Hotels in Santa Fe

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Where to stay in Santa Fe?

A spacious indoor dining area with multiple tables and chairs, large windows offering a view of palm trees and greenery outside.

A modern office space with a reception desk, several chairs, a large window, and a colorful abstract painting on the wall.

A hotel room with a bed, a desk with a chair, a television, and a blue sofa.

A Holiday Inn Express & Suites hotel with a modern design, multiple floors, and a parking lot.

1. Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Alachua

$104

$117 total

includes taxes & fees

Sep 21 - Sep 22

A modern kitchen area with a central counter, various food stations, and a chalkboard menu.

A hotel room with two beds, a desk, a chair, a TV, and a couch.

2. Hampton Inn & Suites Alachua I-75

Alachua

$106

$119 total

includes taxes & fees

Sep 23 - Sep 24

A cozy restaurant with wooden beams, yellow walls, and a bar area with coffee machines.

A spacious lobby with a dining area, a kitchen, and a large window providing a view of the outdoors.

A reception desk with a sign reading "Quality by Choice Hotels," surrounded by various reptile decorations.

A hotel room with a bed, a desk with a chair, a television, a mirror, and a wardrobe.

3. Quality Inn Alachua - Gainesville Area

Alachua

$76

$85 total

includes taxes & fees

Oct 7 - Oct 8

A clean, modern cafe with a marble floor, a counter with coffee machines, and a clock on the wall.

A hotel room with two beds, a wooden headboard, a flat-screen TV, a desk with a chair, and a bathroom visible through an open door.

A two-story motel with a covered entrance, a parking lot, and a clear sky.

A corner of a store with shelves stocked with snacks, beverages, and a refrigerated display case.

4. Clarion Pointe Alachua - Gainesville Area

Alachua

$46

$57 total

includes taxes & fees

Sep 27 - Sep 28

A large, multi-story hotel with a central courtyard, palm trees, and an American flag.

A bar area with wooden chairs, a bar counter, and a television mounted on the wall.

A spacious dining area with multiple tables and chairs, a kitchen area with a coffee station, and large windows allowing natural light.

A living room with a brown leather sofa, a glass-top coffee table, and a framed picture on the wall.

5. Best Western Gateway Grand

Gainesville

$85

$95 total

includes taxes & fees

Sep 23 - Sep 24

A stone water feature with cascading water, surrounded by a brick wall and greenery.

A spacious living area with a wooden floor, a blue sofa, a round coffee table, and a ceiling fan.

A neatly arranged bedroom with a bed, bedside lamps, a TV, and a mirror.

A covered outdoor area with a paved walkway leading to a seating area, surrounded by greenery and a clear sky.

6. BlueGem Motel

High Springs

$95

$107 total

includes taxes & fees

Sep 23 - Sep 24

A modern hotel with a prominent 'La Quinta' sign, a covered entrance, and a well-maintained outdoor area with a parking lot.

A modern kitchen with blue-tiled walls, stainless steel appliances, and a central island.

A modern lounge area with a flat-screen TV, a fireplace, teal and brown seating, patterned carpet, and a wall-mounted clock.

A hotel lobby with a seating area featuring sofas and armchairs, a central coffee table, and a flat-screen TV mounted on the wall.

7. La Quinta by Wyndham Gainesville

Gainesville

$95

$107 total

includes taxes & fees

Sep 20 - Sep 21

A hotel room with two beds, a desk, a chair, and a television.

A bathroom with a white sink, mirror, and towel rack.

A large, empty parking lot with marked parking spaces and a few trees in the background.

A motel with a two-story structure, a covered front entrance, and a parking lot with several cars.

8. Royal Inn

Alachua

$80

$90 total

includes taxes & fees

Sep 18 - Sep 19

A hotel room with a bed, bedside tables, a desk, a chair, a mirror, and a window.

A reception area with a counter, a computer, and a bulletin board with pamphlets.

A bathroom with a large mirror, a sink, and a towel rack.

A corner room with two checkered chairs, a small table, a framed picture on the wall, and a floor lamp.

9. Palms Garden Inn

Lake City

$69

$78 total

includes taxes & fees

Sep 20 - Sep 21

A modern kitchen with a flat-screen TV, a microwave, and a coffee maker on a wooden cabinet. There is a window with a view of a green landscape.

A kitchen with a green refrigerator, a wooden countertop, a black kettle, and a wooden cutting board.

A living room with a grey sofa, a wooden coffee table, and a framed horse picture on the wall.

10. Vista Verde Farm Retreat

Lake City

$118

$203 total

includes taxes & fees

Oct 4 - Oct 5

A modern breakfast area with labeled dispensers for yogurt, eggs, and milk, a coffee machine, and a chalkboard menu.

A hotel room with two beds, a TV, a desk, and a chair.

A modern reception desk area with a blue geometric wall design, wooden accents, and a visible reception counter.

A Holiday Inn Express building with a modern design, featuring multiple windows and a flat roof.

11. Holiday Inn Express Starke by IHG

Starke

$105

$117 total

includes taxes & fees

Sep 20 - Sep 21

A spacious lobby with a sectional sofa, a wooden cabinet, and a television mounted on the wall.

A hotel room with two beds, a large headboard, bedside lamps, and a view of the outdoors through sheer curtains.

A hotel lobby with a stone wall, a flat-screen TV, orange upholstered seating, and a lamp.

A modern kitchen with wooden cabinets, a granite countertop, and pendant lighting.

12. Drury Inn & Suites Gainesville

Gainesville

$130

$146 total

includes taxes & fees

Sep 18 - Sep 19

A room with a wooden ceiling, two beds with patterned bedding, a desk, and a chair.

A row of motel buildings with a fire hydrant and trees in front.

A bedroom with a bed, a chair, a dresser, a ceiling fan, a window with blinds, and a wall-mounted air conditioner.

A stone outdoor seating area with a table and benches, a trash bin, and a building in the background.

13. High Springs Country Inn

High Springs

$72

$81 total

includes taxes & fees

Sep 27 - Sep 28

A modern building with a gray facade, a large window, and a landscaped area with a crocodile sculpture.

A modern dining area with tables and chairs, a kitchen counter, and a sign reading "höm cooking".

A hotel with a modern facade, a covered entrance, and a palm tree in front.

14. HOM Hotel Gainesville, SureStay Collection by Best Western

Gainesville

$72

$82 total

includes taxes & fees

Sep 23 - Sep 24

A swimming pool with a metal ladder, surrounded by a white fence and green chairs.

A hotel room with a bed, a sofa, a coffee table, and a small table with a lamp.

A refrigerated display case with beverages and snacks, and a shelf with bottled water and other beverages.

A living room with a curved sofa, a wooden cabinet, and a fish tank.

15. Best Western Waldo Inn and Suites

Waldo

$84

$95 total

includes taxes & fees

Sep 24 - Sep 25

A modern interior with a staircase, a seating area, and a colorful abstract wall design.

A modern hotel lobby with a round table featuring two drinks, a sofa, and a colorful wall art piece.

A spacious lobby with modern furniture, large windows, and a colorful abstract wall.

A modern bar area with a marble countertop, bar stools, and pendant lighting.

16. Hyatt Place Gainesville Downtown

Downtown Gainesville

$98

$110 total

includes taxes & fees

Sep 28 - Sep 29

A multi-story hotel with a central entrance, palm trees, and a clear sky.

A hotel room with a bed, a desk, a television, a sofa, and artwork on the wall.

A spacious hotel lobby with a modern staircase, a seating area with a sofa and chairs, and a dining area in the background.

A hotel room with a wooden floor, a red armchair, a beige sofa, a TV, and framed artwork on the wall.

17. Country Inn & Suites by Radisson, Gainesville, FL

Gainesville

$83

$94 total

includes taxes & fees

Sep 23 - Sep 24

A modern living room with a fireplace, comfortable seating, a flat-screen TV, and a large window.

A fire pit area surrounded by stone tiles, with a metal fence in the background.

A modern hotel lobby with a long dining table, multiple seating areas, and a large window with curtains.

A hotel room with a bed, a desk, a chair, a sofa, and a window.

18. Comfort Suites Gainesville near University

Gainesville

$80

$90 total

includes taxes & fees

Sep 23 - Sep 24

A modern bar area with wooden bar stools, pendant lighting, and artwork on the walls.

A hotel room with a living area, kitchenette, and a large mirror.

A hotel room with a kitchenette, a bed, a desk with a chair, and a bathroom.

A hotel reception desk with a wooden panel design, a digital kiosk, and a "Welcome to the Sun Shine State" sign.

19. Hampton Inn Gainesville

Gainesville

$97

$109 total

includes taxes & fees

Sep 20 - Sep 21

A hotel room with a bed, two bedside tables with lamps, a large bathtub, and green walls.

A hotel room with two beige armchairs, a small side table, a glass display cabinet with sports memorabilia, a mounted flat-screen TV, and a door with a wooden frame.

A breakfast bar with a juice dispenser, cereal boxes, and fruit bowls.

A Sleep Inn & Suites building with a clear entrance, a covered waiting area, and a parking lot.

20. Sleep Inn & Suites University/Shands

Gainesville

$76

$91 total

includes taxes & fees

Sep 23 - Sep 24

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Go beyond your typical stay in Santa Fe

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Apartment

Pool

Hot tub

Family friendly

Cottage

Check out reviews of Santa Fe hotels guests love

HOM Hotel Gainesville, SureStay Collection by Best Western

10/10 Excellent

"Room was newly renovated & clean. Staff was very nice."

Hyatt Place Gainesville Downtown

10/10 Excellent

"Perfect location that was around a ton of stuff. Clean and cozy."

Drury Inn & Suites Gainesville

10/10 Excellent

"Great!"

Sleep Inn & Suites University/Shands

10/10 Excellent

"W"

Holiday Inn Gainesville - University Center by IHG

10/10 Excellent

"Good location"

Comfort Inn Gainesville - University Area

10/10 Excellent

"Great staff. Game day decorations were fun."

Frequently asked questions

What hotels do travelers like in Santa Fe?

Guests like Holiday Inn Express & Suites Alachua - Gainesville Area by IHG.

Can I book a refundable hotel in Santa Fe?

If you want the flexibility to change your plans to Santa Fe, most accommodations provide refundable* bookable rates. You can see these properties by searching our site and using the "fully refundable" filter to narrow down the results.

What will the weather in Santa Fe be like during my visit?

July and August are typically the warmest months in Santa Fe when the average temp is 80°F. January and February are the coldest months when the average temperature is 59°F. August and June are the months with the most rain.

Why should I book my Santa Fe accommodation with Hotels.com?

There are lots of reasons to book your Santa Fe trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

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