Hotels in Santo Tomé

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Check prices for these dates

Tonight
Nov 15 - Nov 16
Tomorrow
Nov 16 - Nov 17
Next weekend
Nov 20 - Nov 22
In two weeks
Nov 27 - Nov 29

Where to stay in Santo Tomé?

A multi-story hotel with a curved facade, a central entrance, and a balcony on the upper floors.

1. InterTower Hotel

InterTower Hotel
4.0 star property
Santa Fe
9.0 out of 10, Wonderful, (237 reviews)
Soak in panoramic vistas from the terrace of this urban retreat near Museo Del Colegio De Medicos. The outdoor pool, fitness center, and full-service spa offering deep-tissue massages create a rejuvenating atmosphere. Enjoy international cuisine at Giulio restaurant and complimentary breakfast.
The price is $119
$119 total
Nov 29 - Nov 30
InterTower Hotel
A rooftop pool area with lounge chairs and a city skyline at sunset.

2. Los Silos Hotel

Los Silos Hotel
4.0 star property
Santa Fe
9.4 out of 10, Exceptional, (36 reviews)
The price is $129
$129 total
Dec 13 - Dec 14
Los Silos Hotel
A hotel with a sign reading "OMARAN SUITES & Towers" at night, illuminated by purple lighting.

3. Maran Suites & Towers - Hotel & Spa

Maran Suites & Towers - Hotel & Spa
3.5 star property
Parana
9.0 out of 10, Wonderful, (35 reviews)
Steps from Urquiza Park, this hotel offers rejuvenating massages, aromatherapy, and reflexology at its spa. Enjoy complimentary breakfast before exploring nearby Museo de Bellas Artes, or unwind at the bar after a workout in the fitness center.
The price is $105
$105 total
Nov 16 - Nov 17
Maran Suites & Towers - Hotel & Spa
A building with a double wooden door labeled "CASTELAR" and a small mailbox on the right side.

4. Castelar Hotel Santa Fe

Castelar Hotel Santa Fe
3.0 star property
Santa Fe
7.4 out of 10, Good, (108 reviews)
Escape to this inviting hotel with an outdoor pool and convenient bar/lounge. Just minutes from Museo Del Colegio De Medicos and Ribera Shopping, you'll enjoy free breakfast and 24-hour reception service while exploring Santa Fe's attractions.
The price is $66
$66 total
Nov 25 - Nov 26
Castelar Hotel Santa Fe
A hotel room with a large bed, a desk with a chair, a TV, and a window with a city view.

5. Hotel Puerto Amarras

Hotel Puerto Amarras
3.5 star property
Santa Fe
8.2 out of 10, Very good, (82 reviews)
Wake up to waterfront tranquility at this Santa Fe hotel where regional cuisine awaits at Dos Aguas restaurant. Unwind in the outdoor pool after a massage, or explore nearby Ribera Shopping and cultural museums. The fitness center keeps your routine on track.
The price is $97
$97 total
Nov 29 - Nov 30
Hotel Puerto Amarras
A reception area with a modern design, featuring a large wall sign, a seating area, and a potted plant.

6. Agustín 1 Apart

Agustín 1 Apart
3.5 star property
Parana
9.2 out of 10, Wonderful, (7 reviews)
Unwind in this Parana aparthotel where comfy beds with premium linens create a relaxing sanctuary. Free WiFi keeps you connected while an onsite spa melts away stress. Plaza de Mayo and Museu De Sitio await just minutes away.
The price is $61
$61 total
Nov 24 - Nov 25
Agustín 1 Apart
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Go beyond your typical stay in Santo Tomé

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Pet friendly
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Top landmarks in Santo Tomé

El Museo Etnografico y Colonial Juan de Garay

If visiting museums in Santo Tomé are on your list, you might want to check out the upcoming exhibitions at El Museo Etnografico y Colonial Juan de Garay. If you want to see more of the museums in Santo Tomé, Historical Provincial Museum isn't far either.
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Learn more about Santo Tomé

Santo Tomé is well-known for its attractions such as El Museo Etnografico y Colonial Juan de Garay and Museo De Arte Contemporaneo.

See all hotels in Santo Tomé
A person holding a yerba mate cup with a snowy mountain range and a lake in the background.

Check out reviews of Santo Tomé hotels guests love

A rooftop pool area with lounge chairs and a city skyline at sunset.
Los Silos Hotel

Los Silos Hotel

Los Silos Hotel
Santa Fe

10/10 Exceptional

Muy buen hotel, todo el personal muy amable, las instalaciones muy bien, buen desayuno, la suite muy espaciosa y cómoda, la cama muy bien, el baño muy grande, la ducha bien. En general todo muy bien, solo faltaría insonorizar mejor el baño para que no se escuchen a pasajeros de habitaciones contiguas. Hotel recomendable.
United States
Guillermo
Reviewed July 27, 2026
Los Silos Hotel

Frequently Asked Questions

What accommodations do travelers like in Santo Tomé?

Guests like Hotel de Campo Colon, InterTower Hotel and Castelar Hotel Santa Fe.

Can I book a refundable hotel in Santo Tomé?

If you want the flexibility to change your travel plans to Santo Tomé, most properties provide refundable* rates you can book. You can see these accommodations by searching our site and using the "fully refundable" filter to narrow the results down.

What will the weather in Santo Tomé be like during my visit?

The warmest months in Santo Tomé are usually January and December with an average temp of 77°F. July and June are the chilliest months when the average temp is 57°F. The rainiest months are February and December.

Why should I book my Santo Tomé accommodation with Hotels.com?

There are plenty of reasons to book your Santo Tomé travel with us: our free cancellations on selected hotels* gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.