Hotels in San Sisto

November 2026
December 2026

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Check prices for these dates

Next weekend
Oct 23 - Oct 25
In two weeks
Oct 30 - Nov 1

Where to stay in San Sisto?

1. Relais dell'Olmo

Relais dell'Olmo
Perugia
$108
$119 total
includes taxes & fees
Nov 1 - Nov 2
Relais dell'Olmo

2. Best Western Hotel Quattrotorri Perugia

Best Western Hotel Quattrotorri Perugia
Perugia
$106
$123 total
includes taxes & fees
Nov 1 - Nov 2
Best Western Hotel Quattrotorri Perugia

3. La Meridiana Bleisure Hotel

La Meridiana Bleisure Hotel
Perugia
$94
$110 total
includes taxes & fees
Nov 1 - Nov 2
La Meridiana Bleisure Hotel

4. Hotel Perugia Plaza

Hotel Perugia Plaza
Perugia
$140
$160 total
includes taxes & fees
Nov 10 - Nov 11
Hotel Perugia Plaza

5. Hotel Grifone

Hotel Grifone
Perugia
$96
$111 total
includes taxes & fees
Nov 10 - Nov 11
Hotel Grifone

6. Chocohotel

Chocohotel
Perugia
$126
$144 total
includes taxes & fees
Oct 25 - Oct 26
Chocohotel

7. Hotel Sangallo Palace

Hotel Sangallo Palace
Perugia
$111
$129 total
includes taxes & fees
Oct 21 - Oct 22
Hotel Sangallo Palace

8. Locanda Stella

Locanda Stella
Perugia
$99
$113 total
includes taxes & fees
Oct 21 - Oct 22
Locanda Stella

9. Hotel Sacro Cuore

Hotel Sacro Cuore
Perugia
$81
$92 total
includes taxes & fees
Oct 20 - Oct 21
Hotel Sacro Cuore

10. Rosetta Hotel Perugia, Tapestry Collection by Hilton

Rosetta Hotel Perugia, Tapestry Collection by Hilton
Old Town Perugia
$168
$193 total
includes taxes & fees
Nov 8 - Nov 9
Rosetta Hotel Perugia, Tapestry Collection by Hilton

11. Hotel Priori Secret Garden

Hotel Priori Secret Garden
Old Town Perugia
$160
$183 total
includes taxes & fees
Nov 1 - Nov 2
Hotel Priori Secret Garden

12. Locanda della Posta - Etruria Collection

Locanda della Posta - Etruria Collection
Old Town Perugia
$192
$218 total
includes taxes & fees
Oct 29 - Oct 30
Locanda della Posta - Etruria Collection

13. TH Perugia - Castello di Monterone

TH Perugia - Castello di Monterone
Perugia
$224
$255 total
includes taxes & fees
Oct 23 - Oct 24
TH Perugia - Castello di Monterone

14. Hotel Giò Wine e Jazz Area

Hotel Giò Wine e Jazz Area
Perugia
$109
$126 total
includes taxes & fees
Nov 1 - Nov 2
Hotel Giò Wine e Jazz Area

15. Sina Brufani

Sina Brufani
Old Town Perugia
$202
$230 total
includes taxes & fees
Nov 15 - Nov 16
Sina Brufani

16. Posta Donini 1579 UNA Esperienze

Posta Donini 1579 UNA Esperienze
Perugia
$155
$179 total
includes taxes & fees
Oct 28 - Oct 29
Posta Donini 1579 UNA Esperienze

17. Primavera Mini Hotel

Primavera Mini Hotel
Old Town Perugia
$87
$102 total
includes taxes & fees
Oct 25 - Oct 26
Primavera Mini Hotel

18. Hotel Ilgo

Hotel Ilgo
Perugia
$75
$88 total
includes taxes & fees
Nov 17 - Nov 18
Hotel Ilgo

19. Residenza il Punto

Residenza il Punto
Perugia
$131
$148 total
includes taxes & fees
Nov 2 - Nov 3
Residenza il Punto

20. Hotel Sant'Ercolano

Hotel Sant'Ercolano
Old Town Perugia
$69
$81 total
includes taxes & fees
Oct 19 - Oct 20
Hotel Sant'Ercolano
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Go beyond your typical stay in San Sisto

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Apart hotel
Apart hotel
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Cottage
Cottage
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Villa
Villa
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Waterpark
Waterpark
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Farm
Farm

Top landmarks in San Sisto

Perugina Chocolate Factory

8.6/10 (58 reviews)
Perugina Chocolate Factory is 0.5 mi (0.9 km) from central San Sisto, why not stop by during your stay. If you have fun at Perugina Chocolate Factory, you'll love Citta della Domenica and Don Nello Palloni Centro Culturale, both located nearby.
See properties

Check out reviews of San Sisto hotels guests love

Relais dell'Olmo

Relais dell'Olmo
Perugia

10/10 Exceptional

United States
Anonymous traveler
Relais dell'Olmo

La Meridiana Bleisure Hotel

La Meridiana Bleisure Hotel
Perugia

10/10 Exceptional

United States
Tahmina
La Meridiana Bleisure Hotel

Locanda Stella

Locanda Stella
Perugia

10/10 Exceptional

United States
Telma
Locanda Stella

Hotel Priori Secret Garden

Hotel Priori Secret Garden
Old Town Perugia

10/10 Exceptional

United States
Eric
Hotel Priori Secret Garden

TH Perugia - Castello di Monterone

TH Perugia - Castello di Monterone
Perugia

10/10 Exceptional

United States
Mark
TH Perugia - Castello di Monterone

Residenza il Punto

Residenza il Punto
Perugia

10/10 Exceptional

United States
Gina
Residenza il Punto

Hotel Sangallo Palace

Hotel Sangallo Palace
Perugia

10/10 Exceptional

United States
Nicole
Hotel Sangallo Palace

Hotel Perugia Plaza

Hotel Perugia Plaza
Perugia

10/10 Exceptional

United States
Jesmeet
Hotel Perugia Plaza

Sina Brufani

Sina Brufani
Old Town Perugia

10/10 Exceptional

United States
Brian
Sina Brufani

Chocohotel

Chocohotel
Perugia

10/10 Exceptional

United States
Julie
Chocohotel

Hotel Sacro Cuore

Hotel Sacro Cuore
Perugia

10/10 Exceptional

United States
Anaisa
Hotel Sacro Cuore

Posta Donini 1579 UNA Esperienze

Posta Donini 1579 UNA Esperienze
Perugia

10/10 Exceptional

United States
Anonymous traveler
Posta Donini 1579 UNA Esperienze

Primavera Mini Hotel

Primavera Mini Hotel
Old Town Perugia

10/10 Exceptional

United States
Anonymous traveler
Primavera Mini Hotel

The Bank Hotel - Etruria Collection

The Bank Hotel - Etruria Collection
Old Town Perugia

10/10 Exceptional

United States
Luis
The Bank Hotel - Etruria Collection

Hotel Giò Wine e Jazz Area

Hotel Giò Wine e Jazz Area
Perugia

10/10 Exceptional

United States
Della
Hotel Giò Wine e Jazz Area

Borgo Tre Vaselle

Borgo Tre Vaselle
Torgiano

10/10 Exceptional

United States
Alex
Borgo Tre Vaselle

Frequently Asked Questions

What hotels do travelers like in San Sisto?

Can I book refundable hotels in San Sisto?

If you want the flexibility to change your plans to San Sisto, most hotels provide refundable* bookable rates. You can find these accommodations by searching our site and using the "fully refundable" filter to narrow down the results.

What will the weather in San Sisto be like during my vacation?

The warmest months in San Sisto are usually August and July with an average temp of 72°F. January and February are the chilliest months when the average temp is 44°F. The rainiest months are November and October.

Why should I book my San Sisto accommodation with Hotels.com?

There are plenty of reasons to book your San Sisto travel with us: our free cancellations on selected hotels* gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.