Hotels near Main Street Hyannis Hyannis

October 2026
November 2026

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Oct 2 - Oct 4
In two weeks
Oct 9 - Oct 11

Where to stay near Main Street Hyannis?

1. Hyannis Travel Inn

Hyannis Travel Inn
0.2 km from Main Street Hyannis
United States
Harry
$109
$125 total
includes taxes & fees
Sep 28 - Sep 29
Hyannis Travel Inn

2. SeaCoast Inn

SeaCoast Inn
0.1 km from Main Street Hyannis
United States
Laura
$109
$125 total
includes taxes & fees
Oct 6 - Oct 7
SeaCoast Inn

3. The Cove at Yarmouth by Westgate Resorts

The Cove at Yarmouth by Westgate Resorts
2.1 km from Main Street Hyannis
United States
BELKIS
$139
$159 total
includes taxes & fees
Oct 25 - Oct 26
The Cove at Yarmouth by Westgate Resorts

4. Heritage House Inn on Cape Cod, an Ascend Collection Hotel

Heritage House Inn on Cape Cod, an Ascend Collection Hotel
0.3 km from Main Street Hyannis
United States
Bryan
$127
$145 total
includes taxes & fees
Oct 18 - Oct 19
Heritage House Inn on Cape Cod, an Ascend Collection Hotel

5. Bayside Resort Hotel

Bayside Resort Hotel
2.3 km from Main Street Hyannis
United States
Adriana
$140
$172 total
includes taxes & fees
Oct 27 - Oct 28
Bayside Resort Hotel

6. Cape Cod Inn

Cape Cod Inn
0.2 km from Main Street Hyannis
United States
Jerry
$102
$117 total
includes taxes & fees
Sep 28 - Sep 29
Cape Cod Inn

7. Doubletree by Hilton Cape Cod - Hyannis

Doubletree by Hilton Cape Cod - Hyannis
0.9 km from Main Street Hyannis
United States
ashwini
$141
$161 total
includes taxes & fees
Oct 25 - Oct 26
Doubletree by Hilton Cape Cod - Hyannis

8. Sea Breeze Inn

Sea Breeze Inn
1.8 km from Main Street Hyannis
United States
Phillip
$120
$137 total
includes taxes & fees
Oct 23 - Oct 24
Sea Breeze Inn

9. Sunbird Cape Cod Resort

Sunbird Cape Cod Resort
2.3 km from Main Street Hyannis
United States
Eva
$101
$116 total
includes taxes & fees
Oct 5 - Oct 6
Sunbird Cape Cod Resort

10. Econo Lodge West Yarmouth on Cape Cod

Econo Lodge West Yarmouth on Cape Cod
1.5 km from Main Street Hyannis
United States
Dawn
$80
$91 total
includes taxes & fees
Sep 30 - Oct 1
Econo Lodge West Yarmouth on Cape Cod

11. Sea Street Inn

Sea Street Inn
1.5 km from Main Street Hyannis
United States
Frank
$276
$316 total
includes taxes & fees
Oct 25 - Oct 26
Sea Street Inn

12. Green Harbor Resort

Green Harbor Resort
2.1 km from Main Street Hyannis
United States
Doreen
$169
$215 total
includes taxes & fees
Oct 1 - Oct 2
Green Harbor Resort

13. Anchor In Distinctive Waterfront Lodging

Anchor In Distinctive Waterfront Lodging
0.6 km from Main Street Hyannis
United States
Jovian
$161
$212 total
includes taxes & fees
Oct 4 - Oct 5
Anchor In Distinctive Waterfront Lodging

14. Cape Cod Harbor House Inn

Cape Cod Harbor House Inn
0.4 km from Main Street Hyannis
United States
Jeanne
$135
$155 total
includes taxes & fees
Oct 4 - Oct 5
Cape Cod Harbor House Inn

15. Uncommoner Hotel by Reverie Boutique Collection

Uncommoner Hotel by Reverie Boutique Collection
1.9 km from Main Street Hyannis
United States
Richard
$119
$141 total
includes taxes & fees
Oct 13 - Oct 14
Uncommoner Hotel by Reverie Boutique Collection

16. Hampton Inn & Suites Cape Cod-West Yarmouth

Hampton Inn & Suites Cape Cod-West Yarmouth
1.7 km from Main Street Hyannis
United States
robert
$122
$140 total
includes taxes & fees
Oct 13 - Oct 14
Hampton Inn & Suites Cape Cod-West Yarmouth

17. Fairfield Inn & Suites by Marriott Cape Cod Hyannis

Fairfield Inn & Suites by Marriott Cape Cod Hyannis
2.3 km from Main Street Hyannis
United States
Kevin
$152
$174 total
includes taxes & fees
Oct 25 - Oct 26
Fairfield Inn & Suites by Marriott Cape Cod Hyannis

18. Courtyard By Marriott Cape Cod Hyannis

Courtyard By Marriott Cape Cod Hyannis
1.7 km from Main Street Hyannis
United States
Alexis
$136
$156 total
includes taxes & fees
Oct 25 - Oct 26
Courtyard By Marriott Cape Cod Hyannis

19. Cape Sands Inn

Cape Sands Inn
1.9 km from Main Street Hyannis
United States
Barry
$81
$92 total
includes taxes & fees
Sep 28 - Sep 29
Cape Sands Inn

20. Comfort Inn Hyannis - Cape Cod

Comfort Inn Hyannis - Cape Cod
0.3 km from Main Street Hyannis
Canada
Cindy
$107
$123 total
includes taxes & fees
Oct 22 - Oct 23
Comfort Inn Hyannis - Cape Cod
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Compare popular hotels close to Main Street Hyannis

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
A multi-story hotel with balconies, a flat roof, and a clear sky.
Hyannis Travel Inn
9.6
Exceptional
1,019 reviews
View
A hotel room with a large bed, a chair, a table, and a window with curtains.
SeaCoast Inn
9.0
Wonderful
886 reviews
View
A pool area with lounge chairs and flags.
The Cove at Yarmouth by Westgate Resorts
9.2
Wonderful
268 reviews
View
A covered walkway with wooden flooring, planter boxes with plants, and a white exterior wall.
Heritage House Inn on Cape Cod, an Ascend Collection Hotel
9.0
Wonderful
158 reviews
View
An indoor swimming pool with a wooden ceiling, potted plants, and lounge chairs.
Bayside Resort Hotel
8.8
Excellent
1,606 reviews
View

Other landmarks near Main Street Hyannis

A bronze statue of a man in a polo shirt standing in front of a building with a brick facade, white columns, and an American flag.

John F. Kennedy Hyannis Museum

8.8/10 (444 reviews)
The center of Hyannis is home to cultural attractions like John F. Kennedy Hyannis Museum, so you might want to stop by during your stay. Hotels.com travelers also say the area is family-friendly and has lots of nice beaches. If you want to experience more of the culture Hyannis has to offer, head to Main Street Hyannis, Hyannis Harbor, and Cape Cod Hospital.
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A model boat with a rope tied around it, displayed in a museum setting.

Cape Cod Maritime Museum

9.0/10 (16 reviews)
The center of Hyannis is home to cultural attractions like Cape Cod Maritime Museum, so you might want to stop by during your stay. Hotels.com travelers also say the area is family-friendly and has lots of nice beaches. If you want to experience more of the culture Hyannis has to offer, head to Hyannis Harbor, Main Street Hyannis, and John F. Kennedy Hyannis Museum.
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A white church with a steeple and a sign for Saint Francis Xavier Sunday masses.

St. Francis Xavier Church

8.6/10 (58 reviews)
St. Francis Xavier Church is 0.3 mi (0.5 km) from central Hyannis, why not stop by during your stay. Hotels.com travelers also say the area is family-friendly and has lots of nice beaches.
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A memorial plaque with a bust of John F. Kennedy surrounded by a stone wall.

John F. Kennedy Memorial

9.0/10 (262 reviews)
If seeing the sights is on your list of things to do, head to John F. Kennedy Memorial— just one of the landmarks located 0.8 mi (1.3 km) from central Hyannis. Hotels.com travelers also say the area is family-friendly and has lots of nice beaches.
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Hyannis Armory

If you're planning a bit of sightseeing during your trip, head to Hyannis Armory— just one of the monuments in central Hyannis.
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Hyannis Youth & Community Center

8.2/10 (22 reviews)
Hyannis Youth & Community Center is 0.5 mi (0.9 km) from central Hyannis, why not stop by during your stay.
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Zion Union Heritage Museum

6.0/10 (1 review)
Zion Union Heritage Museum is 0.6 mi (0.9 km) from central Hyannis, why not stop by during your stay. If you want to experience more of the culture Hyannis has to offer, head to Cape Cod Melody Tent, John F. Kennedy Hyannis Museum, and Main Street Hyannis.
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Commotion Charters

6.0/10 (3 reviews)
Commotion Charters is 0.6 mi (0.9 km) from central Hyannis, why not stop by during your stay. Why not take a stroll along the beaches and watch the sunset while you're here? If you have fun at Commotion Charters, you'll love Cape Cod Maritime Museum, just a short walk away.
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