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Hotels in Santiago Este

October 2026
4
November 2026

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Check prices for these dates

Next weekend
Oct 9 - Oct 11
In two weeks
Oct 16 - Oct 18

Where to stay in Santiago Este?

A pool area with lounge chairs and a covered seating area, surrounded by modern buildings.
A spacious lobby with a central water feature, multiple seating areas, and a curved ceiling with hanging lights.
A spacious lobby with modern seating, a central coffee table, and decorative hanging lights.
A modern hotel with a prominent entrance, outdoor seating area, and a handicap-accessible parking space.

1. Hotel Mykonos Panama

Hotel Mykonos Panama
Nuevo Santiago
$90
$99 total
includes taxes & fees
Oct 5 - Oct 6
Hotel Mykonos Panama
A pool surrounded by palm trees and a tiled roof structure.
A tree in a stone planter in a well-lit indoor space with a stone wall and a door in the background.
A spacious room with a high ceiling, a large window, and a wooden door leading to another area. There are several potted plants and a small table with a vase.
A hallway with a glass partition leading to a dining area, a stone wall, and a metal gate with decorative patterns.

2. Hotel Gran David

Hotel Gran David
Santiago
$77
$84 total
includes taxes & fees
Oct 5 - Oct 6
Hotel Gran David
A modern lobby with a sofa, armchairs, a desk, and a large window offering a view of the cityscape.
A hotel room with a dark wooden desk, two cushioned chairs, a large mirror, and two table lamps.
A bathroom with a tiled shower wall, a sink, and a towel rack.
A lobby with a reception desk, two armchairs, a sofa, and a table with a lamp.

3. Hotel Plaza Los Tucanes

Hotel Plaza Los Tucanes
Nuevo Santiago
$52
$57 total
includes taxes & fees
Oct 5 - Oct 6
Hotel Plaza Los Tucanes
A beach with a wide sandy shore and gentle waves.
A child crossing a rope bridge over water, with a person assisting.
A table set with a variety of food items, including pastries, fruits, and nuts, arranged on a table with a decorative centerpiece.
A building with a thatched roof, a signboard with text, and a parked car.

4. olivias village room

olivias village room
Capellania
$41
$148 total
includes taxes & fees
Oct 5 - Oct 6
olivias village room
A swimming pool with a water slide, surrounded by palm trees and lounge chairs.
A multi-story hotel with balconies, a pool, and a reflection in the water.
A modern bedroom with a large bed, a small table, and a chair. There is a window with curtains and a lamp on the wall.
A spacious dining area with high ceilings, large windows, and natural light. Tables are set with chairs and centerpieces.

5. HOTEL VISTA LAGO

HOTEL VISTA LAGO
La Pena
$77
$84 total
includes taxes & fees
Oct 5 - Oct 6
HOTEL VISTA LAGO
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Go beyond your typical stay in Santiago Este

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Pet friendly
Pet friendly
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Pool
Pool
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Spa
Spa
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Family friendly
Family friendly

Check out reviews of Santiago Este hotels guests love

A pool area with lounge chairs and a covered seating area, surrounded by modern buildings.
A spacious lobby with a central water feature, multiple seating areas, and a curved ceiling with hanging lights.
A spacious lobby with modern seating, a central coffee table, and decorative hanging lights.
A modern hotel with a prominent entrance, outdoor seating area, and a handicap-accessible parking space.

Hotel Mykonos Panama

Hotel Mykonos Panama
Nuevo Santiago

10/10 Exceptional

United States
BTraveler
Hotel Mykonos Panama
A pool surrounded by palm trees and a tiled roof structure.
A tree in a stone planter in a well-lit indoor space with a stone wall and a door in the background.
A spacious room with a high ceiling, a large window, and a wooden door leading to another area. There are several potted plants and a small table with a vase.
A hallway with a glass partition leading to a dining area, a stone wall, and a metal gate with decorative patterns.

Hotel Gran David

Hotel Gran David
Santiago

10/10 Exceptional

United States
Agostina
Hotel Gran David
A modern lobby with a sofa, armchairs, a desk, and a large window offering a view of the cityscape.
A hotel room with a dark wooden desk, two cushioned chairs, a large mirror, and two table lamps.
A bathroom with a tiled shower wall, a sink, and a towel rack.
A lobby with a reception desk, two armchairs, a sofa, and a table with a lamp.

Hotel Plaza Los Tucanes

Hotel Plaza Los Tucanes
Nuevo Santiago

10/10 Exceptional

United States
Olopilel
Hotel Plaza Los Tucanes
A swimming pool with a water slide, surrounded by palm trees and lounge chairs.
A multi-story hotel with balconies, a pool, and a reflection in the water.
A modern bedroom with a large bed, a small table, and a chair. There is a window with curtains and a lamp on the wall.
A spacious dining area with high ceilings, large windows, and natural light. Tables are set with chairs and centerpieces.

HOTEL VISTA LAGO

HOTEL VISTA LAGO
La Pena

10/10 Exceptional

United States
Victor
HOTEL VISTA LAGO

Frequently Asked Questions

Can I book refundable accommodations in Santiago Este?

If you want the flexibility to change your plans to Santiago Este, most properties offer refundable* bookable rates. You can see these properties by searching our site and using the "fully refundable" filter to narrow the results down.

What will the weather in Santiago Este be like during my trip?

With an average temperature of 77°F during the coldest months, Santiago Este is a great place to visit any time of year.

Why should I book my Santiago Este accommodation with Hotels.com?

There are plenty of reasons to book your Santiago Este travel with us: our free cancellations on selected hotels* gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.