Hotels in Wykoff

Free cancellation options if plans change

Earn rewards on every night you stay

Save more with Member Prices

Check prices for these dates

This weekend
Nov 6 - Nov 8
Next weekend
Nov 13 - Nov 15

Where to stay in Wykoff?

A lobby with leather sofas, a reception desk, a clock, and a map of the museum.

1. Americas Best Value Inn & Suites Spring Valley

Americas Best Value Inn & Suites Spring Valley
2.0 star property
Spring Valley
8.2 out of 10, Very good, (473 reviews)
Stretch out in Spring Valley at this well-maintained motel offering free continental breakfast, WiFi, and parking. Work out in the fitness center before exploring nearby Masonic Park or Four Daughters Vineyard & Winery. Just 26 minutes from Rochester International Airport.
The price is $85
$94 total
includes taxes & fees
Nov 5 - Nov 6
Americas Best Value Inn & Suites Spring Valley
A hotel room with two beds, a desk, a chair, and a lamp.

2. Country Trails Inn & Suites

Country Trails Inn & Suites
2.0 star property
Preston
9.4 out of 10, Exceptional, (162 reviews)
Unwind at this hotel near Old Barn Resort Course, combining country charm with modern comforts. After a morning swim in the indoor pool, relax in the hot tub. Enjoy free breakfast, WiFi, and parking during your Preston getaway.
The price is $126
$140 total
includes taxes & fees
Nov 4 - Nov 5
Country Trails Inn & Suites
A Comfort Inn & Suites hotel with a modern design, featuring a prominent signage and a parking lot.

3. Comfort Inn & Suites Rochester South Mayo Clinic

Comfort Inn & Suites Rochester South Mayo Clinic
2.0 star property
Rochester
8.8 out of 10, Excellent, (1,004 reviews)
Conveniently located just 0.9 mi from the airport, with a free shuttle service during limited hours. Unwind in the indoor pool and hot tub after exploring nearby Mayo Clinic. Guests love the helpful staff, clean rooms, and free amenities including breakfast, WiFi, and parking.
The price is $79
$91 total
includes taxes & fees
Dec 3 - Dec 4
Comfort Inn & Suites Rochester South Mayo Clinic
A spacious living area with a high ceiling, wooden beams, a blue armchair, a sofa, and a glass coffee table.

4. Stone Mill Hotel & Suites

Stone Mill Hotel & Suites
3.0 star property
Lanesboro
9.6 out of 10, Exceptional, (729 reviews)
Nestled alongside a scenic golf course, this charming hotel offers complimentary breakfast, WiFi, and parking. Outdoor enthusiasts can explore nearby hiking trails, kayaking spots, and seasonal skiing, while cultural attractions and the praised staff enhance your countryside escape.
The price is $105
$113 total
includes taxes & fees
Nov 4 - Nov 5
Stone Mill Hotel & Suites
A multi-level interior with wooden beams, a staircase, and a view of the outside through large windows.

5. America's Stay Inn Stewartville

America's Stay Inn Stewartville
2.5 star property
Stewartville
8.0 out of 10, Very good, (498 reviews)
Wake up to a complimentary continental breakfast at this Stewartville hotel before heading to Mayo Clinic, just a short drive away. Clean rooms provide a comfortable retreat after visits to nearby Maple Valley Golf & Country Club.
The price is $68
$78 total
includes taxes & fees
Nov 5 - Nov 6
America's Stay Inn Stewartville
A multi-story building with a balcony, surrounded by various potted plants and flowers.

6. Green Gables Inn

Green Gables Inn
2.0 star property
Lanesboro
9.6 out of 10, Exceptional, (174 reviews)
Nestled in Lanesboro with free continental breakfast served each morning, this welcoming inn offers complimentary WiFi and parking. Discover nearby Root River and Sylvan Park during your stay, with convenient access for outdoor adventures.
The price is $144
$155 total
includes taxes & fees
Nov 6 - Nov 7
Green Gables Inn
A modern hotel lobby with a reception desk, seating area, and a kitchenette.

7. Spark by Hilton Rochester South

Spark by Hilton Rochester South
3.0 star property
Rochester
9.2 out of 10, Wonderful, (603 reviews)
Within 10 minutes of Mayo Clinic, this welcoming Rochester hotel offers free breakfast, WiFi, and parking. Swim in the indoor pool, stay fit at the on-site gym, and experience friendly service that guests consistently praise.
The price is $67
$77 total
includes taxes & fees
Nov 22 - Nov 23
Spark by Hilton Rochester South
A modern hotel lobby with a reception desk, seating area, and a dining space.

8. Holiday Inn Express Rochester South - Mayo Area by IHG

Holiday Inn Express Rochester South - Mayo Area by IHG
2.5 star property
Rochester
8.8 out of 10, Excellent, (1,008 reviews)
Relax at this Rochester hotel just minutes from Mayo Clinic. Wake up to a free hot breakfast, unwind in the indoor pool, or keep up your routine at the fitness center. Clean rooms with fridges and microwaves offer comfort after hospital visits.
The price is $95
$109 total
includes taxes & fees
Nov 13 - Nov 14
Holiday Inn Express Rochester South - Mayo Area by IHG
A La Quinta Inn & Suites hotel with a well-lit entrance, a parking area, and a clear view of the building's facade.

9. La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
3.0 star property
Rochester
7.6 out of 10, Good, (1,057 reviews)
Situated just a 10-minute drive from Mayo Clinic, this hotel offers a complimentary buffet breakfast each morning. Guests appreciate the spotless rooms, free WiFi, and parking. The fitness center and proximity to local attractions add extra value.
The price is $71
$82 total
includes taxes & fees
Nov 22 - Nov 23
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
A bedroom with a sloped ceiling, a brick wall, a bed with floral bedding, two bedside lamps, and a vase with red flowers.

10. Country Lodge inn

Country Lodge inn
2.0 star property
Harmony
9.0 out of 10, Wonderful, (72 reviews)
Discover comfort at this quaint motel in Harmony with free WiFi and parking. Explore nearby Slim's Woodshed and Museum or venture to Niagara Cave. Daily housekeeping ensures a pleasant, hassle-free countryside stay.
The price is $146
$168 total
includes taxes & fees
Nov 4 - Nov 5
Country Lodge inn
A modern interior with a bar area, seating, and a large window.

11. Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG
3.5 star property
Downtown Rochester
8.8 out of 10, Excellent, (1,002 reviews)
Steps from Rochester Public Library and Shops University Square, this hotel offers peaceful rooms and a rooftop terrace. Enjoy American cuisine at Crave restaurant, grab snacks at the deli, or unwind at the bar after using the fitness center.
The price is $93
$107 total
includes taxes & fees
Nov 26 - Nov 27
Hotel Indigo Rochester – Mayo Clinic Area by IHG
A hotel room with a large bed, a desk, a chair, a television, and a window with curtains.

12. Econo Lodge Mayo Clinic Area

Econo Lodge Mayo Clinic Area
2.0 star property
Rochester
9.0 out of 10, Wonderful, (1,002 reviews)
Wake up to a free full breakfast at this quiet hotel just 5 minutes from Mayo Clinic. Enjoy complimentary WiFi and parking, plus a 24-hour fitness center. The helpful staff and convenient location near Olmsted County Fairgrounds make this a peaceful choice.
The price is $69
$79 total
includes taxes & fees
Dec 4 - Dec 5
Econo Lodge Mayo Clinic Area
A reception area with a wooden reception desk, a "Welcome to the Bread & Butter State" sign, and a "Please Center" sign.

13. Hampton Inn Rochester-South

Hampton Inn Rochester-South
2.5 star property
Rochester
9.0 out of 10, Wonderful, (1,003 reviews)
Unwind in this tranquil retreat just 5 minutes from Mayo Clinic. After enjoying the free breakfast, take a refreshing dip in the indoor pool or relax in the hot tub. The helpful staff, free WiFi, and convenient parking enhance your stay near Apache Mall.
The price is $98
$113 total
includes taxes & fees
Nov 15 - Nov 16
Hampton Inn Rochester-South
A modern living room with a sofa, coffee table, and a TV mounted on a stone wall.

14. Quality Inn & Suites Mayo Clinic Area

Quality Inn & Suites Mayo Clinic Area
2.5 star property
Rochester
8.8 out of 10, Excellent, (971 reviews)
This hotel offers peaceful rooms just 5 minutes from Mayo Clinic, with complimentary full breakfast and parking. Nearby restaurants and shops enhance convenience, while attentive staff ensure a comfortable stay near Olmsted County Fairgrounds.
The price is $66
$78 total
includes taxes & fees
Nov 28 - Nov 29
Quality Inn & Suites Mayo Clinic Area
Room

15. AmericInn by Wyndham Rochester Near Mayo Clinic

AmericInn by Wyndham Rochester Near Mayo Clinic
3.0 star property
Rochester
8.2 out of 10, Very good, (1,593 reviews)
Steps from Mayo Clinic, this tranquil hotel offers an indoor pool and on-site dining at Crooked Pint Ale House. Rooms include microwaves and refrigerators while the quiet environment ensures restful recovery. Free breakfast and parking add convenience.
The price is $74
$85 total
includes taxes & fees
Nov 8 - Nov 9
AmericInn by Wyndham Rochester Near Mayo Clinic
An outdoor seating area with wooden pillars, colorful striped cushions, and potted plants.

16. Home2 Suites by Hilton Rochester Mayo Clinic Area

Home2 Suites by Hilton Rochester Mayo Clinic Area
3.0 star property
Rochester
9.6 out of 10, Exceptional, (1,000 reviews)
Relax at this Rochester hotel just 5 minutes from Mayo Clinic. Splash in 2 indoor pools or work out at the fitness center. The comfortable rooms include sofa beds and refrigerators, while free breakfast, WiFi, and parking add value to your stay.
The price is $110
$126 total
includes taxes & fees
Nov 29 - Nov 30
Home2 Suites by Hilton Rochester Mayo Clinic Area
A swimming pool with clear blue water, surrounded by lounge chairs and a view of residential buildings through large windows.

17. Residence Inn by Marriott Rochester Mayo Clinic Area South

Residence Inn by Marriott Rochester Mayo Clinic Area South
3.0 star property
Rochester
9.6 out of 10, Exceptional, (321 reviews)
The price is $132
$152 total
includes taxes & fees
Nov 13 - Nov 14
Residence Inn by Marriott Rochester Mayo Clinic Area South
Interior detail

18. Birch Hill Suite Rochester – Med City

Birch Hill Suite Rochester – Med City
2.5 star property
Rochester
7.4 out of 10, Good, (98 reviews)
This modern Rochester hotel offers free WiFi and parking, plus a fitness center for health-conscious guests. Located within 10 minutes of Mayo Clinic and Saint Marys Campus, it's also near Marcus Cinema and Olmsted County Fairgrounds.
The price is $64
$74 total
includes taxes & fees
Nov 4 - Nov 5
Birch Hill Suite Rochester – Med City
A modern indoor patio with a fire feature, seating, and large windows.

19. EVEN Hotel Rochester - Mayo Clinic Area by IHG

EVEN Hotel Rochester - Mayo Clinic Area by IHG
4.0 star property
Kutzky Park
9.4 out of 10, Exceptional, (1,007 reviews)
This health-minded hotel offers a refreshing indoor pool, hot tub, and 24-hour fitness center. Just a 15-minute walk to Mayo Clinic Campus, EVEN Kitchen & Bar serves breakfast and dinner. Clean rooms and helpful staff ensure a comfortable stay near Kutzky Park.
The price is $114
$145 total
includes taxes & fees
Nov 6 - Nov 7
EVEN Hotel Rochester - Mayo Clinic Area by IHG
A modern living room with a fireplace, comfortable seating, and large windows.

20. Staybridge Suites Rochester - Mayo Clinic Area by IHG

Staybridge Suites Rochester - Mayo Clinic Area by IHG
3.0 star property
Kutzky Park
9.4 out of 10, Exceptional, (560 reviews)
This extended-stay hotel offers convenient access to Mayo Clinic Hospital within a 15-minute walk. Enjoy the indoor pool and hot tub after a long day, plus free breakfast at Even Kitchen & Bar. A 24-hour fitness center and helpful staff enhance your medical or business trip.
The price is $105
$123 total
includes taxes & fees
Nov 25 - Nov 26
Staybridge Suites Rochester - Mayo Clinic Area by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top landmarks in Wykoff

Ed's Museum

If museums are on your list of things to see, then you might want to head to Ed's Museum, located in the heart of Wykoff.
See properties

Check out reviews of Wykoff hotels guests love

Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area

10/10 Excellent
"."
JoAnn 2-night trip
Posted 5 hours ago
Kahler Inn and Suites - Mayo Clinic Area

Frequently asked questions

Can I book a refundable hotel in Wykoff?
If you're looking for the flexibility to change your plans to Wykoff, most accommodations offer refundable* rates you can book. You can find these accommodations by searching our site and using the "fully refundable" filter to narrow the results down.
What will the weather in Wykoff be like during my visit?
The warmest months in Wykoff are usually July and August with an average temp of 68°F. January and February are the chilliest months when the average temp is 22°F. The rainiest months are June and May.
Why should I book my Wykoff hotel through Hotels.com?
There are plenty of reasons to book your Wykoff travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.