kitchen with a refrigerator, microwave, and dishwasher. There is a dining area with a table and chairs, and a living room with a sofa and a TV.

19. MainStay Suites at Discovery Park of America

MainStay Suites at Discovery Park of America
2.5 star property
Union City
8.8 out of 10, Excellent, (47 reviews)
Explore Union City from this welcoming hotel with 24-hour fitness amenities and convenient hiking trails in the area. Near Kiwanis Park and Masquerade Theatre, you'll enjoy free breakfast, WiFi, and parking while rooms offer refrigerators and microwaves.
The price is $99
$118 total
includes taxes & fees
Nov 28 - Nov 29
MainStay Suites at Discovery Park of America
A modern hotel lobby with a reception desk, seating areas, and a large abstract art piece on the wall.

20. Holiday Inn Express & Suites Union City by IHG

Holiday Inn Express & Suites Union City by IHG
2.5 star property
Union City
9.4 out of 10, Exceptional, (358 reviews)
Relax in this Union City hotel where the 24-hour fitness center keeps you energized. Free breakfast, WiFi, and parking await near Discovery Park of America. After exploring nearby attractions, return to rooms praised by guests for comfort and service.
The price is $100
$119 total
includes taxes & fees
Nov 28 - Nov 29
Holiday Inn Express & Suites Union City by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Go beyond your typical stay in East Prairie

pet friendly image
Pet friendly
Pet friendly
Pool image
Pool
Pool

Top landmarks in East Prairie

Big Oak Tree State Park

8.0/10 (20 reviews)
Big Oak Tree State Park is 10.3 mi (16.6 km) from central East Prairie, why not stop by during your stay.
See properties

Learn more about East Prairie

East Prairie is well-known for its attractions such as Big Oak Tree State Park and Mississippi River.

See all hotels in East Prairie
A tree-lined landscape with a river and fields.

Check out reviews of East Prairie hotels guests love

An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
Sikeston

10/10 Exceptional

Food was very good both supper and breakfast. Our room rate was high compared to a couple just checking in before us WHY!! We booked room in September
United States
Judy
Reviewed January 31, 2025
Drury Inn & Suites Sikeston, MO

Frequently Asked Questions

What hotels do travelers like in East Prairie?

Guests like The Riverstone Hotel Charleston-Sikeston.

Can I book a refundable hotel in East Prairie?

If you need the flexibility to change your travel plans to East Prairie, most hotels provide refundable* rates you can book. You can find these properties by searching our site and using the "fully refundable" filter to narrow the results down.

What will the weather in East Prairie be like during my trip?

July and August are typically the warmest months in East Prairie when the average temp is 77°F. January and February are the coldest months when the average temperature is 41°F. March and April are the months with the most rain.

Why should I book my East Prairie accommodation with Hotels.com?

There are lots of reasons to book your East Prairie trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.