Photo by Don Anderson

Business Hotels in Rochester

October 2026
2
November 2026

Free cancellation options if plans change

Earn rewards on every night you stay

Save more with Member Prices

Check prices for these dates

This weekend
Oct 2 - Oct 4
Next weekend
Oct 9 - Oct 11

Business Hotels in Rochester

1. EVEN Hotel Rochester - Mayo Clinic Area by IHG

EVEN Hotel Rochester - Mayo Clinic Area by IHG
Kutzky Park
$122
$154 total
includes taxes & fees
Oct 23 - Oct 24
EVEN Hotel Rochester - Mayo Clinic Area by IHG

2. Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG
Downtown Rochester
$107
$123 total
includes taxes & fees
Oct 23 - Oct 24
Hotel Indigo Rochester – Mayo Clinic Area by IHG

3. Hyatt House Rochester/Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area
Downtown Rochester
$118
$136 total
includes taxes & fees
Oct 17 - Oct 18
Hyatt House Rochester/Mayo Clinic Area

4. AmericInn by Wyndham Rochester Near Mayo Clinic

AmericInn by Wyndham Rochester Near Mayo Clinic
Rochester
$76
$87 total
includes taxes & fees
Oct 4 - Oct 5
AmericInn by Wyndham Rochester Near Mayo Clinic

5. Comfort Inn & Suites Rochester South Mayo Clinic

Comfort Inn & Suites Rochester South Mayo Clinic
Rochester
$78
$90 total
includes taxes & fees
Nov 1 - Nov 2
Comfort Inn & Suites Rochester South Mayo Clinic

6. Hampton Inn & Suites Rochester-North

Hampton Inn & Suites Rochester-North
Rochester
$98
$112 total
includes taxes & fees
Oct 24 - Oct 25
Hampton Inn & Suites Rochester-North

7. Spark by Hilton Rochester South

Spark by Hilton Rochester South
Rochester
$87
$100 total
includes taxes & fees
Nov 1 - Nov 2
Spark by Hilton Rochester South

8. Kahler Grand Hotel

Kahler Grand Hotel
Downtown Rochester
$147
$169 total
includes taxes & fees
Oct 28 - Oct 29
Kahler Grand Hotel

9. Brentwood Inn & Suites

Brentwood Inn & Suites
Downtown Rochester
$106
$122 total
includes taxes & fees
Oct 3 - Oct 4
Brentwood Inn & Suites

10. Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
Historic Southwest
$108
$124 total
includes taxes & fees
Oct 3 - Oct 4
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

11. Hilton Rochester Mayo Clinic Area

Hilton Rochester Mayo Clinic Area
Downtown Rochester
$180
$207 total
includes taxes & fees
Oct 17 - Oct 18
Hilton Rochester Mayo Clinic Area

12. Hilton Garden Inn Rochester Downtown, MN

Hilton Garden Inn Rochester Downtown, MN
Downtown Rochester
$114
$131 total
includes taxes & fees
Oct 23 - Oct 24
Hilton Garden Inn Rochester Downtown, MN

13. Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
Rochester
$95
$109 total
includes taxes & fees
Oct 9 - Oct 10
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

14. Home2 Suites by Hilton Rochester Mayo Clinic Area

Home2 Suites by Hilton Rochester Mayo Clinic Area
Rochester
$122
$141 total
includes taxes & fees
Oct 24 - Oct 25
Home2 Suites by Hilton Rochester Mayo Clinic Area

15. Comfort Inn & Suites West - Medical Center

Comfort Inn & Suites West - Medical Center
Rochester
$86
$99 total
includes taxes & fees
Oct 10 - Oct 11
Comfort Inn & Suites West - Medical Center

16. Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys
Kutzky Park
$112
$128 total
includes taxes & fees
Oct 17 - Oct 18
Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

17. TownePlace Suites by Marriott Rochester Mayo Clinic Area

TownePlace Suites by Marriott Rochester Mayo Clinic Area
Kutzky Park
$137
$158 total
includes taxes & fees
Oct 17 - Oct 18
TownePlace Suites by Marriott Rochester Mayo Clinic Area

18. Holiday Inn Express Rochester South - Mayo Area by IHG

Holiday Inn Express Rochester South - Mayo Area by IHG
Rochester
$100
$115 total
includes taxes & fees
Oct 18 - Oct 19
Holiday Inn Express Rochester South - Mayo Area by IHG

19. Med City Inn & Suites - Mayo Clinic Area

Med City Inn & Suites - Mayo Clinic Area
Kutzky Park
$71
$82 total
includes taxes & fees
Oct 3 - Oct 4
Med City Inn & Suites - Mayo Clinic Area

20. SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys
Kutzky Park
$112
$128 total
includes taxes & fees
Oct 17 - Oct 18
SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys
See more properties

Go beyond your typical stay in Rochester

pet friendly image
Pet friendly
Pet friendly
Pool image
Pool
Pool
hot tub image
Hot tub
Hot tub
spa image
Spa
Spa
Family friendly image
Family friendly
Family friendly
apart-hotel image
Apart hotel
Apart hotel
waterpark image
Waterpark
Waterpark
Apartment image
Apart­ment
Apart­ment
Cottage image
Cottage
Cottage

Top neighborhoods in Rochester

Downtown Rochester

Downtown Rochester revolves around Mayo Clinic's impressive medical campus where modern buildings and the historic Plummer Building create a distinctive skyline. The peaceful Peace Plaza offers a quiet spot with fountains and sculptures between appointments. Rochester Civic Theater and Mayo Civic Center provide cultural experiences, while nearby Silver Lake Park lets visitors unwind with scenic walking paths. Getting around is a breeze with the Mayo shuttle system connecting medical facilities and abundant public transit options. Hotels cater specifically to medical visitors with extended-stay amenities and clinic shuttles. Restaurants offer healthy dining choices with extended hours, understanding that healing happens on its own schedule.

Kutzky Park

Kutzky Park offers a charming retreat with tree-lined streets and well-preserved early 20th-century homes. Wander through the neighborhood's namesake park where mature oaks and maples shade winding paths and playgrounds. Architecture enthusiasts will appreciate the Craftsman and Colonial Revival styles that showcase Rochester's historical development. This quiet residential haven provides a genuine local experience away from tourist crowds. While dining options are limited within the neighborhood, downtown Rochester's restaurants are just a short drive away. Visitors typically stay in private home rentals or intimate bed-and-breakfasts with personalized local recommendations.

Historic Southwest

Historic Southwest offers a window into Rochester's medical heritage through grand century-old homes once built for Mayo Clinic physicians. Take peaceful strolls along tree-canopied streets showcasing Colonial Revival, Tudor, and Prairie architectural styles. The neighborhood's elegant brick facades, wraparound porches, and manicured gardens create a living museum atmosphere perfect for architecture enthusiasts and photographers. Accommodation options include upscale bed & breakfasts in converted physician mansions with period furnishings and personalized service. While dining and shopping require a quick 10-minute drive to downtown Rochester, the quiet residential atmosphere provides a welcome retreat from urban bustle.

East Side Pioneers

East Side Pioneers is a peaceful suburban retreat away from Rochester's downtown buzz. Visit the Rochester Art Center for local creativity or catch a performance at the Rochester Civic Theater. The neighborhood borders Mayo Park and Silver Lake Park, perfect spots for morning walks or afternoon picnics when you need a break from medical appointments or sightseeing. This budget-friendly area offers affordable extended-stay hotels and vacation rentals that won't break the bank. Most dining requires a quick 10-15 minute drive to downtown, where you'll find diverse restaurant options. The wide sidewalks and quiet streets make neighborhood exploration easy, even without a car.

Slatterly Park

Slatterly Park neighborhood invites visitors into authentic Rochester life away from tourist crowds. Tree-lined streets showcase charming Craftsman bungalows and Colonial Revivals, highlighting the city's architectural heritage. The namesake park provides serene green space where locals walk dogs and children play. Just beyond the quiet neighborhood borders, Rochester Art Center and Soldiers Field Veterans Memorial await exploration. This residential area is best navigated by car, though pleasant sidewalks under mature elm and oak trees make for delightful strolls. Downtown Rochester's dining and shopping options are just a short drive away. While accommodations within Slatterly Park are limited, its peaceful atmosphere makes it worth visiting regardless of where travelers choose to stay.

Top landmarks in Rochester

Mayo Civic Center

9.2/10 (818 reviews)
You could catch an event at Mayo Civic Center, a stadium in Downtown Rochester. If you think Mayo Civic Center is cool, you also might like Rochester Recreation Center and Regional Sports Center, both located nearby.
See properties

Apache Mall

8.6/10 (1,101 reviews)
If you like shopping, take time out to go to Apache Mall when in Rochester. It's also full of great shops and restaurants, so you can spend the afternoon having a wander.
See properties

Rochester Recreation Center

8.0/10 (205 reviews)
You can catch an event at Rochester Recreation Center, located 1.4 mi (2.3 km) from central Rochester. If you think Rochester Recreation Center is cool, you also might like Mayo Civic Center and National Volleyball Center, both located nearby.
See properties

National Volleyball Center

7.8/10 (151 reviews)
You can catch an event at National Volleyball Center, located 2.7 mi (4.4 km) from central Rochester. If you think National Volleyball Center is cool, you also might like Rochester Recreation Center and Regional Sports Center, both located nearby.
See properties

Regional Sports Center

8.0/10 (63 reviews)
You can catch an event at Regional Sports Center, located 2 mi (3.2 km) from central Rochester. If you think Regional Sports Center is cool, you also might like Mayo Civic Center and National Volleyball Center, both located nearby.
See properties

Olmsted County Fairgrounds

7.8/10 (177 reviews)
Why not give yourself a treat with a trip to Olmsted County Fairgrounds, one of the family attractions located 1.3 mi (2.1 km) from central Rochester. It's also full of great shops and restaurants, so you can spend the afternoon having a wander. If you have fun at Olmsted County Fairgrounds, you'll love Rochester Art Center and Minnesota Children's Museum, both located nearby.
See properties

Mayowood Mansion

9.4/10 (29 reviews)
You might want to get your camera out and head to Mayowood Mansion— just one of the landmarks located 3.6 mi (5.8 km) from central Rochester.
See properties

Quarry Hill Nature Center

10.0/10 (3 reviews)
Quarry Hill Nature Center is 1.8 mi (2.9 km) from central Rochester, why not stop by during your stay. Want to stretch your legs some more? Head to Silver Lake Park and Douglas State Trail Head Rochester, both nearby.
See properties