Hotels in Santa Cruz de la Sierra

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Tonight
Oct 27 - Oct 28
Tomorrow
Oct 28 - Oct 29
This weekend
Oct 30 - Nov 1
Next weekend
Nov 6 - Nov 8

Where to stay in Santa Cruz de la Sierra?

A stone building with a tiled roof, a stone patio, and a grassy area.

1. Hospedium Hotel Soterraña

Hospedium Hotel Soterraña
3.0 star property
Madronera
8.8 out of 10, Excellent, (41 reviews)
This colonial hotel in Madronera offers a tranquil retreat with 2 restaurants and 2 bars/lounges. Unwind in the garden or terrace after exploring the area. Free WiFi and parking make your countryside escape in Spain convenient and stress-free.
The price is $69
$76 total
includes taxes & fees
Nov 26 - Nov 27
Hospedium Hotel Soterraña
A historic stone courtyard with cobblestone flooring, a central fountain, and buildings with traditional architecture.

2. Parador de Trujillo

Parador de Trujillo
4.0 star property
Trujillo
9.2 out of 10, Wonderful, (250 reviews)
This former palace boasts an outdoor pool where you can soak up the Spanish sun. Close to the Palace of the Dukes of San Carlos, the hotel offers a bar, garden, and café. Explore Trujillo's historic sites then unwind on the scenic terrace.
The price is $81
$89 total
includes taxes & fees
Nov 2 - Nov 3
Parador de Trujillo
A courtyard with white buildings, a cobblestone path, and potted plants.

3. Finca El Azahar

Finca El Azahar
3.0 star property
Trujillo
10.0 out of 10, Exceptional, (7 reviews)
Escape to this tranquil Trujillo retreat featuring an inviting seasonal outdoor pool and its own winery. Enjoy complimentary breakfast, WiFi, and parking while discovering nearby hiking and biking trails.
The price is $154
$169 total
includes taxes & fees
Oct 28 - Oct 29
Finca El Azahar
A historic building with a sign for "Eurostars" and a large entrance door.

4. Eurostars Palacio Santa Marta

Eurostars Palacio Santa Marta
4.0 star property
Trujillo
9.2 out of 10, Wonderful, (361 reviews)
Discover Spanish heritage in this historic hotel near Plaza Mayor and the Statue of Francisco Pizarro. Cool off in the outdoor pool, enjoy a drink at the bar, and savor meals at the restaurant. The helpful staff ensures a memorable stay in charming Trujillo.
The price is $66
$73 total
includes taxes & fees
Nov 2 - Nov 3
Eurostars Palacio Santa Marta
A lobby with a wooden cart displaying food and drinks, surrounded by arches and potted plants.

5. Hotel Izan Trujillo

Hotel Izan Trujillo
4.0 star property
Trujillo
8.6 out of 10, Excellent, (218 reviews)
Immerse yourself in Trujillo's rich culture at this hotel with El Refectorio restaurant serving authentic regional dishes. Swim in the seasonal outdoor pool, enjoy drinks at the bar, or relax on the terrace near Museo de Vino y Queso.
The price is $77
$85 total
includes taxes & fees
Nov 2 - Nov 3
Hotel Izan Trujillo
A sunset view with a stone pathway, trees, and a fence.

6. Finca la Desa

Finca la Desa
3.0 star property
Miajadas
10.0 out of 10, Exceptional, (20 reviews)
The price is $62
$68 total
includes taxes & fees
Oct 28 - Oct 29
Finca la Desa
A restaurant with checkered tablecloths, wooden chairs, and a stone wall.

7. Hostal Hueso

Hostal Hueso
2.0 star property
Trujillo
8.2 out of 10, Very good, (26 reviews)
The price is $66
$73 total
includes taxes & fees
Oct 29 - Oct 30
Hostal Hueso
A stone-walled dining area with tables set for two, each with a red tablecloth and wine glasses.

8. Hostal León

Hostal León
2.0 star property
Trujillo
7.6 out of 10, Good, (55 reviews)
Experience authentic Spanish hospitality at this cozy hostal near Museo de Vino y Queso and Palace of the Dukes of San Carlos. Free WiFi keeps you connected while daily housekeeping ensures a fresh, comfortable atmosphere during your exploration of Trujillo's treasures.
The price is $56
$61 total
includes taxes & fees
Oct 28 - Oct 29
Hostal León
A stone-walled hallway with a dark door, a staircase, and a potted plant.

9. Plaza Sandra

Plaza Sandra
3.0 star property
Trujillo
9.6 out of 10, Exceptional, (59 reviews)
Escape to this tranquil retreat near Palace of the Dukes of San Carlos. Swim in the outdoor pool, unwind with a massage, or explore using free WiFi. Apartments feature convenient kitchens and sofa beds, plus a lovely terrace and garden for peaceful moments.
The price is $63
$70 total
includes taxes & fees
Nov 2 - Nov 3
Plaza Sandra
A bedroom with a bed, bedside tables, a desk, and a chair.

10. Alojamientos Plaza Mayor

Alojamientos Plaza Mayor
3.0 star property
Trujillo
8.0 out of 10, Very good, (56 reviews)
Embrace old-world charm at this cozy pension just steps from Alfiler Tower and Plaza Mayor. Free WiFi keeps you connected while the convenient gift shop offers local treasures to remember your Spanish adventure by.
The price is $42
$46 total
includes taxes & fees
Oct 29 - Oct 30
Alojamientos Plaza Mayor
An outdoor dining area with tables and chairs, a white canopy, and potted plants.

11. Hospedium Hotel Triana

Hospedium Hotel Triana
3.0 star property
Miajadas
8.0 out of 10, Very good, (24 reviews)
Escape to this Spanish hotel offering a restaurant and bar/lounge for relaxed dining. Enjoy complimentary WiFi and parking while the 24-hour front desk ensures around-the-clock assistance. A charming terrace and snack bar complete your countryside stay.
The price is $85
$93 total
includes taxes & fees
Nov 26 - Nov 27
Hospedium Hotel Triana
A hotel room with a large bed, two bedside tables, a nightstand, a door leading to a bathroom, and a wall-mounted light fixture.

12. Hostal Ruralis Altozano

Hostal Ruralis Altozano
1.0 star property
Montánchez
8.8 out of 10, Excellent, (3 reviews)
The price is $45
$50 total
includes taxes & fees
Oct 29 - Oct 30
Hostal Ruralis Altozano
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Go beyond your typical stay in Santa Cruz de la Sierra

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Learn more about Santa Cruz de la Sierra

The region around Santa Cruz de la Sierra is home to attractions such as Plaza Mayor and Pizarro House Museum.

See all hotels in Santa Cruz de la Sierra
A large brick church with two bell towers and palm trees in front.

Check out reviews of Santa Cruz de la Sierra hotels guests love

A historic stone courtyard with cobblestone flooring, a central fountain, and buildings with traditional architecture.
Parador de Trujillo

Parador de Trujillo

Parador de Trujillo
Trujillo

10/10 Exceptional

Very nice hotel, good parking, well located,
United States
Edgar
Reviewed November 18, 2025
Parador de Trujillo

Frequently Asked Questions

What hotels do travelers recommend in Santa Cruz de la Sierra?

Guests like Hotel Izan Trujillo, Eurostars Palacio Santa Marta and Parador de Trujillo.

Can I book refundable hotels in Santa Cruz de la Sierra?

If you need the flexibility to change your plans to Santa Cruz de la Sierra, most properties provide refundable* rates you can book. You can see these accommodations by searching our site and using the "fully refundable" filter to narrow the results down.

What will the weather in Santa Cruz de la Sierra be like during my trip?

July and August are typically the warmest months in Santa Cruz de la Sierra when the average temp is 77°F. January and February are the coldest months when the average temperature is 47°F. October and December are the months with the most rain.

Why should I book my Santa Cruz de la Sierra hotel through Hotels.com?

There are lots of reasons to book your Santa Cruz de la Sierra trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.