Hotels in Santa Clara

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Where to stay in Santa Clara?

A hotel with a swimming pool, a covered area, and a multi-story building with balconies.

A spacious lobby with high ceilings, a central seating area, and large windows offering views of the outdoors.

A spacious atrium with a glass ceiling, a staircase, and lush indoor plants.

A resort with a large swimming pool, multiple balconies, and lush landscaping.

1. Gamboa Rainforest Reserve

Colon

$139

$153 total

includes taxes & fees

Sep 25 - Sep 26

An outdoor patio with wooden tables and beige umbrellas, surrounded by lush greenery and palm trees.

A hotel room with two beds, a nightstand with a phone, and a wall-mounted light fixture.

A white van with floral graphics and text advertising a shuttle service to an airport.

A playground with multiple slides and climbing structures.

2. Riande Aeropuerto Hotel & Casino

Tocumen

$108

$119 total

includes taxes & fees

Sep 6 - Sep 7

A swimming pool with a water feature, surrounded by plants and seating areas.

A hotel courtyard with a swimming pool, outdoor seating, and a building with multiple balconies.

A buffet setup with various food items and a coffee station.

A bar area with a long counter, multiple bar stools, and a television screen displaying a sports event.

3. Holiday Inn Panama Canal by IHG

Panama City

$95

$116 total

includes taxes & fees

Oct 5 - Oct 6

A pool area with a covered patio, outdoor seating, and a bar area.

A building with a covered outdoor area, multiple windows, and a fire extinguisher mounted on the wall.

A modern hotel room with a bed, a desk, and a wardrobe.

A modern hotel room with a dining area, a bed, and a large window.

4. Albrook Inn

Panama City

$67

$74 total

includes taxes & fees

Sep 25 - Sep 26

A buffet with various food items including fruits, juices, and cheeses.

A modern hotel lobby with a sectional sofa, a glass coffee table, and a vibrant green wall mural.

A gym with treadmills, weight machines, and dumbbells.

A hotel reception area with a wooden reception desk, seating area with chairs and ottomans, and a large window providing natural light.

5. Courtyard by Marriott Panama Metromall

San Antonio

$105

$116 total

includes taxes & fees

Sep 12 - Sep 13

A poolside area with lounge chairs and a covered seating area, reflecting the pool and surrounding structures.

A spacious dining area with large windows offering a view of lush greenery.

A room with a large glass window, a wooden chair, and a glass table with a plant.

A spacious lobby with a large glass wall offering a view of the forest. There are multiple seating areas and a bar.

6. Summit Rainforest Golf Resort & All Inclusive

Panama City

$215

$236 total

includes taxes & fees

Sep 13 - Sep 14

A resort with a pool area, lounge chairs, and a view of a bridge at night.

A hotel room with a bed, a TV on a wooden cabinet, a nightstand with a lamp, and a view of the outdoors through a glass door.

A reception desk with three staff members, a green patterned wall, a wooden reception area, and a large plant.

A bar area with a counter, stools, and a seating area with tables and chairs.

7. Radisson Hotel Panama Canal

Amador

$94

$104 total

includes taxes & fees

Sep 6 - Sep 7

A hotel entrance with a central water feature, seating areas, and potted plants.

An outdoor dining area with wicker chairs and tables, a bar with bottles, and a pool in the background.

A pool with a central water feature, surrounded by seating areas and potted plants.

The entrance of The Santa Maria with a covered walkway and a view of the interior.

8. The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

Juan Diaz

$262

$288 total

includes taxes & fees

Sep 6 - Sep 7

A modern, well-lit buffet area with a variety of food items and neatly arranged plates.

An outdoor swimming pool with lounge chairs and umbrellas, surrounded by potted plants.

A modern living room with a sofa, armchairs, a coffee table, and a dining area with a table and chairs.

A spacious indoor area with a high ceiling, potted plants, and a seating arrangement.

9. Best Western El Dorado Panama Hotel

Bethania

$100

$110 total

includes taxes & fees

Sep 10 - Sep 11

A rooftop pool area with lounge chairs and a bar, overlooking a city skyline at sunset.

A rooftop terrace with outdoor seating, potted plants, and a view of a hill with buildings in the distance.

A modern hotel lobby with a glass railing, seating area, and contemporary lighting fixtures.

A buffet setup with various dishes and utensils.

10. Marriott Panama Hotel

Panama City

$161

$177 total

includes taxes & fees

Sep 13 - Sep 14

A balcony with a view of a marina and a hilly landscape.

A modern building with a large metallic sculpture in the foreground, surrounded by palm trees and a clear blue sky.

A couple seated on wicker chairs with a view of a body of water and greenery in the background.

A couple in white robes on a bed with a champagne bottle and ice bucket.

11. The Beach House

Amador

$77

$85 total

includes taxes & fees

Sep 6 - Sep 7

A reception area with a wooden desk, two chairs, and a plant.

A modern interior with a reception desk, seating area, and potted plants.

A balcony with a metal railing overlooking a body of water, with a clear sky in the background.

A hotel entrance with a tropical theme, including a sign that reads "Tropical Vibes Hotel," a well-lit pathway, and a staircase leading to the upper floor.

12. MARINN Tropical Vibes Hotel

Amador

$89

$98 total

includes taxes & fees

Sep 6 - Sep 7

A buffet with various food items and a decorative plant.

A spacious lobby with a high ceiling, a glass railing on the upper level, and a seating area with modern furniture.

A hotel with a swimming pool, outdoor seating, and a modern architectural design.

A gym with treadmills, weight machines, and a red carpet.

13. Sheraton Grand Panama

San Francisco

$176

$193 total

includes taxes & fees

Sep 12 - Sep 13

A balcony with wicker chairs and a view of the cityscape.

A hotel room with a large bed, a desk with a lamp, a chair, and a view of a cityscape through a window.

A rooftop pool area with a view of high-rise buildings in the background.

A multi-story hotel with a modern facade, large windows, and a prominent entrance with a covered area.

14. Ramada Plaza by Wyndham Panama Punta Pacifica

San Francisco

$104

$114 total

includes taxes & fees

Sep 7 - Sep 8

A hotel with a pool, beach, and palm trees.

A beachfront hotel with a large building, a beach, and a clear sky.

A spacious lobby with a modern design, featuring a central seating area with sofas and ottomans, surrounded by large, open spaces and natural light.

A spacious lobby with a large seating area, a reception desk, and large windows offering a view of the ocean and palm trees.

15. The Westin Playa Bonita Panama

Veracruz

$197

$217 total

includes taxes & fees

Sep 25 - Sep 26

A rooftop pool with a city view, lounge chairs, and a clear sky.

A modern lounge area with a bar, seating, and a large window offering a city view.

A modern kitchen with a marble countertop, a refrigerator, and a dining area with a table set for two.

A modern gym with treadmills, weight machines, and exercise balls.

16. Corporate Stays Arcadia | Executive Furnished Apartments

Costa del Este

$110

$128 total

includes taxes & fees

Sep 24 - Sep 25

A rooftop pool with sun loungers and a city skyline in the background.

A modern hotel room with a large bed, a desk, a chair, and a wardrobe.

A bar area with a curved counter, multiple screens, and a patterned carpet.

A spacious lobby with a blue sofa, multiple armchairs, and a coffee table.

17. Waymore Hotel Spa & Casino

Bella Vista

$62

$123 total

includes taxes & fees

Sep 7 - Sep 8

A rooftop pool with sun loungers and umbrellas, surrounded by palm trees and modern buildings.

A modern living room with a sofa set, a coffee table, and a dining area with chairs and a table.

A modern hotel room with a dining area, a TV, and a city view.

A spacious lobby with a central seating area, a chandelier, and a modern ceiling design.

18. Hotel Riu Plaza Panama

Bella Vista

$123

$135 total

includes taxes & fees

Sep 28 - Sep 29

A covered outdoor seating area with a view of a city skyline and water.

A nighttime view of a high-rise building complex with illuminated windows and a prominent red-lit structure.

A restaurant with large windows offering a view of a city skyline and palm trees.

A cityscape with high-rise buildings, a waterfront, and a modern sculpture.

19. Plaza Paitilla Inn Hotel

San Francisco

$103

$114 total

includes taxes & fees

Sep 28 - Sep 29

A spacious living room with blue sofas, a marble coffee table, and framed pictures on the walls.

A blue building with arched windows and balconies, labeled 'Magnolia.'

A hotel room with a large bed, a TV, a balcony with a view of the outside, and a window with decorative ironwork.

20. Hotel Magnolia Boutique

Casco Viejo

$81

$89 total

includes taxes & fees

Oct 4 - Oct 5

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Go beyond your typical stay in Santa Clara

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Spa

Pool

Hot tub

Family friendly

Top landmarks in Santa Clara

Culebra Cut

8.0/10 (14 reviews)

If you're planning a bit of sightseeing during your trip, head to Culebra Cut— just one of the landmarks located 5.8 mi (9.3 km) from central Santa Clara.

See properties

Learn more about Santa Clara

The region around Santa Clara is home to attractions such as Culebra Cut and Albrook Shopping Mall.

See all hotels in Santa Clara

A beach with waves, a boat, and a forested hill in the background.

Check out reviews of Santa Clara hotels guests love

Hospedium Princess Hotel Panama

10/10 Excellent

"Encantada con todo pronto volveré😍"

Central Hotel Panama Casco Viejo

10/10 Excellent

"Clean rooms, great breakfast. Great air conditioning, small small pool. Great location. Friendly staff.. lots to do near by. Stairs and elevators"

Riande Aeropuerto Hotel & Casino

10/10 Excellent

"Great hotel, very close to the airport. Very comfortable. I'd gladly stay again. The hinge on the shower door was loose, therefore preventing the shower door from staying closed I didn't know how to say that in Spanish but if I tried asking then for help I'm certain that they would have fixed it for me."

Hotel Faranda Express Soloy and Casino, a member of Radisson Individuals

10/10 Excellent

"Todas las personas que trabajan en el Hotel son muy amables, disfrute mi descanso en ese hotel con una vista desde la habitación al océano Pacífico increíble, el desayuno muy bueno, solo deben mejorar la piscina, por lo demás a mi gusto excelente."

Dreams Playa Bonita Panama - All Inclusive

10/10 Excellent

"Good food and friendly staff"

Decapolis Hotel Panama City

8/10 Good

"My son and I stayed one night at the Decapolis Hotel, and while the property itself is impressive, the overall experience was mixed. The hotel is immaculately clean, centrally located, and offers great views of the city. We enjoyed the modern amenities, including the large pool, glass elevator, and the convenient skywalk that connects directly to a shopping center. Unfortunately, the service did not match the quality of the facilities. Staff members were curt and unhelpful, and when we asked questions, we were often shrugged off or redirected without explanation. Other guests were assisted while we were ignored, which left a negative impression. The hotel’s open‑lobby design also created a major issue: an event took place late into the night, and the noise carried all the way up to the rooms. We weren’t able to sleep until it ended past midnight. Check‑in was another challenge. Tour groups arrived at the same time, and although two staff members were present, only one was willing to check us in. The other employee was checking in random guests but refused to assist us, pointing us toward the long tour‑group line instead. Checkout, however, was quick and easy. Overall, the hotel has excellent facilities and a great location, but the service and noise issues significantly impacted our stay."

The Executive Hotel

10/10 Excellent

"My five stars said it all. Maybe microwave could be added to the room. Breakfast was lovely"

Ramada Plaza by Wyndham Panama Punta Pacifica

10/10 Excellent

"9.5 out 10. Our Check-In was a bit to slow. Otherwise everything else was fine. Breakfast here is always a highlight. Breakfast here."

Hotel El Panama by Faranda Grand, a member of Radisson Individuals

8/10 Good

"This is our 2nd stay at your hotel and our stay was great as usual. Breakfast was consistent and satisfying. Staff was very helpful and pleasant. Keep it up."

Frequently asked questions

Can I book a refundable accommodation in Santa Clara?

If you want the flexibility to change your plans to Santa Clara, most properties offer refundable* rates you can book. You can find these properties by searching our site and using the "fully refundable" filter to narrow the results down.

What will the weather in Santa Clara be like during my trip?

With an average temperature of 78°F, Santa Clara is a great place if you want to enjoy the sunshine year all year long.

Why should I book my Santa Clara accommodation with Hotels.com?

There are plenty of reasons to book your Santa Clara travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.