Hotels in La Mesa

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Tonight
Sep 27 - Sep 28
Tomorrow
Sep 28 - Sep 29
Next weekend
Oct 2 - Oct 4
In two weeks
Oct 9 - Oct 11

Where to stay in La Mesa?

A multi-story hotel with a brick facade, multiple windows, and a fire escape.
A hotel room with a large walk-in closet, a bed with white bedding, a bedside table with a lamp, and a wall-mounted mirror.
A Starbucks with a modern interior, including a wooden wall and a counter with a coffee machine.
A lobby with a seating area featuring two armchairs and a table, a decorative wall, and a chandelier.

1. The Sofia Hotel

The Sofia Hotel
Downtown San Diego
$151
$203 total
includes taxes & fees
Oct 25 - Oct 26
The Sofia Hotel
A modern bar area with a circular bar, multiple stools, and a large screen.
A Hard Rock Hotel with a prominent Hard Rock Cafe sign, a large marquee, and a modern building facade.
A modern lobby with a digital display wall, reception desks, and a spacious, well-lit area.

2. Hard Rock Hotel San Diego

Hard Rock Hotel San Diego
Downtown San Diego
$195
$274 total
includes taxes & fees
Oct 9 - Oct 10
Hard Rock Hotel San Diego
A hotel courtyard with outdoor seating, palm trees, and a view of the ocean at dusk.
A marina with multiple boats docked and tall buildings in the background.
A modern living room with a green sofa, a round glass table, and a flat-screen TV mounted on the wall.
A grocery store with refrigerated sections for beverages, shelves with snacks, and a display of packaged goods.

3. Wyndham San Diego Bayside

Wyndham San Diego Bayside
Downtown San Diego
$152
$211 total
includes taxes & fees
Oct 25 - Oct 26
Wyndham San Diego Bayside
A resort with a large swimming pool surrounded by lounge chairs and palm trees.
A bar area with wooden chairs and tables, a bar counter with various bottles, and a sign reading "BEACH BUMS CATER HERE".
A lobby with seating areas, a piano, and a reception desk.
A hotel with a curved entrance, palm trees, and a parking lot.

4. Handlery Hotel

Handlery Hotel
Mission Valley
$103
$119 total
includes taxes & fees
Sep 28 - Sep 29
Handlery Hotel
A hotel room with a large window offering a city view, a bed, a chair, and a small table.
A room with a view of a cityscape, a chair with a patterned cushion, and a floor lamp.
A tall, modern hotel with a curved facade, multiple balconies, and an American flag.
A modern reception area with a wooden reception desk, a large flat-screen TV displaying a scenic ocean view, and a seating area with pink chairs.

5. The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection
Downtown San Diego
$144
$167 total
includes taxes & fees
Sep 28 - Sep 29
The DEXTRO Little Italy, BW Premier Collection
A pathway flanked by neatly trimmed hedges and a building with a balcony.
A courtyard with a small water feature surrounded by rocks and greenery.
A courtyard with a small pond, trees, and a fountain.
A courtyard with a small pond, palm trees, and a building with balconies.

6. California Suites Hotel

California Suites Hotel
Clairemont
$89
$102 total
includes taxes & fees
Sep 29 - Sep 30
California Suites Hotel
A modern bar area with a curved counter, multiple bar stools, and a large window offering a view of the cityscape.
A rooftop lounge area with outdoor seating, a pool, and umbrellas.
A spacious lobby with a high ceiling, a large sectional sofa, multiple seating areas, and a modern chandelier.
A spacious lobby with large windows, curved ceiling, and comfortable seating areas.

7. Omni San Diego Hotel at the Ballpark

Omni San Diego Hotel at the Ballpark
Downtown San Diego
$258
$345 total
includes taxes & fees
Oct 5 - Oct 6
Omni San Diego Hotel at the Ballpark
A rectangular swimming pool with lounge chairs and umbrellas, surrounded by tall trees and greenery.
A hotel room with a large window with blinds, a round mirror, two teal chairs, a small round table, and a television on a wooden cabinet.
An outdoor seating area with wooden benches and tables, a shaded canopy, and a sign for a restaurant.
A compact kitchen with a microwave, coffee maker, and sink.

8. Days Inn by Wyndham San Diego Hotel Circle

Days Inn by Wyndham San Diego Hotel Circle
Mission Valley
$84
$97 total
includes taxes & fees
Oct 12 - Oct 13
Days Inn by Wyndham San Diego Hotel Circle
An aerial view of a resort with a central swimming pool, palm trees, and a view of the ocean and beach.
A modern building with a curved roof, surrounded by lush tropical vegetation.
An outdoor dining area with tables and chairs, umbrellas, and string lights against a sunset backdrop.
A waterfront hotel with a dock, palm trees, and a view of the water.

9. Paradise Point Resort & Spa

Paradise Point Resort & Spa
Mission Bay
$199
$282 total
includes taxes & fees
Oct 25 - Oct 26
Paradise Point Resort & Spa
A pool area with a hot tub, lounge chairs, and umbrellas.
A dining table set for a wedding with floral centerpieces and candles, overlooking a marina with boats.
An outdoor seating area with a fire pit table, surrounded by chairs and umbrellas, in a courtyard with palm trees and a building in the background.
A hotel room with a bed, a lamp, and a box of pizza.

10. The Dana on Mission Bay

The Dana on Mission Bay
Mission Bay
$169
$223 total
includes taxes & fees
Sep 28 - Sep 29
The Dana on Mission Bay
A bar area with a glass ceiling, a central bar counter, and multiple stools.
A luxurious interior with a large chandelier, patterned sofas, and a view of a cityscape through a large window.
A dimly lit room with patterned walls, a wooden table, and a chair.
A large swimming pool with lounge chairs and umbrellas, surrounded by palm trees and a building with a striped facade.

11. Lafayette Hotel & Club

Lafayette Hotel & Club
University Heights
$268
$308 total
includes taxes & fees
Oct 4 - Oct 5
Lafayette Hotel & Club
A rooftop pool with lounge chairs and umbrellas, a clear sky, and a high-rise building in the background.
A conference room with a wooden table, six grey upholstered chairs, a white door, two framed pictures on the wall, and a floor lamp.
A spacious hotel lobby with a long reception desk, wooden paneling, and a large window with a view.

12. Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego
Downtown San Diego
$231
$322 total
includes taxes & fees
Oct 25 - Oct 26
Manchester Grand Hyatt San Diego
A spacious lobby with modern furniture, large windows, and a high ceiling with hanging lights.
A modern interior with wooden panel ceilings, patterned seating, and a central bar area.
A pathway leading to a building labeled "LEGACY Hotel."
A swimming pool with blue lounge chairs and umbrellas, surrounded by a building with balconies.

13. Legacy Resort Hotel & Spa

Legacy Resort Hotel & Spa
Mission Valley
$177
$203 total
includes taxes & fees
Oct 28 - Oct 29
Legacy Resort Hotel & Spa
An aerial view of a resort with multiple swimming pools, lounge areas, and palm trees.
An outdoor patio area with tables and chairs, a fire pit, and string lights.
A modern hotel with a prominent circular tower and a glass facade.
A bar area with a long counter, multiple stools, and hanging wicker lamps.

14. Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina
Downtown San Diego
$285
$378 total
includes taxes & fees
Sep 30 - Oct 1
Marriott Marquis San Diego Marina
A hotel lobby with a waterfall feature, outdoor seating area, and multiple floors with balconies.
A swimming pool with a surrounding patio area, lounge chairs, and a building with multiple balconies.
A spacious lobby with two sofas, a reception desk, and a large chandelier.
A bar area with a long counter, multiple stools, and a television screen.

15. Crowne Plaza San Diego - Mission Valley by IHG

Crowne Plaza San Diego - Mission Valley by IHG
Mission Valley
$114
$131 total
includes taxes & fees
Oct 5 - Oct 6
Crowne Plaza San Diego - Mission Valley by IHG
A modern indoor swimming pool with lounge chairs and palm trees.
An outdoor dining area with multiple round tables and chairs, surrounded by palm trees and a view of the sea.
A modern bar area with a curved counter, bar stools, and a large chandelier.
A spacious outdoor lounge area with seating arrangements, a fire feature, and a view of the sunset.

16. Hilton San Diego Bayfront

Hilton San Diego Bayfront
Downtown San Diego
$188
$267 total
includes taxes & fees
Oct 25 - Oct 26
Hilton San Diego Bayfront
A hotel lobby with a 'Lobby' sign, palm trees, and a sunset sky.
An outdoor patio area with tables and chairs, red umbrellas, and a view of palm trees and a building with a 'BLW' sign.
A restaurant with a bar area, booths, and a view of the sunset through large windows.
A modern hotel lobby with a reception desk, seating area with chairs and a sofa, a ceiling fan, and a large window with curtains.

17. Best Western Seven Seas

Best Western Seven Seas
Mission Valley
$85
$97 total
includes taxes & fees
Sep 28 - Sep 29
Best Western Seven Seas
A restaurant with outdoor seating, brick walls, and decorative lighting.
A spacious lobby with a high ceiling, large windows, and a central chandelier.
A vintage car parked in front of a building with a sign that reads "Horton Grand Hotel."
A spacious lobby with a bar area, seating arrangements, and a large chandelier.

18. The Horton Grand, Downtown/Gaslamp Quarter

The Horton Grand, Downtown/Gaslamp Quarter
Downtown San Diego
$148
$199 total
includes taxes & fees
Sep 29 - Sep 30
The Horton Grand, Downtown/Gaslamp Quarter
A cityscape at dusk with high-rise buildings and a bridge in the distance.
A rooftop pool area with lounge chairs and umbrellas, surrounded by modern buildings and a cityscape at sunset.
A high-rise hotel with multiple floors, a prominent entrance, and a view of the surrounding cityscape and waterfront.
A modern bar area with a curved counter, bar stools, and a seating area with tables and chairs.

19. Courtyard by Marriott San Diego Downtown Little Italy

Courtyard by Marriott San Diego Downtown Little Italy
Downtown San Diego
$179
$208 total
includes taxes & fees
Sep 28 - Sep 29
Courtyard by Marriott San Diego Downtown Little Italy
A high-rise hotel with multiple floors, a prominent sign at the top, and a well-lit facade.
A lobby with a purple-lit ceiling, a large wall mural, and seating areas.
A spacious bar/lounge area with leather seating, a bar counter, and hanging pendant lights.
A spacious lobby with a high ceiling, leather seating, multiple tables, and a large flat-screen TV mounted on the wall.

20. Marriott Vacation Club®, San Diego

Marriott Vacation Club®, San Diego
Downtown San Diego
$169
$196 total
includes taxes & fees
Sep 28 - Sep 29
Marriott Vacation Club®, San Diego
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Our prices for hotels in La Mesa are cheapest in January
Price trends for hotels in La Mesa
Pricing is based on two traveler single night rates
View properties in September
Typical weather for La Mesa
September
High 28°C / low 19°C. Sunny most days.
View properties in September
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Monthly weather averages (˚C)

Top neighborhoods in La Mesa

A town with a mountain in the background, a clear sky, and scattered clouds.
A town with a mountain in the background.

Casa de Oro-Mount Helix

La Mesa's Casa de Oro-Mount Helix neighborhood offers attractions including Mount Helix Park.

A large white cross against a cloudy sky.

Mount Helix

The Mount Helix neighborhood offers attractions such as Mount Helix Park and FAITH CHAPEL.

Top landmarks in La Mesa

Mount Helix Park

7.4/10 (59 reviews)
If you're planning a bit of sightseeing head to Mount Helix Park— just one of the monuments in Casa de Oro-Mount Helix. Why not take a stroll along the port and watch the sunset while you're here?
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La Mesa Memorial Fine Arts Center

La Mesa Memorial Fine Arts Center is in the heart of La Mesa, so why not stop by during your stay. If you have fun at La Mesa Memorial Fine Arts Center, you'll love San Diego Zoo, which isn't far.
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FAITH CHAPEL

FAITH CHAPEL is a venue in Mount Helix.
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The Bancroft

If you find yourself in Mount Helix, you can stop off for a few drinks or snacks at The Bancroft.
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Learn more about La Mesa

Between the bustle of San Diego and the quiet of the hills, La Mesa lives up to its 'Jewel of the Hills' nickname without trying too hard. The historic Village area offers boutiques and cafés where locals actually eat, not just places that survive on tourist traffic. Mount Helix rewards a short climb with panoramic views that explain why everyone in California seems suspiciously content. Lake Murray Park provides a refreshing escape where fishing lines dangle alongside kayakers who've discovered this urban oasis. Train enthusiasts find unexpected delight at the Pacific Southwest Railway Museum, where vintage locomotives sit frozen in time.

See all hotels in La Mesa
A sunset over a mountainous landscape with scattered clouds.

Check out reviews of La Mesa hotels guests love

Bay Club Hotel & Marina

Bay Club Hotel & Marina

8/10 Good
"Your app stated that the self parking was free but I was charged $24 for self parking. Kindly refund this asap"
PARUL 1-night trip
Posted less than an hour ago
Bay Club Hotel & Marina
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

10/10 Excellent
"My first time staying at a hard rock hotel and I was very impressed. The staff was very helpful and friendly throughout my stay. Hotel is very clean. It’s within walking distance to everything Will definitely be staying here again if I’m in the San Diego area"
Sonia 1-night trip
Posted less than an hour ago
Hard Rock Hotel San Diego
Handlery Hotel

Handlery Hotel

10/10 Excellent
"To be honest the best we had such a great weekend and stay at this hotel we definitely recommend. It was my daughters birthday and she loved the stay as well."
Giovana 2-night trip
Posted less than an hour ago
Handlery Hotel
Paradise Point Resort & Spa

Paradise Point Resort & Spa

10/10 Excellent
"Loved it! Stayed for pifa weekend and they were even accommodating to my request for late check out"
Raenalyn 2-night trip
Posted 1 hour ago
Paradise Point Resort & Spa
The Sofia Hotel

The Sofia Hotel

8/10 Good
"The room was clean and had enough room for one person. The bathroom could have been a little cleaner and the walk-in shower was nice.."
Christina 4-night trip
Posted 6 hours ago
The Sofia Hotel

Frequently asked questions

What accommodations do travelers like in La Mesa?
Guests like Handlery Hotel, Best Western Seven Seas and California Suites Hotel.
Can I book a refundable accommodation in La Mesa?
If you need the flexibility to change your travel plans to La Mesa, most hotels offer refundable* bookable rates. You can see these accommodations by searching our site and using the "fully refundable" filter to narrow the results down.
Where can I stay in La Mesa if I want a vacation home instead of a hotel?
If you're looking for a good alternative to a hotel, review our selection of 64 vacation homes. In addition, you can choose from 10 apartments.
What will the weather in La Mesa be like during my trip?
August and September are typically the warmest months in La Mesa when the average temp is 72°F. February and January are the coldest months when the average temperature is 56°F. December and February are the months with the most rain.
Why should I book my La Mesa hotel through Hotels.com?
There are lots of reasons to book your La Mesa trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

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