Hotels in De Soto
Free cancellation options if plans change
Earn rewards on every night you stay
Save more with Member Prices
Check prices for these dates
Where to stay in De Soto?
Holiday Inn Express & Suites Murphysboro - Carbondale by IHG
Holiday Inn Express & Suites Murphysboro - Carbondale by IHG
2.5 star property
Murphysboro
9.4 out of 10, Exceptional, (512)
9.4/10
Exceptional
(512)
The price is $97
$97
$108 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Best Western Marion Hotel
Best Western Marion Hotel
2.5 star property
Marion
8.2 out of 10, Very Good, (1000)
8.2/10
Very Good
(1000)
The price is $71
$71
$85 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Comfort Inn & Suites Marion I-57
Comfort Inn & Suites Marion I-57
2.5 star property
Marion
9.4 out of 10, Exceptional, (1004)
9.4/10
Exceptional
(1004)
The price is $108
$108
$130 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Baymont by Wyndham Marion
Baymont by Wyndham Marion
2.5 star property
Marion
8.4 out of 10, Very Good, (1081)
8.4/10
Very Good
(1081)
The price is $76
$76
$91 total
includes taxes & fees
Jan 18 - Jan 19, 2026
Comfort Inn & Suites Carbondale University Area
Comfort Inn & Suites Carbondale University Area
2.5 star property
Carbondale
7.6 out of 10, Good, (519)
7.6/10
Good
(519)
The price is $80
$80
$92 total
includes taxes & fees
Dec 29 - Dec 30
Hampton Inn Carbondale
Hampton Inn Carbondale
2.5 star property
Carbondale
8.4 out of 10, Very Good, (615)
8.4/10
Very Good
(615)
The price is $102
$102
$117 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Super 8 by Wyndham Carbondale
Super 8 by Wyndham Carbondale
2.0 star property
Carbondale
7.4 out of 10, Good, (1005)
7.4/10
Good
(1005)
The price is $55
$55
$63 total
includes taxes & fees
Dec 30 - Dec 31
University Inn of Carbondale
University Inn of Carbondale
2.5 star property
Carbondale
6.0 out of 10, (329)
6.0/10
(329)
The price is $55
$55
$63 total
includes taxes & fees
Dec 29 - Dec 30
Holiday Inn Carbondale-Conference Center by IHG
Holiday Inn Carbondale-Conference Center by IHG
3.0 star property
Carbondale
8.8 out of 10, Excellent, (646)
8.8/10
Excellent
(646)
The price is $114
$114
$131 total
includes taxes & fees
Jan 26 - Jan 27, 2026
Walker's Bluff Casino Resort
Walker's Bluff Casino Resort
4.5 star property
Carterville
9.4 out of 10, Exceptional, (392)
9.4/10
Exceptional
(392)
The price is $125
$125
$139 total
includes taxes & fees
Dec 29 - Dec 30
Holiday Inn Express Hotel & Suites Marion Northeast by IHG
Holiday Inn Express Hotel & Suites Marion Northeast by IHG
2.5 star property
Marion
9.0 out of 10, Wonderful, (929)
9.0/10
Wonderful
(929)
The price is $104
$104
$125 total
includes taxes & fees
Jan 3 - Jan 4, 2026
Best Western Saluki Inn
Best Western Saluki Inn
2.5 star property
Carbondale
8.0 out of 10, Very Good, (1001)
8.0/10
Very Good
(1001)
The price is $87
$87
$102 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Home2 Suites by Hilton Carbondale
Home2 Suites by Hilton Carbondale
3.0 star property
Carbondale
8.8 out of 10, Excellent, (515)
8.8/10
Excellent
(515)
The price is $108
$108
$124 total
includes taxes & fees
Jan 18 - Jan 19, 2026
Fairfield Inn and Suites by Marriott Marion
Fairfield Inn and Suites by Marriott Marion
2.5 star property
Marion
8.4 out of 10, Very Good, (362)
8.4/10
Very Good
(362)
The price is $93
$93
$112 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Quality Inn & Suites Marion
Quality Inn & Suites Marion
2.5 star property
Marion
7.4 out of 10, Good, (1001)
7.4/10
Good
(1001)
The price is $59
$59
$70 total
includes taxes & fees
Jan 26 - Jan 27, 2026
Country Inn & Suites by Radisson, Marion, IL
Country Inn & Suites by Radisson, Marion, IL
2.5 star property
Marion
8.6 out of 10, Excellent, (1002)
8.6/10
Excellent
(1002)
The price is $99
$99
$119 total
includes taxes & fees
Jan 18 - Jan 19, 2026
Super 8 by Wyndham Marion
Super 8 by Wyndham Marion
2.0 star property
Marion
7.6 out of 10, Good, (1002)
7.6/10
Good
(1002)
The price is $74
$74
$89 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Gray Plaza Motel
Gray Plaza Motel
2.5 star property
West Frankfort
6.8 out of 10, (48)
6.8/10
(48)
The price is $71
$71
$79 total
includes taxes & fees
Dec 29 - Dec 30
Americas Best Value Inn West Frankfort
Americas Best Value Inn West Frankfort
2.5 star property
West Frankfort
7.6 out of 10, Good, (474)
7.6/10
Good
(474)
The price is $68
$68
$75 total
includes taxes & fees
Jan 12 - Jan 13, 2026
Drury Inn & Suites Marion
Drury Inn & Suites Marion
3.0 star property
Marion
9.4 out of 10, Exceptional, (1004)
9.4/10
Exceptional
(1004)
The price is $65
$65
$78 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Go beyond your typical stay in De Soto
Pet friendly
Family friendly
Check out reviews of De Soto hotels guests love
Drury Inn & Suites Marion
10/10 Excellent
"Very nice hotel! Friendly staff and great amenities. We will definitely stay again during our travels. "
Walker's Bluff Casino Resort
10/10 Excellent
"Absolutely perfect hotel casino. Very clean and new feeling. Impressive..."
Motel 6 Marion, IL
10/10 Excellent
"Clean and comfortable for a quick overnight stay."
Holiday Inn Carbondale-Conference Center by IHG
10/10 Excellent
"Staff was very friendly from the moment we walked in. The place was very clean. The breakfast that was included was surprising. I did not expect the variety that was offered for a smaller location. Would stay at again if in the area. "
Baymont by Wyndham Marion
10/10 Excellent
"Clean "
Fairgrounds Inn
10/10 Excellent
"Clean, comfortable, discreet, business friendly, and excellent staff. The only knock is the hotel could use a facelift and upgrades. Great stay overall tho."
Country Inn & Suites by Radisson, Marion, IL
10/10 Excellent
"This has always been the hotel we stay the night going to South Dakota or going to NC. It’s our middle point. It’s always so clean, friendly staff, and easy check in and out. "
Quality Inn And Suites
10/10 Excellent
"GRE "
Super 8 by Wyndham Carbondale
10/10 Excellent
"Absolutely amazing staff , very professional and friendly and helpful. Clean rooms and good breakfast. Clean environment."
Frequently asked questions
What accommodations do travelers like in De Soto?
Can I book refundable accommodations in De Soto?
If you need the flexibility to change your plans to De Soto, most accommodations offer refundable* rates you can book. You can find these properties by searching our site and using the "fully refundable" filter to narrow the results down.
What will the weather in De Soto be like during my vacation?
The warmest months in De Soto are usually July and August with an average temp of 76°F. January and February are the chilliest months when the average temp is 39°F. The rainiest months are April and March.
Why should I book my De Soto hotel through Hotels.com?
There are plenty of reasons to book your De Soto travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.