Top 10 Hotels in Center, MO in 2026 (from $49)

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Where to stay in Center?

An indoor swimming pool with a tiled floor, a rock wall, and a palm tree.

A hotel entrance with a central fountain, large columns, and a clear sky.

A spacious dining area with wooden flooring and tables, surrounded by glass walls and wooden paneling.

A hotel room with a bed, desk, chair, and a bathroom with a bathtub.

1. Quality Inn & Suites Hannibal West

Hannibal

$80

$94 total

includes taxes & fees

Oct 4 - Oct 5

A cozy, wooden-floored room with a blue patterned chair, a round glass table, and a variety of decorative items and knick-knacks on shelves and walls.

A cozy, rustic room with wooden floors and furniture, a dining table with chairs, and shelves filled with various items.

A cozy room with a fireplace, a sofa, and various decorative items including clocks and a sign that says "Plus".

A red barn with a porch and white chairs, labeled "VACANCY".

2. Kennedys Red Barn Inn

Perry

$91

$97 total

includes taxes & fees

Sep 12 - Sep 13

A hotel room with a bed, a sofa, a desk, and a lamp.

A Comfort Inn & Suites hotel with a stone facade, a covered entrance, and a clear blue sky.

A hotel reception area with a wooden reception desk, a red chair, and a carpeted floor.

An indoor swimming pool with wooden walls, a tiled floor, and a sign indicating no diving is allowed.

3. Comfort Inn & Suites - Hannibal

Hannibal

$76

$91 total

includes taxes & fees

Sep 20 - Sep 21

A Sleep Inn & Suites building with a covered entrance, stone facade, and a flag.

A modern lobby with a brown sofa, beige armchairs, a round table, and a floor lamp.

An indoor swimming pool with a lifeguard chair, poolside chairs, and a table with chairs.

A lobby with a reception desk, a seating area with sofas and armchairs, a large potted plant, and a door leading outside.

4. Sleep Inn & Suites Hannibal West

Hannibal

$111

$129 total

includes taxes & fees

Oct 11 - Oct 12

A hotel room with a large bed, a separate bathroom with a bathtub, and a desk with a chair.

A multi-level indoor pool area with a clear pool, multiple balconies, and a covered seating area.

A multi-level indoor pool area with a visible water slide, a towel rack, and a notice board.

A hotel kitchen with a buffet setup, including a coffee station and various food items.

5. Best Western On The River

Hannibal

$110

$127 total

includes taxes & fees

Sep 13 - Sep 14

A modern hotel with a flat roof, multiple windows, and a sign indicating it is a Super 8 hotel.

A hotel room with a large bed, a desk with a chair, a window with curtains, and a wall-mounted artwork.

A patio with red Adirondack chairs and a table, surrounded by a pebble border.

A modern dining area with round tables and chairs, a flat-screen TV mounted on the wall, and a brick accent wall.

6. Super 8 by Wyndham Hannibal

Hannibal

$62

$71 total

includes taxes & fees

Oct 4 - Oct 5

An indoor swimming pool with a tiled ceiling, multiple levels with windows, and seating areas around the pool.

A clean, modern reception area with a reception desk, a clock, and a potted plant.

A gym with cardio equipment, mirrored walls, and a view of a Pepsi store outside.

A kitchen with a granite countertop, wooden cabinets, and a herringbone-patterned floor.

7. Baymont by Wyndham Hannibal

Hannibal

$49

$57 total

includes taxes & fees

Sep 13 - Sep 14

A park with a pond, picnic tables, and a gazebo.

A small, well-lit kitchen with a dining table, chairs, a refrigerator, a microwave, and a television mounted on the wall.

A row of rustic, single-story buildings with a grassy lawn and picnic tables.

A grassy area with a picnic table and a dog.

8. Cannon Dam Cabins

Perry

$103

$109 total

includes taxes & fees

Sep 13 - Sep 14

A living room with a sofa, coffee table, and patterned rug. There are large windows with blinds, a chandelier, and a view of the outside.

A hotel hallway with a patterned carpet, doors, and a sign indicating room number 101.

A hotel room with two beds, a television, a lamp, and a painting on the wall.

A building with a covered entrance, American flag, and a sign indicating it's open.

9. FairBridge Inn Express, Monroe City

Monroe City

$87

$94 total

includes taxes & fees

Sep 24 - Sep 25

A spacious lobby with a black leather sofa, a matching armchair, a coffee table, and a chandelier.

A building with a covered entrance and a sign indicating a clearance height of 13 feet.

A spacious lobby with a fireplace, leather sofas, a coffee table, and a large window with blinds.

A coffee station with a coffee machine, cups, and a sign that says "RISE & SHINE."

10. Motel 6 Hannibal, MO

Hannibal

$58

$67 total

includes taxes & fees

Sep 13 - Sep 14

A hotel room with two beds, a wooden headboard, a nightstand with a phone and lamp, and a large sunset painting above the beds.

A reception area with a marble counter, a 'Days Inn' sign, and a welcome mat.

A laundry room with a washing machine, dryer, and a shelf with detergent bottles.

11. Days Inn by Wyndham Hannibal

Hannibal

$60

$69 total

includes taxes & fees

Sep 13 - Sep 14

A hotel room with two beds, a nightstand, and a lamp.

A parking lot with a building that has a clock tower and arched windows.

A hotel room with two beds, a nightstand, and a bathroom visible through an open door.

A hotel room with a bed, desk, chair, TV, and a mirror.

12. The Junction Inn

Perry

$87

$92 total

includes taxes & fees

Sep 12 - Sep 13

A large indoor swimming pool with multiple levels of balconies, surrounded by seating areas and potted plants.

A hotel room with two beds, a desk, a chair, and a telephone.

A kitchen with wooden cabinets, a granite countertop, and various food items and kitchen appliances.

13. Howard Johnson BY Wyndham Hannibal

Hannibal

$61

$71 total

includes taxes & fees

Sep 13 - Sep 14

A room with a beige leather sofa, a wooden coffee table, a floor lamp, and a patterned carpet.

A hotel room with a bed, two bedside lamps, a headboard, and a patterned carpet.

A compact kitchen with a refrigerator, microwave, and sink.

A wooden table with a bottle of champagne, two glasses, and scattered rose petals.

14. Riverside Inn Hannibal

Hannibal

$182

$245 total

includes taxes & fees

Sep 13 - Sep 14

A wooden staircase with a handrail, a small table with a lamp, and a chair in a room with a door and windows.

A fireplace with decorative elements, framed pictures, and a vase of red flowers.

A cozy living room with a fireplace, a red armchair, a globe, and various framed pictures on the mantel.

A large, two-story house with a porch and a sign indicating 'ONE WAY'.

15. Garden House Bed and Breakfast

Hannibal

$93

$107 total

includes taxes & fees

Sep 12 - Sep 13

A spacious living area with a large bed, a dining table, and a brick wall.

A rooftop terrace with a brick wall, a metal railing, and a table with chairs.

A kitchen with wooden cabinets, a stainless steel stove, a dishwasher, and a brick wall.

A spacious living room with a brick wall, wooden beams, and a large window. There are two sofas and a coffee table.

16. Deck + River View: Loft in Downtown Hannibal

Hannibal

$138

$265 total

includes taxes & fees

Sep 14 - Sep 15

A hotel room with a large bed, two bedside lamps, a modern bathroom, and a vibrant abstract painting on the wall.

A swimming pool with lounge chairs and a covered seating area.

A modern living room with a grey sofa, a white armchair, a coffee table, and a patterned rug. There is a kitchen in the background with white cabinets and a black door.

A compact kitchen with white cabinets, a microwave, a coffee maker, and a sink.

17. Lighthouse Inn & Suites

Hannibal

$199

$230 total

includes taxes & fees

Sep 13 - Sep 14

View all properties

Go beyond your typical stay in Center

Check out reviews of Center hotels guests love

Kennedys Red Barn Inn

Perry

10/10 Exceptional

Days Inn by Wyndham Hannibal

Hannibal

10/10 Exceptional

Kevin

Garden House Bed and Breakfast

Hannibal

10/10 Exceptional

Brad

Frequently Asked Questions

What hotels do travelers recommend in Center?

Guests like Cannon Dam Cabins and The Junction Inn.

Can I book a refundable hotel in Center?

If you need the flexibility to change your travel plans to Center, most accommodations provide refundable* rates you can book. You can find these properties by searching our site and using the "fully refundable" filter to narrow the results down.

What will the weather in Center be like during my visit?

July and August are typically the warmest months in Center when the average temp is 74°F. January and February are the coldest months when the average temperature is 35°F. May and June are the months with the most rain.

Why should I book my Center hotel with Hotels.com?

There are lots of reasons to book your Center trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.