Top 10 Hotels in Hillsboro, MO in 2026 (from $57)

Q: What hotels do travelers like in Hillsboro?

Guests like Comfort Inn Festus - St Louis South .

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Where to stay in Hillsboro?

A hotel room with a bed, bedside tables, a desk, a chair, a lamp, and a window.

1. Hampton Inn & Suites By Hilton Festus

Festus

$130 total

includes taxes & fees

Nov 22 - Nov 23

A Holiday Inn Express & Suites building with a gas station in front.

2. Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

Festus

$108 total

includes taxes & fees

Dec 13 - Dec 14

A spacious lobby with a modern design, featuring a large seating area with purple and gray chairs, a patterned carpet, and a cityscape mural on the wall.

3. La Quinta Inn & Suites by Wyndham Festus - St. Louis South

Festus

$96 total

includes taxes & fees

Nov 15 - Nov 16

A modern living room with a sectional sofa, a glass coffee table, and a fireplace.

4. Baymont by Wyndham Festus

Festus

$71 total

includes taxes & fees

Dec 14 - Dec 15

5. Super 8 by Wyndham Pevely

Pevely

$66 total

includes taxes & fees

Dec 8 - Dec 9

A hotel room with a bathroom, a bed, a sofa, a coffee table, a TV, and a microwave.

6. Comfort Inn Festus - St Louis South

Festus

$80 total

includes taxes & fees

Dec 3 - Dec 4

A lobby with a reception desk, blue sofas, a coffee table, and a plant display.

7. Drury Inn & Suites St. Louis Arnold

Arnold

$146 total

includes taxes & fees

Nov 17 - Nov 18

A modern interior with a high ceiling, large windows, and a brick wall. There are orange chairs and a green sofa with orange cushions.

8. Pear Tree Inn St. Louis Arnold

Arnold

$104 total

includes taxes & fees

Nov 17 - Nov 18

9. Days Inn & Suites By Wyndham Festus

Festus

$82 total

includes taxes & fees

Dec 11 - Dec 12

A modern living area with a sofa, armchairs, a coffee table, and a kitchen in the background.

10. Best Western St. Louis Inn

St. Louis

$86 total

includes taxes & fees

Nov 18 - Nov 19

An outdoor seating area with a fire pit, chairs, and two evergreen trees.

11. Pinemark Inn & Suites

St. Clair

$147 total

includes taxes & fees

Nov 14 - Nov 15

A narrow stone pathway leading to a brick house with a dark wooden door and a window with a white frame.

12. Corner George Inn Bed & Breakfast

Maeystown

$143 total

includes taxes & fees

Nov 15 - Nov 16

A modern hotel lobby with a computer desk, a flat-screen TV, and a ceiling fan.

13. Quality Inn Near Six Flags St. Louis

Pacific

$97 total

includes taxes & fees

Nov 17 - Nov 18

A wooden wall with the sign "THE PRINCIPAL HOTEL" and a row of books below.

14. The Principal Hotel

Columbia

$109 total

includes taxes & fees

Nov 15 - Nov 16

A modern dining area with wooden tables and chairs, a kitchen with blue cabinets, and a green accent wall.

15. Spark by Hilton St. Louis Southwest

Valley Park

$106 total

includes taxes & fees

Nov 29 - Nov 30

A hotel with a prominent tower, a fountain, and a landscaped garden.

16. The Wildwood Hotel

Wildwood

$107 total

includes taxes & fees

Dec 1 - Dec 2

A motel with a covered parking area, a brick facade, and a sign indicating it is number 8.

17. Super 8 by Wyndham Potosi

Potosi

$64 total

includes taxes & fees

Nov 17 - Nov 18

A spacious lobby with a grand staircase, a fireplace, and comfortable seating areas.

18. Holiday Inn St. Louis West Six Flags by IHG

Eureka

$151 total

includes taxes & fees

Dec 14 - Dec 15

A modern hotel lobby with a high ceiling, a central seating area with sofas and a coffee table, and a flat-screen TV mounted on the wall.

19. Drury Inn & Suites Southwest St. Louis

Valley Park

$139 total

includes taxes & fees

Nov 22 - Nov 23

A spacious lobby with high ceilings, modern lighting, and a mix of seating areas including tables and chairs.

20. Hampton Inn & Suites St. Louis/South I-55

St. Louis

$126 total

includes taxes & fees

Nov 22 - Nov 23

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Go beyond your typical stay in Hillsboro

Top landmarks in Hillsboro

Lake Trails

Lake Trails is 5.3 mi (8.6 km) from central Hillsboro, why not stop by during your stay.

See properties

Learn more about Hillsboro

Hillsboro is well-known for its attractions such as Villa Antonio Winery and Big River.

See all hotels in Hillsboro

Check out reviews of Hillsboro hotels guests love

Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

Festus

10/10 Exceptional

Anonymous traveler

Hampton Inn & Suites By Hilton Festus

Festus

10/10 Exceptional

KATHY

Comfort Inn Festus - St Louis South

Festus

10/10 Exceptional

CindyLucy

Drury Inn & Suites St. Louis Arnold

Arnold

10/10 Exceptional

Rachel

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

Festus

10/10 Exceptional

Adrian

Pear Tree Inn St. Louis Arnold

Arnold

10/10 Exceptional

Blaine

Pinemark Inn & Suites

St. Clair

10/10 Exceptional

Amber

Corner George Inn Bed & Breakfast

Maeystown

10/10 Exceptional

We stayed from 3/29 through 4/1. Unique place sitting directly next to a clear babbling brook. We stayed in The Loft room and it is very big, with a claw-foot tub and full kitchen that was stocked with dishes. The pillows and bed were devine. We slept completely through the night and woke feeling so refreshed. It was so quiet in the evenings that it was easy to picture yourself there in the 1890's with the world turning much slower around you. Many places were not open though since it was still...

Richard

Drury Inn & Suites Southwest St. Louis

Valley Park

10/10 Exceptional

Tonya

Hampton Inn & Suites St. Louis/South I-55

St. Louis

10/10 Exceptional

Misha

The Wildwood Hotel

Wildwood

10/10 Exceptional

Tabitha

A hotel room with a minibar, a shoe rack, a coat rack, and a TV.

Holiday Inn Express & Suites St. Louis South - I-55 by IHG

St. Louis

10/10 Exceptional

Craig

A Marriott Fairfield hotel with a covered entrance, stone facade, and a clear sky.

Fairfield Inn & Suites by Marriott St. Louis South

St. Louis

10/10 Exceptional

noah

Quality Inn Near Six Flags St. Louis

Pacific

10/10 Exceptional

We were pleasantly surprised. One of the best rooms we’ve been in on our round-trip roadtrip from the west coast to Ohio. The beds were comfortable, pillows were great; we appreciated the bedbug and waterproof covers on the mattresses. Everything seemed clean, the sink had nice counter space; nice table & chairs, area for clothes and luggage; fridge & microwave. It’s the only place we’ve been on this trip that had hot breakfast options, which was nice for getting the morning started off right....

Sasha

Spark by Hilton St. Louis Southwest

Valley Park

10/10 Exceptional

Greg

Frequently Asked Questions

What hotels do travelers like in Hillsboro?

Guests like Comfort Inn Festus - St Louis South.

Can I book a refundable accommodation in Hillsboro?

If you want the flexibility to change your plans to Hillsboro, most hotels offer refundable* bookable rates. You can see these accommodations by searching our site and using the "fully refundable" filter to narrow the results down.

What will the weather in Hillsboro be like during my visit?

July and August are typically the warmest months in Hillsboro when the average temp is 75°F. January and February are the coldest months when the average temperature is 38°F. April and May are the months with the most rain.

Why should I book my Hillsboro hotel through Hotels.com?

There are lots of reasons to book your Hillsboro trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.