A large brick church with two bell towers and palm trees in front.

Hotels in Santa Cruz de la Sierra

Free cancellation options if plans change

Earn rewards on every night you stay

Save more with Member Prices

Check prices for these dates

Tonight

Tomorrow

Next weekend

In two weeks

Where to stay in Santa Cruz de la Sierra?

A stone building with a tiled roof, a stone patio, and a grassy area.

A restaurant with stone walls, wooden beams, and checkered tablecloths. Tables are arranged in rows with chairs.

A rustic bar area with wooden stools, a checkered tablecloth, and a brick wall.

An outdoor dining area with stone flooring, tables, and chairs, surrounded by greenery and a stone building.

1. Hospedium Hotel Soterraña

Madronera

$69

$76 total

includes taxes & fees

Oct 25 - Oct 26

A historic stone courtyard with cobblestone flooring, a central fountain, and buildings with traditional architecture.

A swimming pool with lounge chairs and a stone building in the background.

A corridor with stone arches, a wooden cabinet with glass doors, a table with a lamp, and a door at the end.

A banquet hall with round tables, red chairs, and a high arched ceiling.

2. Parador de Trujillo

Trujillo

$81

$89 total

includes taxes & fees

Nov 2 - Nov 3

A historic building with a sign for "Eurostars" and a large entrance door.

A dining area with tables and chairs, large windows, and a view of the city.

A swimming pool with lounge chairs and a tower structure in the background.

A reception area with a wooden counter, a glass door, and a stone wall.

3. Eurostars Palacio Santa Marta

Trujillo

$62

$69 total

includes taxes & fees

Nov 11 - Nov 12

A courtyard with white buildings, a cobblestone path, and potted plants.

A stone pathway leading to a rustic stone building with a purple flowering tree in the center.

A white-walled room with a large arched mirror, a red vase with green plants, and wooden boxes on a bench.

A covered outdoor seating area with a stone floor, white walls, and arches.

4. Finca El Azahar

Trujillo

$154

$169 total

includes taxes & fees

Oct 13 - Oct 14

A sunset view with a stone pathway, trees, and a fence.

A wine cellar with wooden racks and a bar area.

A dining area with a wooden table set for four, a wine rack with bottles, and a meat display case.

A modern building with a white facade, a red-tiled roof, and a large tree in the center.

5. Finca la Desa

Miajadas

$69

$76 total

includes taxes & fees

Oct 12 - Oct 13

A lobby with a wooden cart displaying food and drinks, surrounded by arches and potted plants.

A spacious courtyard with red seating and tables, stone arches, and potted plants.

A corridor with red walls, stone columns, and a tiled floor.

A banquet hall with a long table set for a formal event, arched ceilings, and a view of the upper level.

6. Hotel Izan Trujillo

Trujillo

$78

$85 total

includes taxes & fees

Nov 2 - Nov 3

A stone-walled dining area with tables set for two, each with a red tablecloth and wine glasses.

A hallway with a potted plant, a glass door leading outside, and a red lamp on a table.

A room with a bed, a wooden chair, and a vase with branches.

A garden with various flowering plants and a stone wall in the background.

7. Hostal León

Trujillo

$56

$62 total

includes taxes & fees

Oct 13 - Oct 14

A stone-walled hallway with a dark door, a staircase, and a potted plant.

A spacious living area with wicker furniture, a stone wall, and a view of the outside.

A hotel lobby with a reception desk, a vase of flowers, a framed artwork, a lamp, and a seating area.

A sign reading "PLAZA SANDRA" on a textured wall, with a tiled pool in front.

8. Plaza Sandra

Trujillo

$64

$70 total

includes taxes & fees

Oct 19 - Oct 20

A restaurant with checkered tablecloths, wooden chairs, and a stone wall.

A stone building with a sign that reads "RESORT".

A stone building with a sign reading "Hotel Center."

A hallway with a brick archway, a staircase, and a potted plant.

9. Hostal Hueso

Trujillo

$66

$73 total

includes taxes & fees

Oct 14 - Oct 15

A bed with a wooden headboard, two pillows, a bedside lamp, and a patterned bedspread.

A wooden desk with a remote control and papers, a wooden chair, and a corner of a room.

A plaza with historic buildings, a fountain, and parked cars.

A bathroom with a bathtub, sink, toilet, and a hand sanitizer dispenser.

10. Alojamientos Plaza Mayor

Trujillo

$35

$38 total

includes taxes & fees

Oct 13 - Oct 14

An outdoor dining area with tables and chairs, a white canopy, and potted plants.

A hotel entrance with a reception desk, a potted plant, and a planter with small plants.

A hotel room with a bed, a sofa, a desk, and a chair. There is a painting on the wall and a lamp on the desk.

A buffet area with a glass display case, a counter with a coffee machine, and a seating area with a striped column.

11. Hospedium Hotel Triana

Miajadas

$86

$94 total

includes taxes & fees

Oct 13 - Oct 14

A hotel room with a large bed, two bedside tables, a nightstand, a door leading to a bathroom, and a wall-mounted light fixture.

A building with a sign reading "Ruralis El Altozano".

A hallway with wooden doors, a tiled floor, and a glass block wall.

A compact kitchen with wooden cabinets, a stainless steel range hood, a microwave, and a refrigerator. There is a dining table with chairs and a coffee maker.

12. Hostal Ruralis Altozano

Montánchez

$45

$50 total

includes taxes & fees

Oct 13 - Oct 14

View all properties

Go beyond your typical stay in Santa Cruz de la Sierra

Learn more about Santa Cruz de la Sierra

The region around Santa Cruz de la Sierra is home to attractions such as Plaza Mayor and Pizarro House Museum.

See all hotels in Santa Cruz de la Sierra

Check out reviews of Santa Cruz de la Sierra hotels guests love

Parador de Trujillo

Trujillo

10/10 Exceptional

Edgar

Finca El Azahar

Trujillo

10/10 Exceptional

Christopher

Plaza Sandra

Trujillo

10/10 Exceptional

Ismael

Hotel Izan Trujillo

Trujillo

10/10 Exceptional

Phil.

Hostal Hueso

Trujillo

10/10 Exceptional

ALFRED

Frequently Asked Questions

What hotels do travelers recommend in Santa Cruz de la Sierra?

Guests like Hotel Izan Trujillo, Eurostars Palacio Santa Marta and Parador de Trujillo.

Can I book refundable hotels in Santa Cruz de la Sierra?

If you need the flexibility to change your plans to Santa Cruz de la Sierra, most properties provide refundable* rates you can book. You can see these accommodations by searching our site and using the "fully refundable" filter to narrow the results down.

What will the weather in Santa Cruz de la Sierra be like during my trip?

July and August are typically the warmest months in Santa Cruz de la Sierra when the average temp is 77°F. January and February are the coldest months when the average temperature is 47°F. October and December are the months with the most rain.

Why should I book my Santa Cruz de la Sierra hotel through Hotels.com?

There are lots of reasons to book your Santa Cruz de la Sierra trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.