Hotels in Jefferson

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Check prices for these dates

Tonight
Dec 26 - Dec 27
Tomorrow
Dec 27 - Dec 28
This weekend
Dec 26 - Dec 28
Next weekend
Jan 2 - Jan 4

Where to stay in Jefferson?

Exterior
Comfort Inn US Hwy 80
Comfort Inn US Hwy 80
2.5 star property
8.8 out of 10, Excellent, (192)
The price is $110
$124 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Comfort Inn US Hwy 80
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Check out reviews of Jefferson hotels guests love

Comfort Inn US Hwy 80

Comfort Inn US Hwy 80

10/10 Excellent
"I love it and it’s easy "
Eric 1-night trip
Posted 12 days ago
Comfort Inn US Hwy 80

Frequently asked questions

What accommodations do travelers like in Jefferson?
Guests like Days Inn by Wyndham Demopolis, Best Western Plus Two Rivers Hotel & Suites and Comfort Inn US Hwy 80.
Can I book a refundable hotel in Jefferson?
If you need the flexibility to change your plans to Jefferson, most hotels offer refundable* rates you can book. You can see these accommodations by searching our site and using the "fully refundable" filter to narrow the results down.
What will the weather in Jefferson be like during my trip?
July and August are typically the warmest months in Jefferson when the average temp is 80°F. January and February are the coldest months when the average temperature is 51°F. March and December are the months with the most rain.
Why should I book my Jefferson hotel through Hotels.com?
There are lots of reasons to book your Jefferson trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.