A forest of tall pine trees at sunset.

Hotels in Perryville

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Dates

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Check prices for these dates

Tonight

Oct 20 - Oct 21

Tomorrow

Oct 21 - Oct 22

This weekend

Oct 23 - Oct 25

Next weekend

Where to stay in Perryville?

A hotel room with a large bed, a nightstand, a lamp, a chair, and a mirror.

A kitchen counter with a coffee machine, a kettle, and storage boxes.

A hotel lobby with seating areas, a television screen, and large windows.

A Holiday Inn Express hotel with a clear sky, a water tower, and a parking area.

1. Holiday Inn Express & Suites Perryville by IHG

Perryville

$101

$116 total

includes taxes & fees

Nov 1 - Nov 2

A hotel room with a large bathtub, a sofa, a small table, a TV, and a window with curtains.

A hotel lobby with two sofas, a coffee table, lamps, and a large window with a plant.

A hotel room with a kitchenette, a large mirror, a sofa, and a patterned carpet.

A hotel room with a large bed, a desk with a chair, a television, and a small table with a lamp.

2. Super 8 by Wyndham Perryville

Perryville

$68

$78 total

includes taxes & fees

Nov 8 - Nov 9

A rustic cabin-style lodging with a covered porch, picnic tables, and a fire pit.

A lakeside RV resort with wooden cabins, a picnic area, and a reflection in the water.

A playground with a wooden playhouse, a slide, and two animal-shaped swings.

A cabin interior with a kitchenette, a ceiling fan, a television, a sofa, and a window with blinds.

3. Perryville RV Resort

Perryville

$66

$76 total

includes taxes & fees

Oct 27 - Oct 28

A hotel room with a large bed, a bathroom with a bathtub, and a mirror reflecting the room.

A swimming pool with a metal ladder, a Days Inn sign, and a blue water tower in the background.

A hotel hallway with a patterned carpet, blue walls, and a sign indicating an office.

A kitchen with wooden cabinets, a dining area with a table and chairs, and various kitchen appliances.

4. Days Inn by Wyndham Perryville

Perryville

$68

$77 total

includes taxes & fees

Nov 2 - Nov 3

A hotel with a clear sign reading "Quality Inn" and "By Choice Hotels".

A hotel room with a large bathtub, a bed with two pillows, a nightstand, and a wall-mounted lamp.

A breakfast bar with a toaster, coffee maker, and fruit juice dispenser.

A lobby with a TV, framed pictures, a plant, and patterned chairs.

5. Quality Inn Perryville I-55

Perryville

$64

$73 total

includes taxes & fees

Nov 9 - Nov 10

A rustic interior with exposed brick walls, wooden railings, and a hanging floral chandelier.

A building with a sign that reads "The Atrium Boutique Hotel".

A building with a dark exterior, a large window, and a sign that reads "The Atrium."

A fireplace with a decorative mantel, a framed sign, and a small table with plants.

6. The Atrium - A Boutique Hotel

Perryville

$88

$101 total

includes taxes & fees

Oct 21 - Oct 22

A modern kitchen with a large island, stainless steel appliances, and exposed brick walls.

A large building with multiple green-roofed structures, surrounded by well-maintained lawns and a parking area.

A hallway with exposed brick walls, wooden flooring, and a white door.

A spacious living area with a large window, a ceiling fan, and a kitchen area with modern appliances.

7. Urban Lofts

Perryville

$224

$338 total

includes taxes & fees

Oct 21 - Oct 22

A modern kitchen with stainless steel appliances, a large window, and a green cabinet.

A room with a white door, a radiator, a blue carpet, and a mural on the wall.

A two-story building with a balcony, a front door with a wreath, and a sign indicating a restaurant.

A wooden interior with a dining area, staircase, and a television mounted on the wall.

8. The Mediterranean House 1858

Perryville

$503

$817 total

includes taxes & fees

Oct 21 - Oct 22

A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.

A hotel room with two beds, a brick wall, and a wooden headboard.

An indoor swimming pool with a wooden ceiling, lounge chairs, and a lifeguard chair.

A restaurant with a brick wall, a flat-screen TV, and a bar area.

9. Drury Inn & Suites Jackson MO

Jackson

$80

$85 total

includes taxes & fees

Oct 25 - Oct 26

A hotel room with a bed, a desk with a chair, a small table, a sofa, a bathtub, and a window with curtains.

A breakfast area with a counter, seating, and kitchen appliances.

A modern bathroom with a large bathtub, a wooden floor, and a dark wall with a colorful abstract painting.

A gym with treadmills, a weight machine, and exercise balls.

10. Baymont by Wyndham Chester IL

Chester

$80

$89 total

includes taxes & fees

Nov 15 - Nov 16

A modern retail area with a display of local items and snacks.

A modern indoor seating area with blue sofas and tables, a patterned carpet, and large windows offering a view of the outdoors.

A hotel room with two beds, a desk, a chair, a TV, and a window with a view.

A modern lounge area with seating options including sofas, chairs, and a hanging chair, with large windows providing a view of the outdoors.

11. Tru By Hilton Cape Girardeau

Cape Girardeau

$89

$102 total

includes taxes & fees

Oct 26 - Oct 27

A row of single-story houses with attached garages, a paved driveway, and a clear sky.

A modern living room with a flat-screen TV, a desk with a computer, two armchairs, a coffee table, and large windows with a view.

A hotel room with two beds, a desk, a chair, and a window with curtains.

A reception desk with a digital map of the USA, a wooden reception area, and a sign for 'MICROHOTEL BY JYNDHAMI'.

12. Microtel Inn & Suites by Wyndham Sainte Genevieve

Ste Genevieve

$84

$98 total

includes taxes & fees

Nov 15 - Nov 16

Room

A room with a wooden table, two patterned chairs, a framed artwork on the wall, and a window with brown curtains.

A compact kitchen with black cabinets, a black refrigerator, a microwave, and a sink.

A parking lot with a sign for Triangle Inn.

13. Triangle Inn Motel

Ste Genevieve

$59

$70 total

includes taxes & fees

Nov 8 - Nov 9

A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.

An indoor swimming pool with a clear blue water, tiled floor, and a ceiling with recessed lighting.

A modern hotel with a prominent 'La Quinta' sign, a covered entrance, and a landscaped entrance area.

A hotel room with a bed, a sofa, a coffee table, a TV, and a lamp.

14. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Jackson

$80

$86 total

includes taxes & fees

Nov 1 - Nov 2

A hotel room with two beds, a desk, a chair, a TV, and a projector screen.

A coffee station with two espresso machines, a coffee press, and various coffee cups and containers.

An indoor swimming pool with four lounge chairs and a metal ladder.

A reception area with two reception desks, a wall-mounted sign, and a refrigerator.

15. Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

Murphysboro

$108

$120 total

includes taxes & fees

Oct 29 - Oct 30

A large, two-story house with a wrap-around porch and a central tower.

A dining room with a wooden table set for four, surrounded by upholstered chairs. A large wooden cabinet with intricate carvings is positioned against the wall.

A covered patio with a picnic table, surrounded by a brick pathway and greenery.

A room with a red velvet sofa, a chandelier, a mirror, and a vanity with a sink.

16. The Conner House B&B

Prairie du Rocher

$156

$173 total

includes taxes & fees

Oct 21 - Oct 22

A motel with a covered entrance, a flag, and a phone number.

A hotel room with two beds, a desk, a chair, a TV, and a bathroom.

A spacious kitchen with a dining area, featuring a ceiling fan, a TV mounted on the wall, and a large rug in the center.

A reception desk with a wooden finish, a framed black and white cityscape, and a large framed Eiffel Tower picture.

17. Madison Inn Lodge

Fredericktown

$88

$96 total

includes taxes & fees

Oct 21 - Oct 22

A kitchen with dark wooden cabinets, a stainless steel refrigerator, a black stove, a microwave, and a sink.

A trophy labeled "Town House Inn" with "Cape Girardeau County, Missouri" and "2025" on it.

A hotel room with two beds, a wooden dresser, a bathroom with a shower, and a kitchen area.

Exterior

18. Town House Inn

Jackson

$71

$77 total

includes taxes & fees

Oct 21 - Oct 22

A spacious lobby with large windows, comfortable seating, and a modern ceiling design.

A breakfast bar with coffee machines, a cereal dispenser, and a fruit display.

A room with large windows, two red upholstered chairs, a small table, and a potted plant.

A hotel room with a bed, a dark sofa, an ottoman, a lamp, and artwork on the wall.

19. Comfort Suites Jackson-Cape Girardeau

Jackson

$76

$82 total

includes taxes & fees

Nov 9 - Nov 10

A hotel room with two beds, a nightstand with a lamp, a small window, and curtains.

A reception area with a 'KEEP OUT' sign, a clock, an American flag, a wall-mounted television, and a plant.

A room with a sofa, a fan, a door with a sign, and a window.

A small, enclosed shower stall with a drain, a towel rack, and a shower control knob.

20. Sparta Motel Near St. Louis / Mississippi River IL

Sparta

$70

$85 total

includes taxes & fees

Nov 1 - Nov 2

View all properties

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Tonight
Tomorrow

A hotel room with a large bathtub, a sofa, a small table, a TV, and a window with curtains.

A hotel lobby with two sofas, a coffee table, lamps, and a large window with a plant.

A hotel room with a kitchenette, a large mirror, a sofa, and a patterned carpet.

A hotel room with a large bed, a desk with a chair, a television, and a small table with a lamp.

Super 8 by Wyndham Perryville

Perryville

$93

per night

$106 total

includes taxes & fees

A hotel room with a large bed, a nightstand, a lamp, a chair, and a mirror.

A kitchen counter with a coffee machine, a kettle, and storage boxes.

A hotel lobby with seating areas, a television screen, and large windows.

A Holiday Inn Express hotel with a clear sky, a water tower, and a parking area.

Holiday Inn Express & Suites Perryville by IHG

Perryville

$139

per night

$159 total

includes taxes & fees

A Days Inn with a covered parking area, a gas station, and a row of parked cars.

A swimming pool with a metal ladder, a Days Inn sign, and a blue water tower in the background.

A Days Inn with a brick facade, a parking lot, and a clear sky.

A hotel room with a large bed, two bedside lamps, a flat-screen TV, a desk with a telephone, a chair, a window with curtains, and a wall-mounted air conditioner.

Days Inn by Wyndham Perryville

Perryville

$73

per night

$84 total

includes taxes & fees

A rustic interior with exposed brick walls, wooden railings, and a hanging floral chandelier.

A building with a sign that reads "The Atrium Boutique Hotel".

A building with a dark exterior, a large window, and a sign that reads "The Atrium."

A fireplace with a decorative mantel, a framed sign, and a small table with plants.

The Atrium - A Boutique Hotel

Perryville

$88

per night

$101 total

includes taxes & fees

A lobby with a TV, framed pictures, a plant, and patterned chairs.

A breakfast bar with a toaster, coffee maker, and fruit juice dispenser.

A hotel room with a large bathtub, a bed with two pillows, a nightstand, and a wall-mounted lamp.

A hotel reception desk with a sign that reads "Quality by Choice Hotels."

Quality Inn Perryville I-55

Perryville

$89

per night

$102 total

includes taxes & fees

A modern kitchen with a large island, stainless steel appliances, and exposed brick walls.

A large building with multiple green-roofed structures, surrounded by well-maintained lawns and a parking area.

A hallway with exposed brick walls, wooden flooring, and a white door.

A spacious living area with a large window, a ceiling fan, and a kitchen area with modern appliances.

Urban Lofts

Perryville

$224

per night

$338 total

includes taxes & fees

A modern kitchen with stainless steel appliances, a large window, and a green cabinet.

A room with a white door, a radiator, a blue carpet, and a mural on the wall.

A two-story building with a balcony, a front door with a wreath, and a sign indicating a restaurant.

A wooden interior with a dining area, staircase, and a television mounted on the wall.

The Mediterranean House 1858

Perryville

$503

per night

$817 total

includes taxes & fees

A rustic cabin-style lodging with a covered porch, picnic tables, and a fire pit.

A lakeside RV resort with wooden cabins, a picnic area, and a reflection in the water.

A playground with a wooden playhouse, a slide, and two animal-shaped swings.

A cabin interior with a kitchenette, a ceiling fan, a television, a sofa, and a window with blinds.

Perryville RV Resort

Perryville

A hotel room with a large bathtub, a sofa, a small table, a TV, and a window with curtains.

A hotel lobby with two sofas, a coffee table, lamps, and a large window with a plant.

A hotel room with a kitchenette, a large mirror, a sofa, and a patterned carpet.

A hotel room with a large bed, a desk with a chair, a television, and a small table with a lamp.

Super 8 by Wyndham Perryville

Perryville

$9 off

$80

per night

$92 total

includes taxes & fees

A hotel room with a large bed, a nightstand, a lamp, a chair, and a mirror.

A kitchen counter with a coffee machine, a kettle, and storage boxes.

A hotel lobby with seating areas, a television screen, and large windows.

A Holiday Inn Express hotel with a clear sky, a water tower, and a parking area.

Holiday Inn Express & Suites Perryville by IHG

Perryville

$144

per night

$165 total

includes taxes & fees

A two-story wooden cabin with a porch, a stone foundation, and a gravel driveway.

A rustic cabin-style lodging with a covered porch, picnic tables, and a fire pit.

A log cabin with a green metal roof, a wooden porch with a bench, and a small window.

A cabin interior with a kitchenette, a ceiling fan, a television, a sofa, and a window with blinds.

Perryville RV Resort

Perryville

$68

per night

$78 total

includes taxes & fees

A rustic interior with exposed brick walls, wooden railings, and a hanging floral chandelier.

A building with a sign that reads "The Atrium Boutique Hotel".

A building with a dark exterior, a large window, and a sign that reads "The Atrium."

A fireplace with a decorative mantel, a framed sign, and a small table with plants.

The Atrium - A Boutique Hotel

Perryville

$88

per night

$101 total

includes taxes & fees

A hotel room with a large bed, a bathroom with a bathtub, and a mirror reflecting the room.

A swimming pool with a metal ladder, a Days Inn sign, and a blue water tower in the background.

A hotel hallway with a patterned carpet, blue walls, and a sign indicating an office.

A kitchen with wooden cabinets, a dining area with a table and chairs, and various kitchen appliances.

Days Inn by Wyndham Perryville

Perryville

$8 off

$69

per night

$79 total

includes taxes & fees

A lobby with a TV, framed pictures, a plant, and patterned chairs.

A breakfast bar with a toaster, coffee maker, and fruit juice dispenser.

A hotel room with a large bathtub, a bed with two pillows, a nightstand, and a wall-mounted lamp.

A hotel reception desk with a sign that reads "Quality by Choice Hotels."

Quality Inn Perryville I-55

Perryville

$89

per night

$102 total

includes taxes & fees

A modern kitchen with a large island, stainless steel appliances, and exposed brick walls.

A large building with multiple green-roofed structures, surrounded by well-maintained lawns and a parking area.

A hallway with exposed brick walls, wooden flooring, and a white door.

A spacious living area with a large window, a ceiling fan, and a kitchen area with modern appliances.

Urban Lofts

Perryville

$224

per night

$338 total

includes taxes & fees

A residential backyard with a patio, outdoor seating, and a barbecue grill.

A historic house with a front porch, a sign indicating it is a museum, and a well-maintained lawn.

A bedroom with a bed, a chest of drawers, a dresser, a television, and a ceiling fan.

A wooden interior with a dining area, staircase, and a television mounted on the wall.

The Mediterranean House 1858

Perryville

$503

per night

$817 total

includes taxes & fees

Check out pet-friendly hotels in Perryville

A hotel room with a large bathtub, a sofa, a small table, a TV, and a window with curtains.

A hotel lobby with two sofas, a coffee table, lamps, and a large window with a plant.

A hotel room with a kitchenette, a large mirror, a sofa, and a patterned carpet.

A hotel room with a large bed, a desk with a chair, a television, and a small table with a lamp.

Super 8 by Wyndham Perryville

Perryville

$68

$78 total

includes taxes & fees

Nov 8 - Nov 9

A hotel room with a large bed, a bathroom with a bathtub, and a mirror reflecting the room.

A swimming pool with a metal ladder, a Days Inn sign, and a blue water tower in the background.

A hotel hallway with a patterned carpet, blue walls, and a sign indicating an office.

A kitchen with wooden cabinets, a dining area with a table and chairs, and various kitchen appliances.

Days Inn by Wyndham Perryville

Perryville

$68

$77 total

includes taxes & fees

Nov 2 - Nov 3

A building with a dark exterior, a large window, and a sign that reads "The Atrium."

A bedroom with a bed, a nightstand, a dresser, a ceiling fan, and a window with curtains.

A modern bathroom with a hexagonal tile wall, a shower with a curved head, and a bathtub.

A living room with a sofa, a coffee table, and a window with curtains.

The Atrium - A Boutique Hotel

Perryville

$88

$101 total

includes taxes & fees

Oct 21 - Oct 22

A rustic cabin-style lodging with a covered porch, picnic tables, and a fire pit.

A lakeside RV resort with wooden cabins, a picnic area, and a reflection in the water.

A playground with a wooden playhouse, a slide, and two animal-shaped swings.

A cabin interior with a kitchenette, a ceiling fan, a television, a sofa, and a window with blinds.

Perryville RV Resort

Perryville

$66

$76 total

includes taxes & fees

Oct 27 - Oct 28

A building with a sign reading "URBAN LOFTS" and a storefront with a sign that says "STREET BREW."

A building with a sign reading "URBANLOFTS" and a staircase leading to an entrance.

A spacious living area with a large window, a ceiling fan, and a kitchen area with modern appliances.

A modern bathroom with a wooden vanity, a large mirror, and a white sink.

Urban Lofts

Perryville

$224

$338 total

includes taxes & fees

Oct 21 - Oct 22

View all properties

Go beyond your typical stay in Perryville

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Our prices for hotels in Perryville are cheapest in December

Top landmarks in Perryville

National Shrine of Our Lady of the Miraculous Medal

8.8/10 (19 reviews)

National Shrine of Our Lady of the Miraculous Medal is just one of the landmarks located 0.8 mi (1.2 km) from central Perryville, so you might want to stop by for a few pics during your trip.

Perryville Country Club

6.6/10 (7 reviews)

You might want to practice your swing at Perryville Country Club, a golf course located 0.8 mi (1.3 km) from central Perryville.

Missouri's National Veterans Memorial

9.2/10 (14 reviews)

You might want to get your camera out and head to Missouri's National Veterans Memorial— just one of the landmarks located 2.3 mi (3.7 km) from central Perryville.

Saint Marys Lake

Saint Marys Lake is 1 mi (1.7 km) from central Perryville, why not stop by during your stay.

Perryville City Hall

Perryville City Hall is worth a visit, located 0.8 mi (1.3 km) from central Perryville.

James M. Eddleman Millitary Museum

James M. Eddleman Millitary Museum is 2.3 mi (3.8 km) from central Perryville, why not stop by during your stay. If you want to experience more of the culture Perryville has to offer, head to National Shrine of Our Lady of the Miraculous Medal, Saint Marys Lake, and Perry County Memorial Hospital.

County Lake State Wildlife Management Area

County Lake State Wildlife Management Area is 1.9 mi (3.1 km) from central Perryville, why not stop by during your stay. Want to stretch your legs some more? Head to Feltz Street Park, located nearby.

Feltz Street Park

Feltz Street Park is 0.3 mi (0.5 km) from central Perryville, why not stop by during your stay. Want to stretch your legs some more? Head to County Lake State Wildlife Management Area, located nearby.

Perryville and related destinations

Perryville is well-known for its attractions such as National Shrine of Our Lady of the Miraculous Medal and Mark Twain National Forest.

See all hotels in Perryville

A forest of tall pine trees at sunset.

Check out reviews of Perryville hotels guests love

A modern kitchen with a large island, stainless steel appliances, and exposed brick walls.

A large building with multiple green-roofed structures, surrounded by well-maintained lawns and a parking area.

A hallway with exposed brick walls, wooden flooring, and a white door.

A spacious living area with a large window, a ceiling fan, and a kitchen area with modern appliances.

Urban Lofts

Perryville

10/10 Exceptional

United States

Gregory

A hotel room with a large bathtub, a sofa, a small table, a TV, and a window with curtains.

A hotel lobby with two sofas, a coffee table, lamps, and a large window with a plant.

A hotel room with a kitchenette, a large mirror, a sofa, and a patterned carpet.

A hotel room with a large bed, a desk with a chair, a television, and a small table with a lamp.

Super 8 by Wyndham Perryville

Perryville

10/10 Exceptional

United States

DAN

A Days Inn with a covered parking area, a gas station, and a row of parked cars.

A swimming pool with a metal ladder, a Days Inn sign, and a blue water tower in the background.

A Days Inn with a brick facade, a parking lot, and a clear sky.

A hotel room with a large bed, two bedside lamps, a flat-screen TV, a desk with a telephone, a chair, a window with curtains, and a wall-mounted air conditioner.

Days Inn by Wyndham Perryville

Perryville

10/10 Exceptional

United States

Anonymous traveler

A large, two-story house with a wrap-around porch and a central tower.

A dining room with a wooden table set for four, surrounded by upholstered chairs. A large wooden cabinet with intricate carvings is positioned against the wall.

A covered patio with a picnic table, surrounded by a brick pathway and greenery.

A room with a red velvet sofa, a chandelier, a mirror, and a vanity with a sink.

The Conner House B&B

Prairie du Rocher

10/10 Exceptional

Waited until the last minute to book a place to stay for an event in Redbud. Everything there was booked so had to expand our search and boy was that a blessing. Ended up at the Conner House and found a beautifully restored 1906 bed and breakfast. Very charming and inviting and took us back in time. Had a wonderful stay, learned a little history and had a great breakfast all thanks to our hostesses Pat & Connie. Forget the national chain - this is a must see house and getting to spend the...

United States

Anonymous traveler

A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.

A hotel room with two beds, a brick wall, and a wooden headboard.

An indoor swimming pool with a wooden ceiling, lounge chairs, and a lifeguard chair.

A restaurant with a brick wall, a flat-screen TV, and a bar area.

Drury Inn & Suites Jackson MO

Jackson

10/10 Exceptional

United States

Nicole

A modern indoor pool area with lounge chairs, a pool rules sign, and a view of the outside.

A multi-story hotel with a modern design, featuring a parking lot in front.

A hotel room with two beds, a desk, a chair, a TV, and a window with a view.

Tru By Hilton Cape Girardeau

Cape Girardeau

10/10 Exceptional

United States

sterling

A breakfast buffet area with a display of cinnamon sweet rolls, a sign indicating the roll selection, and a patterned wall in the background.

A hot tub area with a view of the parking lot through a glass door.

A hotel room with a large flat-screen TV, a desk with drawers, a bench, and a wardrobe.

A coffee station with two coffee machines, a coffee press, and various coffee-related items on a wooden counter.

Holiday Inn Express Hotel & Suites Sparta by IHG

Sparta

10/10 Exceptional

stayed here for a business trip and it was perfect. Staff was very friendly, beds were comfortable, and I appreciated the "fitness center." Breakfast was also great, with a huge array of choices. My only complaint would be that there was a light right outside the window in my room (first floor) and there were no blackout curtains to hide that mean light. Even so, it was a very good overall experience and I would stay there again.

United States

Sarah

A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.

An outdoor patio with tables and chairs, a stone wall, and large windows.

A reception desk with a large mural of a bridge, wooden reception area, and a potted plant.

A breakfast bar with a coffee machine, waffle maker, toaster, and various food items.

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Jackson

10/10 Exceptional

United States

Alexandra

A hotel room with a bed, a desk with a chair, a small table, a sofa, a bathtub, and a window with curtains.

A breakfast area with a counter, seating, and kitchen appliances.

A modern bathroom with a large bathtub, a wooden floor, and a dark wall with a colorful abstract painting.

A gym with treadmills, a weight machine, and exercise balls.

Baymont by Wyndham Chester IL

Chester

10/10 Exceptional

United States

Michael

A hotel room with two beds, each with a patterned bedspread, a nightstand with a lamp, and a wall-mounted light fixture.

Room

Room

A compact room with a bed, a TV on a dresser, a microwave, and a small kitchenette.

Triangle Inn Motel

Ste Genevieve

10/10 Exceptional

United States

Karie

A motel with a covered entrance, a flag, and a phone number.

A hotel room with two beds, a desk, a chair, a TV, and a bathroom.

A spacious kitchen with a dining area, featuring a ceiling fan, a TV mounted on the wall, and a large rug in the center.

A reception desk with a wooden finish, a framed black and white cityscape, and a large framed Eiffel Tower picture.

Madison Inn Lodge

Fredericktown

10/10 Exceptional

United States

Anonymous traveler

A kitchen with dark wooden cabinets, a stainless steel refrigerator, a black stove, a microwave, and a sink.

A trophy labeled "Town House Inn" with "Cape Girardeau County, Missouri" and "2025" on it.

A hotel room with two beds, a wooden dresser, a bathroom with a shower, and a kitchen area.

Exterior

Town House Inn

Jackson

10/10 Exceptional

United States

larry

A modern bedroom with a large bed, a desk with a computer, a chair, and a window with a view of a lake.

A motel with a blue exterior, a central garage entrance, and a parking lot with several cars.

Room

A bathroom with a beige sink, a mirror, a towel rack, and a trash bin.

Briarwood Inn of Sparta

Sparta

10/10 Exceptional

United States

Daniel

Frequently Asked Questions

What hotels do travelers recommend in Perryville?

Guests like Holiday Inn Express & Suites Perryville by IHG, Super 8 by Wyndham Perryville and Days Inn by Wyndham Perryville.

Can I book refundable accommodations in Perryville?

If you're looking for the flexibility to change your plans to Perryville, most hotels provide refundable* bookable rates. You can find these properties by searching our site and using the "fully refundable" filter to narrow down the results.

Where should I consider staying in Perryville if I want a budget-friendly accommodation?

A few inexpensive options worth considering are Holiday Inn Express & Suites Perryville by IHG, Days Inn by Wyndham Perryville and Quality Inn Perryville I-55.

Where can I stay in Perryville if I want a vacation rental instead of a traditional hotel?

You'll find 9 vacation homes on our site. In addition, you can choose from 5 apartments.

What will the weather in Perryville be like during my vacation?

July and August are typically the warmest months in Perryville when the average temp is 75°F. January and February are the coldest months when the average temperature is 39°F. April and May are the months with the most rain.

Why should I book my Perryville hotel with Hotels.com?

There are lots of reasons to book your Perryville trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.