Hotels in Santa Ana

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Top 5 hotels in Santa Ana at a glance

Hotel Caracas - Casco Viejo — 3-star hotel in Santa Ana. Guest rating: 8.0/10 — Very Good.
Hostal La Cigarra — 2-star hotel in Santa Ana. Guest rating: 7.6/10 — Good.
Casco View Apartments — 3.5-star hotel in Santa Ana. Guest rating: 9.0/10 — Wonderful.
Hotel República — 2-star hotel in Santa Ana. Guest rating: 6.8/10.
La Manzana Barrio Vivo by Wynwood — 3-star hotel in Santa Ana. Guest rating: 7.6/10 — Good.

Where to stay in Santa Ana?

Hotel Caracas - Casco Viejo

Santa Ana

$36

$40 total

includes taxes & fees

Aug 30 - Aug 31

A restaurant with a long counter, chairs, and tables. There are plants and lights decorating the space.

A living room with wicker furniture, a yellow sofa, and a bookshelf.

A staircase with white walls and a blue wall at the top. There are green and black safety lines on the stairs.

A hotel lobby with a map of the Caribbean, a fan, and a table with snacks and a flower vase.

Hostal La Cigarra

Santa Ana

Mark

$31

$34 total

includes taxes & fees

Aug 30 - Aug 31

A modern indoor pool area with clear blue water, lounge chairs, and a wall of plants.

A modern bedroom with a large window, a bed with white linens, a nightstand, and a painting on the wall.

A modern kitchen with a central island, stainless steel appliances, and a dining area with black chairs.

A balcony with a view of the sea, a table with a vase and a candle, and a chair.

Casco View Apartments

Santa Ana

melvin

$65

$101 total

includes taxes & fees

Aug 31 - Sep 1

A hotel room with a large bed, a window with curtains, a city view, and a lamp.

A multi-story building with a flat facade, multiple balconies, and a sign indicating it is a public building.

A corridor with tiled flooring, doors, and a fire extinguisher mounted on the wall.

A plaza with a central open space surrounded by buildings, a crosswalk, and a road with vehicles.

Hotel República

Santa Ana

Danilo

$29

$92 total

includes taxes & fees

Aug 30 - Aug 31

A modern hotel room with a large bed, a sofa, a TV, and a view of the city.

A modern kitchen with a bar area, green bar stools, a stainless steel refrigerator, and a patterned floor.

A spacious living area with wicker furniture, a glass coffee table, and large windows providing natural light.

A modern hotel room with a large bed, a wooden headboard, a hanging plant, and a view of the kitchen area.

La Manzana Barrio Vivo by Wynwood

Santa Ana

Javier Alberto Lindauer

$68

$103 total

includes taxes & fees

Aug 30 - Aug 31

A hotel entrance with a green facade and a metal fence.

A spacious living area with a staircase, a dining table, and a television.

A living room with a television on a stand, a Christmas tree, and a small table with two chairs.

A reception desk with a green wall and a sign that reads "CASCO HOTEL".

ART CASCO The Hotel

Santa Ana

Eldris

$25

$27 total

includes taxes & fees

Aug 30 - Aug 31

A bar area with a curved counter, multiple seating options, and a variety of bottles and glasses on display.

A multi-story hotel with a blue and yellow facade, balconies, and a sign reading "HOTEL RIAZOR".

A bathroom with a shower, a window with a view, and a potted plant on the windowsill.

A hotel room with two beds, a bathroom, and a shower area.

Hotel Riazor

Santa Ana

Del

$27

$30 total

includes taxes & fees

Aug 30 - Aug 31

A modern lobby with a green wall, a sofa, and a reception desk.

A high-rise building with a glass balcony overlooking a city skyline and a body of water.

A high-rise building with a grid of windows and balconies.

Room-sofa Bed Stay Rooftop Pool & Gym, A

Santa Ana

Cristian Camilo Betancur

$120

$132 total

includes taxes & fees

Sep 29 - Sep 30

A spacious living room with blue sofas, a marble coffee table, and framed pictures on the walls.

A hotel room with a large bed, a TV, a balcony with a view of the outside, and a window with decorative ironwork.

A blue building with arched windows and balconies, labeled 'Magnolia.'

Hotel Magnolia Boutique

San Felipe, 0.7 km from Santa Ana

Sharon

$78

$86 total

includes taxes & fees

Aug 30 - Aug 31

A multi-story building with balconies, arched windows, and decorative railings.

A rooftop swimming pool with lounge chairs, potted plants, and a view of a city skyline including a prominent building with a dome.

A spacious lobby with a wooden staircase, multiple seating areas, and a reception desk.

A building with a balcony and a street view.

Central Hotel Panama Casco Viejo

San Felipe, 0.9 km from Santa Ana

joaquin

$183

$202 total

includes taxes & fees

Sep 27 - Sep 28

A wooden door with a number plate, a black and white striped bag, and a lantern on the ground.

A rooftop terrace with a city skyline view, a pool, and outdoor seating.

A bedroom with a large bed, a stone wall, a wooden bench, and a hanging light fixture.

A rooftop bar with potted plants, seating, and a view of a city skyline.

Hotel Casa Panamá

San Felipe, 0.6 km from Santa Ana

Liza

$61

$67 total

includes taxes & fees

Sep 16 - Sep 17

A rooftop bar with a city skyline view, outdoor seating, and a bar area with bottles and glasses.

A restaurant interior with tables and chairs, decorative hanging lights, and a mural on the wall.

A room with a kitchenette, a sofa, a bed, and a mural with the phrase "Just Breathe".

A hotel room with a large bed, a painting on the wall, a door, and a small table with a lamp.

Tantalo Hotel

San Felipe, 0.7 km from Santa Ana

SUSAN

$93

$103 total

includes taxes & fees

Sep 6 - Sep 7

A hotel room with a bed, a desk with a computer, a chair, a mirror, and a staircase.

A balcony with a view of a city skyline, a river, and a large tree.

A spacious living area with a staircase leading to a loft, a large mirror, and a television.

A spacious living area with a staircase leading to a second floor, a sofa, a TV, and a dining area.

Hotel Bardot Boutique

San Felipe, 1.1 km from Santa Ana

Gabriela

$84

$92 total

includes taxes & fees

Sep 14 - Sep 15

A balcony with a view of a cityscape, including a river and a bridge.

A spacious living area with a patterned rug, a round ottoman, a sofa, and a coffee table. There is a door leading to another room and a wall-mounted security camera.

A living room with a sofa, coffee table, TV, and artwork on the walls.

A bedroom with a sloped ceiling, a bed with white bedding, a small wooden drying rack, a patterned rug, and an air conditioning unit.

Oasis Hotel

San Felipe, 0.6 km from Santa Ana

MARGARET

$59

$65 total

includes taxes & fees

Sep 2 - Sep 3

A spacious outdoor patio with wicker furniture, potted plants, and umbrellas providing shade.

A hotel with a covered entrance, multiple windows, and a balcony with plants.

A dimly lit restaurant with wooden decor, tables, and chairs arranged for dining.

A modern hotel lobby with beige sofas, marble flooring, and a reception desk.

Hotel San Felipe

San Felipe, 0.7 km from Santa Ana

Helle

$145

$160 total

includes taxes & fees

Aug 30 - Aug 31

A rooftop pool area with lounge chairs and a bar, overlooking a city skyline at sunset.

A buffet setup with various dishes and utensils.

A rooftop terrace with outdoor seating, potted plants, and a view of a hill with buildings in the distance.

A modern hotel lobby with a glass railing, seating area, and contemporary lighting fixtures.

Marriott Panama Hotel

2.1 km from Santa Ana

Jovanny Ariel

$161

$177 total

includes taxes & fees

Sep 13 - Sep 14

A resort with a pool area, lounge chairs, and a view of a bridge at night.

A multi-story hotel with a red-tiled roof, balconies, and a well-maintained lawn.

A balcony with two wooden chairs, overlooking a marina with boats and palm trees.

Radisson Hotel Panama Canal

Amador, 2.3 km from Santa Ana

Maxima

$94

$103 total

includes taxes & fees

Aug 30 - Aug 31

A restaurant interior with checkered flooring, wooden tables, wicker chairs, and hanging wicker lamps.

A room with a brick wall, a wooden staircase, and hanging pendant lights.

A multi-level interior with a checkered floor, wooden railings, and potted plants.

A rooftop terrace with a hot tub, wooden deck, outdoor seating, and a view of a cityscape including a clock tower.

Amarla Boutique Hotel Casco Viejo Adults Only

San Felipe, 1 km from Santa Ana

Natalie

$213

$234 total

includes taxes & fees

Sep 27 - Sep 28

A balcony with a table, chairs, and a view of a city skyline across a body of water.

A spacious lobby with high ceilings, modern furniture, and decorative lighting fixtures.

A spacious living room with a high ceiling, large windows, and a decorative ceiling fan.

A spacious lobby with a round coffee table, seating areas, and a large wall clock.

Sofitel Legend Casco Viejo, Panama City

San Felipe, 1.1 km from Santa Ana

Eduardo

$347

$381 total

includes taxes & fees

Sep 20 - Sep 21

A spacious indoor area with high ceilings, large windows, and multiple dining tables.

A white building with multiple balconies, large windows, and decorative railings.

A multi-story hotel with a central courtyard, balconies, and a view of the city skyline.

A spacious lobby with a tiled floor, large windows, and potted plants.

American Trade Hotel

San Felipe, 0.7 km from Santa Ana

iriela

$246

$270 total

includes taxes & fees

Sep 3 - Sep 4

View all properties

Compare popular hotels in Santa Ana

Property	Property class	Guest rating
Hostal La Cigarra	7.6 Good 73 reviews	View
Casco View Apartments	9.0 Wonderful 105 reviews	View
Hotel Caracas - Casco Viejo	8.0 Very Good 7 reviews	View
Hotel Riazor	3.8 11 reviews	View
Hotel República	6.8 196 reviews	View

Our prices for hotels in Santa Ana are cheapest in February

Top landmarks in Santa Ana

El Machetazo Santa Ana

If you want to give your credit card some exercise, head out to El Machetazo Santa Ana in Santa Ana. Splash some more cash at Avenida Central and Paseo de Las Bovedas.

See properties

Check out reviews of Santa Ana hotels guests love

Courtyard by Marriott Panama Metromall

10/10 Excellent

"Hermoso todo"

Hotel Riu Plaza Panama

10/10 Excellent

"The breakfast was excellent and the staff was great. All in all, the hotel is an A+"

Dreams Playa Bonita Panama - All Inclusive

10/10 Excellent

"A Beautiful and Memorable Stay My wife and I had the pleasure of spending an entire week at this beautiful hotel, and our experience was truly memorable from beginning to end. What stood out to us most was the exceptional customer service. Every member of staff we encountered was incredibly polite, welcoming, and always willing to assist in any way they could. Their kindness and attentiveness made us feel genuinely cared for throughout our stay and added something special to the entire experience. The atmosphere of the property was absolutely beautiful—peaceful, relaxing, and very well maintained. You can clearly see the attention that goes into keeping the hotel and its surroundings in excellent condition. We were especially impressed by the pools. They were consistently spotless, beautifully maintained, and easily became one of our favorite parts of the resort. Being able to relax by such clean and inviting pools while enjoying the atmosphere made our vacation even more enjoyable. Overall, my wife and I thoroughly enjoyed our week here. Between the beautiful surroundings, cleanliness, relaxing atmosphere, and outstanding hospitality, we left with wonderful memories of our stay. Thank you to the entire team for making our vacation such an enjoyable one. We would definitely visit again and would happily recommend this hotel to anyone looking for a beautiful and welcoming place to stay."

Crowne Plaza Panama Airport by IHG

8/10 Good

"Staff was friendly."

Central Hotel Panama Casco Viejo

10/10 Excellent

"Breakfast is superb, a must have. Attentive staff, perfect location. Rooms facing main square can receive street noise but dies down by 11pm (but you get the best view)"

The Executive Hotel

10/10 Excellent

"Everything was fine"

Principe Hotel and Suites

10/10 Excellent

"This hotel was awesome all round 10 out of 10. Close or mins away from basically everything you would like, supermarket/restaurants/24 hours mini marts/bus station/Metro station etc. For the price this hotel was the best, quality service for your money. I just was would like a small refrigerator inside the room to put the cherry on top but trust me this hotel is the go!"

Ramada Plaza by Wyndham Panama Punta Pacifica

10/10 Excellent

"👌"

Renaissance Panama City Hotel

10/10 Excellent

"I was very satisfied"

Find out more about Santa Ana

Hotels in Santa Ana

Free cancellation options if plans change

Earn rewards on every night you stay

Save more with Member Prices

Check prices for these dates

Top 5 hotels in Santa Ana at a glance

Where to stay in Santa Ana?

Hotel Caracas - Casco Viejo

Hostal La Cigarra

Casco View Apartments

Hotel República

La Manzana Barrio Vivo by Wynwood

ART CASCO The Hotel

Hotel Riazor

Room-sofa Bed Stay Rooftop Pool & Gym, A

Hotel Magnolia Boutique

Central Hotel Panama Casco Viejo

Hotel Casa Panamá

Tantalo Hotel

Hotel Bardot Boutique

Oasis Hotel

Hotel San Felipe

Marriott Panama Hotel

Radisson Hotel Panama Canal

Amarla Boutique Hotel Casco Viejo Adults Only

Sofitel Legend Casco Viejo, Panama City

American Trade Hotel

Compare popular hotels in Santa Ana

Price trends for hotels in Santa Ana

Typical weather for Panama City

Top landmarks in Santa Ana

El Machetazo Santa Ana

Check out reviews of Santa Ana hotels guests love

Courtyard by Marriott Panama Metromall

Hotel Riu Plaza Panama

Dreams Playa Bonita Panama - All Inclusive

Crowne Plaza Panama Airport by IHG

Central Hotel Panama Casco Viejo

The Executive Hotel

Principe Hotel and Suites

Ramada Plaza by Wyndham Panama Punta Pacifica

Renaissance Panama City Hotel