Hotels in La Mesa

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1. The Sofia Hotel

The Sofia Hotel
3.5 star property
Downtown San Diego
8.8 out of 10, Excellent, (2,778 reviews)
Unwind in the heart of San Diego at this historic hotel, just minutes from the convention center and Port. A 24-hour fitness center, on-site café, and room service enhance your stay. Within walking distance of USS Midway Museum and convenient transit options.
The price is $140
$187 total
includes taxes & fees
Dec 7 - Dec 8
The Sofia Hotel

2. Hard Rock Hotel San Diego

Hard Rock Hotel San Diego
4.0 star property
Downtown San Diego
9.0 out of 10, Wonderful, (4,594 reviews)
The price is $163
$237 total
includes taxes & fees
Nov 25 - Nov 26
Hard Rock Hotel San Diego

3. Wyndham San Diego Bayside

Wyndham San Diego Bayside
4.0 star property
Downtown San Diego
8.4 out of 10, Very good, (6,371 reviews)
Wake to stunning bay views at this waterfront hotel near Port of San Diego. Hop on the trolley at America Plaza Station, just 7 minutes away, or enjoy lunch at Hazelwoods Bayside Deli. The outdoor pool offers a refreshing retreat after exploring nearby Petco Park.
The price is $140
$197 total
includes taxes & fees
Nov 22 - Nov 23
Wyndham San Diego Bayside

4. Handlery Hotel

Handlery Hotel
3.5 star property
Mission Valley
8.4 out of 10, Very good, (3,053 reviews)
Experience a peaceful retreat with an outdoor pool, 2 restaurants, and poolside bar. Just 5 minutes from Mission Bay and steps to Fashion Valley Transit, you'll enjoy quiet surroundings while staying connected to San Diego Zoo and beach adventures.
The price is $90
$104 total
includes taxes & fees
Dec 1 - Dec 2
Handlery Hotel

5. The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection
3.0 star property
Downtown San Diego
8.8 out of 10, Excellent, (2,369 reviews)
Immerse yourself in San Diego's vibrant Little Italy at this Art Deco hotel. Take a dip in the outdoor pool, enjoy dinner at Ottutto, or grab drinks at the bar. Just 8 minutes from County Center station and a short drive to major attractions.
The price is $127
$147 total
includes taxes & fees
Nov 18 - Nov 19
The DEXTRO Little Italy, BW Premier Collection

6. California Suites Hotel

California Suites Hotel
2.0 star property
Clairemont
8.0 out of 10, Very good, (3,089 reviews)
The price is $99
$114 total
includes taxes & fees
Nov 15 - Nov 16
California Suites Hotel

7. Omni San Diego Hotel at the Ballpark

Omni San Diego Hotel at the Ballpark
4.0 star property
Downtown San Diego
9.4 out of 10, Exceptional, (2,432 reviews)
Immerse yourself in downtown San Diego at this welcoming hotel with an outdoor pool and poolside bar. Located minutes from the Convention Center and near public transit, this hotel offers massage services and a 24-hour fitness center for relaxation between adventures.
The price is $169
$241 total
includes taxes & fees
Nov 22 - Nov 23
Omni San Diego Hotel at the Ballpark

8. Days Inn by Wyndham San Diego Hotel Circle

Days Inn by Wyndham San Diego Hotel Circle
3.0 star property
Mission Valley
8.0 out of 10, Very good, (3,176 reviews)
This San Diego hotel offers an outdoor pool and hot tub for relaxation after sightseeing. Located just minutes from San Diego Zoo and Balboa Park with Fashion Valley Transit Center a 13-minute walk away.
The price is $84
$97 total
includes taxes & fees
Nov 29 - Nov 30
Days Inn by Wyndham San Diego Hotel Circle

9. Paradise Point Resort & Spa

Paradise Point Resort & Spa
4.0 star property
Mission Bay
8.8 out of 10, Excellent, (2,973 reviews)
Discover a serene paradise with lush tropical gardens and easy beach access. Rent boats right from the marina, dine at the Californian cuisine restaurant, or unwind with deep-tissue massages at the spa. Mission Bay's treasures and Port of San Diego are just minutes away.
The price is $199
$282 total
includes taxes & fees
Dec 13 - Dec 14
Paradise Point Resort & Spa

10. The Dana on Mission Bay

The Dana on Mission Bay
3.5 star property
Mission Bay
9.0 out of 10, Wonderful, (4,489 reviews)
Immerse yourself in coastal serenity at this Mission Bay hotel with stunning sunset vistas. Just minutes from Mission Beach, this haven offers 2 outdoor pools with poolside bars, plus a restaurant serving California cuisine. The marina location and garden landscapes create perfect vacation vibes.
The price is $157
$209 total
includes taxes & fees
Dec 1 - Dec 2
The Dana on Mission Bay

11. Lafayette Hotel & Club

Lafayette Hotel & Club
4.0 star property
University Heights
9.4 out of 10, Exceptional, (2,146 reviews)
Splash into vacation at the outdoor pool or grab lunch at Quixote, one of 2 restaurants at this San Diego gem. With Balboa Park nearby and free WiFi throughout, you're perfectly placed for both work and play.
The price is $273
$314 total
includes taxes & fees
Nov 16 - Nov 17
Lafayette Hotel & Club

12. Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego
4.0 star property
Downtown San Diego
9.0 out of 10, Wonderful, (2,900 reviews)
Coastal elegance awaits at this bayfront retreat just steps from Seaport Village. Enjoy 6 restaurants including Sally's Fish House, 3 bars, and an outdoor pool with stunning sunset views. The San Diego Convention Center and port are minutes away.
The price is $167
$248 total
includes taxes & fees
Dec 9 - Dec 10
Manchester Grand Hyatt San Diego

13. Legacy Resort Hotel & Spa

Legacy Resort Hotel & Spa
4.0 star property
Mission Valley
9.2 out of 10, Wonderful, (3,099 reviews)
Relax at this San Diego spa hotel just minutes from Old Town State Park. After enjoying the outdoor pool and poolside bar, recharge with deep-tissue massages and facials. The fitness center and coffee shop add convenience while nearby attractions await exploration.
The price is $199
$229 total
includes taxes & fees
Nov 15 - Nov 16
Legacy Resort Hotel & Spa

14. Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina
4.0 star property
Downtown San Diego
9.2 out of 10, Wonderful, (2,234 reviews)
The price is $209
$290 total
includes taxes & fees
Dec 11 - Dec 12
Marriott Marquis San Diego Marina

15. Crowne Plaza San Diego - Mission Valley by IHG

Crowne Plaza San Diego - Mission Valley by IHG
3.5 star property
Mission Valley
8.4 out of 10, Very good, (1,502 reviews)
Unwind at this San Diego hotel with an inviting outdoor pool and hot tub after exploring nearby attractions. The coffee shop and bar provide refreshing options, while the fitness center keeps your routine on track. Morena-Linda Vista Station is a 20-minute walk away.
The price is $114
$131 total
includes taxes & fees
Nov 16 - Nov 17
Crowne Plaza San Diego - Mission Valley by IHG

16. Hilton San Diego Bayfront

Hilton San Diego Bayfront
4.0 star property
Downtown San Diego
8.8 out of 10, Excellent, (2,539 reviews)
Luxurious retreat with an outdoor pool and poolside bar, just steps from Petco Park. Indulge in aromatherapy at the full-service spa, enjoy Californian cuisine at Hudson & Nash, and access the Gaslamp Quarter in 6 minutes.
The price is $156
$229 total
includes taxes & fees
Dec 11 - Dec 12
Hilton San Diego Bayfront

17. Best Western Seven Seas

Best Western Seven Seas
3.0 star property
Mission Valley
7.8 out of 10, Good, (4,045 reviews)
Tropical oasis near Fashion Valley Mall offers peaceful gardens and an outdoor pool with poolside bar. The Seven Seas Cafe serves meals all day, while 2 hot tubs provide relaxation. San Diego Zoo and Balboa Park are just minutes away.
The price is $85
$97 total
includes taxes & fees
Nov 15 - Nov 16
Best Western Seven Seas

18. The Horton Grand, Downtown/Gaslamp Quarter

The Horton Grand, Downtown/Gaslamp Quarter
3.5 star property
Downtown San Diego
9.2 out of 10, Wonderful, (2,998 reviews)
Immerse yourself in this beautifully preserved historic hotel with comfortable beds and a peaceful courtyard. Just minutes from the Convention Center, Seaport Village, and local cafes. Salt & Whiskey serves American cuisine after a day of nearby sightseeing.
The price is $138
$188 total
includes taxes & fees
Nov 24 - Nov 25
The Horton Grand, Downtown/Gaslamp Quarter

19. Courtyard by Marriott San Diego Downtown Little Italy

Courtyard by Marriott San Diego Downtown Little Italy
4.0 star property
Downtown San Diego
9.0 out of 10, Wonderful, (1,143 reviews)
Tucked into San Diego's Little Italy, this Courtyard boasts bay vistas and easy walks to local cafes. After exploring nearby Port of San Diego or USS Midway Museum, unwind at the outdoor pool or savor Mediterranean cuisine at Orexi.
The price is $152
$176 total
includes taxes & fees
Nov 19 - Nov 20
Courtyard by Marriott San Diego Downtown Little Italy

20. Marriott Vacation Club®, San Diego

Marriott Vacation Club®, San Diego
3.5 star property
Downtown San Diego
9.4 out of 10, Exceptional, (1,266 reviews)
The price is $144
$167 total
includes taxes & fees
Nov 30 - Dec 1
Marriott Vacation Club®, San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Go beyond your typical stay in La Mesa

When is the best time to visit La Mesa?

Our prices for hotels in La Mesa are cheapest in January

Price trends for hotels in La Mesa

Pricing is based on two traveler single night rates
View properties in November
Currently viewing crowd sizes and weather for November.

November

High 22°C / low 13°C. Sunny most days.
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November, no crowd data, average high temperature 22 degrees Celsius, average low temperature 13 degrees Celsius. Sunny most days.
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December, no crowd data, average high temperature 18 degrees Celsius, average low temperature 10 degrees Celsius. Sunny most days.
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January, no crowd data, average high temperature 19 degrees Celsius, average low temperature 10 degrees Celsius. Sunny most days.
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February, no crowd data, average high temperature 19 degrees Celsius, average low temperature 9 degrees Celsius. Sunny most days.
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March, no crowd data, average high temperature 20 degrees Celsius, average low temperature 10 degrees Celsius. Sunny most days.
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April, no crowd data, average high temperature 21 degrees Celsius, average low temperature 12 degrees Celsius. Sunny most days.
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May, no crowd data, average high temperature 22 degrees Celsius, average low temperature 13 degrees Celsius. Sunny most days.
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June, no crowd data, average high temperature 25 degrees Celsius, average low temperature 16 degrees Celsius. Sunny most days.
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July, no crowd data, average high temperature 28 degrees Celsius, average low temperature 19 degrees Celsius. Sunny most days.
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August, no crowd data, average high temperature 29 degrees Celsius, average low temperature 20 degrees Celsius. Sunny most days.
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September, no crowd data, average high temperature 28 degrees Celsius, average low temperature 19 degrees Celsius. Sunny most days.
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October, no crowd data, average high temperature 26 degrees Celsius, average low temperature 16 degrees Celsius. Sunny most days.
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Monthly weather averages (˚C)

Top neighborhoods in La Mesa

Casa de Oro-Mount Helix

La Mesa's Casa de Oro-Mount Helix neighborhood offers attractions including Mount Helix Park.

Mount Helix

The Mount Helix neighborhood offers attractions such as Mount Helix Park and FAITH CHAPEL.

Top landmarks in La Mesa

Learn more about La Mesa

Between the bustle of San Diego and the quiet of the hills, La Mesa lives up to its 'Jewel of the Hills' nickname without trying too hard. The historic Village area offers boutiques and cafés where locals actually eat, not just places that survive on tourist traffic. Mount Helix rewards a short climb with panoramic views that explain why everyone in California seems suspiciously content. Lake Murray Park provides a refreshing escape where fishing lines dangle alongside kayakers who've discovered this urban oasis. Train enthusiasts find unexpected delight at the Pacific Southwest Railway Museum, where vintage locomotives sit frozen in time.

A sunset over a mountainous landscape with scattered clouds.

Check out reviews of La Mesa hotels guests love

Frequently Asked Questions

What accommodations do travelers like in La Mesa?

Can I book a refundable accommodation in La Mesa?

If you need the flexibility to change your travel plans to La Mesa, most hotels offer refundable* bookable rates. You can see these accommodations by searching our site and using the "fully refundable" filter to narrow the results down.

Where can I stay in La Mesa if I want a vacation home instead of a hotel?

If you're looking for a good alternative to a hotel, review our selection of 65 vacation homes. In addition, you can choose from 10 apartments.

What will the weather in La Mesa be like during my trip?

August and September are typically the warmest months in La Mesa when the average temp is 72°F. February and January are the coldest months when the average temperature is 56°F. December and February are the months with the most rain.

Why should I book my La Mesa hotel through Hotels.com?

There are lots of reasons to book your La Mesa trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.