Hotels in Effingham

Free cancellation options if plans change

Earn rewards on every night you stay

Save more with Member Prices

Check prices for these dates

Next weekend
In two weeks

Where to stay in Effingham?

Quality Inn Mullins - Marion
Quality Inn Mullins - Marion
2.5 star property
Marion
7.8 out of 10, Good, (397 reviews)
This clean, comfortable Marion hotel features free WiFi, breakfast, and parking, just 27 minutes from Florence Regional Airport. Guests consistently praise the exceptionally helpful staff and well-maintained rooms.
The price is $97
$106 total
includes taxes & fees
May 16 - May 17
Quality Inn Mullins - Marion
Holiday Inn Express & Suites Latta by IHG
Holiday Inn Express & Suites Latta by IHG
2.5 star property
Latta
9.4 out of 10, Exceptional, (581 reviews)
Escape to this Latta hotel with a refreshing seasonal outdoor pool and complimentary full breakfast served daily. Located just a 23-minute drive from Florence Regional Airport, guests praise the helpful staff and spotless rooms. Dillon Station is only 13 minutes away.
The price is $110
$120 total
includes taxes & fees
May 17 - May 18
Holiday Inn Express & Suites Latta by IHG
Best Western Executive Inn
Best Western Executive Inn
2.5 star property
Latta
8.2 out of 10, Very Good, (987 reviews)
Set in a peaceful area, this Latta hotel offers an indoor pool where you can unwind after exploring. Free breakfast, WiFi, and parking add value while the fitness center provides workout options. Clean rooms and a helpful staff create a restful business-friendly atmosphere.
The price is $106
$116 total
includes taxes & fees
May 3 - May 4
Best Western Executive Inn
The Inn at the Crossroads
The Inn at the Crossroads
2.0 star property
Lake City
9.4 out of 10, Exceptional, (879 reviews)
Set in a peaceful area with easy shopping and dining access, this Lake City hotel offers free breakfast, WiFi, and parking. Unwind at the 24-hour fitness center or grab American cuisine at the bistro. Guests rave about the helpful staff and clean, quiet rooms.
The price is $165
$185 total
includes taxes & fees
May 24 - May 25
The Inn at the Crossroads
Quality Inn & Suites Lake City
Quality Inn & Suites Lake City
2.5 star property
Lake City
7.2 out of 10, Good, (178 reviews)
Discover tranquility at this quiet Lake City hotel where complimentary continental breakfast starts each morning. The fitness center keeps you energized while helpful staff ensure a pleasant stay. Nearby attractions include Lynches Lake Historical Society and The Bean Market.
The price is $116
$130 total
includes taxes & fees
May 18 - May 19
Quality Inn & Suites Lake City
Days Inn by Wyndham Lake City
Days Inn by Wyndham Lake City
2.0 star property
Lake City
6.4 out of 10, (251 reviews)
Unwind at this welcoming Lake City motel offering a refreshing seasonal outdoor pool and convenient free perks. With complimentary WiFi, parking, and on-the-go breakfast daily, you're perfectly positioned near Lynches Lake Historical Society and The Bean Market.
The price is $110
$123 total
includes taxes & fees
May 10 - May 11
Days Inn by Wyndham Lake City
Hyatt Place Florence Downtown
Hyatt Place Florence Downtown
3.0 star property
Florence
9.0 out of 10, Wonderful, (1,003 reviews)
This business-friendly hotel offers free breakfast and WiFi just minutes from Florence Regional Airport. Comfortable rooms with sofa beds and refrigerators await after exploring nearby museums and libraries. The outdoor pool and terrace provide relaxation spots after a busy day.
The price is $122
$137 total
includes taxes & fees
May 4 - May 5
Hyatt Place Florence Downtown
Hotel Florence, Tapestry Collection by Hilton
Hotel Florence, Tapestry Collection by Hilton
3.0 star property
Florence
8.8 out of 10, Excellent, (629 reviews)
This Tapestry Collection hotel offers deep-tissue massages and body wraps at the full-service spa. Enjoy breakfast through dinner at Victors Bistro, grab a drink at the bar, and squeeze in a workout at the 24-hour fitness center, all with free WiFi and parking.
The price is $130
$146 total
includes taxes & fees
May 10 - May 11
Hotel Florence, Tapestry Collection by Hilton
Rodeway Inn Florence Downtown
Rodeway Inn Florence Downtown
2.0 star property
Florence
5.6 out of 10, (5 reviews)
Located minutes from Florence Regional Airport, this welcoming hotel offers free WiFi and easy access to Florence Museum. Nearby Florence Station connects you to the area while the Drs Bruce and Lee Foundation Library awaits exploration.
The price is $55
$63 total
includes taxes & fees
May 26 - May 27
Rodeway Inn Florence Downtown
Super 8 by Wyndham Florence
Super 8 by Wyndham Florence
2.0 star property
Florence
7.0 out of 10, Good, (1,002 reviews)
Located minutes from Florence Regional Airport, this motel offers comfortable beds and clean rooms praised by guests. Enjoy free Wi-Fi, parking, and daily on-the-go breakfast. The seasonal outdoor pool provides relaxation near Dr. Eddie Floyd Tennis Center and War Between the States Museum.
The price is $51
$57 total
includes taxes & fees
May 3 - May 4
Super 8 by Wyndham Florence
Clarion Inn & Suites Florence - Darlington
Clarion Inn & Suites Florence - Darlington
2.5 star property
Florence
4.4 out of 10, (321 reviews)
Located just 15 minutes from Darlington Raceway, this hotel offers a seasonal outdoor pool and on-site restaurant with bar. Free breakfast, WiFi, and parking add value, while rooms include convenient sofa beds and refrigerators.
The price is $47
$52 total
includes taxes & fees
May 13 - May 14
Clarion Inn & Suites Florence - Darlington
Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327 by IHG
Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327 by IHG
2.5 star property
Florence
8.6 out of 10, Excellent, (1,000 reviews)
Conveniently positioned near I-95 and Highway 327, this hotel features an indoor pool and 24-hour fitness center. Guests appreciate the helpful staff, clean rooms, free breakfast, and easy parking, with Eastern Carolina Agricultural Fairgrounds just minutes away.
The price is $122
$137 total
includes taxes & fees
Apr 30 - May 1
Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327 by IHG
Best Western Inn
Best Western Inn
2.5 star property
Florence
7.8 out of 10, Good, (1,000 reviews)
Escape to peaceful surroundings in Florence, just a 9-minute drive from the regional airport. Take a refreshing dip in the seasonal outdoor pool after enjoying the complimentary continental breakfast. With free WiFi and parking, plus easy access to local attractions, this hotel offers exceptional value.
The price is $99
$111 total
includes taxes & fees
Apr 26 - Apr 27
Best Western Inn
MainStay Suites Florence - Darlington
MainStay Suites Florence - Darlington
2.5 star property
Florence
3.8 out of 10, (85 reviews)
Convenient for business travelers with a fitness center and seasonal pool to recharge. Free breakfast, WiFi, and parking add value. Explore the Dr. Eddie Floyd Tennis Center or War Between the States Museum, both nearby this practical MainStay Suites.
The price is $76
$85 total
includes taxes & fees
May 24 - May 25
MainStay Suites Florence - Darlington
Suburban Studios Florence I-95
Suburban Studios Florence I-95
2.0 star property
Florence
5.6 out of 10, (593 reviews)
Wake up in Florence near the iconic Darlington Raceway and War Between the States Museum. This practical hotel offers free WiFi, complimentary parking, and 24-hour front desk service, plus onsite dining at Quiznos for lunch and dinner.
The price is $60
$68 total
includes taxes & fees
Apr 26 - Apr 27
Suburban Studios Florence I-95
Econo Lodge Florence - Darlington
Econo Lodge Florence - Darlington
2.0 star property
Florence
5.8 out of 10, (1,001 reviews)
Located in Florence, this hotel puts racing enthusiasts near Darlington Raceway and local attractions like Dr. Eddie Floyd Tennis Center. Enjoy convenient free parking, business facilities, and round-the-clock front desk service while exploring NASCAR country.
The price is $55
$62 total
includes taxes & fees
Apr 26 - Apr 27
Econo Lodge Florence - Darlington
Studio 6 Florence , SC
Studio 6 Florence , SC
2.5 star property
Florence
3.6 out of 10, (7 reviews)
The price is $55
$62 total
includes taxes & fees
Apr 26 - Apr 27
Studio 6 Florence , SC
Motel 6 Florence, SC
Motel 6 Florence, SC
2.0 star property
Florence
6.2 out of 10, (683 reviews)
This convenient Florence motel offers a 24-hour front desk and complimentary amenities including WiFi and parking. Located just minutes from Dr. Eddie Floyd Tennis Center and Palmetto Shores Lake, with Florence Station only a 7-minute drive away.
The price is $60
$67 total
includes taxes & fees
Apr 26 - Apr 27
Motel 6 Florence, SC
Spark by Hilton Florence North I-95, SC
Spark by Hilton Florence North I-95, SC
2.5 star property
Florence
8.2 out of 10, Very Good, (80 reviews)
The price is $89
$104 total
includes taxes & fees
May 3 - May 4
Spark by Hilton Florence North I-95, SC
La Quinta Inn & Suites by Wyndham Florence
La Quinta Inn & Suites by Wyndham Florence
3.0 star property
Florence
7.8 out of 10, Good, (1,601 reviews)
Situated conveniently near local restaurants and highways, this Florence hotel offers a seasonal outdoor pool and fitness center. Guests appreciate the comfortable beds, helpful staff, and complimentary breakfast, WiFi and parking.
The price is $97
$109 total
includes taxes & fees
May 3 - May 4
La Quinta Inn & Suites by Wyndham Florence
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Check out reviews of Effingham hotels guests love

Frequently asked questions

What accommodations do travelers like in Effingham?
Can I book refundable accommodations in Effingham?
If you need the flexibility to change your plans to Effingham, most properties offer refundable* bookable rates. You can see these accommodations by searching our site and using the "fully refundable" filter to narrow down the results.
What will the weather in Effingham be like during my trip?
July and August are typically the warmest months in Effingham when the average temp is 78°F. January and February are the coldest months when the average temperature is 50°F. August and July are the months with the most rain.
Why should I book my Effingham accommodation with Hotels.com?
There are lots of reasons to book your Effingham trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.