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Hotels in O Brien

October 2026
3
November 2026

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Next weekend
Oct 9 - Oct 11
In two weeks
Oct 16 - Oct 18

Where to stay in O Brien?

A hotel room with a gray sofa, a bed with white linens, a desk with a chair, and a window with blinds.
Exterior
A modern hotel lobby with a central island table, seating area with chairs, a fireplace, and a bar area.
A modern living room with a sectional sofa, a round coffee table, a hanging chair, and a flat-screen TV on a glass stand.

1. Comfort Suites Lake City

Comfort Suites Lake City
Lake City
$93
$105 total
includes taxes & fees
Oct 18 - Oct 19
Comfort Suites Lake City
A La Quinta hotel with a modern facade, multiple windows, and a well-lit entrance.
A modern lobby with a large map mural, a wooden column, and a seating area with a yellow cushion.
A modern restaurant with a long counter, multiple seating options including red and yellow chairs, and a large window providing a view.
A modern kitchen area with a coffee station, including a coffee machine, cups, and a toaster.

2. La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City
Lake City
$95
$106 total
includes taxes & fees
Oct 4 - Oct 5
La Quinta Inn & Suite by Wyndham Lake City
A multi-story hotel with a modern design, featuring a prominent entrance and a parking area.
A modern restaurant with round tables and yellow chairs, a bar area with a TV, and a menu display.
A reception area with two wooden reception desks, a wall-mounted decorative piece, and a refrigerator stocked with beverages.
Lobby

3. Courtyard By Marriott Lake City

Courtyard By Marriott Lake City
Lake City
$107
$120 total
includes taxes & fees
Oct 11 - Oct 12
Courtyard By Marriott Lake City
An indoor swimming pool with clear water, surrounded by glass doors and windows, and a wooden deck area.
A modern living room with two green sofas, a white coffee table, and a flat-screen TV mounted on the wall.
A modern dining area with multiple tables and chairs, a kitchen in the background, and a 'Hello Fall' sign on the wall.
A modern lounge area with a fireplace, comfortable seating, a dining table, and a large window offering a view.

4. Fairfield Inn & Suites Lake City

Fairfield Inn & Suites Lake City
Lake City
$104
$116 total
includes taxes & fees
Oct 11 - Oct 12
Fairfield Inn & Suites Lake City
A spacious living area with a grey sofa, a coffee table, and a TV stand.
A hotel room with a sofa, a small table, a lamp, and artwork on the wall.
A hotel room with two beds, a desk, a TV, and a large window with curtains.
A hotel entrance with a covered walkway, palm trees, and a clear sky.

5. Best Western Plus Lake City

Best Western Plus Lake City
Lake City
$80
$90 total
includes taxes & fees
Nov 1 - Nov 2
Best Western Plus Lake City
A picnic table with a potted plant, located in a grassy area with a tree and a road in the background.
A hotel lobby with a view of the street, a reception desk, and a large map on the wall.
A living room with a black leather sofa, a wooden coffee table with a plant, and framed pictures on the wall.
A hotel room with two beds, a nightstand with a phone and remote, and a patterned curtain.

6. Americas Best Value Inn Lake City

Americas Best Value Inn Lake City
Lake City
$67
$76 total
includes taxes & fees
Oct 4 - Oct 5
Americas Best Value Inn Lake City
A covered outdoor area with a paved walkway, benches, and potted plants.
A compact RV kitchen with wooden cabinets, a microwave, a stove, and a sink.
A grassy area with a picnic table, a car parked in front of a building with a sloped roof, and trees with hanging moss.
A bedroom with a bed, a desk, a chair, and a ceiling fan.

7. Cindys Motel

Cindys Motel
Mayo
$89
$96 total
includes taxes & fees
Oct 4 - Oct 5
Cindys Motel
A hotel pool area with lounge chairs and umbrellas, a pool with metal railings, and a building with multiple floors and large windows.
An EV charging station with two signs indicating it is for guest use only while charging.
Reception
An outdoor patio area with tables and chairs, surrounded by a metal fence, and umbrellas providing shade.

8. Hampton Inn & Suites Lake City

Hampton Inn & Suites Lake City
Lake City
$105
$118 total
includes taxes & fees
Oct 18 - Oct 19
Hampton Inn & Suites Lake City
A self-service beverage station with a variety of drinks, snacks, and a refrigerated section.
A modern hotel with a flat roof, multiple windows, and a covered entrance.
An outdoor patio with a stone fire feature, blue cushioned seating, and a grill.
A modern interior with two red chairs and a small table, large windows, and hanging pendant lights.

9. Tru by Hilton Lake City

Tru by Hilton Lake City
Lake City
$100
$113 total
includes taxes & fees
Oct 15 - Oct 16
Tru by Hilton Lake City
A hotel room with a large bed, a desk with a computer, a television, and a window with curtains.
An aerial view of a hotel with a swimming pool, parking lot, and surrounding greenery.
A restaurant with a yellow accent wall, white tiled floor, and black and blue chairs.
Lobby

10. Super 8 by Wyndham Lake City

Super 8 by Wyndham Lake City
Lake City
$61
$69 total
includes taxes & fees
Nov 2 - Nov 3
Super 8 by Wyndham Lake City
An outdoor patio area with wicker chairs, a round table, and a fire pit.
A modern interior with a dark wood desk, a blue chair, a sofa, and a patterned rug.
A modern interior with a sofa, round tables, and chairs, a TV mounted on the wall, and a patterned wall.
A hotel room with a bed, a sofa, a small table, a wardrobe, and a kitchenette.

11. TownePlace Suites by Marriott Lake City

TownePlace Suites by Marriott Lake City
Lake City
$119
$134 total
includes taxes & fees
Oct 4 - Oct 5
TownePlace Suites by Marriott Lake City
A spacious lobby with a high ceiling, a large window, a dining area with green chairs, and a black door leading outside.
A reception area with a counter, a coffee machine, and a potted plant.
A hotel dining area with tables and chairs, a reception desk, and a kitchen in the background.
A hotel room with two beds, a desk, a chair, a painting on the wall, and a patterned carpet.

12. Quality Inn Lake City

Quality Inn Lake City
Lake City
$80
$90 total
includes taxes & fees
Nov 2 - Nov 3
Quality Inn Lake City
A hotel room with two beds, a blue wall, and a window with curtains.
A modern living room with a sofa, armchairs, a coffee table, and a reception desk.
Exterior
A bathroom with a beige sink, a large mirror, and a white trash bin.

13. Gateway Inn

Gateway Inn
Lake City
$47
$53 total
includes taxes & fees
Oct 4 - Oct 5
Gateway Inn
A reception area with a Baymont Inn & Suites sign, a reception desk, a glass-top table, and a door.
A breakfast bar with a coffee machine, a microwave, and a sign reading "Breakfast Corner." There are several wooden tables and chairs arranged around the bar.
A gazebo with a red roof and green walls, surrounded by trees and a pool.
A hotel room with a large bed, two bedside tables with lamps, a desk with a chair, a television, and a bathroom visible in the background.

14. Baymont by Wyndham Lake City I-75

Baymont by Wyndham Lake City I-75
Lake City
$58
$65 total
includes taxes & fees
Oct 4 - Oct 5
Baymont by Wyndham Lake City I-75
An outdoor patio with a stone fire pit, grey cushioned seating, and wicker ottomans.
A modern hotel with a two-story structure, a covered outdoor seating area, and a parking lot with marked spaces.
A modern hotel room with a bed, a desk with a computer, a TV, and a lamp.
A modern kitchen with stainless steel appliances, a dishwasher, and a built-in oven.

15. Home2 Suites by Hilton Lake City

Home2 Suites by Hilton Lake City
Lake City
$114
$128 total
includes taxes & fees
Oct 18 - Oct 19
Home2 Suites by Hilton Lake City
A room with a window, a sofa, a table, and a wall-mounted heater.
A reception desk with a large number '6' sign, a mounted television, and a digital information kiosk.
A building with a flat roof, large windows, and a parking lot in front.
A kitchen with a coffee station, including a coffee maker, cups, and condiments.

16. Motel 6 – Lake City, Fl – Medical Center

Motel 6 – Lake City, Fl – Medical Center
Lake City
$68
$77 total
includes taxes & fees
Oct 4 - Oct 5
Motel 6 – Lake City, Fl – Medical Center
A modern kitchen with a large window, a flat-screen TV, and a coffee machine.
A hotel with a swimming pool, white lounge chairs, and a fenced area.
A hotel lobby with a dining area, a reception desk, and a view of the outside.
A reception area with a tiled counter, a computer, a sign reading 'Quality,' and two decorative vases.

17. Quality Inn White Springs Suwanee

Quality Inn White Springs Suwanee
White Springs
$66
$72 total
includes taxes & fees
Oct 27 - Oct 28
Quality Inn White Springs Suwanee
A hotel room with two beds, a TV, a desk, and a painting of a sunset.
A kitchen with a black refrigerator and a microwave on a wooden shelf.
A swimming pool with lounge chairs, a small pool house, and a yellow multi-story building with balconies.
A reception area with a wooden counter, a clock, and a computer on a desk.

18. Days Inn by Wyndham Lake City I-75

Days Inn by Wyndham Lake City I-75
Lake City
$72
$81 total
includes taxes & fees
Oct 5 - Oct 6
Days Inn by Wyndham Lake City I-75
A hotel room with a teal accent wall, a sofa, a desk with a chair, a small table, and two framed artworks.
A hotel lobby with multiple seating areas, a bar, and an elevator.
A reception desk with a Holiday Inn sign, two computer monitors, and a security camera.
A hotel room with a beige sofa, a small table with a book, a TV on a wooden cabinet, and a window with blinds.

19. Holiday Inn & Suites Lake City by IHG

Holiday Inn & Suites Lake City by IHG
Lake City
$99
$111 total
includes taxes & fees
Nov 1 - Nov 2
Holiday Inn & Suites Lake City by IHG
A hotel reception area with a reception desk, seating area, and a view of the parking lot.
A dining area with wooden chairs and tables, a coffee machine, and a counter with various items.
A reception area with a wooden floor, a reception desk, a seating area with chairs, and a view through the glass doors to the outside.
A hotel room with two beds, a bedside table with a lamp, a phone, and a window with curtains.

20. Econo Lodge Live Oak

Econo Lodge Live Oak
Live Oak
$73
$80 total
includes taxes & fees
Oct 6 - Oct 7
Econo Lodge Live Oak
View all properties

Go beyond your typical stay in O Brien

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Pet friendly
Pet friendly
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Pool
Pool
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Hot tub
Hot tub
Resort image
Resort
Resort
Family friendly image
Family friendly
Family friendly
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Cabin
Cabin
Cottage image
Cottage
Cottage

Learn more about O Brien

O Brien is well-known for its attractions such as Suwannee River and Ichetucknee River.

See all hotels in O Brien
A calm river surrounded by trees reflecting in the water.

Check out reviews of O Brien hotels guests love

An outdoor patio area with wicker chairs, a round table, and a fire pit.
A modern interior with a dark wood desk, a blue chair, a sofa, and a patterned rug.
A modern interior with a sofa, round tables, and chairs, a TV mounted on the wall, and a patterned wall.
A hotel room with a bed, a sofa, a small table, a wardrobe, and a kitchenette.

TownePlace Suites by Marriott Lake City

TownePlace Suites by Marriott Lake City
Lake City

10/10 Exceptional

United States
Penny
TownePlace Suites by Marriott Lake City
A picnic table with a potted plant, located in a grassy area with a tree and a road in the background.
A hotel lobby with a view of the street, a reception desk, and a large map on the wall.
A living room with a black leather sofa, a wooden coffee table with a plant, and framed pictures on the wall.
A hotel room with two beds, a nightstand with a phone and remote, and a patterned curtain.

Americas Best Value Inn Lake City

Americas Best Value Inn Lake City
Lake City

10/10 Exceptional

United States
Nathaly
Americas Best Value Inn Lake City
An aerial view of a campground with RVs, a swimming pool, and tennis courts.
A covered outdoor dining area with a table and chairs, large windows, and a view of greenery.
A wooden cabin with a kitchen, a bathroom, and a loft bedroom.
A wooden cabin with a porch, a front door, and a small window.

Suwannee River Rendezvous

Suwannee River Rendezvous
Mayo

10/10 Exceptional

United States
Beth
Suwannee River Rendezvous
A hotel room with a teal accent wall, a sofa, a desk with a chair, a small table, and two framed artworks.
A hotel lobby with multiple seating areas, a bar, and an elevator.
A reception desk with a Holiday Inn sign, two computer monitors, and a security camera.
A hotel room with a beige sofa, a small table with a book, a TV on a wooden cabinet, and a window with blinds.

Holiday Inn & Suites Lake City by IHG

Holiday Inn & Suites Lake City by IHG
Lake City

10/10 Exceptional

United States
Franziska
Holiday Inn & Suites Lake City by IHG
A hotel room with two beds, a TV, a desk, and a painting of a sunset.
A kitchen with a black refrigerator and a microwave on a wooden shelf.
A swimming pool with lounge chairs, a small pool house, and a yellow multi-story building with balconies.
A reception area with a wooden counter, a clock, and a computer on a desk.

Days Inn by Wyndham Lake City I-75

Days Inn by Wyndham Lake City I-75
Lake City

10/10 Exceptional

United States
Anonymous traveler
Days Inn by Wyndham Lake City I-75
A room with a wooden ceiling, two beds with patterned bedding, a desk, and a chair.
A stone outdoor seating area with a table and benches, a trash bin, and a building in the background.
A row of motel buildings with a fire hydrant and trees in front.
A small building with a green roof, a covered porch with wicker chairs, and a table.

High Springs Country Inn

High Springs Country Inn
High Springs

10/10 Exceptional

United States
Patrick
High Springs Country Inn
A hotel room with a gray sofa, a bed with white linens, a desk with a chair, and a window with blinds.
Exterior
A modern hotel lobby with a central island table, seating area with chairs, a fireplace, and a bar area.
A modern living room with a sectional sofa, a round coffee table, a hanging chair, and a flat-screen TV on a glass stand.

Comfort Suites Lake City

Comfort Suites Lake City
Lake City

10/10 Exceptional

United States
Robert
Comfort Suites Lake City
A hotel pool area with lounge chairs and umbrellas, a pool with metal railings, and a building with multiple floors and large windows.
An EV charging station with two signs indicating it is for guest use only while charging.
Reception
An outdoor patio area with tables and chairs, surrounded by a metal fence, and umbrellas providing shade.

Hampton Inn & Suites Lake City

Hampton Inn & Suites Lake City
Lake City

10/10 Exceptional

United States
Strother
Hampton Inn & Suites Lake City
A La Quinta hotel with a modern facade, multiple windows, and a well-lit entrance.
A modern lobby with a large map mural, a wooden column, and a seating area with a yellow cushion.
A modern restaurant with a long counter, multiple seating options including red and yellow chairs, and a large window providing a view.
A modern kitchen area with a coffee station, including a coffee machine, cups, and a toaster.

La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City
Lake City

10/10 Exceptional

United States
Christopher
La Quinta Inn & Suite by Wyndham Lake City
An indoor swimming pool with clear water, surrounded by glass doors and windows, and a wooden deck area.
A modern living room with two green sofas, a white coffee table, and a flat-screen TV mounted on the wall.
A modern dining area with multiple tables and chairs, a kitchen in the background, and a 'Hello Fall' sign on the wall.
A modern lounge area with a fireplace, comfortable seating, a dining table, and a large window offering a view.

Fairfield Inn & Suites Lake City

Fairfield Inn & Suites Lake City
Lake City

10/10 Exceptional

United States
Steven
Fairfield Inn & Suites Lake City
A spacious living area with a grey sofa, a coffee table, and a TV stand.
A hotel room with a sofa, a small table, a lamp, and artwork on the wall.
A hotel room with two beds, a desk, a TV, and a large window with curtains.
A hotel entrance with a covered walkway, palm trees, and a clear sky.

Best Western Plus Lake City

Best Western Plus Lake City
Lake City

10/10 Exceptional

United States
waqar
Best Western Plus Lake City
A covered outdoor area with a paved walkway, benches, and potted plants.
A compact RV kitchen with wooden cabinets, a microwave, a stove, and a sink.
A grassy area with a picnic table, a car parked in front of a building with a sloped roof, and trees with hanging moss.
A bedroom with a bed, a desk, a chair, and a ceiling fan.

Cindys Motel

Cindys Motel
Mayo

10/10 Exceptional

United States
Michelle
Cindys Motel
A self-service beverage station with a variety of drinks, snacks, and a refrigerated section.
A modern hotel with a flat roof, multiple windows, and a covered entrance.
An outdoor patio with a stone fire feature, blue cushioned seating, and a grill.
A modern interior with two red chairs and a small table, large windows, and hanging pendant lights.

Tru by Hilton Lake City

Tru by Hilton Lake City
Lake City

10/10 Exceptional

United States
Richard
Tru by Hilton Lake City
An outdoor patio with a stone fire pit, grey cushioned seating, and wicker ottomans.
A modern hotel with a two-story structure, a covered outdoor seating area, and a parking lot with marked spaces.
A modern hotel room with a bed, a desk with a computer, a TV, and a lamp.
A modern kitchen with stainless steel appliances, a dishwasher, and a built-in oven.

Home2 Suites by Hilton Lake City

Home2 Suites by Hilton Lake City
Lake City

10/10 Exceptional

United States
Kimberly
Home2 Suites by Hilton Lake City
A spacious lobby with a high ceiling, a large window, a dining area with green chairs, and a black door leading outside.
A reception area with a counter, a coffee machine, and a potted plant.
A hotel dining area with tables and chairs, a reception desk, and a kitchen in the background.
A hotel room with two beds, a desk, a chair, a painting on the wall, and a patterned carpet.

Quality Inn Lake City

Quality Inn Lake City
Lake City

10/10 Exceptional

United States
Anonymous traveler
Quality Inn Lake City
A spacious living area with a large chandelier, a sofa set, a coffee table, and a patterned floor.
A spacious hotel lobby with high ceilings, chandeliers, and a central round table.
A storefront with a glass door and a brick wall. The sign above the door reads "The Blanche."
A hotel with a classic facade, featuring a prominent sign reading "HOTEL BLANCHE".

The Blanche

The Blanche
Lake City

10/10 Exceptional

United States
John
The Blanche
A hotel room with two beds, a blue wall, and a window with curtains.
A modern living room with a sofa, armchairs, a coffee table, and a reception desk.
Exterior
A bathroom with a beige sink, a large mirror, and a white trash bin.

Gateway Inn

Gateway Inn
Lake City

10/10 Exceptional

United States
Hugo
Gateway Inn

Frequently Asked Questions

Can I book refundable hotels in O Brien?

If you want the flexibility to change your travel plans to O Brien, most accommodations provide refundable* bookable rates. You can find these accommodations by searching our site and using the "fully refundable" filter to narrow the results down.

Where can I stay in O Brien if I want a vacation home instead of a traditional hotel?

You'll find 5 vacation homes on our site.

What will the weather in O Brien be like during my vacation?

July and August are typically the warmest months in O Brien when the average temp is 80°F. January and February are the coldest months when the average temperature is 58°F. June and August are the months with the most rain.

Why should I book my O Brien hotel with Hotels.com?

There are lots of reasons to book your O Brien trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.